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Entry version 143 (02 Jun 2021)
Sequence version 2 (01 Feb 1996)
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Protein

Protein MLF3

Gene

MLF3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Disruption of the MLF3 gene causes increased sensitivity to the immunosuppressant leflunomide.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • establishment or maintenance of actin cytoskeleton polarity Source: SGD

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein MLF3
Alternative name(s):
Multicopy suppressor of leflunomide sensitivity 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MLF3
Synonyms:YMK1
Ordered Locus Names:YNL074C
ORF Names:N2359
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

Organism-specific databases

Saccharomyces Genome Database

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SGDi
S000005018, MLF3

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
FungiDB:YNL074C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000964991 – 452Protein MLF3Add BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei8PhosphoserineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei56PhosphoserineCombined sources1
Modified residuei74PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei121PhosphothreonineCombined sources1
Modified residuei145PhosphoserineCombined sources1
Modified residuei156PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Modified residuei169PhosphothreonineCombined sources1
Modified residuei171PhosphoserineCombined sources1
Modified residuei173PhosphothreonineCombined sources1
Modified residuei183PhosphoserineCombined sources1
Modified residuei189PhosphoserineCombined sources1
Modified residuei227PhosphotyrosineCombined sources1
Modified residuei228PhosphoserineCombined sources1
Modified residuei257PhosphoserineCombined sources1
Modified residuei265PhosphoserineCombined sources1
Modified residuei295PhosphotyrosineCombined sources1
Modified residuei297PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei439PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P32047

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P32047

PRoteomics IDEntifications database

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PRIDEi
P32047

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P32047

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P32047

SwissPalm database of S-palmitoylation events

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SwissPalmi
P32047

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
35749, 61 interactors

Protein interaction database and analysis system

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IntActi
P32047, 5 interactors

Molecular INTeraction database

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MINTi
P32047

STRING: functional protein association networks

More...
STRINGi
4932.YNL074C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P32047, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P32047

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni61 – 94DisorderedSequence analysisAdd BLAST34
Regioni171 – 220DisorderedSequence analysisAdd BLAST50
Regioni290 – 321DisorderedSequence analysisAdd BLAST32
Regioni335 – 402DisorderedSequence analysisAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi365 – 402Polar residuesSequence analysisAdd BLAST38

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

To yeast VHS2.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502S4KQ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176806

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_061868_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P32047

Identification of Orthologs from Complete Genome Data

More...
OMAi
NINNTGM

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P32047-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCVYKSNSNN SNPSFIFERT VQEASSNDLF LQPPVSASNT SHSSRSNSFY
60 70 80 90 100
NLQTISPIPI SGSEVRTPSL RKNSNNVSSP LDNVIPTSRS ASNSTTSSLA
110 120 130 140 150
HQEYILNPIC NMQNHHHRRR TLENSVAPAL DASCSIVNDE NTDLSDVDMV
160 170 180 190 200
YSRRPSSAVS LNMALLARTN SATLPSSESS PASPDLKLSR SHSHSAATRP
210 220 230 240 250
TLNNINNTGM TTTTSNGEPN SRILRFYSYV DMLNDEKLAQ ANNTPTSRPP
260 270 280 290 300
MKSQAYSCPF ILKRSPPQAY SSSSATTTFS NPFIKTTELP ATSPYVSPQQ
310 320 330 340 350
SARQYSNNAN NNAKSPKNRS SSILFQRQSI LSNVDPVANM HKNPKFQIES
360 370 380 390 400
SDSEEEDLTM DMLDPSFPLS SSLRSSANLA SNPELATQTP LSTSSSYTAI
410 420 430 440 450
GKPMPLSTDP SYVSSSNTLS SEHELRVEKV SEVLKKKVSN GGFSTEFNSC

DT
Length:452
Mass (Da):49,210
Last modified:February 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C4FB02D38D6963E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X86470 Genomic DNA Translation: CAA60186.1
Z71350 Genomic DNA Translation: CAA95948.1
AY692774 Genomic DNA Translation: AAT92793.1
X57360 Genomic DNA No translation available.
BK006947 Genomic DNA Translation: DAA10471.1

Protein sequence database of the Protein Information Resource

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PIRi
S53906

NCBI Reference Sequences

More...
RefSeqi
NP_014325.3, NM_001182912.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YNL074C_mRNA; YNL074C; YNL074C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855650

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YNL074C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86470 Genomic DNA Translation: CAA60186.1
Z71350 Genomic DNA Translation: CAA95948.1
AY692774 Genomic DNA Translation: AAT92793.1
X57360 Genomic DNA No translation available.
BK006947 Genomic DNA Translation: DAA10471.1
PIRiS53906
RefSeqiNP_014325.3, NM_001182912.3

3D structure databases

SMRiP32047
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi35749, 61 interactors
IntActiP32047, 5 interactors
MINTiP32047
STRINGi4932.YNL074C

PTM databases

iPTMnetiP32047
SwissPalmiP32047

Proteomic databases

MaxQBiP32047
PaxDbiP32047
PRIDEiP32047
TopDownProteomicsiP32047

Genome annotation databases

EnsemblFungiiYNL074C_mRNA; YNL074C; YNL074C
GeneIDi855650
KEGGisce:YNL074C

Organism-specific databases

SGDiS000005018, MLF3
VEuPathDBiFungiDB:YNL074C

Phylogenomic databases

eggNOGiENOG502S4KQ, Eukaryota
GeneTreeiENSGT00940000176806
HOGENOMiCLU_061868_0_0_1
InParanoidiP32047
OMAiNINNTGM

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P32047
RNActiP32047, protein

Family and domain databases

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMLF3_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32047
Secondary accession number(s): D6W1A5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 1, 1996
Last modified: June 2, 2021
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
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