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Protein

C-C chemokine receptor type 7

Gene

CCR7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.

GO - Molecular functioni

  • C-C chemokine binding Source: GO_Central
  • C-C chemokine receptor activity Source: BHF-UCL
  • C-C motif chemokine 19 receptor activity Source: UniProtKB
  • C-C motif chemokine 21 receptor activity Source: UniProtKB
  • chemokine (C-C motif) ligand 19 binding Source: BHF-UCL
  • chemokine (C-C motif) ligand 21 binding Source: BHF-UCL
  • chemokine binding Source: GO_Central
  • G protein-coupled receptor activity Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
SIGNORiP32248

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 7
Short name:
C-C CKR-7
Short name:
CC-CKR-7
Short name:
CCR-7
Alternative name(s):
BLR2
CDw197
Epstein-Barr virus-induced G-protein coupled receptor 1
Short name:
EBI1
Short name:
EBV-induced G-protein coupled receptor 1
MIP-3 beta receptor
CD_antigen: CD197
Gene namesi
Name:CCR7
Synonyms:CMKBR7, EBI1, EVI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000126353.3
HGNCiHGNC:1608 CCR7
MIMi600242 gene
neXtProtiNX_P32248

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 59ExtracellularSequence analysisAdd BLAST35
Transmembranei60 – 86Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini87 – 95CytoplasmicSequence analysis9
Transmembranei96 – 116Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini117 – 130ExtracellularSequence analysisAdd BLAST14
Transmembranei131 – 152Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini153 – 170CytoplasmicSequence analysisAdd BLAST18
Transmembranei171 – 191Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini192 – 219ExtracellularSequence analysisAdd BLAST28
Transmembranei220 – 247Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini248 – 263CytoplasmicSequence analysisAdd BLAST16
Transmembranei264 – 289Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini290 – 313ExtracellularSequence analysisAdd BLAST24
Transmembranei314 – 331Helical; Name=7Sequence analysisAdd BLAST18
Topological domaini332 – 378CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1236
OpenTargetsiENSG00000126353
PharmGKBiPA26172

Chemistry databases

ChEMBLiCHEMBL4594
GuidetoPHARMACOLOGYi64

Polymorphism and mutation databases

BioMutaiCCR7
DMDMi1352335

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001273525 – 378C-C chemokine receptor type 7Add BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi129 ↔ 210PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP32248
PaxDbiP32248
PeptideAtlasiP32248
PRIDEiP32248
ProteomicsDBi54856

PTM databases

iPTMnetiP32248
PhosphoSitePlusiP32248

Expressioni

Tissue specificityi

Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.

Inductioni

By Epstein-Barr virus (EBV).

Gene expression databases

BgeeiENSG00000126353 Expressed in 122 organ(s), highest expression level in blood
CleanExiHS_CCR7
HS_EVI1
ExpressionAtlasiP32248 baseline and differential
GenevisibleiP32248 HS

Organism-specific databases

HPAiCAB003796
HPA031383
HPA074467

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107641, 2 interactors
DIPiDIP-5855N
IntActiP32248, 4 interactors
MINTiP32248
STRINGi9606.ENSP00000246657

Chemistry databases

BindingDBiP32248

Structurei

3D structure databases

ProteinModelPortaliP32248
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMBE Eukaryota
ENOG4110ZGY LUCA
GeneTreeiENSGT00930000150843
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiP32248
KOiK04182
OMAiRCCLNPF
OrthoDBiEOG091G0BDV
PhylomeDBiP32248
TreeFamiTF330966

Family and domain databases

InterProiView protein in InterPro
IPR001718 Chemokine_CCR7
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR00641 CHEMOKINER7
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P32248-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLGKPMKSV LVVALLVIFQ VCLCQDEVTD DYIGDNTTVD YTLFESLCSK
60 70 80 90 100
KDVRNFKAWF LPIMYSIICF VGLLGNGLVV LTYIYFKRLK TMTDTYLLNL
110 120 130 140 150
AVADILFLLT LPFWAYSAAK SWVFGVHFCK LIFAIYKMSF FSGMLLLLCI
160 170 180 190 200
SIDRYVAIVQ AVSAHRHRAR VLLISKLSCV GIWILATVLS IPELLYSDLQ
210 220 230 240 250
RSSSEQAMRC SLITEHVEAF ITIQVAQMVI GFLVPLLAMS FCYLVIIRTL
260 270 280 290 300
LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVVLAQTVAN FNITSSTCEL
310 320 330 340 350
SKQLNIAYDV TYSLACVRCC VNPFLYAFIG VKFRNDLFKL FKDLGCLSQE
360 370
QLRQWSSCRH IRRSSMSVEA ETTTTFSP
Length:378
Mass (Da):42,874
Last modified:February 1, 1996 - v2
Checksum:iD4CB4213841A1BD4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KSS9J3KSS9_HUMAN
C-C chemokine receptor type 7
CCR7
372Annotation score:
J3KTN5J3KTN5_HUMAN
C-C chemokine receptor type 7
CCR7
199Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182 – 183IW → SA in AAA58615 (PubMed:8383238).Curated2
Sequence conflicti337L → I in AAA58615 (PubMed:8383238).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0493837M → V. Corresponds to variant dbSNP:rs2228015Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08176 mRNA Translation: AAA58615.1
L31584, L31582, L31583 Genomic DNA Translation: AAA74230.1
L31581 mRNA Translation: AAA74231.1
AY587876 mRNA Translation: AAT52232.1
BC035343 mRNA Translation: AAH35343.1
CCDSiCCDS11369.1
PIRiA45680
B55735
RefSeqiNP_001288643.1, NM_001301714.1
NP_001288645.1, NM_001301716.1
NP_001288646.1, NM_001301717.1
NP_001288647.1, NM_001301718.1
NP_001829.1, NM_001838.3
UniGeneiHs.370036

Genome annotation databases

EnsembliENST00000246657; ENSP00000246657; ENSG00000126353
GeneIDi1236
KEGGihsa:1236
UCSCiuc002huw.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CC chemokine receptors entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08176 mRNA Translation: AAA58615.1
L31584, L31582, L31583 Genomic DNA Translation: AAA74230.1
L31581 mRNA Translation: AAA74231.1
AY587876 mRNA Translation: AAT52232.1
BC035343 mRNA Translation: AAH35343.1
CCDSiCCDS11369.1
PIRiA45680
B55735
RefSeqiNP_001288643.1, NM_001301714.1
NP_001288645.1, NM_001301716.1
NP_001288646.1, NM_001301717.1
NP_001288647.1, NM_001301718.1
NP_001829.1, NM_001838.3
UniGeneiHs.370036

3D structure databases

ProteinModelPortaliP32248
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107641, 2 interactors
DIPiDIP-5855N
IntActiP32248, 4 interactors
MINTiP32248
STRINGi9606.ENSP00000246657

Chemistry databases

BindingDBiP32248
ChEMBLiCHEMBL4594
GuidetoPHARMACOLOGYi64

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP32248
PhosphoSitePlusiP32248

Polymorphism and mutation databases

BioMutaiCCR7
DMDMi1352335

Proteomic databases

MaxQBiP32248
PaxDbiP32248
PeptideAtlasiP32248
PRIDEiP32248
ProteomicsDBi54856

Protocols and materials databases

DNASUi1236
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246657; ENSP00000246657; ENSG00000126353
GeneIDi1236
KEGGihsa:1236
UCSCiuc002huw.4 human

Organism-specific databases

CTDi1236
DisGeNETi1236
EuPathDBiHostDB:ENSG00000126353.3
GeneCardsiCCR7
HGNCiHGNC:1608 CCR7
HPAiCAB003796
HPA031383
HPA074467
MIMi600242 gene
neXtProtiNX_P32248
OpenTargetsiENSG00000126353
PharmGKBiPA26172
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMBE Eukaryota
ENOG4110ZGY LUCA
GeneTreeiENSGT00930000150843
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiP32248
KOiK04182
OMAiRCCLNPF
OrthoDBiEOG091G0BDV
PhylomeDBiP32248
TreeFamiTF330966

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
SIGNORiP32248

Miscellaneous databases

GeneWikiiC-C_chemokine_receptor_type_7
GenomeRNAii1236
PROiPR:P32248
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126353 Expressed in 122 organ(s), highest expression level in blood
CleanExiHS_CCR7
HS_EVI1
ExpressionAtlasiP32248 baseline and differential
GenevisibleiP32248 HS

Family and domain databases

InterProiView protein in InterPro
IPR001718 Chemokine_CCR7
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR00641 CHEMOKINER7
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCR7_HUMAN
AccessioniPrimary (citable) accession number: P32248
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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