UniProtKB - P32304 (5HT7R_MOUSE)

BLAST

>sp|P32304|5HT7R_MOUSE 5-hydroxytryptamine receptor 7 OS=Mus musculus OX=10090 GN=Htr7 PE=2 SV=2
MMDVNSSGRPDLYGHLRSLILPEVGRRLQDLSPDGGAHSVVSSWMPHLLSGFPEVTASPA
PTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSN
YLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS
IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDF
GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFSGFPRVQPESVISLNGVVKLQK
EVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTS
CSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHE
ALKLAERPERSEFVLQNCDHCGKKGHDT

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History
Entry version 137 (07 Nov 2018)
Sequence version 2 (27 Jul 2011)
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Protein

5-hydroxytryptamine receptor 7

Gene

Htr7

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

GO - Molecular functionⁱ

G protein-coupled receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled serotonin receptor activity Source: MGI
neurotransmitter receptor activity Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-activating serotonin receptor signaling pathway Source: MGI
behavioral response to pain Source: MGI
chemical synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
circadian rhythm Source: InterPro
detection of mechanical stimulus involved in sensory perception of pain Source: MGI
dopaminergic neuron differentiation Source: MGI
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
long-term synaptic potentiation Source: MGI
memory Source: MGI
micturition Source: MGI
negative regulation of circadian sleep/wake cycle, REM sleep Source: MGI
negative regulation of serotonin secretion Source: MGI
positive regulation of neuron projection development Source: MGI
regulation of synaptic vesicle exocytosis Source: MGI
response to corticosterone Source: MGI
serotonin receptor signaling pathway Source: MGI
urinary bladder smooth muscle contraction Source: MGI
vasoconstriction Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-MMU-390666 Serotonin receptors R-MMU-418555 G alpha (s) signalling events

Reactomeⁱ

R-MMU-390666 Serotonin receptors
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 5-hydroxytryptamine receptor 7 Short name: 5-HT-7 Short name: 5-HT7 Alternative name(s): 5-HT-X Serotonin receptor 7
Gene namesⁱ	Name:Htr7
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 19

Organism-specific databases

MGIⁱ	MGI:99841 Htr7

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 84	ExtracellularBy similarityAdd BLAST	84
Transmembraneⁱ	85 – 111	Helical; Name=1By similarityAdd BLAST	27
Topological domainⁱ	112 – 121	CytoplasmicBy similarity	10
Transmembraneⁱ	122 – 147	Helical; Name=2By similarityAdd BLAST	26
Topological domainⁱ	148 – 159	ExtracellularBy similarityAdd BLAST	12
Transmembraneⁱ	160 – 181	Helical; Name=3By similarityAdd BLAST	22
Topological domainⁱ	182 – 201	CytoplasmicBy similarityAdd BLAST	20
Transmembraneⁱ	202 – 225	Helical; Name=4By similarityAdd BLAST	24
Topological domainⁱ	226 – 240	ExtracellularBy similarityAdd BLAST	15
Transmembraneⁱ	241 – 263	Helical; Name=5By similarityAdd BLAST	23
Topological domainⁱ	264 – 331	CytoplasmicBy similarityAdd BLAST	68
Transmembraneⁱ	332 – 355	Helical; Name=6By similarityAdd BLAST	24
Topological domainⁱ	356 – 367	ExtracellularBy similarityAdd BLAST	12
Transmembraneⁱ	368 – 390	Helical; Name=7By similarityAdd BLAST	23
Topological domainⁱ	391 – 448	CytoplasmicBy similarityAdd BLAST	58

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL4764
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	12

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000068980	1 – 448	5-hydroxytryptamine receptor 7Add BLAST		448

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	5	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	69	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	158 ↔ 234	PROSITE-ProRule annotation
Lipidationⁱ	404	S-palmitoyl cysteineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbⁱ	P32304
PRIDEⁱ	P32304

PTM databases

iPTMnetⁱ	P32304
PhosphoSitePlusⁱ	P32304
SwissPalmⁱ	P32304

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000024798 Expressed in 184 organ(s), highest expression level in medial dorsal nucleus of thalamus
CleanExⁱ	MM_HTR7
ExpressionAtlasⁱ	P32304 baseline and differential
Genevisibleⁱ	P32304 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000126847

STRINGⁱ

10090.ENSMUSP00000126847

Chemistry databases

BindingDBⁱ

P32304

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P32304
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118795
HOVERGENⁱ	HBG106962
InParanoidⁱ	P32304
KEGG Orthology (KO) More...KOⁱ	K04163
PhylomeDBⁱ	P32304
TreeFamⁱ	TF331895

Family and domain databases

InterProⁱ	View protein in InterPro IPR001069 5HT_7_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00652 5HT7RECEPTR PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

P32304-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MMDVNSSGRP DLYGHLRSLI LPEVGRRLQD LSPDGGAHSV VSSWMPHLLS 
        60         70         80         90        100
GFPEVTASPA PTWDAPPDNV SGCGEQINYG RVEKVVIGSI LTLITLLTIA 
       110        120        130        140        150
GNCLVVISVC FVKKLRQPSN YLIVSLALAD LSVAVAVMPF VSVTDLIGGK 
       160        170        180        190        200
WIFGHFFCNV FIAMDVMCCT ASIMTLCVIS IDRYLGITRP LTYPVRQNGK 
       210        220        230        240        250
CMAKMILSVW LLSASITLPP LFGWAQNVND DKVCLISQDF GYTIYSTAVA 
       260        270        280        290        300
FYIPMSVMLF MYYQIYKAAR KSAAKHKFSG FPRVQPESVI SLNGVVKLQK 
       310        320        330        340        350
EVEECANLSR LLKHERKNIS IFKREQKAAT TLGIIVGAFT VCWLPFFLLS 
       360        370        380        390        400
TARPFICGTS CSCIPLWVER TCLWLGYANS LINPFIYAFF NRDLRTTYRS 
       410        420        430        440 
LLQCQYRNIN RKLSAAGMHE ALKLAERPER SEFVLQNCDH CGKKGHDT

