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Protein

Homeobox protein OTX1

Gene

OTX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi38 – 97HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Enzyme and pathway databases

SIGNORiP32242

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein OTX1
Alternative name(s):
Orthodenticle homolog 1
Gene namesi
Name:OTX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115507.9
HGNCiHGNC:8521 OTX1
MIMi600036 gene
neXtProtiNX_P32242

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5013
OpenTargetsiENSG00000115507
PharmGKBiPA32848

Polymorphism and mutation databases

BioMutaiOTX1
DMDMi417425

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492071 – 354Homeobox protein OTX1Add BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki344Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP32242
MaxQBiP32242
PaxDbiP32242
PeptideAtlasiP32242
PRIDEiP32242
ProteomicsDBi54850

PTM databases

iPTMnetiP32242
PhosphoSitePlusiP32242

Expressioni

Tissue specificityi

Expressed in brain. Detected in the anterior part of the neural fetal retina (at protein level).1 Publication

Developmental stagei

Embryo.

Gene expression databases

BgeeiENSG00000115507
CleanExiHS_OTX1
ExpressionAtlasiP32242 baseline and differential
GenevisibleiP32242 HS

Organism-specific databases

HPAiCAB012341
HPA052122

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi111053, 42 interactors
IntActiP32242, 137 interactors
MINTiP32242
STRINGi9606.ENSP00000282549

Structurei

3D structure databases

ProteinModelPortaliP32242
SMRiP32242
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi275 – 301His-richAdd BLAST27

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2251 Eukaryota
ENOG4111XIJ LUCA
GeneTreeiENSGT00920000148948
HOVERGENiHBG004028
InParanoidiP32242
KOiK09326
OMAiYGVNGLG
OrthoDBiEOG091G0K9K
PhylomeDBiP32242
TreeFamiTF351179

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003026 Otx1_TF
IPR003025 Otx_TF
IPR013851 Otx_TF_C
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03529 TF_Otx, 1 hit
PRINTSiPR01256 OTX1HOMEOBOX
PR01255 OTXHOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P32242-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSYLKQPPY GMNGLGLAGP AMDLLHPSVG YPATPRKQRR ERTTFTRSQL
60 70 80 90 100
DVLEALFAKT RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQSG
110 120 130 140 150
SGTKSRPAKK KSSPVRESSG SESSGQFTPP AVSSSASSSS SASSSSANPA
160 170 180 190 200
AAAAAGLGGN PVAAASSLST PAASSIWSPA SISPGSAPAS VSVPEPLAAP
210 220 230 240 250
SNTSCMQRSV AAGAATAAAS YPMSYGQGGS YGQGYPTPSS SYFGGVDCSS
260 270 280 290 300
YLAPMHSHHH PHQLSPMAPS SMAGHHHHHP HAHHPLSQSS GHHHHHHHHH
310 320 330 340 350
HQGYGGSGLA FNSADCLDYK EPGAAAASSA WKLNFNSPDC LDYKDQASWR

FQVL
Length:354
Mass (Da):37,327
Last modified:October 1, 1993 - v1
Checksum:iE32C1E47464BDDAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095680 mRNA Translation: BAG53106.1
AC009501 Genomic DNA Translation: AAY24357.1
CH471053 Genomic DNA Translation: EAW99967.1
BC007621 mRNA Translation: AAH07621.1
CCDSiCCDS1873.1
PIRiS39406
RefSeqiNP_001186699.1, NM_001199770.1
NP_055377.1, NM_014562.3
UniGeneiHs.734360

Genome annotation databases

EnsembliENST00000282549; ENSP00000282549; ENSG00000115507
ENST00000366671; ENSP00000355631; ENSG00000115507
GeneIDi5013
KEGGihsa:5013
UCSCiuc002scd.4 human

Similar proteinsi

Entry informationi

Entry nameiOTX1_HUMAN
AccessioniPrimary (citable) accession number: P32242
Secondary accession number(s): A6NHA2, B3KTJ4, Q53TG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: July 18, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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