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Protein

Glycerol kinase

Gene

GK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key enzyme in the regulation of glycerol uptake and metabolism.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol.
Proteins known to be involved in this subpathway in this organism are:
  1. Glycerol kinase (GK), Glycerol kinase 2 (GK2), Glycerol kinase 3 (GK3P), Putative glycerol kinase 5 (GK5)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol, the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei20SubstrateBy similarity1
Binding sitei24ATPBy similarity1
Binding sitei94SubstrateBy similarity1
Binding sitei148SubstrateBy similarity1
Binding sitei265SubstrateBy similarity1
Binding sitei287ATPBy similarity1
Binding sitei332ATP; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi433 – 437ATPBy similarity5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • glycerol kinase activity Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processGlycerol metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.1.30 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-75109 Triglyceride biosynthesis

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P32189

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00618;UER00672

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
P32189 Curated

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycerol kinase (EC:2.7.1.30)
Short name:
GK
Short name:
Glycerokinase
Alternative name(s):
ATP:glycerol 3-phosphotransferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000198814.12

Human Gene Nomenclature Database

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HGNCi
HGNC:4289 GK

Online Mendelian Inheritance in Man (OMIM)

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MIMi
300474 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P32189

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Glycerol kinase deficiency (GKD)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA metabolic disorder manifesting as 3 clinically distinct forms: infantile, juvenile, and adult. The infantile form is the most severe and is associated with severe developmental delay and adrenal insufficiency. Patients with the adult form have no symptoms and are often detected fortuitously. GKD results in hyperglycerolemia, a condition characterized by the accumulation of glycerol in the blood and urine.
See also OMIM:307030
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_015433294N → D in GKD. 1 PublicationCorresponds to variant dbSNP:rs132630331EnsemblClinVar.1
Natural variantiVAR_001377446D → V in GKD. 1 PublicationCorresponds to variant dbSNP:rs132630328EnsemblClinVar.1
Natural variantiVAR_010138509W → R in GKD. 1 PublicationCorresponds to variant dbSNP:rs132630330EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
2710

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
GK

MalaCards human disease database

More...
MalaCardsi
GK
MIMi307030 phenotype

Open Targets

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OpenTargetsi
ENSG00000198814

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
284414 Glycerol kinase deficiency, adult form
284408 Glycerol kinase deficiency, infantile form
284411 Glycerol kinase deficiency, juvenile form

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA28700

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2300

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GK

Domain mapping of disease mutations (DMDM)

More...
DMDMi
205830913

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000595351 – 559Glycerol kinaseAdd BLAST559

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P32189

PeptideAtlas

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PeptideAtlasi
P32189

PRoteomics IDEntifications database

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PRIDEi
P32189

ProteomicsDB human proteome resource

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ProteomicsDBi
54841
54842 [P32189-1]
54843 [P32189-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P32189

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P32189

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the liver, kidney and testis. Isoform 2 and isoform 3 are expressed specifically in testis and fetal liver, but not in the adult liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000198814 Expressed in 193 organ(s), highest expression level in adrenal tissue

CleanEx database of gene expression profiles

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CleanExi
HS_GK

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P32189 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P32189 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA060687

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
NR4A1P227363EBI-3926629,EBI-721550

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108975, 56 interactors

Protein interaction database and analysis system

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IntActi
P32189, 15 interactors

Molecular INTeraction database

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MINTi
P32189

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P32189

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P32189

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P32189

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2517 Eukaryota
COG0554 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153896

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000222134

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG002451

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P32189

KEGG Orthology (KO)

