UniProtKB - P32297 (ACHA3_HUMAN)
Neuronal acetylcholine receptor subunit alpha-3
CHRNA3
Functioni
GO - Molecular functioni
- acetylcholine binding Source: UniProtKB
- acetylcholine-gated cation-selective channel activity Source: UniProtKB
- acetylcholine receptor activity Source: UniProtKB
- ligand-gated ion channel activity Source: DFLAT
- neurotransmitter receptor activity Source: GO_Central
GO - Biological processi
- acetylcholine receptor signaling pathway Source: ARUK-UCL
- activation of transmembrane receptor protein tyrosine kinase activity Source: UniProtKB
- behavioral response to nicotine Source: UniProtKB
- chemical synaptic transmission Source: GO_Central
- excitatory postsynaptic potential Source: UniProtKB
- ion transmembrane transport Source: GO_Central
- ion transport Source: UniProtKB
- locomotory behavior Source: UniProtKB
- nervous system development Source: UniProtKB
- nervous system process Source: GO_Central
- regulation of acetylcholine secretion, neurotransmission Source: UniProtKB
- regulation of dendrite morphogenesis Source: UniProtKB
- regulation of membrane potential Source: UniProtKB
- regulation of smooth muscle contraction Source: UniProtKB
- response to acetylcholine Source: ARUK-UCL
- signal transduction Source: UniProtKB
- synaptic transmission, cholinergic Source: UniProtKB
- synaptic transmission involved in micturition Source: UniProtKB
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Ion transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | P32297 |
Reactomei | R-HSA-629587, Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629594, Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629597, Highly calcium permeable nicotinic acetylcholine receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Neuronal acetylcholine receptor subunit alpha-3 |
Gene namesi | Name:CHRNA3 Synonyms:NACHRA3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1957, CHRNA3 |
MIMi | 118503, gene |
neXtProti | NX_P32297 |
VEuPathDBi | HostDB:ENSG00000080644.15 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- acetylcholine-gated channel complex Source: UniProtKB
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
- plasma membrane raft Source: ARUK-UCL
- postsynaptic membrane Source: UniProtKB-SubCell
Other locations
- dendrite Source: UniProtKB
- integral component of membrane Source: UniProtKB
- neuron projection Source: GO_Central
- neuronal cell body Source: UniProtKB
- postsynaptic density Source: UniProtKB
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 32 – 240 | ExtracellularSequence analysisAdd BLAST | 209 | |
Transmembranei | 241 – 265 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 273 – 291 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 307 – 328 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 329 – 477 | CytoplasmicSequence analysisAdd BLAST | 149 | |
Transmembranei | 478 – 497 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Involvement in diseasei
Bladder dysfunction, autonomic, with impaired pupillary reflex and secondary CAKUT (BAIPRCK)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_083543 | 340 – 505 | Missing in BAIPRCK; loss-of-function variant affecting ion transmembrane transport in response to acetylcholine; does not localize to plasma membrane. 1 PublicationAdd BLAST | 166 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 1136 |
MalaCardsi | CHRNA3 |
MIMi | 191800, phenotype 612052, phenotype |
OpenTargetsi | ENSG00000080644 |
PharmGKBi | PA113 |
Miscellaneous databases
Pharosi | P32297, Tclin |
Chemistry databases
ChEMBLi | CHEMBL3068 |
DrugBanki | DB00915, Amantadine DB01156, Bupropion DB00237, Butabarbital DB09028, Cytisine DB00514, Dextromethorphan DB07720, Epibatidine DB00898, Ethanol DB00472, Fluoxetine DB05710, Gantacurium DB01227, Levacetylmethadol DB00848, Levamisole DB00333, Methadone DB00184, Nicotine DB01090, Pentolinium DB01273, Varenicline |
DrugCentrali | P32297 |
GuidetoPHARMACOLOGYi | 464 |
Genetic variation databases
BioMutai | CHRNA3 |
DMDMi | 254763435 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Sequence analysisAdd BLAST | 31 | |
ChainiPRO_0000000346 | 32 – 505 | Neuronal acetylcholine receptor subunit alpha-3Add BLAST | 474 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 55 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 159 ↔ 173 | By similarity | ||
Glycosylationi | 172 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 223 ↔ 224 | Associated with receptor activationBy similarity | ||
Modified residuei | 413 | PhosphoserineBy similarity | 1 | |
Modified residuei | 416 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | P32297 |
PaxDbi | P32297 |
PeptideAtlasi | P32297 |
PRIDEi | P32297 |
ProteomicsDBi | 54858 [P32297-2] 54859 [P32297-1] 54860 [P32297-3] |
PTM databases
GlyGeni | P32297, 2 sites |
iPTMneti | P32297 |
PhosphoSitePlusi | P32297 |
Expressioni
Gene expression databases
Bgeei | ENSG00000080644, Expressed in pigmented layer of retina and 156 other tissues |
ExpressionAtlasi | P32297, baseline and differential |
Genevisiblei | P32297, HS |
Organism-specific databases
HPAi | ENSG00000080644, Group enriched (adrenal gland, lymphoid tissue, retina) |
Interactioni
Subunit structurei
Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-3 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors.
Interacts with RIC3; which is required for proper folding and assembly (PubMed:16120769).
Interacts with LYPD6 (PubMed:27344019). The heteropentamer alpha-3-beta-2 interacts with alpha-conotoxins ImI and ImII (PubMed:15609996). The heteropentamer alpha-3-beta-2 interacts with alpha-conotoxins ImI, ImII, PnIA, GID and MII (By similarity). The heteropentamer alpha-3-beta-4 interacts with the alpha-conotoxin ImI (PubMed:15609996).
By similarity3 PublicationsProtein-protein interaction databases
BioGRIDi | 107558, 31 interactors |
ComplexPortali | CPX-187, Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta2 CPX-210, Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta4 CPX-213, Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta4 CPX-2192, Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3 CPX-2193, Neuronal nicotinic acetylcholine receptor complex, alpha3-beta2 CPX-2200, Neuronal nicotinic acetylcholine receptor complex, alpha3-beta4 |
IntActi | P32297, 31 interactors |
STRINGi | 9606.ENSP00000315602 |
Chemistry databases
BindingDBi | P32297 |
Miscellaneous databases
RNActi | P32297, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P32297 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3645, Eukaryota |
GeneTreei | ENSGT00940000158487 |
HOGENOMi | CLU_018074_1_0_1 |
InParanoidi | P32297 |
OMAi | QKPRPFY |
OrthoDBi | 381858at2759 |
PhylomeDBi | P32297 |
TreeFami | TF315605 |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS IPR002394, Nicotinic_acetylcholine_rcpt |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00254, NICOTINICR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGSGPLSLPL ALSPPRLLLL LLLSLLPVAR ASEAEHRLFE RLFEDYNEII
60 70 80 90 100
RPVANVSDPV IIHFEVSMSQ LVKVDEVNQI METNLWLKQI WNDYKLKWNP
110 120 130 140 150
SDYGGAEFMR VPAQKIWKPD IVLYNNAVGD FQVDDKTKAL LKYTGEVTWI
160 170 180 190 200
PPAIFKSSCK IDVTYFPFDY QNCTMKFGSW SYDKAKIDLV LIGSSMNLKD
210 220 230 240 250
YWESGEWAII KAPGYKHDIK YNCCEEIYPD ITYSLYIRRL PLFYTINLII
260 270 280 290 300
PCLLISFLTV LVFYLPSDCG EKVTLCISVL LSLTVFLLVI TETIPSTSLV
310 320 330 340 350
IPLIGEYLLF TMIFVTLSIV ITVFVLNVHY RTPTTHTMPS WVKTVFLNLL
360 370 380 390 400
PRVMFMTRPT SNEGNAQKPR PLYGAELSNL NCFSRAESKG CKEGYPCQDG
410 420 430 440 450
MCGYCHHRRI KISNFSANLT RSSSSESVDA VLSLSALSPE IKEAIQSVKY
460 470 480 490 500
IAENMKAQNE AKEIQDDWKY VAMVIDRIFL WVFTLVCILG TAGLFLQPLM
AREDA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0YNF9 | H0YNF9_HUMAN | Neuronal acetylcholine receptor sub... | CHRNA3 | 17 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 5 – 14 | PLSLPLALSP → ALAAPGAVA in AAA59942 (PubMed:1989896).Curated | 10 | |
Sequence conflicti | 12 – 15 | LSPP → CRA in AAC84176 (PubMed:2336208).Curated | 4 | |
Sequence conflicti | 102 | D → G in AAC84176 (PubMed:2336208).Curated | 1 | |
Sequence conflicti | 134 – 135 | DD → TT in AAC84176 (PubMed:2336208).Curated | 2 | |
Sequence conflicti | 237 | I → S in AAC84176 (PubMed:2336208).Curated | 1 | |
Sequence conflicti | 432 | L → V in AAC84176 (PubMed:2336208).Curated | 1 |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013240 | 23 | Missing 4 Publications | 1 | |
Natural variantiVAR_059110 | 37 | R → H. Corresponds to variant dbSNP:rs8192475Ensembl. | 1 | |
