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Protein

Tricarboxylate transport protein, mitochondrial

Gene

Slc25a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in citrate-H+/malate exchange. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD+ for the glycolytic pathway.

GO - Molecular functioni

  • citrate transmembrane transporter activity Source: RGD

GO - Biological processi

  • mitochondrial citrate transmembrane transport Source: RGD
  • mitochondrial transport Source: GO_Central

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-RNO-70263 Gluconeogenesis
R-RNO-75105 Fatty acyl-CoA biosynthesis

Protein family/group databases

TCDBi2.A.29.7.1 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Tricarboxylate transport protein, mitochondrial
Alternative name(s):
Citrate transport protein
Short name:
CTP
Solute carrier family 25 member 1
Tricarboxylate carrier protein
Gene namesi
Name:Slc25a1
Synonyms:Slc20a3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi3703 Slc25a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 46Helical; Name=1Sequence analysisAdd BLAST18
Transmembranei86 – 105Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei129 – 143Helical; Name=3Sequence analysisAdd BLAST15
Transmembranei183 – 202Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei224 – 241Helical; Name=5Sequence analysisAdd BLAST18
Transmembranei278 – 297Helical; Name=6Sequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 13Mitochondrion1 PublicationAdd BLAST13
ChainiPRO_000001926314 – 311Tricarboxylate transport protein, mitochondrialAdd BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei156PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP32089
PRIDEiP32089

PTM databases

CarbonylDBiP32089
iPTMnetiP32089
PhosphoSitePlusiP32089

Expressioni

Gene expression databases

BgeeiENSRNOG00000038001
GenevisibleiP32089 RN

Interactioni

Protein-protein interaction databases

IntActiP32089, 3 interactors
STRINGi10116.ENSRNOP00000000306

Structurei

3D structure databases

ProteinModelPortaliP32089
SMRiP32089
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 111Solcar 1Add BLAST89
Repeati122 – 208Solcar 2Add BLAST87
Repeati218 – 303Solcar 3Add BLAST86

Sequence similaritiesi

Keywords - Domaini

Repeat, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0756 Eukaryota
ENOG410YAYP LUCA
GeneTreeiENSGT00550000074856
HOGENOMiHOG000168307
HOVERGENiHBG103009
InParanoidiP32089
KOiK15100
OMAiLTFWSGA
OrthoDBiEOG091G0KE7
PhylomeDBiP32089
TreeFamiTF105786

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPRAPRAL TAAAPGSGKA KLTHPGKAIL AGGLAGGIEI CITFPTEYVK
60 70 80 90 100
TQLQLDERAN PPRYRGIGDC VRQTVRSHGV LGLYRGLSSL LYGSIPKAAV
110 120 130 140 150
RFGMFEFLSN HMRDAQGRLD SRRGLLCGLG AGVAEAVVVV CPMETVKVKF
160 170 180 190 200
IHDQTSSNPK YRGFFHGVRE IVREQGLKGT YQGLTATVLK QGSNQAIRFF
210 220 230 240 250
VMTSLRNWYQ GDNPNKPMNP LITGVFGAVA GAASVFGNTP LDVIKTRMQG
260 270 280 290 300
LEAHKYRNTL DCGVQILKNE GPKAFYKGTV PRLGRVCLDV AIVFVIYDEV
310
VKLLNKVWKT D
Length:311
Mass (Da):33,835
Last modified:October 1, 1993 - v1
Checksum:iC7B5B8D82311F6D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12016 mRNA Translation: AAA18899.1
BC100077 mRNA Translation: AAI00078.1
PIRiA46595
RefSeqiNP_059003.1, NM_017307.3
UniGeneiRn.8368

Genome annotation databases

EnsembliENSRNOT00000000306; ENSRNOP00000000306; ENSRNOG00000038001
GeneIDi29743
KEGGirno:29743

Similar proteinsi

Entry informationi

Entry nameiTXTP_RAT
AccessioniPrimary (citable) accession number: P32089
Secondary accession number(s): Q498T8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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