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Protein

Growth hormone-releasing hormone receptor

Gene

Ghrhr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.

GO - Molecular functioni

  • G protein-coupled peptide receptor activity Source: GO_Central
  • growth factor binding Source: MGI
  • growth hormone-releasing hormone receptor activity Source: MGI
  • peptide hormone binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events
R-MMU-420092 Glucagon-type ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Growth hormone-releasing hormone receptor
Short name:
GHRH receptor
Alternative name(s):
Growth hormone-releasing factor receptor
Short name:
GRF receptor
Short name:
GRFR
Gene namesi
Name:Ghrhr
Synonyms:Grfr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:95710 Ghrhr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 132ExtracellularSequence analysisAdd BLAST110
Transmembranei133 – 152Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini153 – 162CytoplasmicSequence analysis10
Transmembranei163 – 181Helical; Name=2Sequence analysisAdd BLAST19
Topological domaini182 – 204ExtracellularSequence analysisAdd BLAST23
Transmembranei205 – 227Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini228 – 240CytoplasmicSequence analysisAdd BLAST13
Transmembranei241 – 262Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini263 – 280ExtracellularSequence analysisAdd BLAST18
Transmembranei281 – 304Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini305 – 329CytoplasmicSequence analysisAdd BLAST25
Transmembranei330 – 348Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini349 – 361ExtracellularSequence analysisAdd BLAST13
Transmembranei362 – 381Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini382 – 423CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Little (lit) mice exhibits anterior pituitary hypoplasia.

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001282923 – 423Growth hormone-releasing hormone receptorAdd BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 64By similarity
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi55 ↔ 96By similarity
Disulfide bondi78 ↔ 112By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP32082
PRIDEiP32082

PTM databases

iPTMnetiP32082
PhosphoSitePlusiP32082

Expressioni

Tissue specificityi

Pituitary gland.

Gene expression databases

BgeeiENSMUSG00000004654 Expressed in 23 organ(s), highest expression level in pituitary gland
CleanExiMM_GHRHR
ExpressionAtlasiP32082 baseline and differential
GenevisibleiP32082 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199917, 1 interactor
STRINGi10090.ENSMUSP00000068120

Structurei

3D structure databases

ProteinModelPortaliP32082
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
HOGENOMiHOG000008249
HOVERGENiHBG008318
InParanoidiP32082
KOiK04584
OMAiNTDHCSF
OrthoDBiEOG091G0NF8
TreeFamiTF315710

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR003288 GPCR_2_GHRH_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PANTHERiPTHR12011:SF209 PTHR12011:SF209, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR01352 GHRHRECEPTOR
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P32082-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGLMWATRI LCLLSLCGVT LGHLHLECDF ITQLRDDELA CLQAAEGTNN
60 70 80 90 100
TSLGCPGTWD GLLCWPPTGS GQWVSLPCPE FFSHFGSDTG FVKRDCTITG
110 120 130 140 150
WSNPFPPYPV ACPVPLELLT KEKSYFSTVK IIYTTGHSIS IVALCVAIAI
160 170 180 190 200
LVALRRLHCP RNYIHTQLFA TFILKASAVF LKDAAIFQGD STDHCSMSTV
210 220 230 240 250
LCKVSVAISH LATMTNFSWL LAEAVYLSCL LASTSPRSKP AFWWLVLAGW
260 270 280 290 300
GLPVLCTGTW VGCKLAFEDT ECWDLDNSSP CWWIIKGPIV LSVGVNFGLF
310 320 330 340 350
LNIICILLRK LEPAQGGLHT RAQYWRLSKS TLLLIPLFGI HYIIFNFLPD
360 370 380 390 400
SAGLDIRVPL ELGLGSFQGF IVAVLYCFLN QEVRTEISRK WYGHDPELLP
410 420
ARRTCTEWTT PPRSRLKVLT SEC
Length:423
Mass (Da):47,004
Last modified:July 27, 2011 - v2
Checksum:iA2BC658E719A8033
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SVS4A0A0N4SVS4_MOUSE
Growth hormone-releasing hormone re...
Ghrhr
386Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti265 – 266LA → HS in L07379 (PubMed:1334535).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti60D → G in lit. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07379 mRNA No translation available.
BC120748 mRNA Translation: AAI20749.1
BC120774 mRNA Translation: AAI20775.1
CCDSiCCDS20165.1
PIRiS29753
RefSeqiNP_001003685.2, NM_001003685.3
UniGeneiMm.89928

Genome annotation databases

EnsembliENSMUST00000063578; ENSMUSP00000068120; ENSMUSG00000004654
GeneIDi14602
KEGGimmu:14602
UCSCiuc009cas.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07379 mRNA No translation available.
BC120748 mRNA Translation: AAI20749.1
BC120774 mRNA Translation: AAI20775.1
CCDSiCCDS20165.1
PIRiS29753
RefSeqiNP_001003685.2, NM_001003685.3
UniGeneiMm.89928

3D structure databases

ProteinModelPortaliP32082
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199917, 1 interactor
STRINGi10090.ENSMUSP00000068120

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP32082
PhosphoSitePlusiP32082

Proteomic databases

PaxDbiP32082
PRIDEiP32082

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063578; ENSMUSP00000068120; ENSMUSG00000004654
GeneIDi14602
KEGGimmu:14602
UCSCiuc009cas.2 mouse

Organism-specific databases

CTDi2692
MGIiMGI:95710 Ghrhr

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
HOGENOMiHOG000008249
HOVERGENiHBG008318
InParanoidiP32082
KOiK04584
OMAiNTDHCSF
OrthoDBiEOG091G0NF8
TreeFamiTF315710

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events
R-MMU-420092 Glucagon-type ligand receptors

Miscellaneous databases

PROiPR:P32082
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004654 Expressed in 23 organ(s), highest expression level in pituitary gland
CleanExiMM_GHRHR
ExpressionAtlasiP32082 baseline and differential
GenevisibleiP32082 MM

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR003288 GPCR_2_GHRH_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PANTHERiPTHR12011:SF209 PTHR12011:SF209, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR01352 GHRHRECEPTOR
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGHRHR_MOUSE
AccessioniPrimary (citable) accession number: P32082
Secondary accession number(s): Q0VB62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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