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Protein

Protein MLF3

Gene

MLF3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Disruption of the MLF3 gene causes increased sensitivity to the immunosuppressant leflunomide.

GO - Biological processi

  • establishment or maintenance of actin cytoskeleton polarity Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-33103-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MLF3
Alternative name(s):
Multicopy suppressor of leflunomide sensitivity 3
Gene namesi
Name:MLF3
Synonyms:YMK1
Ordered Locus Names:YNL074C
ORF Names:N2359
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL074C
SGDiS000005018 MLF3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000964991 – 452Protein MLF3Add BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei56PhosphoserineCombined sources1
Modified residuei74PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei121PhosphothreonineCombined sources1
Modified residuei145PhosphoserineCombined sources1
Modified residuei156PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Modified residuei169PhosphothreonineCombined sources1
Modified residuei171PhosphoserineCombined sources1
Modified residuei173PhosphothreonineCombined sources1
Modified residuei183PhosphoserineCombined sources1
Modified residuei189PhosphoserineCombined sources1
Modified residuei227PhosphotyrosineCombined sources1
Modified residuei228PhosphoserineCombined sources1
Modified residuei257PhosphoserineCombined sources1
Modified residuei265PhosphoserineCombined sources1
Modified residuei295PhosphotyrosineCombined sources1
Modified residuei297PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei439PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32047
PaxDbiP32047
PRIDEiP32047
TopDownProteomicsiP32047

PTM databases

iPTMnetiP32047
SwissPalmiP32047

Interactioni

Protein-protein interaction databases

BioGridi35749, 60 interactors
IntActiP32047, 5 interactors
MINTiP32047
STRINGi4932.YNL074C

Structurei

3D structure databases

ProteinModelPortaliP32047
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi211 – 214Poly-Thr4
Compositional biasi271 – 274Poly-Ser4

Sequence similaritiesi

To yeast VHS2.Curated

Phylogenomic databases

GeneTreeiENSGT00530000066455
InParanoidiP32047
OrthoDBiEOG092C5NHW

Sequencei

Sequence statusi: Complete.

P32047-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCVYKSNSNN SNPSFIFERT VQEASSNDLF LQPPVSASNT SHSSRSNSFY
60 70 80 90 100
NLQTISPIPI SGSEVRTPSL RKNSNNVSSP LDNVIPTSRS ASNSTTSSLA
110 120 130 140 150
HQEYILNPIC NMQNHHHRRR TLENSVAPAL DASCSIVNDE NTDLSDVDMV
160 170 180 190 200
YSRRPSSAVS LNMALLARTN SATLPSSESS PASPDLKLSR SHSHSAATRP
210 220 230 240 250
TLNNINNTGM TTTTSNGEPN SRILRFYSYV DMLNDEKLAQ ANNTPTSRPP
260 270 280 290 300
MKSQAYSCPF ILKRSPPQAY SSSSATTTFS NPFIKTTELP ATSPYVSPQQ
310 320 330 340 350
SARQYSNNAN NNAKSPKNRS SSILFQRQSI LSNVDPVANM HKNPKFQIES
360 370 380 390 400
SDSEEEDLTM DMLDPSFPLS SSLRSSANLA SNPELATQTP LSTSSSYTAI
410 420 430 440 450
GKPMPLSTDP SYVSSSNTLS SEHELRVEKV SEVLKKKVSN GGFSTEFNSC

DT
Length:452
Mass (Da):49,210
Last modified:February 1, 1996 - v2
Checksum:i9C4FB02D38D6963E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86470 Genomic DNA Translation: CAA60186.1
Z71350 Genomic DNA Translation: CAA95948.1
AY692774 Genomic DNA Translation: AAT92793.1
X57360 Genomic DNA No translation available.
BK006947 Genomic DNA Translation: DAA10471.1
PIRiS53906
RefSeqiNP_014325.3, NM_001182912.3

Genome annotation databases

EnsemblFungiiYNL074C; YNL074C; YNL074C
GeneIDi855650
KEGGisce:YNL074C

Similar proteinsi

Entry informationi

Entry nameiMLF3_YEAST
AccessioniPrimary (citable) accession number: P32047
Secondary accession number(s): D6W1A5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 1, 1996
Last modified: July 18, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

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