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Protein

Developmentally-regulated GTP-binding protein 1

Gene

Drg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi71 – 78GTPPROSITE-ProRule annotation8
Nucleotide bindingi117 – 121GTPPROSITE-ProRule annotation5
Nucleotide bindingi248 – 251GTPPROSITE-ProRule annotation4

GO - Molecular functioni

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Developmentally-regulated GTP-binding protein 1
Short name:
DRG-1
Alternative name(s):
Neural precursor cell expressed developmentally down-regulated protein 3
Short name:
NEDD-3
Gene namesi
Name:Drg1
Synonyms:Drg, Nedd-3, Nedd3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1343297 Drg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002054252 – 367Developmentally-regulated GTP-binding protein 1Add BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei100Phosphothreonine; by STK16By similarity1

Post-translational modificationi

Polyubiquitinated; which induces proteolytic degradation and is impaired by interaction with ZC3H15.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP32233
PaxDbiP32233
PeptideAtlasiP32233
PRIDEiP32233

PTM databases

iPTMnetiP32233
PhosphoSitePlusiP32233

Expressioni

Tissue specificityi

Fairly high levels in liver, heart, kidney, testis and brain. Very low levels in lung, spleen, and skeletal muscle.1 Publication

Developmental stagei

Predominantly expressed in the embryo and down-regulated during development.1 Publication

Gene expression databases

BgeeiENSMUSG00000020457 Expressed in 305 organ(s), highest expression level in pituitary gland
CleanExiMM_DRG1
ExpressionAtlasiP32233 baseline and differential
GenevisibleiP32233 MM

Interactioni

Subunit structurei

Interacts (via its C-terminal) with TAL10. Interacts with STK16; the interaction phosphorylates DRG1 (By similarity). Interacts with ZC3H15; the interaction forms a polysomal DRG1-DFRP1/ZC3H15 complex which provides protein stability to DRG1 possibly by blocking poly-ubiquitination.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
STK16O757164EBI-8429215,EBI-749295From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199310, 4 interactors
DIPiDIP-29599N
IntActiP32233, 3 interactors
MINTiP32233
STRINGi10090.ENSMUSP00000020741

Structurei

3D structure databases

ProteinModelPortaliP32233
SMRiP32233
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 290OBG-type GPROSITE-ProRule annotationAdd BLAST226

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 16Required for interaction with STK16By similarityAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi47 – 56Poly-Gly10

Domaini

Its C-terminal domain interacts with TAL1.

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1487 Eukaryota
COG1163 LUCA
GeneTreeiENSGT00550000075013
HOGENOMiHOG000112078
HOVERGENiHBG000948
InParanoidiP32233
OMAiSAKHPGQ
OrthoDBiEOG091G0A12
PhylomeDBiP32233
TreeFamiTF105677

Family and domain databases

Gene3Di3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR012675 Beta-grasp_dom_sf
IPR031167 G_OBG
IPR031662 GTP-binding_2
IPR006074 GTP1-OBG_CS
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR004095 TGS
IPR012676 TGS-like
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
PF16897 MMR_HSR1_Xtn, 1 hit
PF02824 TGS, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
SSF81271 SSF81271, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51710 G_OBG, 1 hit
PS00905 GTP1_OBG, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P32233-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGTLAKIAE IEAEMARTQK NKATAHHLGL LKARLAKLRR ELITPKGGGG
60 70 80 90 100
GGPGEGFDVA KTGDARIGFV GFPSVGKSTL LSNLAGVYSE VAAYEFTTLT
110 120 130 140 150
TVPGVIRYKG AKIQLLDLPG IIEGAKDGKG RGRQVIAVAR TCNLILIVLD
160 170 180 190 200
VLKPLGHKKI IENELEGFGI RLNSKPPNIG FKKKDKGGIN LTATCPQSEL
210 220 230 240 250
DAETVKSILA EYKIHNADVT LRSDATADDL IDVVEGNRVY IPCIYVLNKI
260 270 280 290 300
DQISIEELDI IYKVPHCVPI SAHHRWNFDD LLEKIWDYLK LVRIYTKPKG
310 320 330 340 350
QLPDYTSPVV LPYSRTTVED FCMKIHKNLI KEFKYALVWG LSVKHNPQKV
360
GKDHTLEDED VIQIVKK
Length:367
Mass (Da):40,512
Last modified:October 1, 1993 - v1
Checksum:i87D77767CA0E89E2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7BQ65F7BQ65_MOUSE
Developmentally-regulated GTP-bindi...
Drg1
69Annotation score:
D6RHA5D6RHA5_MOUSE
Developmentally-regulated GTP-bindi...
Drg1
39Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10715 mRNA Translation: BAA01555.1
CCDSiCCDS24355.1
PIRiJC1349
RefSeqiNP_031905.1, NM_007879.1
UniGeneiMm.3250

Genome annotation databases

EnsembliENSMUST00000020741; ENSMUSP00000020741; ENSMUSG00000020457
GeneIDi13494
KEGGimmu:13494
UCSCiuc007hsh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10715 mRNA Translation: BAA01555.1
CCDSiCCDS24355.1
PIRiJC1349
RefSeqiNP_031905.1, NM_007879.1
UniGeneiMm.3250

3D structure databases

ProteinModelPortaliP32233
SMRiP32233
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199310, 4 interactors
DIPiDIP-29599N
IntActiP32233, 3 interactors
MINTiP32233
STRINGi10090.ENSMUSP00000020741

PTM databases

iPTMnetiP32233
PhosphoSitePlusiP32233

Proteomic databases

EPDiP32233
PaxDbiP32233
PeptideAtlasiP32233
PRIDEiP32233

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020741; ENSMUSP00000020741; ENSMUSG00000020457
GeneIDi13494
KEGGimmu:13494
UCSCiuc007hsh.1 mouse

Organism-specific databases

CTDi4733
MGIiMGI:1343297 Drg1

Phylogenomic databases

eggNOGiKOG1487 Eukaryota
COG1163 LUCA
GeneTreeiENSGT00550000075013
HOGENOMiHOG000112078
HOVERGENiHBG000948
InParanoidiP32233
OMAiSAKHPGQ
OrthoDBiEOG091G0A12
PhylomeDBiP32233
TreeFamiTF105677

Miscellaneous databases

ChiTaRSiDrg1 mouse
PROiPR:P32233
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020457 Expressed in 305 organ(s), highest expression level in pituitary gland
CleanExiMM_DRG1
ExpressionAtlasiP32233 baseline and differential
GenevisibleiP32233 MM

Family and domain databases

Gene3Di3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR012675 Beta-grasp_dom_sf
IPR031167 G_OBG
IPR031662 GTP-binding_2
IPR006074 GTP1-OBG_CS
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR004095 TGS
IPR012676 TGS-like
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
PF16897 MMR_HSR1_Xtn, 1 hit
PF02824 TGS, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
SSF81271 SSF81271, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51710 G_OBG, 1 hit
PS00905 GTP1_OBG, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDRG1_MOUSE
AccessioniPrimary (citable) accession number: P32233
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 12, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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