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Protein

C-C chemokine receptor type 1

Gene

CCR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.

GO - Molecular functioni

  • C-C chemokine binding Source: UniProtKB
  • C-C chemokine receptor activity Source: UniProtKB
  • chemokine (C-C motif) ligand 5 binding Source: UniProtKB
  • chemokine (C-C motif) ligand 7 binding Source: UniProtKB
  • chemokine receptor activity Source: UniProtKB
  • phosphatidylinositol phospholipase C activity Source: UniProtKB

GO - Biological processi

  • calcium ion transport Source: UniProtKB
  • cell adhesion Source: ProtInc
  • cell-cell signaling Source: UniProtKB
  • cell surface receptor signaling pathway Source: ProtInc
  • cellular calcium ion homeostasis Source: UniProtKB
  • chemokine-mediated signaling pathway Source: UniProtKB
  • chemotaxis Source: UniProtKB
  • cytokine-mediated signaling pathway Source: Reactome
  • dendritic cell chemotaxis Source: BHF-UCL
  • exocytosis Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: Reactome
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  • immune response Source: UniProtKB
  • inflammatory response Source: ProtInc
  • negative regulation of bone mineralization Source: UniProtKB
  • negative regulation of gene expression Source: UniProtKB
  • positive regulation of calcium ion transport Source: UniProtKB
  • positive regulation of cell migration Source: CACAO
  • positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  • positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • positive regulation of monocyte chemotaxis Source: UniProtKB
  • positive regulation of osteoclast differentiation Source: UniProtKB
  • response to wounding Source: ProtInc

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-6783783 Interleukin-10 signaling
SIGNORiP32246

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 1
Short name:
C-C CKR-1
Short name:
CC-CKR-1
Short name:
CCR-1
Short name:
CCR1
Alternative name(s):
HM145
LD78 receptor
Macrophage inflammatory protein 1-alpha receptor
Short name:
MIP-1alpha-R
RANTES-R
CD_antigen: CD191
Gene namesi
Name:CCR1
Synonyms:CMKBR1, CMKR1, SCYAR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163823.3
HGNCiHGNC:1602 CCR1
MIMi601159 gene
neXtProtiNX_P32246

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
Transmembranei35 – 60Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini61 – 64CytoplasmicSequence analysis4
Transmembranei65 – 91Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini92 – 107ExtracellularSequence analysisAdd BLAST16
Transmembranei108 – 129Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini130 – 146CytoplasmicSequence analysisAdd BLAST17
Transmembranei147 – 171Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini172 – 197ExtracellularSequence analysisAdd BLAST26
Transmembranei198 – 223Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini224 – 239CytoplasmicSequence analysisAdd BLAST16
Transmembranei240 – 264Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini265 – 281ExtracellularSequence analysisAdd BLAST17
Transmembranei282 – 305Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini306 – 355CytoplasmicSequence analysisAdd BLAST50

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1230
MalaCardsiCCR1
OpenTargetsiENSG00000163823
PharmGKBiPA26166

Chemistry databases

ChEMBLiCHEMBL2413
GuidetoPHARMACOLOGYi58

Polymorphism and mutation databases

BioMutaiCCR1
DMDMi416802

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692281 – 355C-C chemokine receptor type 1Add BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP32246
PeptideAtlasiP32246
PRIDEiP32246
ProteomicsDBi54854

PTM databases

iPTMnetiP32246
PhosphoSitePlusiP32246

Expressioni

Tissue specificityi

Widely expressed in different hematopoietic cells.

Inductioni

Up-regulated by CREB3.1 Publication

Gene expression databases

BgeeiENSG00000163823
CleanExiHS_CCR1
ExpressionAtlasiP32246 baseline and differential
GenevisibleiP32246 HS

Interactioni

Subunit structurei

Interacts with CREB3.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • C-C chemokine binding Source: UniProtKB
  • chemokine (C-C motif) ligand 5 binding Source: UniProtKB
  • chemokine (C-C motif) ligand 7 binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107635, 19 interactors
DIPiDIP-5832N
IntActiP32246, 3 interactors
STRINGi9606.ENSP00000296140

Chemistry databases

BindingDBiP32246

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y5Dmodel-A1-355[»]
ProteinModelPortaliP32246
SMRiP32246
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118785
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiP32246
KOiK04176
OMAiLHFPHES
OrthoDBiEOG091G0B7A
PhylomeDBiP32246
TreeFamiTF330966

Family and domain databases

InterProiView protein in InterPro
IPR002236 Chemokine_CCR1
IPR034321 Chemokine_CCR1_euk
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR10489:SF711 PTHR10489:SF711, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01106 CHEMOKINER1
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P32246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METPNTTEDY DTTTEFDYGD ATPCQKVNER AFGAQLLPPL YSLVFVIGLV
60 70 80 90 100
GNILVVLVLV QYKRLKNMTS IYLLNLAISD LLFLFTLPFW IDYKLKDDWV
110 120 130 140 150
FGDAMCKILS GFYYTGLYSE IFFIILLTID RYLAIVHAVF ALRARTVTFG
160 170 180 190 200
VITSIIIWAL AILASMPGLY FSKTQWEFTH HTCSLHFPHE SLREWKLFQA
210 220 230 240 250
LKLNLFGLVL PLLVMIICYT GIIKILLRRP NEKKSKAVRL IFVIMIIFFL
260 270 280 290 300
FWTPYNLTIL ISVFQDFLFT HECEQSRHLD LAVQVTEVIA YTHCCVNPVI
310 320 330 340 350
YAFVGERFRK YLRQLFHRRV AVHLVKWLPF LSVDRLERVS STSPSTGEHE

LSAGF
Length:355
Mass (Da):41,173
Last modified:October 1, 1993 - v1
Checksum:iB2C100FFED275985
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti337E → D in BAA01723 (PubMed:7505609).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09230 mRNA Translation: AAA58408.1
L10918 mRNA Translation: AAA36543.1
D10925 mRNA Translation: BAA01723.1
BC051306 mRNA Translation: AAH51306.2
BC064991 mRNA Translation: AAH64991.1
CCDSiCCDS2737.1
PIRiA45177
RefSeqiNP_001286.1, NM_001295.2
UniGeneiHs.301921

Genome annotation databases

EnsembliENST00000296140; ENSP00000296140; ENSG00000163823
GeneIDi1230
KEGGihsa:1230

Similar proteinsi

Entry informationi

Entry nameiCCR1_HUMAN
AccessioniPrimary (citable) accession number: P32246
Secondary accession number(s): Q86VA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 20, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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