UniProtKB - P32191 (GPDM_YEAST)
Protein
Glycerol-3-phosphate dehydrogenase, mitochondrial
Gene
GUT2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Miscellaneous
Present with 1670 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
- EC:1.1.5.3
Cofactori
: glycerol degradation via glycerol kinase pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route).Proteins known to be involved in this subpathway in this organism are:
- Glycerol-3-phosphate dehydrogenase, mitochondrial (GUT2)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route), the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 69 – 97 | FADSequence analysisAdd BLAST | 29 |
GO - Molecular functioni
- glycerol-3-phosphate dehydrogenase (quinone) activity Source: SGD
- sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC
GO - Biological processi
- glycerol-3-phosphate metabolic process Source: InterPro
- glycerol catabolic process Source: UniProtKB-UniPathway
- glycerol metabolic process Source: SGD
- NADH oxidation Source: SGD
Keywordsi
Molecular function | Oxidoreductase |
Ligand | FAD, Flavoprotein |
Enzyme and pathway databases
Reactomei | R-SCE-1483166, Synthesis of PA R-SCE-163560, Triglyceride catabolism |
SABIO-RKi | P32191 |
UniPathwayi | UPA00618;UER00673 |
Names & Taxonomyi
Protein namesi | Recommended name: Glycerol-3-phosphate dehydrogenase, mitochondrial (EC:1.1.5.3)Short name: GPD-M Short name: GPDH-M |
Gene namesi | Name:GUT2 Ordered Locus Names:YIL155C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001417, GUT2 |
VEuPathDBi | FungiDB:YIL155C |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 1 Publication
- Mitochondrion intermembrane space 1 Publication
Mitochondrion
- integral component of mitochondrial outer membrane Source: SGD
- mitochondrial inner membrane Source: UniProtKB-SubCell
- mitochondrial intermembrane space Source: UniProtKB-SubCell
- mitochondrion Source: SGD
Other locations
- glycerol-3-phosphate dehydrogenase complex Source: InterPro
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – ? | MitochondrionSequence analysis | ||
ChainiPRO_0000010434 | ? – 649 | Glycerol-3-phosphate dehydrogenase, mitochondrial |
Proteomic databases
MaxQBi | P32191 |
PaxDbi | P32191 |
PRIDEi | P32191 |
PTM databases
iPTMneti | P32191 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 34837, 76 interactors |
DIPi | DIP-7385N |
IntActi | P32191, 3 interactors |
STRINGi | 4932.YIL155C |
Miscellaneous databases
RNActi | P32191, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0042, Eukaryota |
GeneTreei | ENSGT00390000001718 |
HOGENOMi | CLU_015740_4_1_1 |
InParanoidi | P32191 |
OMAi | AHGFSKT |
Family and domain databases
Gene3Di | 1.10.8.870, 1 hit 3.50.50.60, 1 hit |
InterProi | View protein in InterPro IPR031656, DAO_C IPR038299, DAO_C_sf IPR006076, FAD-dep_OxRdtase IPR036188, FAD/NAD-bd_sf IPR000447, G3P_DH_FAD-dep |
PANTHERi | PTHR11985, PTHR11985, 1 hit |
Pfami | View protein in Pfam PF01266, DAO, 1 hit PF16901, DAO_C, 1 hit |
PRINTSi | PR01001, FADG3PDH |
SUPFAMi | SSF51905, SSF51905, 1 hit |
PROSITEi | View protein in PROSITE PS00977, FAD_G3PDH_1, 1 hit PS00978, FAD_G3PDH_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P32191-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFSVTRRRAA GAAAAMATAT GTLYWMTSQG DRPLVHNDPS YMVQFPTAAP
60 70 80 90 100
PQVSRRDLLD RLAKTHQFDV LIIGGGATGT GCALDAATRG LNVALVEKGD
110 120 130 140 150
FASGTSSKST KMIHGGVRYL EKAFWEFSKA QLDLVIEALN ERKHLINTAP
160 170 180 190 200
HLCTVLPILI PIYSTWQVPY IYMGCKFYDF FAGSQNLKKS YLLSKSATVE
210 220 230 240 250
KAPMLTTDNL KASLVYHDGS FNDSRLNATL AITAVENGAT VLNYVEVQKL
260 270 280 290 300
IKDPTSGKVI GAEARDVETN ELVRINAKCV VNATGPYSDA ILQMDRNPSG
310 320 330 340 350