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KOi
K00864

Identification of Orthologs from Complete Genome Data

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OMAi
WQDTRTQ

Database of Orthologous Groups

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OrthoDBi
EOG091G04EJ

Database for complete collections of gene phylogenies

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PhylomeDBi
P32189

TreeFam database of animal gene trees

More...
TreeFami
TF321504

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000577 Carb_kinase_FGGY
IPR018485 Carb_kinase_FGGY_C
IPR018483 Carb_kinase_FGGY_CS
IPR018484 Carb_kinase_FGGY_N
IPR005999 Glycerol_kin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02782 FGGY_C, 1 hit
PF00370 FGGY_N, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF000538 GlpK, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR01311 glycerol_kin, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00933 FGGY_KINASES_1, 1 hit
PS00445 FGGY_KINASES_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: P32189-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASKKAVLG PLVGAVDQGT SSTRFLVFNS KTAELLSHHQ VEIKQEFPRE
60 70 80 90 100
GWVEQDPKEI LHSVYECIEK TCEKLGQLNI DISNIKAIGV SNQRETTVVW
110 120 130 140 150
DKITGEPLYN AVVWLDLRTQ STVESLSKRI PGNNNFVKSK TGLPLSTYFS
160 170 180 190 200
AVKLRWLLDN VRKVQKAVEE KRALFGTIDS WLIWSLTGGV NGGVHCTDVT
210 220 230 240 250
NASRTMLFNI HSLEWDKQLC EFFGIPMEIL PNVRSSSEIY GLMKISHSVK
260 270 280 290 300
AGALEGVPIS GCLGDQSAAL VGQMCFQIGQ AKNTYGTGCF LLCNTGHKCV
310 320 330 340 350
FSDHGLLTTV AYKLGRDKPV YYALEGSVAI AGAVIRWLRD NLGIIKTSEE
360 370 380 390 400
IEKLAKEVGT SYGCYFVPAF SGLYAPYWEP SARGIICGLT QFTNKCHIAF
410 420 430 440 450
AALEAVCFQT REILDAMNRD CGIPLSHLQV DGGMTSNKIL MQLQADILYI
460 470 480 490 500
PVVKPSMPET TALGAAMAAG AAEGVGVWSL EPEDLSAVTM ERFEPQINAE
510 520 530 540 550
ESEIRYSTWK KAVMKSMGWV TTQSPESGDP SIFCSLPLGF FIVSSMVMLI

GARYISGIP
Length:559
Mass (Da):61,245
Last modified:July 22, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i18268B7A4C6A09F3
GO
Isoform 1 (identifier: P32189-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     245-250: Missing.
     528-556: Missing.

Show »
Length:524
Mass (Da):57,489
Checksum:i0FAA29ADC6054154
GO
Isoform 2 (identifier: P32189-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     245-250: Missing.

Show »
Length:553
Mass (Da):60,593
Checksum:i145FA42A6BEA104F
GO
Isoform 4 (identifier: P32189-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     528-556: Missing.

