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UniProtKB - P32304 (5HT7R_MOUSE)
Protein
5-hydroxytryptamine receptor 7
Gene
Htr7
Organism
Mus musculus (Mouse)
Status
Functioni
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
GO - Molecular functioni
- G protein-coupled serotonin receptor activity Source: GO_Central
- neurotransmitter receptor activity Source: GO_Central
GO - Biological processi
- chemical synaptic transmission Source: GO_Central
- circadian rhythm Source: InterPro
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
- smooth muscle contraction Source: InterPro
- vasoconstriction Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-390666, Serotonin receptors R-MMU-418555, G alpha (s) signalling events R-MMU-9706019, RHOBTB3 ATPase cycle |
Names & Taxonomyi
Protein namesi | Recommended name: 5-hydroxytryptamine receptor 7Short name: 5-HT-7 Short name: 5-HT7 Alternative name(s): 5-HT-X Serotonin receptor 7 |
Gene namesi | Name:Htr7 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99841, Htr7 |
VEuPathDBi | HostDB:ENSMUSG00000024798 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 84 | ExtracellularBy similarityAdd BLAST | 84 | |
Transmembranei | 85 – 111 | Helical; Name=1By similarityAdd BLAST | 27 | |
Topological domaini | 112 – 121 | CytoplasmicBy similarity | 10 | |
Transmembranei | 122 – 147 | Helical; Name=2By similarityAdd BLAST | 26 | |
Topological domaini | 148 – 159 | ExtracellularBy similarityAdd BLAST | 12 | |
Transmembranei | 160 – 181 | Helical; Name=3By similarityAdd BLAST | 22 | |
Topological domaini | 182 – 201 | CytoplasmicBy similarityAdd BLAST | 20 | |
Transmembranei | 202 – 225 | Helical; Name=4By similarityAdd BLAST | 24 | |
Topological domaini | 226 – 240 | ExtracellularBy similarityAdd BLAST | 15 | |
Transmembranei | 241 – 263 | Helical; Name=5By similarityAdd BLAST | 23 | |
Topological domaini | 264 – 331 | CytoplasmicBy similarityAdd BLAST | 68 | |
Transmembranei | 332 – 355 | Helical; Name=6By similarityAdd BLAST | 24 | |
Topological domaini | 356 – 367 | ExtracellularBy similarityAdd BLAST | 12 | |
Transmembranei | 368 – 390 | Helical; Name=7By similarityAdd BLAST | 23 | |
Topological domaini | 391 – 448 | CytoplasmicBy similarityAdd BLAST | 58 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068980 | 1 – 448 | 5-hydroxytryptamine receptor 7Add BLAST | 448 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 69 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 158 ↔ 234 | PROSITE-ProRule annotation | ||
Lipidationi | 404 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | P32304 |
PRIDEi | P32304 |
ProteomicsDBi | 285691 |
PTM databases
GlyGeni | P32304, 2 sites |
iPTMneti | P32304 |
PhosphoSitePlusi | P32304 |
SwissPalmi | P32304 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000024798, Expressed in medial dorsal nucleus of thalamus and 207 other tissues |
ExpressionAtlasi | P32304, baseline and differential |
Genevisiblei | P32304, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000126847 |
Chemistry databases
BindingDBi | P32304 |
Miscellaneous databases
RNActi | P32304, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222287 |
InParanoidi | P32304 |
OMAi | GCWEQIN |
PhylomeDBi | P32304 |
TreeFami | TF331895 |
Family and domain databases
InterProi | View protein in InterPro IPR001069, 5HT_7_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00652, 5HT7RECEPTR PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
P32304-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMDVNSSGRP DLYGHLRSLI LPEVGRRLQD LSPDGGAHSV VSSWMPHLLS
60 70 80 90 100
GFPEVTASPA PTWDAPPDNV SGCGEQINYG RVEKVVIGSI LTLITLLTIA
110 120 130 140 150
GNCLVVISVC FVKKLRQPSN YLIVSLALAD LSVAVAVMPF VSVTDLIGGK
160 170 180 190 200
