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Protein

Melanocortin receptor 4

Gene

MC4R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • melanocortin receptor activity Source: ProtInc
  • melanocyte-stimulating hormone receptor activity Source: UniProtKB
  • neuropeptide binding Source: UniProtKB
  • peptide hormone binding Source: Ensembl
  • ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418555 G alpha (s) signalling events

SIGNOR Signaling Network Open Resource

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SIGNORi
P32245

Protein family/group databases

Transport Classification Database

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TCDBi
9.A.14.2.3 the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Melanocortin receptor 4
Short name:
MC4-R
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MC4R
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000166603.4

Human Gene Nomenclature Database

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HGNCi
HGNC:6932 MC4R

Online Mendelian Inheritance in Man (OMIM)

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MIMi
155541 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P32245

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 43ExtracellularSequence analysisAdd BLAST43
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei44 – 69Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini70 – 81CytoplasmicSequence analysisAdd BLAST12
Transmembranei82 – 106Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini107 – 123ExtracellularSequence analysisAdd BLAST17
Transmembranei124 – 145Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini146 – 165CytoplasmicSequence analysisAdd BLAST20
Transmembranei166 – 186Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini187 – 191ExtracellularSequence analysis5
Transmembranei192 – 215Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini216 – 248CytoplasmicSequence analysisAdd BLAST33
Transmembranei249 – 271Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini272 – 280ExtracellularSequence analysis9
Transmembranei281 – 304Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini305 – 332CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Obesity (OBESITY)8 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
See also OMIM:601665

Keywords - Diseasei

Disease mutation, Obesity

Organism-specific databases

DisGeNET

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DisGeNETi
4160

MalaCards human disease database

More...
MalaCardsi
MC4R
MIMi601665 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000166603

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
71529 Obesity due to melanocortin 4 receptor deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA30676

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL259

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
285

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MC4R

Domain mapping of disease mutations (DMDM)

More...
DMDMi
60392672

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000697221 – 332Melanocortin receptor 4Add BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi84Interchain
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi318S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P32245

PRoteomics IDEntifications database

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PRIDEi
P32245

ProteomicsDB human proteome resource

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ProteomicsDBi
54853

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P32245

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P32245

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain, placental, and gut tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166603 Expressed in 37 organ(s), highest expression level in caudate nucleus

CleanEx database of gene expression profiles

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CleanExi
HS_MC4R

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P32245 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA016719

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ATRNL1 (By similarity). Homodimer; disulfide-linked, also forms higher order oligomers. Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production. Interacts with MRAP and MRAP2; these associated factors increase ligand-sensitivity and generation of cAMP.By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MRAPQ8TCY52EBI-3910694,EBI-9538727

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110330, 6 interactors

Database of interacting proteins

More...
DIPi
DIP-48791N

Protein interaction database and analysis system

More...
IntActi
P32245, 3 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000299766

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P32245

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P32245

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P32245

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154338

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000246927

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108148

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P32245

KEGG Orthology (KO)

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KOi
K04202

Identification of Orthologs from Complete Genome Data

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OMAi
GTGTIRQ

Database of Orthologous Groups

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OrthoDBi
EOG091G0BVW

Database for complete collections of gene phylogenies

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PhylomeDBi
P32245

TreeFam database of animal gene trees

More...
TreeFami
TF332646

Family and domain databases

Conserved Domains Database

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CDDi
cd15353 7tmA_MC4R, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000155 Mcort_rcpt_4
IPR001908 Melancort_rcpt
IPR001671 Melcrt_ACTH_rcpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00237 GPCRRHODOPSN
PR00534 MCRFAMILY
PR00535 MELNOCORTINR
PR01062 MELNOCORTN4R

