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Protein

5-hydroxytryptamine receptor 7

Gene

Htr7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-390666 Serotonin receptors
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 7
Short name:
5-HT-7
Short name:
5-HT7
Alternative name(s):
5-HT-X
Serotonin receptor 7
Gene namesi
Name:Htr7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:99841 Htr7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 84ExtracellularBy similarityAdd BLAST84
Transmembranei85 – 111Helical; Name=1By similarityAdd BLAST27
Topological domaini112 – 121CytoplasmicBy similarity10
Transmembranei122 – 147Helical; Name=2By similarityAdd BLAST26
Topological domaini148 – 159ExtracellularBy similarityAdd BLAST12
Transmembranei160 – 181Helical; Name=3By similarityAdd BLAST22
Topological domaini182 – 201CytoplasmicBy similarityAdd BLAST20
Transmembranei202 – 225Helical; Name=4By similarityAdd BLAST24
Topological domaini226 – 240ExtracellularBy similarityAdd BLAST15
Transmembranei241 – 263Helical; Name=5By similarityAdd BLAST23
Topological domaini264 – 331CytoplasmicBy similarityAdd BLAST68
Transmembranei332 – 355Helical; Name=6By similarityAdd BLAST24
Topological domaini356 – 367ExtracellularBy similarityAdd BLAST12
Transmembranei368 – 390Helical; Name=7By similarityAdd BLAST23
Topological domaini391 – 448CytoplasmicBy similarityAdd BLAST58

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4764
GuidetoPHARMACOLOGYi12

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689801 – 4485-hydroxytryptamine receptor 7Add BLAST448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi158 ↔ 234PROSITE-ProRule annotation
Lipidationi404S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP32304
PRIDEiP32304

PTM databases

iPTMnetiP32304
PhosphoSitePlusiP32304
SwissPalmiP32304

Expressioni

Gene expression databases

BgeeiENSMUSG00000024798
CleanExiMM_HTR7
ExpressionAtlasiP32304 baseline and differential
GenevisibleiP32304 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126847

Chemistry databases

BindingDBiP32304

Structurei

3D structure databases

ProteinModelPortaliP32304
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118795
HOVERGENiHBG106962
InParanoidiP32304
KOiK04163
PhylomeDBiP32304
TreeFamiTF331895

Family and domain databases

InterProiView protein in InterPro
IPR001069 5HT_7_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00652 5HT7RECEPTR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P32304-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDVNSSGRP DLYGHLRSLI LPEVGRRLQD LSPDGGAHSV VSSWMPHLLS
60 70 80 90 100
GFPEVTASPA PTWDAPPDNV SGCGEQINYG RVEKVVIGSI LTLITLLTIA
110 120 130 140 150
GNCLVVISVC FVKKLRQPSN YLIVSLALAD LSVAVAVMPF VSVTDLIGGK
160 170 180 190 200
WIFGHFFCNV FIAMDVMCCT ASIMTLCVIS IDRYLGITRP LTYPVRQNGK
210 220 230 240 250
CMAKMILSVW LLSASITLPP LFGWAQNVND DKVCLISQDF GYTIYSTAVA
260 270 280 290 300
FYIPMSVMLF MYYQIYKAAR KSAAKHKFSG FPRVQPESVI SLNGVVKLQK
310 320 330 340 350
EVEECANLSR LLKHERKNIS IFKREQKAAT TLGIIVGAFT VCWLPFFLLS
360 370 380 390 400
TARPFICGTS CSCIPLWVER TCLWLGYANS LINPFIYAFF NRDLRTTYRS
410 420 430 440
LLQCQYRNIN RKLSAAGMHE ALKLAERPER SEFVLQNCDH CGKKGHDT
Length:448
Mass (Da):49,916
Last modified:July 27, 2011 - v2
Checksum:i85A525FD90792CB1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114 – 115KL → NV in CAA80654 (PubMed:8394987).Curated2
Sequence conflicti211L → P in CAA80654 (PubMed:8394987).Curated1
Sequence conflicti321I → S in CAA80654 (PubMed:8394987).Curated1
Sequence conflicti388A → S in CAA80654 (PubMed:8394987).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23107 mRNA Translation: CAA80654.1
CH466534 Genomic DNA Translation: EDL41763.1
BC116986 mRNA Translation: AAI16987.1
CCDSiCCDS29769.1
PIRiI48779 S36402
RefSeqiNP_032341.2, NM_008315.2
UniGeneiMm.254266

Genome annotation databases

EnsembliENSMUST00000164639; ENSMUSP00000126847; ENSMUSG00000024798
GeneIDi15566
KEGGimmu:15566
UCSCiuc008hhd.1 mouse

Similar proteinsi

Entry informationi

Entry namei5HT7R_MOUSE
AccessioniPrimary (citable) accession number: P32304
Secondary accession number(s): Q14A50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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