Note: No experimental confirmation available.
Show »
Length:530
Mass (Da):58,141
Checksum:iAC9EEBB80003DEE7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BYD2H7BYD2_HUMAN
Glycerol kinase
GK
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2A0H7C2A0_HUMAN
Glycerol kinase
GK
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WC39F8WC39_HUMAN
Glycerol kinase
GK
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6NP46A6NP46_HUMAN
Glycerol kinase
GK
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDA9F8WDA9_HUMAN
Glycerol kinase
GK
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBI8F8WBI8_HUMAN
Glycerol kinase
GK
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF44F8WF44_HUMAN
Glycerol kinase
GK
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5F6H7C5F6_HUMAN
Glycerol kinase
GK
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA48346 differs from that shown. Reason: Frameshift at positions 201, 210 and 459.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06898079N → K1 PublicationCorresponds to variant dbSNP:rs17857267Ensembl.1
Natural variantiVAR_068981131P → T1 PublicationCorresponds to variant dbSNP:rs17854203Ensembl.1
Natural variantiVAR_001374185S → N. 1
Natural variantiVAR_001375232N → H. 1
Natural variantiVAR_015433294N → D in GKD. 1 PublicationCorresponds to variant dbSNP:rs132630331EnsemblClinVar.1
Natural variantiVAR_001376382A → T. 1
Natural variantiVAR_001377446D → V in GKD. 1 PublicationCorresponds to variant dbSNP:rs132630328EnsemblClinVar.1
Natural variantiVAR_010138509W → R in GKD. 1 PublicationCorresponds to variant dbSNP:rs132630330EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000770245 – 250Missing in isoform 1 and isoform 2. 5 Publications6
Alternative sequenceiVSP_000771528 – 556Missing in isoform 1 and isoform 4. 4 PublicationsAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L13943 mRNA Translation: AAA52576.1
X78211 Genomic DNA No translation available.
AJ252550
, AJ252551, AJ252552, AJ252553, AJ252554, AJ252555, AJ252556, AJ252557, AJ252558, AJ252559, AJ252560, AJ252561, AJ252562, AJ252563, AJ252564, AJ252565, AJ252566, AJ252567, AJ252568, AJ252569, AJ252570 Genomic DNA Translation: CAB54859.1
AJ252550
, AJ252551, AJ252552, AJ252553, AJ252554, AJ252555, AJ252556, AJ252557, AJ252559, AJ252560, AJ252561, AJ252562, AJ252563, AJ252564, AJ252565, AJ252566, AJ252567, AJ252568, AJ252569, AJ252570 Genomic DNA Translation: CAB54858.1
AJ252550
, AJ252551, AJ252552, AJ252553, AJ252554, AJ252555, AJ252556, AJ252557, AJ252559, AJ252560, AJ252561, AJ252562, AJ252563, AJ252564, AJ252565, AJ252566, AJ252567, AJ252568, AJ252570 Genomic DNA Translation: CAB54857.1
AK313215 mRNA Translation: BAG36030.1
AC005913 Genomic DNA No translation available.
AC112496 Genomic DNA No translation available.
AC117404 Genomic DNA No translation available.
BC037549 mRNA Translation: AAH37549.1
BC042421 mRNA Translation: AAH42421.1
BC071595 mRNA Translation: AAH71595.1
X68285 mRNA Translation: CAA48346.1 Frameshift.
X69886 mRNA Translation: CAA49512.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14225.1 [P32189-4]
CCDS35224.1 [P32189-1]
CCDS48090.1 [P32189-2]
CCDS75963.1 [P32189-3]

Protein sequence database of the Protein Information Resource

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PIRi
I37427 S36175

NCBI Reference Sequences

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RefSeqi
NP_000158.1, NM_000167.5 [P32189-1]
NP_001121599.1, NM_001128127.2 [P32189-2]
NP_001191948.1, NM_001205019.1 [P32189-3]
NP_976325.1, NM_203391.3 [P32189-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.1466

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000378943; ENSP00000368226; ENSG00000198814 [P32189-2]
ENST00000378945; ENSP00000368228; ENSG00000198814 [P32189-1]
ENST00000378946; ENSP00000368229; ENSG00000198814 [P32189-4]
ENST00000427190; ENSP00000401720; ENSG00000198814 [P32189-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2710

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2710

UCSC genome browser

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UCSCi
uc004dch.5 human [P32189-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13943 mRNA Translation: AAA52576.1
X78211 Genomic DNA No translation available.
AJ252550
, AJ252551, AJ252552, AJ252553, AJ252554, AJ252555, AJ252556, AJ252557, AJ252558, AJ252559, AJ252560, AJ252561, AJ252562, AJ252563, AJ252564, AJ252565, AJ252566, AJ252567, AJ252568, AJ252569, AJ252570 Genomic DNA Translation: CAB54859.1
AJ252550
, AJ252551, AJ252552, AJ252553, AJ252554, AJ252555, AJ252556, AJ252557, AJ252559, AJ252560, AJ252561, AJ252562, AJ252563, AJ252564, AJ252565, AJ252566, AJ252567, AJ252568, AJ252569, AJ252570 Genomic DNA Translation: CAB54858.1
AJ252550
, AJ252551, AJ252552, AJ252553, AJ252554, AJ252555, AJ252556, AJ252557, AJ252559, AJ252560, AJ252561, AJ252562, AJ252563, AJ252564, AJ252565, AJ252566, AJ252567, AJ252568, AJ252570 Genomic DNA Translation: CAB54857.1
AK313215 mRNA Translation: BAG36030.1
AC005913 Genomic DNA No translation available.
AC112496 Genomic DNA No translation available.
AC117404 Genomic DNA No translation available.
BC037549 mRNA Translation: AAH37549.1
BC042421 mRNA Translation: AAH42421.1
BC071595 mRNA Translation: AAH71595.1
X68285 mRNA Translation: CAA48346.1 Frameshift.
X69886 mRNA Translation: CAA49512.1
CCDSiCCDS14225.1 [P32189-4]
CCDS35224.1 [P32189-1]
CCDS48090.1 [P32189-2]
CCDS75963.1 [P32189-3]
PIRiI37427 S36175
RefSeqiNP_000158.1, NM_000167.5 [P32189-1]
NP_001121599.1, NM_001128127.2 [P32189-2]
NP_001191948.1, NM_001205019.1 [P32189-3]
NP_976325.1, NM_203391.3 [P32189-4]
UniGeneiHs.1466