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P32245-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNSTHRGMH TSLHLWNRSS YRLHSNASES LGKGYSDGGC YEQLFVSPEV
60 70 80 90 100
FVTLGVISLL ENILVIVAIA KNKNLHSPMY FFICSLAVAD MLVSVSNGSE
110 120 130 140 150
TIVITLLNST DTDAQSFTVN IDNVIDSVIC SSLLASICSL LSIAVDRYFT
160 170 180 190 200
IFYALQYHNI MTVKRVGIII SCIWAACTVS GILFIIYSDS SAVIICLITM
210 220 230 240 250
FFTMLALMAS LYVHMFLMAR LHIKRIAVLP GTGAIRQGAN MKGAITLTIL
260 270 280 290 300
IGVFVVCWAP FFLHLIFYIS CPQNPYCVCF MSHFNLYLIL IMCNSIIDPL
310 320 330
IYALRSQELR KTFKEIICCY PLGGLCDLSS RY
Length:332
Mass (Da):36,943
Last modified:October 25, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE80010BAADBED2B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti169I → S in AAB33341 (PubMed:7854347).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03863211T → A in obesity; partial activity. 1 PublicationCorresponds to variant dbSNP:rs372794914Ensembl.1
Natural variantiVAR_01070430S → F in obesity. 1 PublicationCorresponds to variant dbSNP:rs13447323Ensembl.1
Natural variantiVAR_03863336S → Y in obesity; shows the same affinity as the wild-type but significant impairment of cAMP-induced activity in response to melanotan II compared with the wild-type receptor. 1 Publication1
Natural variantiVAR_01070537D → V in obesity. 1 PublicationCorresponds to variant dbSNP:rs13447325EnsemblClinVar.1
Natural variantiVAR_03863450V → M in obesity. 1 PublicationCorresponds to variant dbSNP:rs121913557EnsemblClinVar.1
Natural variantiVAR_03863558S → C in obesity. 1 PublicationCorresponds to variant dbSNP:rs121913558EnsemblClinVar.1
Natural variantiVAR_03863662N → S in obesity; shows a partial cAMP response to alpha-MSH. 2 PublicationsCorresponds to variant dbSNP:rs121913566EnsemblClinVar.1
Natural variantiVAR_07757072N → K Probable disease-associated mutation found in a patient with early onset obesity and hyperphagia; loss of plasma membrane localization; loss of receptor function. 1 Publication1
Natural variantiVAR_01070678P → L in obesity. 1 PublicationCorresponds to variant dbSNP:rs13447326Ensembl.1
Natural variantiVAR_03863788 – 92Missing in obesity; the mutant receptor is expressed well on the cell surface but is completely devoid of ligand binding and cAMP generation in response to agonist stimulation. 1 Publication5
Natural variantiVAR_03863897N → D in obesity; completely unable to generate cAMP in response to ligand; shows evidence of impaired cell surface expression. 2 PublicationsCorresponds to variant dbSNP:rs121913565EnsemblClinVar.1
Natural variantiVAR_038639102I → S in obesity; shows the same affinity as the wild-type but significant impairment of cAMP-induced activity in response to melanotan II compared with the wild-type receptor. 1 PublicationCorresponds to variant dbSNP:rs121913559EnsemblClinVar.1
Natural variantiVAR_038640102I → T in obesity. 1 PublicationCorresponds to variant dbSNP:rs121913559EnsemblClinVar.1
Natural variantiVAR_010707103V → I6 PublicationsCorresponds to variant dbSNP:rs2229616EnsemblClinVar.1
Natural variantiVAR_038641106L → P in obesity; completely unable to generate cAMP in response to ligand; shows evidence of impaired cell surface expression. 1 Publication1
Natural variantiVAR_010708112T → M Polymorphism; no effect on MC4R signaling. 4 PublicationsCorresponds to variant dbSNP:rs13447329Ensembl.1
Natural variantiVAR_038642125I → K in obesity; completely unable to generate cAMP in response to ligand; shows evidence of impaired cell surface expression. 2 Publications1
Natural variantiVAR_038643127S → L in obesity; signaling properties in response to alpha-MSH, beta-MSH and gamma-1-MSH are impaired. 1 PublicationCorresponds to variant dbSNP:rs13447331EnsemblClinVar.1
Natural variantiVAR_038644165R → Q in obesity; shows a partial cAMP response to alpha-MSH. 3 PublicationsCorresponds to variant dbSNP:rs13447332Ensembl.1
Natural variantiVAR_010709165R → W in obesity. 1 PublicationCorresponds to variant dbSNP:rs13447332Ensembl.1
Natural variantiVAR_038645170I → V in obesity. 1 PublicationCorresponds to variant dbSNP:rs121913560EnsemblClinVar.1
Natural variantiVAR_038646175A → T in obesity; shows a partial cAMP response to alpha-MSH. 3 PublicationsCorresponds to variant dbSNP:rs121913563EnsemblClinVar.1
Natural variantiVAR_038647181G → D in obesity; does not bind alpha-MSH. 1 PublicationCorresponds to variant dbSNP:rs13447333Ensembl.1
Natural variantiVAR_038648219A → V in obesity; shows significantly impairment of cAMP-induced activity in response to melanotan II compared with the wild-type receptor. 1 PublicationCorresponds to variant dbSNP:rs121913567EnsemblClinVar.1
Natural variantiVAR_038649226I → T1 PublicationCorresponds to variant dbSNP:rs193922686EnsemblClinVar.1
Natural variantiVAR_010710251I → L5 PublicationsCorresponds to variant dbSNP:rs52820871EnsemblClinVar.1
Natural variantiVAR_010711252G → S in obesity. 1 PublicationCorresponds to variant dbSNP:rs13447336Ensembl.1
Natural variantiVAR_038650253V → I in obesity; shows a partial cAMP response to alpha-MSH. 1 PublicationCorresponds to variant dbSNP:rs187152753EnsemblClinVar.1
Natural variantiVAR_038651271C → R in obesity; completely unable to generate cAMP in response to ligand; shows impaired cell surface expression. 1 PublicationCorresponds to variant dbSNP:rs1057517991Ensembl.1
Natural variantiVAR_038652271C → Y in obesity; no activity. 2 PublicationsCorresponds to variant dbSNP:rs121913562EnsemblClinVar.1
Natural variantiVAR_015357274N → S in obesity. 1 PublicationCorresponds to variant dbSNP:rs121913561EnsemblClinVar.1
Natural variantiVAR_038653316I → S in obesity; shows reduced cAMP response to alpha-MSH; retains normal affinity for the antagonist AGRP. 2 PublicationsCorresponds to variant dbSNP:rs121913564EnsemblClinVar.1
Natural variantiVAR_010712317I → T in obesity. 1 PublicationCorresponds to variant dbSNP:rs13447337Ensembl.1
Natural variantiVAR_038654325L → F in obesity; does not bind alpha-MSH. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L08603 Genomic DNA Translation: AAA35791.1
S77415 Genomic DNA Translation: AAB33341.1
AY236539 Genomic DNA Translation: AAO92061.1
AK314130 mRNA Translation: BAG36820.1
CH471096 Genomic DNA Translation: EAW63105.1
BC069172 mRNA Translation: AAH69172.1
BC101802 mRNA Translation: AAI01803.1
BC111992 mRNA Translation: AAI11993.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11976.1