WIFGHFFCNV FIAMDVMCCT ASIMTLCVIS IDRYLGITRP LTYPVRQNGK
210 220 230 240 250
CMAKMILSVW LLSASITLPP LFGWAQNVND DKVCLISQDF GYTIYSTAVA
260 270 280 290 300
FYIPMSVMLF MYYQIYKAAR KSAAKHKFSG FPRVQPESVI SLNGVVKLQK
310 320 330 340 350
EVEECANLSR LLKHERKNIS IFKREQKAAT TLGIIVGAFT VCWLPFFLLS
360 370 380 390 400
TARPFICGTS CSCIPLWVER TCLWLGYANS LINPFIYAFF NRDLRTTYRS
410 420 430 440
LLQCQYRNIN RKLSAAGMHE ALKLAERPER SEFVLQNCDH CGKKGHDT
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB6VJS3 | B6VJS3_MOUSE | 5-hydroxytryptamine receptor 7 | Htr7 | 470 | Annotation score: | ||
B6VJS2 | B6VJS2_MOUSE | 5-hydroxytryptamine receptor 7 | Htr7 | 435 | Annotation score: | ||
E9Q1X2 | E9Q1X2_MOUSE | 5-hydroxytryptamine receptor 7 | Htr7 | 344 | Annotation score: | ||
E9Q4Q7 | E9Q4Q7_MOUSE | 5-hydroxytryptamine receptor 7 | Htr7 | 198 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 114 – 115 | KL → NV in CAA80654 (PubMed:8394987).Curated | 2 | |
Sequence conflicti | 211 | L → P in CAA80654 (PubMed:8394987).Curated | 1 | |
Sequence conflicti | 321 | I → S in CAA80654 (PubMed:8394987).Curated | 1 | |
Sequence conflicti | 388 | A → S in CAA80654 (PubMed:8394987).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z23107 mRNA Translation: CAA80654.1 CH466534 Genomic DNA Translation: EDL41763.1 BC116986 mRNA Translation: AAI16987.1 |
CCDSi | CCDS29769.1 |
PIRi | I48779, S36402 |
RefSeqi | NP_032341.2, NM_008315.2 |
Genome annotation databases
Ensembli | ENSMUST00000164639; ENSMUSP00000126847; ENSMUSG00000024798 |
GeneIDi | 15566 |
KEGGi | mmu:15566 |
UCSCi | uc008hhd.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z23107 mRNA Translation: CAA80654.1 CH466534 Genomic DNA Translation: EDL41763.1 BC116986 mRNA Translation: AAI16987.1 |
CCDSi | CCDS29769.1 |
PIRi | I48779, S36402 |
RefSeqi | NP_032341.2, NM_008315.2 |
3D structure databases
SMRi | P32304 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000126847 |
Chemistry databases
BindingDBi | P32304 |
ChEMBLi | CHEMBL4764 |
DrugCentrali | P32304 |
GuidetoPHARMACOLOGYi | 12 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P32304, 2 sites |
iPTMneti | P32304 |
PhosphoSitePlusi | P32304 |
SwissPalmi | P32304 |
Proteomic databases
PaxDbi | P32304 |
PRIDEi | P32304 |
ProteomicsDBi | 285691 |
Protocols and materials databases
Antibodypediai | 16324, 429 antibodies from 36 providers |
DNASUi | 15566 |
Genome annotation databases
Ensembli | ENSMUST00000164639; ENSMUSP00000126847; ENSMUSG00000024798 |
GeneIDi | 15566 |
KEGGi | mmu:15566 |
UCSCi | uc008hhd.1, mouse |
Organism-specific databases
CTDi | 3363 |
MGIi | MGI:99841, Htr7 |
VEuPathDBi | HostDB:ENSMUSG00000024798 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222287 |
InParanoidi | P32304 |
OMAi | GCWEQIN |
PhylomeDBi | P32304 |
TreeFami | TF331895 |
Enzyme and pathway databases
Reactomei | R-MMU-390666, Serotonin receptors R-MMU-418555, G alpha (s) signalling events R-MMU-9706019, RHOBTB3 ATPase cycle |
Miscellaneous databases
BioGRID-ORCSi | 15566, 2 hits in 65 CRISPR screens |
ChiTaRSi | Htr7, mouse |
PROi | PR:P32304 |
RNActi | P32304, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024798, Expressed in medial dorsal nucleus of thalamus and 207 other tissues |
ExpressionAtlasi | P32304, baseline and differential |
Genevisiblei | P32304, MM |
Family and domain databases
InterProi | View protein in InterPro IPR001069, 5HT_7_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00652, 5HT7RECEPTR PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | 5HT7R_MOUSE | |
Accessioni | P32304Primary (citable) accession number: P32304 Secondary accession number(s): Q14A50 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 23, 2022 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families