UniProtKB - P32067 (LA_MOUSE)
Protein
Lupus La protein homolog
Gene
Ssb
Organism
Mus musculus (Mouse)
Status
Functioni
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.
GO - Molecular functioni
- poly(U) RNA binding Source: MGI
- RNA binding Source: MGI
- sequence-specific mRNA binding Source: MGI
- tRNA binding Source: MGI
GO - Biological processi
- IRES-dependent viral translational initiation Source: MGI
- nuclear histone mRNA catabolic process Source: MGI
- protein localization to cytoplasmic stress granule Source: MGI
- tRNA 3'-end processing Source: MGI
- tRNA 5'-leader removal Source: MGI
- tRNA export from nucleus Source: MGI
- tRNA processing Source: MGI
Keywordsi
Molecular function | RNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Lupus La protein homologAlternative name(s): La autoantigen homolog La ribonucleoprotein |
Gene namesi | Name:Ssb Synonyms:Ss-b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98423, Ssb |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: MGI
Other locations
- cytoplasm Source: MGI
- ribonucleoprotein complex Source: InterPro
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000207600 | 1 – 415 | Lupus La protein homologAdd BLAST | 415 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 92 | PhosphoserineBy similarity | 1 | |
Modified residuei | 94 | PhosphoserineBy similarity | 1 | |
Modified residuei | 116 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 120 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 128 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 327 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 356 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 377 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Phosphorylated.By similarity
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P32067 |
jPOSTi | P32067 |
PaxDbi | P32067 |
PeptideAtlasi | P32067 |
PRIDEi | P32067 |
ProteomicsDBi | 264979 |
PTM databases
iPTMneti | P32067 |
PhosphoSitePlusi | P32067 |
SwissPalmi | P32067 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000068882, Expressed in forelimb bud and 302 other tissues |
ExpressionAtlasi | P32067, baseline and differential |
Genevisiblei | P32067, MM |
Interactioni
Subunit structurei
Interacts with DDX15. May interact with RUFY1 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 203508, 39 interactors |
DIPi | DIP-37706N |
IntActi | P32067, 7 interactors |
MINTi | P32067 |
STRINGi | 10090.ENSMUSP00000088365 |
Miscellaneous databases
RNActi | P32067, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 99 | HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 111 – 187 | RRMPROSITE-ProRule annotationAdd BLAST | 77 | |
Domaini | 226 – 346 | xRRMPROSITE-ProRule annotationAdd BLAST | 121 |
Phylogenomic databases
eggNOGi | KOG4213, Eukaryota |
GeneTreei | ENSGT00830000128380 |
HOGENOMi | CLU_042341_0_0_1 |
InParanoidi | P32067 |
OMAi | EYYFGNH |
OrthoDBi | 882725at2759 |
PhylomeDBi | P32067 |
TreeFami | TF314476 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR006630, La_HTH IPR014886, La_RRM IPR002344, Lupus_La IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit PF00076, RRM_1, 1 hit PF08777, RRM_3, 1 hit |
PRINTSi | PR00302, LUPUSLA |
SMARTi | View protein in SMART SM00715, LA, 1 hit SM00360, RRM, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit PS50102, RRM, 1 hit PS51939, XRRM, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P32067-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAENGDNEKM TALEAKICHQ IEYYFGDFNL PRDKFLKEQI KLDEGWVPLE
60 70 80 90 100
