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Entry version 191 (17 Jun 2020)
Sequence version 3 (03 Apr 2007)
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Protein

G protein-coupled receptor kinase 4

Gene

GRK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by heparin.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei216ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei312Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi193 – 201ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.16 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade [P32298-1]

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P32298

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P32298

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G protein-coupled receptor kinase 4 (EC:2.7.11.16)
Alternative name(s):
G protein-coupled receptor kinase GRK4
ITI1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GRK4
Synonyms:GPRK2L, GPRK4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000125388.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4543 GRK4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
137026 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P32298

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2868

Open Targets

More...
OpenTargetsi
ENSG00000125388

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28941

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P32298 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5861

DrugCentral

More...
DrugCentrali
P32298

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1468

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GRK4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
143811400

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000859671 – 578G protein-coupled receptor kinase 4Add BLAST578

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei485PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylated.1 Publication

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P32298

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P32298

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P32298

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P32298

PeptideAtlas

More...
PeptideAtlasi
P32298

PRoteomics IDEntifications database

More...
PRIDEi
P32298

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
54861 [P32298-1]
54862 [P32298-2]
54863 [P32298-3]
54864 [P32298-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P32298

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P32298

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed in myometrium.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000125388 Expressed in testis and 127 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P32298 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P32298 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000125388 Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DRD3.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
109126, 12 interactors

Protein interaction database and analysis system

More...
IntActi
P32298, 3 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000381129

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P32298

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P32298 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1578
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P32298

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini52 – 172RGSPROSITE-ProRule annotationAdd BLAST121
Domaini187 – 449Protein kinasePROSITE-ProRule annotationAdd BLAST263
Domaini450 – 515AGC-kinase C-terminalAdd BLAST66

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 154N-terminalAdd BLAST154

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0986 Eukaryota
ENOG410YRQZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160151

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000288_63_41_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P32298

KEGG Orthology (KO)

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KOi
K08291

Identification of Orthologs from Complete Genome Data

More...
OMAi
TRIVHEY

Database of Orthologous Groups

More...
OrthoDBi
1104340at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P32298

TreeFam database of animal gene trees

More...
TreeFami
TF313940

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000961 AGC-kinase_C
IPR000239 GPCR_kinase
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR016137 RGS
IPR036305 RGS_sf
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit
PF00615 RGS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00717 GPCRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00315 RGS, 1 hit
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48097 SSF48097, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50132 RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P32298-1) [UniParc]FASTAAdd to basket
Also known as: GRK4-alpha, GRK4D

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELENIVANS LLLKARQGGY GKKSGRSKKW KEILTLPPVS QCSELRHSIE
60 70 80 90 100
KDYSSLCDKQ PIGRRLFRQF CDTKPTLKRH IEFLDAVAEY EVADDEDRSD
110 120 130 140 150
CGLSILDRFF NDKLAAPLPE IPPDVVTECR LGLKEENPSK KAFEECTRVA
160 170 180 190 200
HNYLRGEPFE EYQESSYFSQ FLQWKWLERQ PVTKNTFRHY RVLGKGGFGE
210 220 230 240 250
VCACQVRATG KMYACKKLQK KRIKKRKGEA MALNEKRILE KVQSRFVVSL
260 270 280 290 300
AYAYETKDAL CLVLTIMNGG DLKFHIYNLG NPGFDEQRAV FYAAELCCGL
310 320 330 340 350
EDLQRERIVY RDLKPENILL DDRGHIRISD LGLATEIPEG QRVRGRVGTV
360 370 380 390 400
GYMAPEVVNN EKYTFSPDWW GLGCLIYEMI QGHSPFKKYK EKVKWEEVDQ
410 420 430 440 450
RIKNDTEEYS EKFSEDAKSI CRMLLTKNPS KRLGCRGEGA AGVKQHPVFK
460 470 480 490 500
DINFRRLEAN MLEPPFCPDP HAVYCKDVLD IEQFSVVKGI YLDTADEDFY
510 520 530 540 550
ARFATGCVSI PWQNEMIESG CFKDINKSES EEALPLDLDK NIHTPVSRPN
560 570
RGFFYRLFRR GGCLTMVPSE KEVEPKQC
Length:578
Mass (Da):66,583
Last modified:April 3, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i72FCF94ED551F2D0
GO
Isoform 2 (identifier: P32298-2) [UniParc]FASTAAdd to basket
Also known as: GRK4-beta, GRK4C

The sequence of this isoform differs from the canonical sequence as follows:
     18-49: Missing.

