Bdkrb2

Functionⁱ

Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functionⁱ

beta-2 adrenergic receptor binding Source: MGI
bradykinin receptor activity Source: MGI
protease binding Source: MGI
protein heterodimerization activity Source: MGI
type 1 angiotensin receptor binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acute inflammatory response to antigenic stimulus Source: MGI
arachidonic acid secretion Source: MGI
maintenance of permeability of blood-brain barrier Source: MGI
negative regulation of blood pressure Source: MGI
negative regulation of cell proliferation Source: MGI
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
Source: MGI
Inferred from mutant phenotypeⁱ
- 16571598
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
Source: MGI
Inferred from genetic interactionⁱ
- 16571598
negative regulation of peptidyl-serine phosphorylation
Source: MGI
Inferred from mutant phenotypeⁱ
- 16571598
positive regulation of cytosolic calcium ion concentration Source: MGI
response to salt stress
Source: MGI
Inferred from genetic interactionⁱ
- 16571598
smooth muscle contraction Source: InterPro
vasoconstriction Source: InterPro
vasodilation
Source: MGI
Inferred from mutant phenotypeⁱ
- 11282893

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-MMU-375276 Peptide ligand-binding receptors R-MMU-416476 G alpha (q) signalling events R-MMU-418594 G alpha (i) signalling events

Reactomeⁱ

R-MMU-375276 Peptide ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: B2 bradykinin receptor Short name: B2R Short name: BK-2 receptor
Gene namesⁱ	Name:Bdkrb2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 12

Organism-specific databases

MGIⁱ	MGI:102845 Bdkrb2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 61	ExtracellularSequence analysisAdd BLAST	61
Transmembraneⁱ	62 – 85	Helical; Name=1Sequence analysisAdd BLAST	24
Topological domainⁱ	86 – 94	CytoplasmicSequence analysis	9
Transmembraneⁱ	95 – 119	Helical; Name=2Sequence analysisAdd BLAST	25
Topological domainⁱ	120 – 132	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	133 – 154	Helical; Name=3Sequence analysisAdd BLAST	22
Topological domainⁱ	155 – 176	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	177 – 199	Helical; Name=4Sequence analysisAdd BLAST	23
Topological domainⁱ	200 – 222	ExtracellularSequence analysisAdd BLAST	23
Transmembraneⁱ	223 – 249	Helical; Name=5Sequence analysisAdd BLAST	27
Topological domainⁱ	250 – 268	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	269 – 293	Helical; Name=6Sequence analysisAdd BLAST	25
Topological domainⁱ	294 – 312	ExtracellularSequence analysisAdd BLAST	19
Transmembraneⁱ	313 – 336	Helical; Name=7Sequence analysisAdd BLAST	24
Topological domainⁱ	337 – 392	CytoplasmicSequence analysisAdd BLAST	56

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	42

GuidetoPHARMACOLOGYⁱ

42

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069191	1 – 392	B2 bradykinin receptorAdd BLAST		392

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	29	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	40	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	131 ↔ 212	PROSITE-ProRule annotation
Modified residueⁱ	157	PhosphotyrosineBy similarity	1
Glycosylationⁱ	208	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	348	PhosphotyrosineBy similarity	1
Lipidationⁱ	352	S-palmitoyl cysteineSequence analysis	1
Modified residueⁱ	367	PhosphoserineBy similarity	1
Modified residueⁱ	370	PhosphothreonineBy similarity	1
Modified residueⁱ	374	Phosphoserine; by GRK6By similarity	1
Modified residueⁱ	376	Phosphoserine; by GRK6By similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbⁱ	P32299
PRIDEⁱ	P32299

PTM databases

iPTMnetⁱ	P32299
PhosphoSitePlusⁱ	P32299
SwissPalmⁱ	P32299

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000021070 Expressed in 20 organ(s), highest expression level in placenta
CleanExⁱ	MM_BDKRB2
Genevisibleⁱ	P32299 MM

Interactionⁱ

Subunit structureⁱ

Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1 (By similarity).By similarity

GO - Molecular functionⁱ

beta-2 adrenergic receptor binding Source: MGI
protease binding Source: MGI
protein heterodimerization activity Source: MGI
type 1 angiotensin receptor binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000001652

STRINGⁱ

10090.ENSMUSP00000001652

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P32299
SMRⁱ	P32299
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410INT3 Eukaryota ENOG41117RA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119055
HOGENOMⁱ	HOG000010314
HOVERGENⁱ	HBG103183
InParanoidⁱ	P32299
KEGG Orthology (KO) More...KOⁱ	K03916
OMAⁱ	ENSMGTL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AAK
PhylomeDBⁱ	P32299
TreeFamⁱ	TF330024