Natural variantiVAR_083543 | 340 – 505 | Missing in BAIPRCK; loss-of-function variant affecting ion transmembrane transport in response to acetylcholine; does not localize to plasma membrane. 1 PublicationAdd BLAST | 166 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037750 | 1 – 6 | MGSGPL → MALAV in isoform 1. 3 Publications | 6 | |
Alternative sequenceiVSP_037751 | 464 – 505 | IQDDW…AREDA → EQKAQEIQQLKRKEKSTETS DQEPGL in isoform 3. 2 PublicationsAdd BLAST | 42 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M86383 mRNA Translation: AAC84176.1 M37981 mRNA Translation: AAA59942.1 U62432 mRNA Translation: AAB40110.1 Y08418 mRNA Translation: CAA69695.1 AJ007783 , AJ007784, AJ007785, AJ007786, AJ007787 Genomic DNA Translation: CAA07682.1 BT006646 mRNA Translation: AAP35292.1 BT006897 mRNA Translation: AAP35543.1 AC027228 Genomic DNA No translation available. AC067863 Genomic DNA No translation available. BC000513 mRNA Translation: AAH00513.1 BC001642 mRNA Translation: AAH01642.1 BC002996 mRNA Translation: AAH02996.1 BC006114 mRNA Translation: AAH06114.1 BC098443 mRNA Translation: AAH98443.1 AF385584 mRNA Translation: AAK68110.1 X53559 mRNA Translation: CAA37625.1 |
CCDSi | CCDS10305.1 [P32297-2] CCDS53964.1 [P32297-3] |
PIRi | A37040 A53956 |
RefSeqi | NP_000734.2, NM_000743.4 [P32297-2] NP_001160166.1, NM_001166694.1 [P32297-3] |
Genome annotation databases
Ensembli | ENST00000326828; ENSP00000315602; ENSG00000080644 [P32297-2] ENST00000348639; ENSP00000267951; ENSG00000080644 [P32297-3] ENST00000559658; ENSP00000452896; ENSG00000080644 [P32297-2] |
GeneIDi | 1136 |
KEGGi | hsa:1136 |
UCSCi | uc002beb.4, human [P32297-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M86383 mRNA Translation: AAC84176.1 M37981 mRNA Translation: AAA59942.1 U62432 mRNA Translation: AAB40110.1 Y08418 mRNA Translation: CAA69695.1 AJ007783 , AJ007784, AJ007785, AJ007786, AJ007787 Genomic DNA Translation: CAA07682.1 BT006646 mRNA Translation: AAP35292.1 BT006897 mRNA Translation: AAP35543.1 AC027228 Genomic DNA No translation available. AC067863 Genomic DNA No translation available. BC000513 mRNA Translation: AAH00513.1 BC001642 mRNA Translation: AAH01642.1 BC002996 mRNA Translation: AAH02996.1 BC006114 mRNA Translation: AAH06114.1 BC098443 mRNA Translation: AAH98443.1 AF385584 mRNA Translation: AAK68110.1 X53559 mRNA Translation: CAA37625.1 |
CCDSi | CCDS10305.1 [P32297-2] CCDS53964.1 [P32297-3] |
PIRi | A37040 A53956 |
RefSeqi | NP_000734.2, NM_000743.4 [P32297-2] NP_001160166.1, NM_001166694.1 [P32297-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4ZK4 | X-ray | 1.90 | A/B/C/D/E | 215-230 | [»] | |
5SYO | X-ray | 2.00 | A/B/C/D/E | 215-230 | [»] | |
5TVC | X-ray | 1.93 | A/B/C/D/E | 215-230 | [»] | |
6PV7 | electron microscopy | 3.34 | A/D | 32-378 | [»] | |
A/D | 434-505 | [»] | ||||
6PV8 | electron microscopy | 3.87 | A/D | 32-378 | [»] | |
A/D | 434-505 | [»] | ||||
SMRi | P32297 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107558, 31 interactors |
ComplexPortali | CPX-187, Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta2 CPX-210, Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta4 CPX-213, Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta4 CPX-2192, Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3 CPX-2193, Neuronal nicotinic acetylcholine receptor complex, alpha3-beta2 CPX-2200, Neuronal nicotinic acetylcholine receptor complex, alpha3-beta4 |