Show »
Length:546
Mass (Da):63,030
Checksum:iAD60D125A5839CA3
GO
Isoform 3 (identifier: P32298-3) [UniParc]FASTAAdd to basket
Also known as: GRK4-delta, GRK4A

The sequence of this isoform differs from the canonical sequence as follows:
     18-49: Missing.
     516-561: Missing.

Show »
Length:500
Mass (Da):57,663
Checksum:i6AF0953E8D1F7A06
GO
Isoform 4 (identifier: P32298-4) [UniParc]FASTAAdd to basket
Also known as: GRK4-gamma, GRK4B

The sequence of this isoform differs from the canonical sequence as follows:
     516-561: Missing.

Show »
Length:532
Mass (Da):61,216
Checksum:i1DD49402FCB381E5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6REW5D6REW5_HUMAN
G protein-coupled receptor kinase 4
GRK4
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti562G → D in CAA66468 (PubMed:1338872).Curated1
Sequence conflicti562G → D in CAA66802 (PubMed:1338872).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02457365R → L1 PublicationCorresponds to variant dbSNP:rs2960306Ensembl.1
Natural variantiVAR_05162195D → H. Corresponds to variant dbSNP:rs13305979Ensembl.1
Natural variantiVAR_046043116A → T1 PublicationCorresponds to variant dbSNP:rs34857805Ensembl.1
Natural variantiVAR_024574142A → V1 PublicationCorresponds to variant dbSNP:rs1024323Ensembl.1
Natural variantiVAR_051622183T → R. Corresponds to variant dbSNP:rs45538934Ensembl.1
Natural variantiVAR_007806247V → I1 PublicationCorresponds to variant dbSNP:rs1140085Ensembl.1
Natural variantiVAR_046044383H → Q1 PublicationCorresponds to variant dbSNP:rs55852353Ensembl.1
Natural variantiVAR_040516425L → P1 Publication1
Natural variantiVAR_051623440A → V. Corresponds to variant dbSNP:rs747003103Ensembl.1
Natural variantiVAR_046045473V → I1 PublicationCorresponds to variant dbSNP:rs35024854Ensembl.1
Natural variantiVAR_024575486V → A6 PublicationsCorresponds to variant dbSNP:rs1801058Ensembl.1
Natural variantiVAR_046046495A → T1 PublicationCorresponds to variant dbSNP:rs35463176Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00493618 – 49Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST32
Alternative sequenceiVSP_004937516 – 561Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L03718 Genomic DNA Translation: AAB04045.1
X97879 mRNA Translation: CAA66468.1
X97880 mRNA Translation: CAA66469.1
X97881 mRNA Translation: CAA66470.1
U33054 mRNA Translation: AAC50406.1
U33055 mRNA Translation: AAC50407.1
U33056 mRNA Translation: AAC50408.1
U33168 U33167 Genomic DNA Translation: AAC50409.1
U33168 U33167 Genomic DNA Translation: AAC50410.1
U33168 U33166 Genomic DNA Translation: AAC50411.1
U33168 U33166 Genomic DNA Translation: AAC50412.1
AK223581 mRNA Translation: BAD97301.1
X98118 mRNA Translation: CAA66802.1
X75897 mRNA Translation: CAA53506.1
Z68192 Genomic DNA Translation: CAA92341.1
BC117320 mRNA Translation: AAI17321.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS33946.1 [P32298-1]
CCDS33947.1 [P32298-4]
CCDS47002.1 [P32298-2]
CCDS68656.1 [P32298-3]

Protein sequence database of the Protein Information Resource

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PIRi
I54326
JC2127

NCBI Reference Sequences

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RefSeqi
NP_001004056.1, NM_001004056.1 [P32298-2]
NP_001004057.1, NM_001004057.1 [P32298-4]
NP_005298.2, NM_005307.2 [P32298-3]
NP_892027.2, NM_182982.2 [P32298-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000345167; ENSP00000264764; ENSG00000125388 [P32298-2]
ENST00000398051; ENSP00000381128; ENSG00000125388 [P32298-3]
ENST00000398052; ENSP00000381129; ENSG00000125388 [P32298-1]
ENST00000504933; ENSP00000427445; ENSG00000125388 [P32298-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2868