LPDSPLNDNS KIKSTFNQIA VMDPKMVIPS IGVHIVLPSF YCPKDMGLLD
360 370 380 390 400
VRTSDGRVMF FLPWQGKVLA GTTDIPLKQV PENPMPTEAD IQDILKELQH
410 420 430 440 450
YIEFPVKRED VLSAWAGVRP LVRDPRTIPA DGKKGSATQG VVRSHFLFTS
460 470 480 490 500
DNGLITIAGG KWTTYRQMAE ETVDKVVEVG GFHNLKPCHT RDIKLAGAEE
510 520 530 540 550
WTQNYVALLA QNYHLSSKMS NYLVQNYGTR SSIICEFFKE SMENKLPLSL
560 570 580 590 600
ADKENNVIYS SEENNLVNFD TFRYPFTIGE LKYSMQYEYC RTPLDFLLRR
610 620 630 640
TRFAFLDAKE ALNAVHATVK VMGDEFNWSE KKRQWELEKT VNFIKTFGV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1 – 51 | MFSVT…TAAPP → MTRATWCNSPPPLHR (PubMed:8256521).CuratedAdd BLAST | 51 | |
Sequence conflicti | 63 | A → D in CAA50652 (PubMed:8256521).Curated | 1 | |
Sequence conflicti | 182 | A → G in CAA50652 (PubMed:8256521).Curated | 1 | |
Sequence conflicti | 234 | A → G in CAA50652 (PubMed:8256521).Curated | 1 | |
Sequence conflicti | 243 | N → I in CAA50652 (PubMed:8256521).Curated | 1 | |
Sequence conflicti | 249 | K → R in AAT92886 (PubMed:17322287).Curated | 1 | |
Sequence conflicti | 320 | A → S in CAA50652 (PubMed:8256521).Curated | 1 | |
Sequence conflicti | 342 | C → S in CAA50652 (PubMed:8256521).Curated | 1 | |
Sequence conflicti | 645 – 646 | KT → QGR in CAA50652 (PubMed:8256521).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z38059 Genomic DNA Translation: CAA86123.1 X71660 Genomic DNA Translation: CAA50652.1 AY692867 Genomic DNA Translation: AAT92886.1 BK006942 Genomic DNA Translation: DAA08398.1 |
PIRi | S38190, S48379 |
RefSeqi | NP_012111.1, NM_001179503.1 |
Genome annotation databases
EnsemblFungii | YIL155C_mRNA; YIL155C; YIL155C |
GeneIDi | 854651 |
KEGGi | sce:YIL155C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z38059 Genomic DNA Translation: CAA86123.1 X71660 Genomic DNA Translation: CAA50652.1 AY692867 Genomic DNA Translation: AAT92886.1 BK006942 Genomic DNA Translation: DAA08398.1 |
PIRi | S38190, S48379 |
RefSeqi | NP_012111.1, NM_001179503.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 34837, 76 interactors |
DIPi | DIP-7385N |
IntActi | P32191, 3 interactors |
STRINGi | 4932.YIL155C |
PTM databases
iPTMneti | P32191 |
Proteomic databases
MaxQBi | P32191 |
PaxDbi | P32191 |
PRIDEi | P32191 |
Genome annotation databases
EnsemblFungii | YIL155C_mRNA; YIL155C; YIL155C |
GeneIDi | 854651 |
KEGGi | sce:YIL155C |
Organism-specific databases
SGDi | S000001417, GUT2 |
VEuPathDBi | FungiDB:YIL155C |
Phylogenomic databases
eggNOGi | KOG0042, Eukaryota |
GeneTreei | ENSGT00390000001718 |
HOGENOMi | CLU_015740_4_1_1 |
InParanoidi | P32191 |
OMAi | AHGFSKT |
Enzyme and pathway databases
UniPathwayi | UPA00618;UER00673 |
Reactomei | R-SCE-1483166, Synthesis of PA R-SCE-163560, Triglyceride catabolism |
SABIO-RKi | P32191 |
Miscellaneous databases
PROi | PR:P32191 |
RNActi | P32191, protein |
Family and domain databases
Gene3Di | 1.10.8.870, 1 hit 3.50.50.60, 1 hit |
InterProi | View protein in InterPro IPR031656, DAO_C IPR038299, DAO_C_sf IPR006076, FAD-dep_OxRdtase IPR036188, FAD/NAD-bd_sf IPR000447, G3P_DH_FAD-dep |
PANTHERi | PTHR11985, PTHR11985, 1 hit |
Pfami | View protein in Pfam PF01266, DAO, 1 hit PF16901, DAO_C, 1 hit |
PRINTSi | PR01001, FADG3PDH |
SUPFAMi | SSF51905, SSF51905, 1 hit |
PROSITEi | View protein in PROSITE PS00977, FAD_G3PDH_1, 1 hit PS00978, FAD_G3PDH_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPDM_YEAST | |
Accessioni | P32191Primary (citable) accession number: P32191 Secondary accession number(s): D6VVD2, E9P8Y2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | February 1, 1995 | |
Last modified: | April 7, 2021 | |
This is version 176 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IX
Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families