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Protein

Antithrombin-III

Gene

Serpinc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei82HeparinBy similarity1
Binding sitei162HeparinBy similarity1
Binding sitei178HeparinBy similarity1
Sitei426 – 427Reactive bond2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding, Protease inhibitor, Serine protease inhibitor
Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-MMU-140837 Intrinsic Pathway of Fibrin Clot Formation
R-MMU-140875 Common Pathway of Fibrin Clot Formation
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiI04.018

Names & Taxonomyi

Protein namesi
Recommended name:
Antithrombin-III
Short name:
ATIII
Alternative name(s):
Serpin C1
Gene namesi
Name:Serpinc1
Synonyms:At3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88095 Serpinc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32By similarityAdd BLAST32
ChainiPRO_000003249033 – 465Antithrombin-IIIAdd BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 161By similarity
Disulfide bondi54 ↔ 128By similarity
Modified residuei64PhosphothreonineBy similarity1
Modified residuei69PhosphoserineBy similarity1
Glycosylationi129N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi168N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi188N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi225N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi280 ↔ 463By similarity

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP32261
PeptideAtlasiP32261
PRIDEiP32261

PTM databases

iPTMnetiP32261
PhosphoSitePlusiP32261
SwissPalmiP32261

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiENSMUSG00000026715 Expressed in 76 organ(s), highest expression level in liver
ExpressionAtlasiP32261 baseline and differential
GenevisibleiP32261 MM

Interactioni

Subunit structurei

Forms protease inhibiting heterodimer with TMPRSS7.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP32261, 3 interactors
MINTiP32261
STRINGi10090.ENSMUSP00000068971

Structurei

3D structure databases

ProteinModelPortaliP32261
SMRiP32261
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00900000140788
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiP32261
KOiK03911
OMAiKFRYRRV
OrthoDBiEOG091G0ION
PhylomeDBiP32261
TreeFamiTF343094

Family and domain databases

CDDicd02045 antithrombin-III_like, 1 hit
InterProiView protein in InterPro
IPR033829 Antithrombin_domain
IPR015555 AT-III
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PTHR11461:SF53 PTHR11461:SF53, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.iShow all

P32261-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYSPGAGSGA AGERKLCLLS LLLIGALGCA ICHGNPVDDI CIAKPRDIPV
60 70 80 90 100
NPLCIYRSPG KKATEEDGSE QKVPEATNRR VWELSKANSR FATNFYQHLA
110 120 130 140 150
DSKNDNDNIF LSPLSISTAF AMTKLGACND TLKQLMEVFK FDTISEKTSD
160 170 180 190 200
QIHFFFAKLN CRLYRKANKS SDLVSANRLF GDKSLTFNES YQDVSEVVYG
210 220 230 240 250
AKLQPLDFKE NPEQSRVTIN NWVANKTEGR IKDVIPQGAI NELTALVLVN
260 270 280 290 300
TIYFKGLWKS KFSPENTRKE PFYKVDGQSC PVPMMYQEGK FKYRRVAEGT
310 320 330 340 350
QVLELPFKGD DITMVLILPK PEKSLAKVEQ ELTPELLQEW LDELSETMLV
360 370 380 390 400
VHMPRFRTED GFSLKEQLQD MGLIDLFSPE KSQLPGIVAG GRDDLYVSDA
410 420 430 440 450
FHKAFLEVNE EGSEAAASTS VVITGRSLNP NRVTFKANRP FLVLIREVAL
460
NTIIFMGRVA NPCVN
Length:465
Mass (Da):52,004
Last modified:October 1, 1993 - v1
Checksum:i5CE087E98874E35D
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YWH7A0A0A6YWH7_MOUSE
Antithrombin-III
Serpinc1
286Annotation score:
A0A0A6YX70A0A0A6YX70_MOUSE
Antithrombin-III
Serpinc1
107Annotation score:
A0A0A6YXS8A0A0A6YXS8_MOUSE
Antithrombin-III
Serpinc1
92Annotation score:
A0A0A6YX49A0A0A6YX49_MOUSE
Antithrombin-III
Serpinc1
103Annotation score:
A0A0A6YX85A0A0A6YX85_MOUSE
Antithrombin-III
Serpinc1
65Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S47225 mRNA Translation: AAB23965.1
BC019447 mRNA Translation: AAH19447.1
BC033377 mRNA Translation: AAH33377.1
CCDSiCCDS15411.1
RefSeqiNP_543120.1, NM_080844.4
XP_006496689.1, XM_006496626.2
UniGeneiMm.260770

Genome annotation databases

EnsembliENSMUST00000064725; ENSMUSP00000068971; ENSMUSG00000026715
GeneIDi11905
KEGGimmu:11905
UCSCiuc007dem.2 mouse

Similar proteinsi

Entry informationi

Entry nameiANT3_MOUSE
AccessioniPrimary (citable) accession number: P32261
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 12, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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