UniProtKB - P32119 (PRDX2_HUMAN)
Peroxiredoxin-2
PRDX2
Functioni
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2.
1 PublicationMiscellaneous
Catalytic activityi
- EC:1.11.1.242 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 51 | Cysteine sulfenic acid (-SOH) intermediate1 Publication | 1 |
GO - Molecular functioni
- antioxidant activity Source: UniProtKB
- thioredoxin peroxidase activity Source: UniProtKB
GO - Biological processi
- cell redox homeostasis Source: GO_Central
- cellular response to oxidative stress Source: BHF-UCL
- defense response to tumor cell Source: ARUK-UCL
- homeostasis of number of cells Source: Ensembl
- hydrogen peroxide catabolic process Source: BHF-UCL
- leukocyte activation Source: GO_Central
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
- negative regulation of lipopolysaccharide-mediated signaling pathway Source: Ensembl
- negative regulation of NF-kappaB transcription factor activity Source: Ensembl
- negative regulation of T cell differentiation Source: Ensembl
- positive regulation of blood coagulation Source: Ensembl
- positive regulation of MAPK cascade Source: Ensembl
- regulation of apoptotic process Source: UniProtKB
- regulation of hydrogen peroxide metabolic process Source: Ensembl
- removal of superoxide radicals Source: BHF-UCL
- respiratory burst involved in inflammatory response Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- response to oxidative stress Source: UniProtKB
- T cell proliferation Source: Ensembl
- thymus development Source: Ensembl
Keywordsi
Molecular function | Antioxidant, Oxidoreductase, Peroxidase |
Enzyme and pathway databases
BRENDAi | 1.11.1.24, 2681 |
PathwayCommonsi | P32119 |
Reactomei | R-HSA-3299685, Detoxification of Reactive Oxygen Species R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-8862803, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
SignaLinki | P32119 |
Protein family/group databases
PeroxiBasei | 4475, Hs2CysPrx02 |
Names & Taxonomyi
Protein namesi | Recommended name: Peroxiredoxin-2 (EC:1.11.1.242 Publications)Alternative name(s): Natural killer cell-enhancing factor B Short name: NKEF-B PRP Thiol-specific antioxidant protein Short name: TSA Thioredoxin peroxidase 1 Thioredoxin-dependent peroxide reductase 1 Thioredoxin-dependent peroxiredoxin 2Curated |
Gene namesi | Name:PRDX2 Synonyms:NKEFB, TDPX1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9353, PRDX2 |
MIMi | 600538, gene |
neXtProti | NX_P32119 |
VEuPathDBi | HostDB:ENSG00000167815 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: GO_Central
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 7001 |
OpenTargetsi | ENSG00000167815 |
PharmGKBi | PA33723 |
Miscellaneous databases
Pharosi | P32119, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295744 |
DrugBanki | DB02153, 3-sulfino-L-alanine DB09130, Copper DB04048, N-Carbamoyl-Alanine |
Genetic variation databases
BioMutai | PRDX2 |
DMDMi | 2507169 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000135080 | 2 – 198 | Peroxiredoxin-2Add BLAST | 197 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Disulfide bondi | 51 | Interchain (with C-172); in linked formCombined sources1 Publication | ||
Modified residuei | 112 | PhosphoserineCombined sources | 1 | |
Disulfide bondi | 172 | Interchain (with C-51); in linked formCombined sources1 Publication | ||
Modified residuei | 182 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Disulfide bond, PhosphoproteinProteomic databases
CPTACi | CPTAC-1445 CPTAC-1446 CPTAC-1447 CPTAC-710 CPTAC-727 non-CPTAC-1143 non-CPTAC-1144 |
EPDi | P32119 |
jPOSTi | P32119 |
MassIVEi | P32119 |
MaxQBi | P32119 |
PaxDbi | P32119 |
PeptideAtlasi | P32119 |
PRIDEi | P32119 |
ProteomicsDBi | 54836 [P32119-1] 54837 [P32119-2] |
TopDownProteomicsi | P32119-1 [P32119-1] |
2D gel databases
DOSAC-COBS-2DPAGEi | P32119 |
OGPi | P32119 |
REPRODUCTION-2DPAGEi | IPI00027350 |
SWISS-2DPAGEi | P32119 |
UCD-2DPAGEi | P32119 |
PTM databases
GlyGeni | P32119, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | P32119 |
PhosphoSitePlusi | P32119 |
SwissPalmi | P32119 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167815, Expressed in liver and 253 other tissues |
ExpressionAtlasi | P32119, baseline and differential |
Genevisiblei | P32119, HS |
Organism-specific databases
HPAi | ENSG00000167815, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Protein-protein interaction databases
BioGRIDi | 112860, 225 interactors |
DIPi | DIP-39882N |
IntActi | P32119, 73 interactors |
MINTi | P32119 |
STRINGi | 9606.ENSP00000301522 |
Miscellaneous databases
RNActi | P32119, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P32119 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P32119 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 164 | ThioredoxinPROSITE-ProRule annotationAdd BLAST | 159 |
Sequence similaritiesi
Keywords - Domaini
Redox-active centerPhylogenomic databases
eggNOGi | KOG0852, Eukaryota |
GeneTreei | ENSGT00940000155828 |
HOGENOMi | CLU_042529_21_0_1 |
InParanoidi | P32119 |
OMAi | EKGCAVR |
PhylomeDBi | P32119 |
TreeFami | TF105181 |
Family and domain databases
InterProi | View protein in InterPro IPR000866, AhpC/TSA IPR024706, Peroxiredoxin_AhpC-typ IPR019479, Peroxiredoxin_C IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF10417, 1-cysPrx_C, 1 hit PF00578, AhpC-TSA, 1 hit |
PIRSFi | PIRSF000239, AHPC, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASGNARIGK PAPDFKATAV VDGAFKEVKL SDYKGKYVVL FFYPLDFTFV
60 70 80 90 100
CPTEIIAFSN RAEDFRKLGC EVLGVSVDSQ FTHLAWINTP RKEGGLGPLN
110 120 130 140 150
IPLLADVTRR LSEDYGVLKT DEGIAYRGLF IIDGKGVLRQ ITVNDLPVGR
160 170 180 190
SVDEALRLVQ AFQYTDEHGE VCPAGWKPGS DTIKPNVDDS KEYFSKHN
The sequence of this isoform differs from the canonical sequence as follows:
87-198: INTPRKEGGL...DSKEYFSKHN → YEQGPKREVA...SLRMMTVISI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA6NIW5 | A6NIW5_HUMAN | Peroxiredoxin 2, isoform CRA_a | PRDX2 hCG_172488 | 136 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 59 – 66 | SNRAEDFR → TTVKRTSA in CAA80269 (PubMed:8144038).Curated | 8 | |
Sequence conflicti | 82 | T → N in AAA50465 (PubMed:8026862).Curated | 1 | |
Sequence conflicti | 105 | A → G in AAA50465 (PubMed:8026862).Curated | 1 | |
Sequence conflicti | 120 | T → N in CAA80269 (PubMed:8144038).Curated | 1 | |
Sequence conflicti | 126 – 127 | YR → TT AA sequence (PubMed:8313871).Curated | 2 | |
Sequence conflicti | 175 | G → A in CAA80269 (PubMed:8144038).Curated | 1 | |
Sequence conflicti | 180 | S → R in CAA80269 (PubMed:8144038).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_025051 | 153 | D → E1 PublicationCorresponds to variant dbSNP:rs34012472Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042924 | 87 – 198 | INTPR…FSKHN → YEQGPKREVAAKLTPSGPSS VASWPLLNLWNLRFPIVKIM ETLPPKSLRMMTVISI in isoform 2. 1 PublicationAdd BLAST | 112 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z22548 mRNA Translation: CAA80269.1 L19185 mRNA Translation: AAA50465.1 CR450356 mRNA Translation: CAG29352.1 CR541789 mRNA Translation: CAG46588.1 AK289485 mRNA Translation: BAF82174.1 DQ231563 Genomic DNA Translation: ABB02182.1 AC018761 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84311.1 BC000452 mRNA Translation: AAH00452.1 BC003022 mRNA Translation: AAH03022.1 BC039428 mRNA Translation: AAH39428.1 X82321 mRNA Translation: CAA57764.1 |
CCDSi | CCDS12281.1 [P32119-1] |
PIRi | I68897 |
RefSeqi | NP_005800.3, NM_005809.5 [P32119-1] |
Genome annotation databases
Ensembli | ENST00000301522; ENSP00000301522; ENSG00000167815 |
GeneIDi | 7001 |
KEGGi | hsa:7001 |
MANE-Selecti | ENST00000301522.3; ENSP00000301522.2; NM_005809.6; NP_005800.3 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z22548 mRNA Translation: CAA80269.1 L19185 mRNA Translation: AAA50465.1 CR450356 mRNA Translation: CAG29352.1 CR541789 mRNA Translation: CAG46588.1 AK289485 mRNA Translation: BAF82174.1 DQ231563 Genomic DNA Translation: ABB02182.1 AC018761 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84311.1 BC000452 mRNA Translation: AAH00452.1 BC003022 mRNA Translation: AAH03022.1 BC039428 mRNA Translation: AAH39428.1 X82321 mRNA Translation: CAA57764.1 |