Family and domain databases

InterProⁱ	View protein in InterPro IPR001504 Brdyknn_2_rcpt IPR000496 Brdyknn_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00425 BRADYKININR PR00994 BRADYKINNB2R PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform Long (identifier: P32299-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPCSWKLLGF LSVHEPMPTA ASFGIEMFNV TTQVLGSALN GTLSKDNCPD 
        60         70         80         90        100
TEWWSWLNAI QAPFLWVLFL LAALENLFVL SVFFLHKNSC TVAEIYLGNL 
       110        120        130        140        150
AAADLILACG LPFWAITIAN NFDWVFGEVL CRVVNTMIYM NLYSSICFLM 
       160        170        180        190        200
LVSIDRYLAL VKTMSMGRMR GVRWAKLYSL VIWGCTLLLS SPMLVFRTMR 
       210        220        230        240        250
EYSEEGHNVT ACVIVYPSRS WEVFTNVLLN LVGFLLPLSV ITFCTVRILQ 
       260        270        280        290        300
VLRNNEMKKF KEVQTERKAT VLVLAVLGLF VLCWVPFQIS TFLDTLLRLG 
       310        320        330        340        350
VLSGCWDEHA VDVITQISSY VAYSNSGLNP LVYVIVGKRF RKKSREVYRV 
       360        370        380        390 
LCQKGGCMGE PVQMENSMGT LRTSISVERQ IHKLQDWAGK KQ

Length:392

Mass (Da):44,389

Last modified:May 30, 2000 - v4

Checksum:ⁱFB1AA59BCBFFF5F9

GO

Isoform Short (identifier: P32299-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-26: Missing.

« Hide

        10         20         30         40         50
MFNVTTQVLG SALNGTLSKD NCPDTEWWSW LNAIQAPFLW VLFLLAALEN 
        60         70         80         90        100
LFVLSVFFLH KNSCTVAEIY LGNLAAADLI LACGLPFWAI TIANNFDWVF 
       110        120        130        140        150
GEVLCRVVNT MIYMNLYSSI CFLMLVSIDR YLALVKTMSM GRMRGVRWAK 
       160        170        180        190        200
LYSLVIWGCT LLLSSPMLVF RTMREYSEEG HNVTACVIVY PSRSWEVFTN 
       210        220        230        240        250
VLLNLVGFLL PLSVITFCTV RILQVLRNNE MKKFKEVQTE RKATVLVLAV 
       260        270        280        290        300
LGLFVLCWVP FQISTFLDTL LRLGVLSGCW DEHAVDVITQ ISSYVAYSNS 
       310        320        330        340        350
GLNPLVYVIV GKRFRKKSRE VYRVLCQKGG CMGEPVQMEN SMGTLRTSIS 
       360 
VERQIHKLQD WAGKKQ

Show »

Length:366

Mass (Da):41,558

Checksum:ⁱ9276DBA985F42379

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	298	R → A (PubMed:8394991).Curated		1
Sequence conflictⁱ	298	R → A (PubMed:7959003).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_001866	1 – 26	Missing in isoform Short. 2 PublicationsAdd BLAST		26

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X69676 Genomic DNA Translation: CAA49357.1 X69682 mRNA Translation: CAA49362.1 L26047 Unassigned DNA Translation: AAA19797.1 X78438 mRNA Translation: CAA55202.1 L27595 Genomic DNA Translation: AAA62616.1 BC137755 mRNA Translation: AAI37756.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS49160.1 [P32299-1]
PIRⁱ	I49519
NCBI Reference Sequences More...RefSeqⁱ	NP_033877.3, NM_009747.2 [P32299-1] XP_006515505.1, XM_006515442.3 [P32299-1]
UniGeneⁱ	Mm.390475

Genome annotation databases

Ensemblⁱ	ENSMUST00000001652; ENSMUSP00000001652; ENSMUSG00000021070 [P32299-1]
GeneIDⁱ	12062
KEGGⁱ	mmu:12062
UCSC genome browser More...UCSCⁱ	uc007oym.1 mouse [P32299-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P32299	Bradykinin receptor, beta 2, isoform CRA_b		MOUSE		366	UniRef100_P32299
Isoform Short of B2 bradykinin receptor		MOUSE		366
UPI0003D7542D		MOUSE		406

Protein	Similar proteins		Species	Score	Length	Source
P32299	Bradykinin receptor, beta 2, isoform CRA_b		MOUSE		366	UniRef90_P32299
UPI000A3176EE		MUSCR		392
UPI000A3043AC		MUSPA		384
Isoform Short of B2 bradykinin receptor		MOUSE		366
UPI0003D7542D		MOUSE		406

Protein	Similar proteins		Species	Score	Length	Source
P32299	B2 bradykinin receptor		RAT		396	UniRef50_P25023
B2 bradykinin receptor		RABIT		367
B2 bradykinin receptor		CAVPO		372
B2 bradykinin receptor		TURTR		350
B2 bradykinin receptor isoform X1		PHYCD		399
+52

Entry informationⁱ

Entry nameⁱ	BKRB2_MOUSE
Accessionⁱ	P32299Primary (citable) accession number: P32299 Secondary accession number(s): B9EHE3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
	Last sequence update:	May 30, 2000
	Last modified:	September 12, 2018
	This is version 152 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P32299 (BKRB2_MOUSE)

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B2 bradykinin receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endosome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