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Protein

Glucagon-like peptide 1 receptor

Gene

Glp1r

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:1326760, PubMed:7813606). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:1326760, PubMed:7813606). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).By similarity2 Publications

GO - Molecular functioni

  • glucagon-like peptide 1 receptor activity Source: UniProtKB
  • glucagon receptor activity Source: InterPro
  • G-protein coupled peptide receptor activity Source: RGD
  • G-protein coupled receptor activity Source: RGD
  • peptide hormone binding Source: RGD
  • peptide receptor activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon-like peptide 1 receptor
Short name:
GLP-1 receptor
Short name:
GLP-1-R
Short name:
GLP-1R
Gene namesi
Name:Glp1r
Synonyms:Glpr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2703 Glp1r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 139ExtracellularCuratedAdd BLAST118
Transmembranei140 – 164Helical; Name=1By similarityAdd BLAST25
Topological domaini165 – 175CytoplasmicCuratedAdd BLAST11
Transmembranei176 – 201Helical; Name=2By similarityAdd BLAST26
Topological domaini202 – 227ExtracellularCuratedAdd BLAST26
Transmembranei228 – 251Helical; Name=3By similarityAdd BLAST24
Topological domaini252 – 265CytoplasmicCuratedAdd BLAST14
Transmembranei266 – 290Helical; Name=4By similarityAdd BLAST25
Topological domaini291 – 305ExtracellularCuratedAdd BLAST15
Transmembranei306 – 328Helical; Name=5By similarityAdd BLAST23
Topological domaini329 – 348CytoplasmicCuratedAdd BLAST20
Transmembranei349 – 370Helical; Name=6By similarityAdd BLAST22
Topological domaini371 – 383ExtracellularCuratedAdd BLAST13
Transmembranei384 – 404Helical; Name=7By similarityAdd BLAST21
Topological domaini405 – 463CytoplasmicCuratedAdd BLAST59

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5862
GuidetoPHARMACOLOGYi249

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001283722 – 463Glucagon-like peptide 1 receptorAdd BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 71By similarity
Disulfide bondi62 ↔ 104By similarity
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi85 ↔ 126By similarity
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi226 ↔ 296By similarity
Modified residuei341ADP-ribosylcysteineBy similarity1
Modified residuei348ADP-ribosylarginineBy similarity1

Post-translational modificationi

N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.By similarity

Keywords - PTMi

ADP-ribosylation, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP32301
PRIDEiP32301

PTM databases

iPTMnetiP32301
PhosphoSitePlusiP32301
SwissPalmiP32301

Expressioni

Tissue specificityi

Pancreatic islets, stomach, lung, rat insulinoma cell line.1 Publication

Interactioni

Subunit structurei

May form homodimers and heterodimers with GIPR.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei121Interaction with the endogenous ligand GLP-1By similarity1
Sitei128Interaction with the endogenous ligand GLP-1By similarity1

Protein-protein interaction databases

BioGridi247128, 1 interactor
STRINGi10116.ENSRNOP00000001527

Chemistry databases

BindingDBiP32301

Structurei

3D structure databases

ProteinModelPortaliP32301
SMRiP32301
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni352 – 355Important for allosteric inhibitor bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
HOGENOMiHOG000008250
HOVERGENiHBG008318
InParanoidiP32301
KOiK04581

Family and domain databases

CDDicd15268 7tmB1_GLP1R, 1 hit
Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR003290 GPCR_2_GLP1/glucagon_rcpt
IPR003292 GPCR_2_GLP1_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PANTHERiPTHR12011:SF245 PTHR12011:SF245, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR01353 GLUCAGNFAMLY
PR01355 GLUCAGNLIKER
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

P32301-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVTPSLLRL ALLLLGAVGR AGPRPQGATV SLSETVQKWR EYRHQCQRFL
60 70 80 90 100
TEAPLLATGL FCNRTFDDYA CWPDGPPGSF VNVSCPWYLP WASSVLQGHV
110 120 130 140 150
YRFCTAEGIW LHKDNSSLPW RDLSECEESK QGERNSPEEQ LLSLYIIYTV
160 170 180 190 200
GYALSFSALV IASAILVSFR HLHCTRNYIH LNLFASFILR ALSVFIKDAA
210 220 230 240 250
LKWMYSTAAQ QHQWDGLLSY QDSLGCRLVF LLMQYCVAAN YYWLLVEGVY
260 270 280 290 300
LYTLLAFSVF SEQRIFKLYL SIGWGVPLLF VIPWGIVKYL YEDEGCWTRN
310 320 330 340 350
SNMNYWLIIR LPILFAIGVN FLVFIRVICI VIAKLKANLM CKTDIKCRLA
360 370 380 390 400
KSTLTLIPLL GTHEVIFAFV MDEHARGTLR FVKLFTELSF TSFQGFMVAV
410 420 430 440 450
LYCFVNNEVQ MEFRKSWERW RLERLNIQRD SSMKPLKCPT SSVSSGATVG
460
SSVYAATCQN SCS
Length:463
Mass (Da):52,877
Last modified:October 1, 1993 - v1
Checksum:iABE2183E8EBE621F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LRH2F1LRH2_RAT
Glucagon-like peptide 1 receptor
Glp1r
463Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti323V → I in AAP31860 (PubMed:7813606).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97797 mRNA Translation: AAA73377.1
S75952 mRNA Translation: AAP31860.1
PIRiA46172
RefSeqiNP_036860.1, NM_012728.1
UniGeneiRn.11408

Genome annotation databases

GeneIDi25051
KEGGirno:25051

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97797 mRNA Translation: AAA73377.1
S75952 mRNA Translation: AAP31860.1
PIRiA46172
RefSeqiNP_036860.1, NM_012728.1
UniGeneiRn.11408

3D structure databases

ProteinModelPortaliP32301
SMRiP32301
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247128, 1 interactor
STRINGi10116.ENSRNOP00000001527

Chemistry databases

BindingDBiP32301
ChEMBLiCHEMBL5862
GuidetoPHARMACOLOGYi249

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP32301
PhosphoSitePlusiP32301
SwissPalmiP32301

Proteomic databases

PaxDbiP32301
PRIDEiP32301

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25051
KEGGirno:25051

Organism-specific databases

CTDi2740
RGDi2703 Glp1r

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
HOGENOMiHOG000008250
HOVERGENiHBG008318
InParanoidiP32301
KOiK04581

Miscellaneous databases

PROiPR:P32301

Family and domain databases

CDDicd15268 7tmB1_GLP1R, 1 hit
Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR003290 GPCR_2_GLP1/glucagon_rcpt
IPR003292 GPCR_2_GLP1_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PANTHERiPTHR12011:SF245 PTHR12011:SF245, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR01353 GLUCAGNFAMLY
PR01355 GLUCAGNLIKER
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLP1R_RAT
AccessioniPrimary (citable) accession number: P32301
Secondary accession number(s): Q64073, Q6LD83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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