Length:448

Mass (Da):49,916

Last modified:July 27, 2011 - v2

Checksum:ⁱ85A525FD90792CB1

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B6VJS2	B6VJS2_MOUSE	5-hydroxytryptamine receptor 7 5-hydroxytryptamine receptor 7	Htr7	435	Annotation score:
B6VJS3	B6VJS3_MOUSE	5-hydroxytryptamine receptor 7 5-hydroxytryptamine receptor 7	Htr7	470	Annotation score:
E9Q1X2	E9Q1X2_MOUSE	5-hydroxytryptamine receptor 7 5-hydroxytryptamine receptor 7	Htr7	344	Annotation score:
E9Q4Q7	E9Q4Q7_MOUSE	5-hydroxytryptamine receptor 7 5-hydroxytryptamine receptor 7	Htr7	198	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	114 – 115	KL → NV in CAA80654 (PubMed:8394987).Curated	2
Sequence conflictⁱ	211	L → P in CAA80654 (PubMed:8394987).Curated	1
Sequence conflictⁱ	321	I → S in CAA80654 (PubMed:8394987).Curated	1
Sequence conflictⁱ	388	A → S in CAA80654 (PubMed:8394987).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z23107 mRNA Translation: CAA80654.1 CH466534 Genomic DNA Translation: EDL41763.1 BC116986 mRNA Translation: AAI16987.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29769.1
PIRⁱ	I48779 S36402
NCBI Reference Sequences More...RefSeqⁱ	NP_032341.2, NM_008315.2
UniGeneⁱ	Mm.254266

Genome annotation databases

Ensemblⁱ	ENSMUST00000164639; ENSMUSP00000126847; ENSMUSG00000024798
GeneIDⁱ	15566
KEGGⁱ	mmu:15566
UCSC genome browser More...UCSCⁱ	uc008hhd.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P32304	Uncharacterized protein (Fragment)		MOUSE		417	UniRef100_P32304
UPI0007ECF271		MOUSE		247

Protein	Similar proteins		Species	Score	Length	Source
P32304	5-hydroxytryptamine receptor 7		RAT		448	UniRef90_P32305
5-hydroxytryptamine receptor 7		CAVPO		446
Uncharacterized protein		PROCO		465
HTR7 isoform 2		PONAB		460
5-hydroxytryptamine receptor 7 isoform X1		DIPOR		452
+142

Protein	Similar proteins		Species	Score	Length	Source
P32304	5-hydroxytryptamine receptor 7		RAT		448	UniRef50_P32305
5-hydroxytryptamine receptor 7		CAVPO		446
5-hydroxytryptamine receptor 7		HUMAN		479
Uncharacterized protein		PROCO		465
HTR7 isoform 2		PONAB		460
+507

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z23107 mRNA Translation: CAA80654.1 CH466534 Genomic DNA Translation: EDL41763.1 BC116986 mRNA Translation: AAI16987.1
CCDSⁱ	CCDS29769.1
PIRⁱ	I48779 S36402
RefSeqⁱ	NP_032341.2, NM_008315.2
UniGeneⁱ	Mm.254266

3D structure databases

ProteinModelPortalⁱ	P32304
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000126847

STRINGⁱ

10090.ENSMUSP00000126847

Chemistry databases

BindingDBⁱ	P32304
ChEMBLⁱ	CHEMBL4764
GuidetoPHARMACOLOGYⁱ	12

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	P32304
PhosphoSitePlusⁱ	P32304
SwissPalmⁱ	P32304

Proteomic databases

PaxDbⁱ	P32304
PRIDEⁱ	P32304

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000164639; ENSMUSP00000126847; ENSMUSG00000024798
GeneIDⁱ	15566
KEGGⁱ	mmu:15566
UCSCⁱ	uc008hhd.1 mouse

Organism-specific databases

CTDⁱ	3363
MGIⁱ	MGI:99841 Htr7

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00760000118795
HOVERGENⁱ	HBG106962
InParanoidⁱ	P32304
KOⁱ	K04163
PhylomeDBⁱ	P32304
TreeFamⁱ	TF331895

Enzyme and pathway databases

Reactomeⁱ	R-MMU-390666 Serotonin receptors R-MMU-418555 G alpha (s) signalling events

Reactomeⁱ

R-MMU-390666 Serotonin receptors
R-MMU-418555 G alpha (s) signalling events

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P32304
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000024798 Expressed in 184 organ(s), highest expression level in medial dorsal nucleus of thalamus
CleanExⁱ	MM_HTR7
ExpressionAtlasⁱ	P32304 baseline and differential
Genevisibleⁱ	P32304 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR001069 5HT_7_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00652 5HT7RECEPTR PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	5HT7R_MOUSE
Accessionⁱ	P32304Primary (citable) accession number: P32304 Secondary accession number(s): Q14A50
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniParc

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UniRef

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Supporting data

UniProtKB - P32304 (5HT7R_MOUSE)

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5-hydroxytryptamine receptor 7

Htr7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endoplasmic reticulum

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