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2868

UCSC genome browser

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UCSCi
uc003ggn.2 human [P32298-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03718 Genomic DNA Translation: AAB04045.1
X97879 mRNA Translation: CAA66468.1
X97880 mRNA Translation: CAA66469.1
X97881 mRNA Translation: CAA66470.1
U33054 mRNA Translation: AAC50406.1
U33055 mRNA Translation: AAC50407.1
U33056 mRNA Translation: AAC50408.1
U33168 U33167 Genomic DNA Translation: AAC50409.1
U33168 U33167 Genomic DNA Translation: AAC50410.1
U33168 U33166 Genomic DNA Translation: AAC50411.1
U33168 U33166 Genomic DNA Translation: AAC50412.1
AK223581 mRNA Translation: BAD97301.1
X98118 mRNA Translation: CAA66802.1
X75897 mRNA Translation: CAA53506.1
Z68192 Genomic DNA Translation: CAA92341.1
BC117320 mRNA Translation: AAI17321.1
CCDSiCCDS33946.1 [P32298-1]
CCDS33947.1 [P32298-4]
CCDS47002.1 [P32298-2]
CCDS68656.1 [P32298-3]
PIRiI54326
JC2127
RefSeqiNP_001004056.1, NM_001004056.1 [P32298-2]
NP_001004057.1, NM_001004057.1 [P32298-4]
NP_005298.2, NM_005307.2 [P32298-3]
NP_892027.2, NM_182982.2 [P32298-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YHJX-ray2.60A/B1-578[»]
SMRiP32298
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109126, 12 interactors
IntActiP32298, 3 interactors
STRINGi9606.ENSP00000381129

Chemistry databases

BindingDBiP32298
ChEMBLiCHEMBL5861
DrugCentraliP32298
GuidetoPHARMACOLOGYi1468

PTM databases

iPTMnetiP32298
PhosphoSitePlusiP32298

Polymorphism and mutation databases

BioMutaiGRK4
DMDMi143811400

Proteomic databases

jPOSTiP32298
MassIVEiP32298
MaxQBiP32298
PaxDbiP32298
PeptideAtlasiP32298
PRIDEiP32298
ProteomicsDBi54861 [P32298-1]
54862 [P32298-2]
54863 [P32298-3]
54864 [P32298-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
3832 257 antibodies

The DNASU plasmid repository

More...
DNASUi
2868

Genome annotation databases

EnsembliENST00000345167; ENSP00000264764; ENSG00000125388 [P32298-2]
ENST00000398051; ENSP00000381128; ENSG00000125388 [P32298-3]
ENST00000398052; ENSP00000381129; ENSG00000125388 [P32298-1]
ENST00000504933; ENSP00000427445; ENSG00000125388 [P32298-4]
GeneIDi2868
KEGGihsa:2868
UCSCiuc003ggn.2 human [P32298-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2868
DisGeNETi2868
EuPathDBiHostDB:ENSG00000125388.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GRK4
HGNCiHGNC:4543 GRK4
HPAiENSG00000125388 Tissue enhanced (testis)
MIMi137026 gene
neXtProtiNX_P32298
OpenTargetsiENSG00000125388
PharmGKBiPA28941

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0986 Eukaryota
ENOG410YRQZ LUCA
GeneTreeiENSGT00940000160151
HOGENOMiCLU_000288_63_41_1
InParanoidiP32298
KOiK08291
OMAiTRIVHEY
OrthoDBi1104340at2759
PhylomeDBiP32298
TreeFamiTF313940

Enzyme and pathway databases

BRENDAi2.7.11.16 2681
ReactomeiR-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade [P32298-1]
SignaLinkiP32298
SIGNORiP32298

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
2868 3 hits in 817 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GRK4 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GRK4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2868
PharosiP32298 Tchem

Protein Ontology

More...
PROi
PR:P32298
RNActiP32298 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000125388 Expressed in testis and 127 other tissues
ExpressionAtlasiP32298 baseline and differential
GenevisibleiP32298 HS

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR000239 GPCR_kinase
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR016137 RGS
IPR036305 RGS_sf
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR00717 GPCRKINASE
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50132 RGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRK4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32298
Secondary accession number(s): O00641
, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316, Q17RH6, Q53EQ8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: April 3, 2007
Last modified: June 17, 2020
This is version 191 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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