Protein sequence database of the Protein Information Resource

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PIRi
A57055

NCBI Reference Sequences

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RefSeqi
NP_005903.2, NM_005912.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.532833

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000299766; ENSP00000299766; ENSG00000166603

Database of genes from NCBI RefSeq genomes

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GeneIDi
4160

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4160

UCSC genome browser

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UCSCi
uc002lie.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Melanocortin receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08603 Genomic DNA Translation: AAA35791.1
S77415 Genomic DNA Translation: AAB33341.1
AY236539 Genomic DNA Translation: AAO92061.1
AK314130 mRNA Translation: BAG36820.1
CH471096 Genomic DNA Translation: EAW63105.1
BC069172 mRNA Translation: AAH69172.1
BC101802 mRNA Translation: AAI01803.1
BC111992 mRNA Translation: AAI11993.1
CCDSiCCDS11976.1
PIRiA57055
RefSeqiNP_005903.2, NM_005912.2
UniGeneiHs.532833

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IQPmodel-A29-321[»]
2IQRmodel-A28-321[»]
2IQSmodel-A28-321[»]
2IQUmodel-A28-321[»]
2IQVmodel-A40-321[»]
2IQWmodel-A40-321[»]
ProteinModelPortaliP32245
SMRiP32245
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110330, 6 interactors
DIPiDIP-48791N
IntActiP32245, 3 interactors
STRINGi9606.ENSP00000299766

Chemistry databases

BindingDBiP32245
ChEMBLiCHEMBL259
GuidetoPHARMACOLOGYi285

Protein family/group databases

TCDBi9.A.14.2.3 the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

iPTMnetiP32245
PhosphoSitePlusiP32245

Polymorphism and mutation databases

BioMutaiMC4R
DMDMi60392672

Proteomic databases

PaxDbiP32245
PRIDEiP32245
ProteomicsDBi54853

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299766; ENSP00000299766; ENSG00000166603
GeneIDi4160
KEGGihsa:4160
UCSCiuc002lie.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4160
DisGeNETi4160
EuPathDBiHostDB:ENSG00000166603.4

GeneCards: human genes, protein and diseases

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GeneCardsi
MC4R
HGNCiHGNC:6932 MC4R
HPAiHPA016719
MalaCardsiMC4R
MIMi155541 gene
601665 phenotype
neXtProtiNX_P32245
OpenTargetsiENSG00000166603
Orphaneti71529 Obesity due to melanocortin 4 receptor deficiency
PharmGKBiPA30676

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000154338
HOGENOMiHOG000246927
HOVERGENiHBG108148
InParanoidiP32245
KOiK04202
OMAiGTGTIRQ
OrthoDBiEOG091G0BVW
PhylomeDBiP32245
TreeFamiTF332646

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418555 G alpha (s) signalling events
SIGNORiP32245

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Melanocortin_4_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4160

Protein Ontology

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PROi
PR:P32245

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166603 Expressed in 37 organ(s), highest expression level in caudate nucleus
CleanExiHS_MC4R
GenevisibleiP32245 HS

Family and domain databases

CDDicd15353 7tmA_MC4R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000155 Mcort_rcpt_4
IPR001908 Melancort_rcpt
IPR001671 Melcrt_ACTH_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00534 MCRFAMILY
PR00535 MELNOCORTINR
PR01062 MELNOCORTN4R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMC4R_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32245
Secondary accession number(s): B2RAC3, Q16317, Q3MIJ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 25, 2004
Last modified: December 5, 2018
This is version 188 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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