IntActi | P32297, 31 interactors |
STRINGi | 9606.ENSP00000315602 |
Chemistry databases
BindingDBi | P32297 |
ChEMBLi | CHEMBL3068 |
DrugBanki | DB00915, Amantadine DB01156, Bupropion DB00237, Butabarbital DB09028, Cytisine DB00514, Dextromethorphan DB07720, Epibatidine DB00898, Ethanol DB00472, Fluoxetine DB05710, Gantacurium DB01227, Levacetylmethadol DB00848, Levamisole DB00333, Methadone DB00184, Nicotine DB01090, Pentolinium DB01273, Varenicline |
DrugCentrali | P32297 |
GuidetoPHARMACOLOGYi | 464 |
PTM databases
GlyGeni | P32297, 2 sites |
iPTMneti | P32297 |
PhosphoSitePlusi | P32297 |
Genetic variation databases
BioMutai | CHRNA3 |
DMDMi | 254763435 |
Proteomic databases
MassIVEi | P32297 |
PaxDbi | P32297 |
PeptideAtlasi | P32297 |
PRIDEi | P32297 |
ProteomicsDBi | 54858 [P32297-2] 54859 [P32297-1] 54860 [P32297-3] |
Protocols and materials databases
Antibodypediai | 15113, 288 antibodies |
DNASUi | 1136 |
Genome annotation databases
Ensembli | ENST00000326828; ENSP00000315602; ENSG00000080644 [P32297-2] ENST00000348639; ENSP00000267951; ENSG00000080644 [P32297-3] ENST00000559658; ENSP00000452896; ENSG00000080644 [P32297-2] |
GeneIDi | 1136 |
KEGGi | hsa:1136 |
UCSCi | uc002beb.4, human [P32297-2] |
Organism-specific databases
CTDi | 1136 |
DisGeNETi | 1136 |
GeneCardsi | CHRNA3 |
HGNCi | HGNC:1957, CHRNA3 |
HPAi | ENSG00000080644, Group enriched (adrenal gland, lymphoid tissue, retina) |
MalaCardsi | CHRNA3 |
MIMi | 118503, gene 191800, phenotype 612052, phenotype |
neXtProti | NX_P32297 |
OpenTargetsi | ENSG00000080644 |
PharmGKBi | PA113 |
VEuPathDBi | HostDB:ENSG00000080644.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3645, Eukaryota |
GeneTreei | ENSGT00940000158487 |
HOGENOMi | CLU_018074_1_0_1 |
InParanoidi | P32297 |
OMAi | QKPRPFY |
OrthoDBi | 381858at2759 |
PhylomeDBi | P32297 |
TreeFami | TF315605 |
Enzyme and pathway databases
PathwayCommonsi | P32297 |
Reactomei | R-HSA-629587, Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629594, Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629597, Highly calcium permeable nicotinic acetylcholine receptors |
Miscellaneous databases
BioGRID-ORCSi | 1136, 6 hits in 871 CRISPR screens |
ChiTaRSi | CHRNA3, human |
GeneWikii | CHRNA3 |
GenomeRNAii | 1136 |
Pharosi | P32297, Tclin |
PROi | PR:P32297 |
RNActi | P32297, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000080644, Expressed in pigmented layer of retina and 156 other tissues |
ExpressionAtlasi | P32297, baseline and differential |
Genevisiblei | P32297, HS |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS IPR002394, Nicotinic_acetylcholine_rcpt |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00254, NICOTINICR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACHA3_HUMAN | |
Accessioni | P32297Primary (citable) accession number: P32297 Secondary accession number(s): Q15823 Q9BRR4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | July 28, 2009 | |
Last modified: | February 10, 2021 | |
This is version 209 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families