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UniProtKB - P32237 (GNRHR_SHEEP)
Protein
Gonadotropin-releasing hormone receptor
Gene
GNRHR
Organism
Ovis aries (Sheep)
Status
Functioni
Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- protein-hormone receptor activity Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Gonadotropin-releasing hormone receptorShort name: GnRH receptor Short name: GnRH-R |
Gene namesi | Name:GNRHR |
Organismi | Ovis aries (Sheep) |
Taxonomic identifieri | 9940 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 38 | ExtracellularSequence analysisAdd BLAST | 38 | |
Transmembranei | 39 – 58 | Helical; Name=1Sequence analysisAdd BLAST | 20 | |
Topological domaini | 59 – 77 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 78 – 97 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Topological domaini | 98 – 115 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 116 – 137 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 138 – 164 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 165 – 184 | Helical; Name=4Sequence analysisAdd BLAST | 20 | |
Topological domaini | 185 – 212 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 213 – 232 | Helical; Name=5Sequence analysisAdd BLAST | 20 | |
Topological domaini | 233 – 281 | CytoplasmicSequence analysisAdd BLAST | 49 | |
Transmembranei | 282 – 300 | Helical; Name=6Sequence analysisAdd BLAST | 19 | |
Topological domaini | 301 – 306 | ExtracellularSequence analysis | 6 | |
Transmembranei | 307 – 326 | Helical; Name=7Sequence analysisAdd BLAST | 20 | |
Topological domaini | 327 – 328 | CytoplasmicSequence analysis | 2 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069492 | 1 – 328 | Gonadotropin-releasing hormone receptorAdd BLAST | 328 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 18 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 102 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 114 ↔ 196 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinFamily & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
HOGENOMi | CLU_009579_15_2_1 |
OMAi | PYYVMSL |
OrthoDBi | 858238at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001658, GphnRH_fam_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00529, GNADOTRPHINR PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P32237-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MANGDSPDQN ENHCSAINSS ILLTPGSLPT LTLSGKIRVT VTFFLFLLST
60 70 80 90 100
IFNTSFLLKL QNWTQRKEKR KKLSKMKVLL KHLTLANLLE TLIVMPLDGM
110 120 130 140 150
WNITVQWYAG ELLCKVLSYL KLFSMYAPAF MMVVISLDRS LAITRPLAVK
160 170 180 190 200
SNSKLGQFMI GLAWLLSSIF AGPQLYIFGM IHLADDSGQT EGFSQCVTHC
210 220 230 240 250
SFPQWWHQAF YNFFTFSCLF IIPLLIMLIC NAKIIFTLTR VLHQDPHKLQ
260 270 280 290 300
LNQSKNNIPQ ARLRTLKMTV AFATSFTVCW TPYYVLGIWY WFDPDMVNRV
310 320
SDPVNHFFFL FAFLNPCFDP LIYGYFSL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 8 | D → N in CAA50978 (PubMed:8224516).Curated | 1 | |
Sequence conflicti | 27 | S → R in CAA50978 (PubMed:8224516).Curated | 1 | |
Sequence conflicti | 64 | T → A in CAA50978 (PubMed:8224516).Curated | 1 | |
Sequence conflicti | 312 | A → G in CAA50978 (PubMed:8224516).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L22215 mRNA Translation: AAC37336.1 X72088 mRNA Translation: CAA50978.1 L42937 Genomic DNA Translation: AAB38515.1 AH004943 Genomic DNA Translation: AAB41939.1 |
PIRi | JN0882 |
RefSeqi | NP_001009397.1, NM_001009397.1 |
Genome annotation databases
Ensembli | ENSOART00000008195; ENSOARP00000008075; ENSOARG00000007526 ENSOART00020000471; ENSOARP00020000363; ENSOARG00020000382 |
GeneIDi | 443413 |
KEGGi | oas:443413 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L22215 mRNA Translation: AAC37336.1 X72088 mRNA Translation: CAA50978.1 L42937 Genomic DNA Translation: AAB38515.1 AH004943 Genomic DNA Translation: AAB41939.1 |
PIRi | JN0882 |
RefSeqi | NP_001009397.1, NM_001009397.1 |
3D structure databases
SMRi | P32237 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9940.ENSOARP00000008075 |
Protein family/group databases
GPCRDBi | Search... |
Genome annotation databases
Ensembli | ENSOART00000008195; ENSOARP00000008075; ENSOARG00000007526 ENSOART00020000471; ENSOARP00020000363; ENSOARG00020000382 |
GeneIDi | 443413 |
KEGGi | oas:443413 |
Organism-specific databases
CTDi | 2798 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
HOGENOMi | CLU_009579_15_2_1 |
OMAi | PYYVMSL |
OrthoDBi | 858238at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001658, GphnRH_fam_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00529, GNADOTRPHINR PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GNRHR_SHEEP | |
Accessioni | P32237Primary (citable) accession number: P32237 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | October 1, 1993 | |
Last modified: | February 23, 2022 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families