3D structure databases

ProteinModelPortaliP32189
SMRiP32189
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108975, 56 interactors
IntActiP32189, 15 interactors
MINTiP32189

Chemistry databases

BindingDBiP32189
ChEMBLiCHEMBL2300

Protein family/group databases

MoonDBiP32189 Curated

PTM databases

iPTMnetiP32189
PhosphoSitePlusiP32189

Polymorphism and mutation databases

BioMutaiGK
DMDMi205830913

Proteomic databases

EPDiP32189
PeptideAtlasiP32189
PRIDEiP32189
ProteomicsDBi54841
54842 [P32189-1]
54843 [P32189-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2710
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378943; ENSP00000368226; ENSG00000198814 [P32189-2]
ENST00000378945; ENSP00000368228; ENSG00000198814 [P32189-1]
ENST00000378946; ENSP00000368229; ENSG00000198814 [P32189-4]
ENST00000427190; ENSP00000401720; ENSG00000198814 [P32189-3]
GeneIDi2710
KEGGihsa:2710
UCSCiuc004dch.5 human [P32189-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2710
DisGeNETi2710
EuPathDBiHostDB:ENSG00000198814.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GK
GeneReviewsiGK
HGNCiHGNC:4289 GK
HPAiHPA060687
MalaCardsiGK
MIMi300474 gene
307030 phenotype
neXtProtiNX_P32189
OpenTargetsiENSG00000198814
Orphaneti284414 Glycerol kinase deficiency, adult form
284408 Glycerol kinase deficiency, infantile form
284411 Glycerol kinase deficiency, juvenile form
PharmGKBiPA28700

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2517 Eukaryota
COG0554 LUCA
GeneTreeiENSGT00940000153896
HOGENOMiHOG000222134
HOVERGENiHBG002451
InParanoidiP32189
KOiK00864
OMAiWQDTRTQ
OrthoDBiEOG091G04EJ
PhylomeDBiP32189
TreeFamiTF321504

Enzyme and pathway databases

UniPathwayi
UPA00618;UER00672

BRENDAi2.7.1.30 2681
ReactomeiR-HSA-75109 Triglyceride biosynthesis
SIGNORiP32189

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GK human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2710

Protein Ontology

More...
PROi
PR:P32189

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198814 Expressed in 193 organ(s), highest expression level in adrenal tissue
CleanExiHS_GK
ExpressionAtlasiP32189 baseline and differential
GenevisibleiP32189 HS

Family and domain databases

InterProiView protein in InterPro
IPR000577 Carb_kinase_FGGY
IPR018485 Carb_kinase_FGGY_C
IPR018483 Carb_kinase_FGGY_CS
IPR018484 Carb_kinase_FGGY_N
IPR005999 Glycerol_kin
PfamiView protein in Pfam
PF02782 FGGY_C, 1 hit
PF00370 FGGY_N, 1 hit
PIRSFiPIRSF000538 GlpK, 1 hit
TIGRFAMsiTIGR01311 glycerol_kin, 1 hit
PROSITEiView protein in PROSITE
PS00933 FGGY_KINASES_1, 1 hit
PS00445 FGGY_KINASES_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLPK_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32189
Secondary accession number(s): A6NJP5
, B2R833, Q6IQ27, Q8IVR5, Q9UMP0, Q9UMP1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 22, 2008
Last modified: December 5, 2018
This is version 188 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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