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UniProtKB - P32156 (RHAM_ECOLI)
Protein
L-rhamnose mutarotase
Gene
rhaM
Organism
Escherichia coli (strain K12)
Status
Functioni
Involved in the anomeric conversion of L-rhamnose.
1 PublicationCatalytic activityi
- EC:5.1.3.322 Publications
: L-rhamnose metabolism Pathwayi
This protein is involved in the pathway L-rhamnose metabolism, which is part of Carbohydrate metabolism.View all proteins of this organism that are known to be involved in the pathway L-rhamnose metabolism and in Carbohydrate metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 18 | Substrate | 1 | |
Active sitei | 22 | Proton donorCurated | 1 | |
Binding sitei | 41 | Substrate | 1 |
GO - Molecular functioni
- L-rhamnose mutarotase activity Source: EcoCyc
- racemase and epimerase activity, acting on carbohydrates and derivatives Source: GO_Central
GO - Biological processi
- rhamnose catabolic process Source: EcoCyc
Keywordsi
Molecular function | Isomerase |
Biological process | Carbohydrate metabolism, Rhamnose metabolism |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11865-MONOMER |
BRENDAi | 5.1.3.32, 2026 |
UniPathwayi | UPA00125 |
Names & Taxonomyi
Protein namesi | Recommended name: L-rhamnose mutarotase (EC:5.1.3.322 Publications)Alternative name(s): Rhamnose 1-epimerase Type-3 mutarotase |
Gene namesi | Name:rhaM Synonyms:yiiL Ordered Locus Names:b3901, JW3872 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 18 | Y → F: Loss of mutarotase activity. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000169687 | 1 – 104 | L-rhamnose mutarotaseAdd BLAST | 104 |
Proteomic databases
PaxDbi | P32156 |
PRIDEi | P32156 |
Interactioni
Subunit structurei
Homodimer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 4262642, 28 interactors |
IntActi | P32156, 2 interactors |
STRINGi | 511145.b3901 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P32156 |
SMRi | P32156 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P32156 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 76 – 77 | Substrate binding | 2 |
Sequence similaritiesi
Belongs to the rhamnose mutarotase family.Curated
Phylogenomic databases
eggNOGi | COG3254, Bacteria |
HOGENOMi | CLU_100689_2_0_6 |
InParanoidi | P32156 |
OMAi | KRHDEIW |
PhylomeDBi | P32156 |
Family and domain databases
HAMAPi | MF_01663, L_rham_rotase, 1 hit |
InterProi | View protein in InterPro IPR011008, Dimeric_a/b-barrel IPR013448, L-rhamnose_mutarotase IPR008000, Rham/fucose_mutarotase |
Pfami | View protein in Pfam PF05336, rhaM, 1 hit |
SUPFAMi | SSF54909, SSF54909, 1 hit |
TIGRFAMsi | TIGR02625, YiiL_rotase, 1 hit |
i Sequence
Sequence statusi: Complete.
P32156-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIRKAFVMQV NPDAHEEYQR RHNPIWPELE AVLKSHGAHN YAIYLDKARN
60 70 80 90 100
LLFAMVEIES EERWNAVAST DVCQRWWKYM TDVMPANPDN SPVSSELQEV
FYLP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L19201 Genomic DNA Translation: AAB03034.1 U00096 Genomic DNA Translation: AAC76883.1 AP009048 Genomic DNA Translation: BAE77408.1 |
PIRi | S40845 |
RefSeqi | NP_418337.1, NC_000913.3 WP_000619493.1, NZ_SSZK01000026.1 |
Genome annotation databases
EnsemblBacteriai | AAC76883; AAC76883; b3901 BAE77408; BAE77408; BAE77408 |
GeneIDi | 948402 |
KEGGi | ecj:JW3872 eco:b3901 |
PATRICi | fig|1411691.4.peg.2805 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L19201 Genomic DNA Translation: AAB03034.1 U00096 Genomic DNA Translation: AAC76883.1 AP009048 Genomic DNA Translation: BAE77408.1 |
PIRi | S40845 |
RefSeqi | NP_418337.1, NC_000913.3 WP_000619493.1, NZ_SSZK01000026.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1X8D | X-ray | 1.80 | A/B/C/D | 1-104 | [»] | |
AlphaFoldDBi | P32156 | |||||
SMRi | P32156 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4262642, 28 interactors |
IntActi | P32156, 2 interactors |
STRINGi | 511145.b3901 |
Proteomic databases
PaxDbi | P32156 |
PRIDEi | P32156 |
Genome annotation databases
EnsemblBacteriai | AAC76883; AAC76883; b3901 BAE77408; BAE77408; BAE77408 |
GeneIDi | 948402 |
KEGGi | ecj:JW3872 eco:b3901 |
PATRICi | fig|1411691.4.peg.2805 |
Organism-specific databases
EchoBASEi | EB1811 |
Phylogenomic databases
eggNOGi | COG3254, Bacteria |
HOGENOMi | CLU_100689_2_0_6 |
InParanoidi | P32156 |
OMAi | KRHDEIW |
PhylomeDBi | P32156 |
Enzyme and pathway databases
UniPathwayi | UPA00125 |
BioCyci | EcoCyc:EG11865-MONOMER |
BRENDAi | 5.1.3.32, 2026 |
Miscellaneous databases
EvolutionaryTracei | P32156 |
PROi | PR:P32156 |
Family and domain databases
HAMAPi | MF_01663, L_rham_rotase, 1 hit |
InterProi | View protein in InterPro IPR011008, Dimeric_a/b-barrel IPR013448, L-rhamnose_mutarotase IPR008000, Rham/fucose_mutarotase |
Pfami | View protein in Pfam PF05336, rhaM, 1 hit |
SUPFAMi | SSF54909, SSF54909, 1 hit |
TIGRFAMsi | TIGR02625, YiiL_rotase, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RHAM_ECOLI | |
Accessioni | P32156Primary (citable) accession number: P32156 Secondary accession number(s): Q2M8J8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | October 1, 1993 | |
Last modified: | May 25, 2022 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families