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Protein

Protegrin-3

Gene

NPG3

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Microbicidal activity. Active against E.coli, Listeria monocytogenes and C.albicans, in vitro.

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Protegrin-3
Short name:
PG-3
Gene namesi
Name:NPG3
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
PropeptideiPRO_000000474830 – 1301 PublicationAdd BLAST101
PeptideiPRO_0000004749131 – 148Protegrin-3Add BLAST18

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi85 ↔ 96
Disulfide bondi107 ↔ 124
Disulfide bondi136 ↔ 145By similarity
Disulfide bondi138 ↔ 143By similarity
Modified residuei148Arginine amideBy similarity1

Keywords - PTMi

Amidation, Disulfide bond

Proteomic databases

PeptideAtlasiP32196
PRIDEiP32196

Expressioni

Gene expression databases

ExpressionAtlasiP32196 differential

Structurei

Secondary structure

1149
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP32196
SMRiP32196
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP32196

Family & Domainsi

Sequence similaritiesi

Belongs to the cathelicidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J18R Eukaryota
ENOG41119S0 LUCA
GeneTreeiENSGT00390000000410
HOVERGENiHBG006116
InParanoidiP32196

Family and domain databases

InterProiView protein in InterPro
IPR001894 Cathelicidin
IPR018216 Cathelicidin_CS
PANTHERiPTHR10206 PTHR10206, 1 hit
PROSITEiView protein in PROSITE
PS00946 CATHELICIDINS_1, 1 hit
PS00947 CATHELICIDINS_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

P32196-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METQRASLCL GRWSLWLLLL ALVVPSASAQ ALSYREAVLR AVDRLNEQSS
60 70 80 90 100
EANLYRLLEL DQPPKADEDP GTPKPVSFTV KETVCPRPTR QPPELCDFKE
110 120 130 140
NGRVKQCVGT VTLDQIKDPL DITCNEVQGV RGGGLCYCRR RFCVCVGRG
Length:149
Mass (Da):16,578
Last modified:October 1, 1996 - v2
Checksum:i6F4BA98429CD6ED4
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3LU31I3LU31_PIG
Uncharacterized protein
PMAP-23
228Annotation score:
A0A286ZKJ1A0A286ZKJ1_PIG
Uncharacterized protein
PMAP-23
153Annotation score:
A0A287AFU9A0A287AFU9_PIG
Uncharacterized protein
PMAP-23
258Annotation score:
A0A287B4U4A0A287B4U4_PIG
Uncharacterized protein
PMAP-23
153Annotation score:
A0A287BKL9A0A287BKL9_PIG
Uncharacterized protein
PMAP-23
168Annotation score:
A0A286ZR49A0A286ZR49_PIG
Uncharacterized protein
PMAP-23
153Annotation score:
A0A286ZRJ1A0A286ZRJ1_PIG
Uncharacterized protein
PMAP-23
179Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83267 mRNA Translation: CAA58240.1
X84095 Genomic DNA Translation: CAA58891.1
PIRiS66285 A53895
RefSeqiNP_001116622.1, NM_001123150.1
UniGeneiSsc.420

Genome annotation databases

EnsembliENSSSCT00000012426; ENSSSCP00000012102; ENSSSCG00000011349
ENSSSCT00000040644; ENSSSCP00000031180; ENSSSCG00000011349
ENSSSCT00000062800; ENSSSCP00000042988; ENSSSCG00000011349
GeneIDi100144484

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83267 mRNA Translation: CAA58240.1
X84095 Genomic DNA Translation: CAA58891.1
PIRiS66285 A53895
RefSeqiNP_001116622.1, NM_001123150.1
UniGeneiSsc.420

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KWIX-ray2.19A30-130[»]
1LXEX-ray2.50A30-130[»]
1PFPX-ray2.30A30-130[»]
2MZ6NMR-A/B131-148[»]
ProteinModelPortaliP32196
SMRiP32196
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiP32196
PRIDEiP32196

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000012426; ENSSSCP00000012102; ENSSSCG00000011349
ENSSSCT00000040644; ENSSSCP00000031180; ENSSSCG00000011349
ENSSSCT00000062800; ENSSSCP00000042988; ENSSSCG00000011349
GeneIDi100144484

Organism-specific databases

CTDi100144484

Phylogenomic databases

eggNOGiENOG410J18R Eukaryota
ENOG41119S0 LUCA
GeneTreeiENSGT00390000000410
HOVERGENiHBG006116
InParanoidiP32196

Miscellaneous databases

EvolutionaryTraceiP32196

Gene expression databases

ExpressionAtlasiP32196 differential

Family and domain databases

InterProiView protein in InterPro
IPR001894 Cathelicidin
IPR018216 Cathelicidin_CS
PANTHERiPTHR10206 PTHR10206, 1 hit
PROSITEiView protein in PROSITE
PS00946 CATHELICIDINS_1, 1 hit
PS00947 CATHELICIDINS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPG3_PIG
AccessioniPrimary (citable) accession number: P32196
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1996
Last modified: January 31, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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