CCDSi | CCDS12281.1 [P32119-1] |
PIRi | I68897 |
RefSeqi | NP_005800.3, NM_005809.5 [P32119-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1QMV | X-ray | 1.70 | A/B/C/D/E/F/G/H/I/J | 2-198 | [»] | |
5B8A | X-ray | 2.70 | A/B/C/D/E/F/G/H/I/J | 46-198 | [»] | |
5B8B | X-ray | 3.10 | A/B/C/D/E/F/G/H/I/J | 46-163 | [»] | |
A/B/C/D/E/F/G/H/I/J | 80-198 | [»] | ||||
5IJT | X-ray | 2.15 | A/B/C/D/E/F/G/H/I/J | 1-198 | [»] | |
7KIZ | X-ray | 1.70 | A/B/C/D/E/F/G/H/I/J | 2-198 | [»] | |
7KJ0 | X-ray | 2.29 | A/B/C/D/E/F/G/H/I/J | 2-198 | [»] | |
7KJ1 | X-ray | 2.15 | A/B/C/D/E/F/G/H/I/J | 2-198 | [»] | |
SMRi | P32119 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112860, 225 interactors |
DIPi | DIP-39882N |
IntActi | P32119, 73 interactors |
MINTi | P32119 |
STRINGi | 9606.ENSP00000301522 |
Chemistry databases
ChEMBLi | CHEMBL4295744 |
DrugBanki | DB02153, 3-sulfino-L-alanine DB09130, Copper DB04048, N-Carbamoyl-Alanine |
Protein family/group databases
PeroxiBasei | 4475, Hs2CysPrx02 |
PTM databases
GlyGeni | P32119, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | P32119 |
PhosphoSitePlusi | P32119 |
SwissPalmi | P32119 |
Genetic variation databases
BioMutai | PRDX2 |
DMDMi | 2507169 |
2D gel databases
DOSAC-COBS-2DPAGEi | P32119 |
OGPi | P32119 |
REPRODUCTION-2DPAGEi | IPI00027350 |
SWISS-2DPAGEi | P32119 |
UCD-2DPAGEi | P32119 |
Proteomic databases
CPTACi | CPTAC-1445 CPTAC-1446 CPTAC-1447 CPTAC-710 CPTAC-727 non-CPTAC-1143 non-CPTAC-1144 |
EPDi | P32119 |
jPOSTi | P32119 |
MassIVEi | P32119 |
MaxQBi | P32119 |
PaxDbi | P32119 |
PeptideAtlasi | P32119 |
PRIDEi | P32119 |
ProteomicsDBi | 54836 [P32119-1] 54837 [P32119-2] |
TopDownProteomicsi | P32119-1 [P32119-1] |
Protocols and materials databases
ABCDi | P32119, 13 sequenced antibodies |
Antibodypediai | 3283, 576 antibodies from 45 providers |
CPTCi | P32119, 2 antibodies |
DNASUi | 7001 |
Genome annotation databases
Ensembli | ENST00000301522; ENSP00000301522; ENSG00000167815 |
GeneIDi | 7001 |
KEGGi | hsa:7001 |
MANE-Selecti | ENST00000301522.3; ENSP00000301522.2; NM_005809.6; NP_005800.3 |
Organism-specific databases
CTDi | 7001 |
DisGeNETi | 7001 |
GeneCardsi | PRDX2 |
HGNCi | HGNC:9353, PRDX2 |
HPAi | ENSG00000167815, Low tissue specificity |
MIMi | 600538, gene |
neXtProti | NX_P32119 |
OpenTargetsi | ENSG00000167815 |
PharmGKBi | PA33723 |
VEuPathDBi | HostDB:ENSG00000167815 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0852, Eukaryota |
GeneTreei | ENSGT00940000155828 |
HOGENOMi | CLU_042529_21_0_1 |
InParanoidi | P32119 |
OMAi | EKGCAVR |
PhylomeDBi | P32119 |
TreeFami | TF105181 |
Enzyme and pathway databases
BRENDAi | 1.11.1.24, 2681 |
PathwayCommonsi | P32119 |
Reactomei | R-HSA-3299685, Detoxification of Reactive Oxygen Species R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-8862803, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
SignaLinki | P32119 |
Miscellaneous databases
BioGRID-ORCSi | 7001, 58 hits in 1045 CRISPR screens |
ChiTaRSi | PRDX2, human |
EvolutionaryTracei | P32119 |
GeneWikii | Peroxiredoxin_2 |
GenomeRNAii | 7001 |
Pharosi | P32119, Tbio |
PROi | PR:P32119 |
RNActi | P32119, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167815, Expressed in liver and 253 other tissues |
ExpressionAtlasi | P32119, baseline and differential |
Genevisiblei | P32119, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000866, AhpC/TSA IPR024706, Peroxiredoxin_AhpC-typ IPR019479, Peroxiredoxin_C IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF10417, 1-cysPrx_C, 1 hit PF00578, AhpC-TSA, 1 hit |
PIRSFi | PIRSF000239, AHPC, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PRDX2_HUMAN | |
Accessioni | P32119Primary (citable) accession number: P32119 Secondary accession number(s): A8K0C0 Q9UC23 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 235 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families