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Entry version 160 (16 Oct 2019)
Sequence version 2 (01 Feb 1994)
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Protein

Pituitary adenylate cyclase-activating polypeptide type I receptor

Gene

Adcyap1r1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processDifferentiation, Spermatogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-418555 G alpha (s) signalling events [P32215-3]
R-RNO-420092 Glucagon-type ligand receptors [P32215-3]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pituitary adenylate cyclase-activating polypeptide type I receptor
Short name:
PACAP type I receptor
Short name:
PACAP-R-1
Short name:
PACAP-R1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Rat genome database

More...
RGDi
2038 Adcyap1r1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 154ExtracellularSequence analysisAdd BLAST135
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei155 – 177Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini178 – 185CytoplasmicSequence analysis8
Transmembranei186 – 204Helical; Name=2Sequence analysisAdd BLAST19
Topological domaini205 – 226ExtracellularSequence analysisAdd BLAST22
Transmembranei227 – 252Helical; Name=3Sequence analysisAdd BLAST26
Topological domaini253 – 267CytoplasmicSequence analysisAdd BLAST15
Transmembranei268 – 290Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini291 – 308ExtracellularSequence analysisAdd BLAST18
Transmembranei309 – 331Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini332 – 405CytoplasmicSequence analysisAdd BLAST74
Transmembranei406 – 426Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini427 – 440ExtracellularSequence analysisAdd BLAST14
Transmembranei441 – 460Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini461 – 523CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1075233

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
370

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001284320 – 523Pituitary adenylate cyclase-activating polypeptide type I receptorAdd BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi33 ↔ 62By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi53 ↔ 117By similarity
Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi76 ↔ 133By similarity
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei489PhosphoserineBy similarity1
Modified residuei502PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P32215

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P32215

PRoteomics IDEntifications database

More...
PRIDEi
P32215

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P32215

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P32215

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Hypothalamus, anterior pituitary, adrenal medulla, testicular germ cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000012098 Expressed in 9 organ(s), highest expression level in brain

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P32215 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminal extracellular domain) with ADCYAP1.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000016175

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni124 – 138Important for ligand binding and specificityBy similarityAdd BLAST15

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4564 Eukaryota
ENOG410XRS2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157362

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000008249

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P32215

KEGG Orthology (KO)

More...
KOi
K04587

Identification of Orthologs from Complete Genome Data

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OMAi
TCWQPAR

Database of Orthologous Groups

More...
OrthoDBi
651627at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P32215

TreeFam database of animal gene trees

More...
TreeFami
TF315710

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR002285 GPCR_2_PACAP_1_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00249 GPCRSECRETIN
PR01156 PACAPRECEPTR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00008 HormR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111418 SSF111418, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform HIP-HOP1 (identifier: P32215-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARVLQLSLT ALLLPVAIAM HSDCIFKKEQ AMCLERIQRA NDLMGLNESS
60 70 80 90 100
PGCPGMWDNI TCWKPAQVGE MVLVSCPEVF RIFNPDQVWM TETIGDSGFA
110 120 130 140 150
DSNSLEITDM GVVGRNCTED GWSEPFPHYF DACGFDDYEP ESGDQDYYYL
160 170 180 190 200
SVKALYTVGY STSLATLTTA MVILCRFRKL HCTRNFIHMN LFVSFMLRAI
210 220 230 240 250
SVFIKDWILY AEQDSSHCFV STVECKAVMV FFHYCVVSNY FWLFIEGLYL
260 270 280 290 300
FTLLVETFFP ERRYFYWYTI IGWGTPTVCV TVWAVLRLYF DDAGCWDMND
310 320 330 340 350
STALWWVIKG PVVGSIMVNF VLFIGIIIIL VQKLQSPDMG GNESSIYLTN
360 370 380 390 400
LRLRVPKKTR EDPLPVPSDQ HSPPFLSCVQ KCYCKPQRAQ QHSCKMSELS
410 420 430 440 450
TITLRLARST LLLIPLFGIH YTVFAFSPEN VSKRERLVFE LGLGSFQGFV
460 470 480 490 500
VAVLYCFLNG EVQAEIKRKW RSWKVNRYFT MDFKHRHPSL ASSGVNGGTQ
510 520
LSILSKSSSQ LRMSSLPADN LAT
Length:523
Mass (Da):59,637
Last modified:February 1, 1994 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i038CA413EED37E44
GO
Isoform HOP1 (identifier: P32215-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-348: L → F
     349-376: Missing.

Show »
Length:495
Mass (Da):56,450
Checksum:iCB6A851A3C426176
GO
Isoform HOP2 (identifier: P32215-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-348: L → F
     349-377: Missing.

Show »
Length:494
Mass (Da):56,363
Checksum:iC1C969B5075952BD
GO
Isoform HIP (identifier: P32215-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     377-404: Missing.

Show »
Length:495
Mass (Da):56,453
Checksum:i971EBE6AE9901570
GO
Isoform PACAP-R (identifier: P32215-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     349-404: Missing.

Show »
Length:467
Mass (Da):53,233
Checksum:i9F6180156064CFC6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti449F → L in AAA41792 (PubMed:8392197).Curated1
Sequence conflicti510 – 511QL → HV in AAA02990 (Ref. 6) Curated2
Sequence conflicti510 – 511QL → HV in CAA80429 (Ref. 6) Curated2
Sequence conflicti515 – 516SL → TV in AAA02990 (Ref. 6) Curated2
Sequence conflicti515 – 516SL → TV in CAA80429 (Ref. 6) Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002005348L → F in isoform HOP1 and isoform HOP2. Curated1
Alternative sequenceiVSP_002009349 – 404Missing in isoform PACAP-R. CuratedAdd BLAST56
Alternative sequenceiVSP_002007349 – 377Missing in isoform HOP2. CuratedAdd BLAST29
Alternative sequenceiVSP_002006349 – 376Missing in isoform HOP1. CuratedAdd BLAST28
Alternative sequenceiVSP_002008377 – 404Missing in isoform HIP. CuratedAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D16465 mRNA Translation: BAA03932.1
L16680 mRNA Translation: AAA41792.1
D14908 mRNA Translation: BAA03608.1
D14909 mRNA Translation: BAA03609.1
Z23272 mRNA Translation: CAA80810.1
Z23273 mRNA Translation: CAA80811.1
Z23274 mRNA Translation: CAA80812.1
Z23275 mRNA Translation: CAA80813.1
Z23279 mRNA Translation: CAA80817.1
Z23282 mRNA Translation: CAA80821.1
Z23282 mRNA Translation: CAA80820.1
L16506 mRNA Translation: AAA02990.1
Z22735 mRNA Translation: CAA80429.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JN0616
S33449
S36114
S39060
S39061

NCBI Reference Sequences

More...
RefSeqi
NP_001257508.1, NM_001270579.1 [P32215-1]
NP_001257509.1, NM_001270580.1 [P32215-4]
NP_001257510.1, NM_001270581.1 [P32215-5]
NP_001257511.1, NM_001270582.1 [P32215-5]
NP_001257512.1, NM_001270583.1 [P32215-3]
NP_598195.1, NM_133511.2 [P32215-2]
XP_017447918.1, XM_017592429.1 [P32215-2]
XP_017447919.1, XM_017592430.1 [P32215-2]
XP_017447920.1, XM_017592431.1 [P32215-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000016175; ENSRNOP00000016175; ENSRNOG00000012098 [P32215-1]
ENSRNOT00000035722; ENSRNOP00000030759; ENSRNOG00000012098 [P32215-2]
ENSRNOT00000043851; ENSRNOP00000044267; ENSRNOG00000012098 [P32215-5]
ENSRNOT00000046192; ENSRNOP00000050048; ENSRNOG00000012098 [P32215-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
24167

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:24167

UCSC genome browser

More...
UCSCi
RGD:2038 rat [P32215-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16465 mRNA Translation: BAA03932.1
L16680 mRNA Translation: AAA41792.1
D14908 mRNA Translation: BAA03608.1
D14909 mRNA Translation: BAA03609.1
Z23272 mRNA Translation: CAA80810.1
Z23273 mRNA Translation: CAA80811.1
Z23274 mRNA Translation: CAA80812.1
Z23275 mRNA Translation: CAA80813.1
Z23279 mRNA Translation: CAA80817.1
Z23282 mRNA Translation: CAA80821.1
Z23282 mRNA Translation: CAA80820.1
L16506 mRNA Translation: AAA02990.1
Z22735 mRNA Translation: CAA80429.1
PIRiJN0616
S33449
S36114
S39060
S39061
RefSeqiNP_001257508.1, NM_001270579.1 [P32215-1]
NP_001257509.1, NM_001270580.1 [P32215-4]
NP_001257510.1, NM_001270581.1 [P32215-5]
NP_001257511.1, NM_001270582.1 [P32215-5]
NP_001257512.1, NM_001270583.1 [P32215-3]
NP_598195.1, NM_133511.2 [P32215-2]
XP_017447918.1, XM_017592429.1 [P32215-2]
XP_017447919.1, XM_017592430.1 [P32215-2]
XP_017447920.1, XM_017592431.1 [P32215-5]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016175

Chemistry databases

ChEMBLiCHEMBL1075233
GuidetoPHARMACOLOGYi370

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
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PTM databases

iPTMnetiP32215
PhosphoSitePlusiP32215

Proteomic databases

jPOSTiP32215
PaxDbiP32215
PRIDEiP32215

Genome annotation databases

EnsembliENSRNOT00000016175; ENSRNOP00000016175; ENSRNOG00000012098 [P32215-1]
ENSRNOT00000035722; ENSRNOP00000030759; ENSRNOG00000012098 [P32215-2]
ENSRNOT00000043851; ENSRNOP00000044267; ENSRNOG00000012098 [P32215-5]
ENSRNOT00000046192; ENSRNOP00000050048; ENSRNOG00000012098 [P32215-4]
GeneIDi24167
KEGGirno:24167
UCSCiRGD:2038 rat [P32215-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
117
RGDi2038 Adcyap1r1

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00940000157362
HOGENOMiHOG000008249
InParanoidiP32215
KOiK04587
OMAiTCWQPAR
OrthoDBi651627at2759
PhylomeDBiP32215
TreeFamiTF315710

Enzyme and pathway databases

ReactomeiR-RNO-418555 G alpha (s) signalling events [P32215-3]
R-RNO-420092 Glucagon-type ligand receptors [P32215-3]

Miscellaneous databases

Protein Ontology

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PROi
PR:P32215

Gene expression databases

BgeeiENSRNOG00000012098 Expressed in 9 organ(s), highest expression level in brain
GenevisibleiP32215 RN

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR002285 GPCR_2_PACAP_1_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR00249 GPCRSECRETIN
PR01156 PACAPRECEPTR
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPACR_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32215
Secondary accession number(s): Q63414
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1994
Last modified: October 16, 2019
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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