TMIKFNRLNR LTTDFNVIVQ ALSKSKAKLM EVSADKTKIR RSPSRPLPEV
110 120 130 140 150
TDEYKNDVKN RSVYIKGFPT DATLDDIKEW LDDKGQILNI QMRRTLHKTF
160 170 180 190 200
KGSIFAVFDS IQSAKKFVEI PGQKYKDTNL LILFKEDYFA KKNEERKQSK
210 220 230 240 250
VEAKLKAKQE HEGRHKPGST ETRALEGKMG CLLKFSGDLD DQTCREDLHF
260 270 280 290 300
LFSNHGEIKW VDFARGAKEG IILFKEKAKE ALEKARNANN GNLLLRNKKV
310 320 330 340 350
TWKVLEGHAE KEALKKITDD QQESLNKWKS KGGHAGGRFK GSHVFTAARR
360 370 380 390 400
FKGKGKGNRP GYAGAPKGRG QFHGRRTRFD DDDRRRGPMK RGRDGRDREE
410
PASKHKKREN GARDK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2AR07 | A2AR07_MOUSE | Lupus La protein homolog | Ssb | 184 | Annotation score: | ||
D6RI87 | D6RI87_MOUSE | Lupus La protein homolog | Ssb | 159 | Annotation score: | ||
F6SXM5 | F6SXM5_MOUSE | Lupus La protein homolog | Ssb | 230 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L00993 mRNA Translation: AAA39415.1 BC003820 mRNA Translation: AAH03820.1 Y07951 mRNA Translation: CAA69249.1 |
CCDSi | CCDS16101.1 |
RefSeqi | NP_001103615.1, NM_001110145.1 NP_033304.1, NM_009278.4 |
Genome annotation databases
Ensembli | ENSMUST00000090852; ENSMUSP00000088365; ENSMUSG00000068882 ENSMUST00000166411; ENSMUSP00000130313; ENSMUSG00000068882 |
GeneIDi | 20823 |
KEGGi | mmu:20823 |
UCSCi | uc008jyt.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L00993 mRNA Translation: AAA39415.1 BC003820 mRNA Translation: AAH03820.1 Y07951 mRNA Translation: CAA69249.1 |
CCDSi | CCDS16101.1 |
RefSeqi | NP_001103615.1, NM_001110145.1 NP_033304.1, NM_009278.4 |
3D structure databases
SMRi | P32067 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203508, 39 interactors |
DIPi | DIP-37706N |
IntActi | P32067, 7 interactors |
MINTi | P32067 |
STRINGi | 10090.ENSMUSP00000088365 |
PTM databases
iPTMneti | P32067 |
PhosphoSitePlusi | P32067 |
SwissPalmi | P32067 |
Proteomic databases
EPDi | P32067 |
jPOSTi | P32067 |
PaxDbi | P32067 |
PeptideAtlasi | P32067 |
PRIDEi | P32067 |
ProteomicsDBi | 264979 |
Protocols and materials databases
Antibodypediai | 2797, 532 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000090852; ENSMUSP00000088365; ENSMUSG00000068882 ENSMUST00000166411; ENSMUSP00000130313; ENSMUSG00000068882 |
GeneIDi | 20823 |
KEGGi | mmu:20823 |
UCSCi | uc008jyt.2, mouse |
Organism-specific databases
CTDi | 6741 |
MGIi | MGI:98423, Ssb |
Phylogenomic databases
eggNOGi | KOG4213, Eukaryota |
GeneTreei | ENSGT00830000128380 |
HOGENOMi | CLU_042341_0_0_1 |
InParanoidi | P32067 |
OMAi | EYYFGNH |
OrthoDBi | 882725at2759 |
PhylomeDBi | P32067 |
TreeFami | TF314476 |
Miscellaneous databases
BioGRID-ORCSi | 20823, 13 hits in 52 CRISPR screens |
ChiTaRSi | Ssb, mouse |
PROi | PR:P32067 |
RNActi | P32067, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000068882, Expressed in forelimb bud and 302 other tissues |
ExpressionAtlasi | P32067, baseline and differential |
Genevisiblei | P32067, MM |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR006630, La_HTH IPR014886, La_RRM IPR002344, Lupus_La IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit PF00076, RRM_1, 1 hit PF08777, RRM_3, 1 hit |
PRINTSi | PR00302, LUPUSLA |
SMARTi | View protein in SMART SM00715, LA, 1 hit SM00360, RRM, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit PS50102, RRM, 1 hit PS51939, XRRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LA_MOUSE | |
Accessioni | P32067Primary (citable) accession number: P32067 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | October 1, 1993 | |
Last modified: | April 7, 2021 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot