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Protein

Prostaglandin E2 receptor EP4 subtype

Gene

Ptger4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

Caution

Was originally designated as the EP2 subtype.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-391908 Prostanoid ligand receptors
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E2 receptor EP4 subtype
Short name:
PGE receptor EP4 subtype
Short name:
PGE2 receptor EP4 subtype
Alternative name(s):
Prostanoid EP4 receptor
Gene namesi
Name:Ptger4
Synonyms:Ptgerep4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:104311 Ptger4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44ExtracellularSequence analysisAdd BLAST44
Transmembranei45 – 68Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini69 – 80CytoplasmicSequence analysisAdd BLAST12
Transmembranei81 – 104Helical; Name=2Sequence analysisAdd BLAST24
Topological domaini105 – 121ExtracellularSequence analysisAdd BLAST17
Transmembranei122 – 140Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini141 – 160CytoplasmicSequence analysisAdd BLAST20
Transmembranei161 – 185Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini186 – 209ExtracellularSequence analysisAdd BLAST24
Transmembranei210 – 236Helical; Name=5Sequence analysisAdd BLAST27
Topological domaini237 – 295CytoplasmicSequence analysisAdd BLAST59
Transmembranei296 – 323Helical; Name=6Sequence analysisAdd BLAST28
Topological domaini324 – 340ExtracellularSequence analysisAdd BLAST17
Transmembranei341 – 360Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini361 – 513CytoplasmicSequence analysisAdd BLAST153

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2489
GuidetoPHARMACOLOGYi343

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700651 – 513Prostaglandin E2 receptor EP4 subtypeAdd BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi117 ↔ 195PROSITE-ProRule annotation
Modified residuei402PhosphoserineBy similarity1
Modified residuei405PhosphoserineBy similarity1
Modified residuei407PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP32240
PeptideAtlasiP32240
PRIDEiP32240

PTM databases

iPTMnetiP32240
PhosphoSitePlusiP32240

Expressioni

Tissue specificityi

Abundant expression in ileum, thymus and mastocytoma P-815 cells. Also observed in lung, spleen, heart and uterus.

Gene expression databases

BgeeiENSMUSG00000039942
CleanExiMM_PTGER4
ExpressionAtlasiP32240 baseline and differential
GenevisibleiP32240 MM

Interactioni

Subunit structurei

Interacts with FEM1A.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048736

Chemistry databases

BindingDBiP32240

Structurei

3D structure databases

ProteinModelPortaliP32240
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi255 – 260Poly-Ala6

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119188
HOGENOMiHOG000251595
HOVERGENiHBG053556
InParanoidiP32240
KOiK04261
OMAiHSVSVTM
OrthoDBiEOG091G060C
PhylomeDBiP32240
TreeFamiTF324982

Family and domain databases

CDDicd15142 7tmA_PGE2_EP4, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001758 Prost_EP4_rcpt
IPR008365 Prostanoid_rcpt
IPR001244 Prostglndn_DP_rcpt
PANTHERiPTHR11866 PTHR11866, 1 hit
PTHR11866:SF6 PTHR11866:SF6, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00428 PROSTAGLNDNR
PR01788 PROSTANOIDR
PR00586 PRSTNOIDEP4R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P32240-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVGGTIPR SNRELQRCVL LTTTIMSIPG VNASFSSTPE RLNSPVTIPA
60 70 80 90 100
VMFIFGVVGN LVAIVVLCKS RKEQKETTFY TLVCGLAVTD LLGTLLVSPV
110 120 130 140 150
TIATYMKGQW PGDQALCDYS TFILLFFGLS GLSIICAMSI ERYLAINHAY
160 170 180 190 200
FYSHYVDKRL AGLTLFAIYA SNVLFCALPN MGLGRSERQY PGTWCFIDWT
210 220 230 240 250
TNVTAYAAFS YMYAGFSSFL ILATVLCNVL VCGALLRMHR QFMRRTSLGT
260 270 280 290 300
EQHHAAAAAA VASVACRGHA GASPALQRLS DFRRRRSFRR IAGAEIQMVI
310 320 330 340 350
LLIATSLVVL ICSIPLVVRV FINQLYQPNV VKDISRNPDL QAIRIASVNP
360 370 380 390 400
ILDPWIYILL RKTVLSKAIE KIKCLFCRIG GSGRDSSAQH CSESRRTSSA
410 420 430 440 450
MSGHSRSFLA RELKEISSTS QTLLYLPDLT ESSLGGRNLL PGSHGMGLTQ
460 470 480 490 500
ADTTSLRTLR ISETSDSSQG QDSESVLLVD EVSGSHREEP ASKGNSLQVT
510
FPSETLKLSE KCI
Length:513
Mass (Da):56,158
Last modified:October 1, 1993 - v1
Checksum:iE29216087A561473
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13458 mRNA Translation: BAA02714.1
U70365 Genomic DNA Translation: AAC52897.1
CCDSiCCDS27365.1
PIRiA46638
RefSeqiNP_032991.1, NM_008965.2
UniGeneiMm.18509

Genome annotation databases

EnsembliENSMUST00000047379; ENSMUSP00000048736; ENSMUSG00000039942
GeneIDi19219
KEGGimmu:19219
UCSCiuc007vcy.3 mouse

Similar proteinsi

Entry informationi

Entry nameiPE2R4_MOUSE
AccessioniPrimary (citable) accession number: P32240
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 20, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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