Hoxc5

Functionⁱ

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	155 – 214	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II distal enhancer sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein Hox-C5 Alternative name(s): Homeobox protein Hox-3.4 Homeobox protein Hox-6.2
Gene namesⁱ	Name:Hoxc5 Synonyms:Hox-3.4, Hoxc-5
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 15

Organism-specific databases

MGIⁱ	MGI:96196 Hoxc5

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000200170	1 – 222	Homeobox protein Hox-C5Add BLAST		222

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P32043
PaxDbⁱ	P32043
PRIDEⁱ	P32043

PTM databases

PhosphoSitePlusⁱ	P32043

PhosphoSitePlusⁱ

P32043

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000022485 Expressed in 128 organ(s), highest expression level in mesonephros
CleanExⁱ	MM_HOXC5
Genevisibleⁱ	P32043 MM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	200387, 3 interactors
STRINGⁱ	10090.ENSMUSP00000001709

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P32043
SMRⁱ	P32043
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	140 – 145	Antp-type hexapeptide		6

Sequence similaritiesⁱ

Belongs to the Antp homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143983
HOGENOMⁱ	HOG000231178
HOVERGENⁱ	HBG016849
InParanoidⁱ	P32043
KEGG Orthology (KO) More...KOⁱ	K09305
OMAⁱ	NPGMYNQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09XD
PhylomeDBⁱ	P32043
TreeFamⁱ	TF316310

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017995 Homeobox_antennapedia IPR001827 Homeobox_Antennapedia_CS IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00025 ANTENNAPEDIA PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00032 ANTENNAPEDIA, 1 hit PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P32043-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSYVANSFY KQSPNIPAYN MQTCGNYGSA SEVQASRYCY GGLDLSITFP 
        60         70         80         90        100
PPAPSNSLHG VDMAANPRAH PDRPACSAAA APGHALGRDE AAPLNPGMYS 
       110        120        130        140        150
QKAARPALEE RAKSSGEIKE EQAQTGQPAG LSQPPAPPQI YPWMTKLHMS 
       160        170        180        190        200
HETDGKRSRT SYTRYQTLEL EKEFHFNRYL TRRRRIEIAN NLCLNERQIK 
       210        220 
IWFQNRRMKW KKDSKMKSKE AL

Length:222

Mass (Da):24,992

Last modified:September 5, 2006 - v3

Checksum:ⁱ95D763BF5E4E7AC7

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	86	L → P in AAA79876 (PubMed:8903739).Curated		1
Sequence conflictⁱ	125	T → R in AAA79876 (PubMed:8903739).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U28071 Genomic DNA Translation: AAA79876.1 AK078527 mRNA Translation: BAC37324.1 BC115551 mRNA Translation: AAI15552.1 BC115552 mRNA Translation: AAI15553.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27896.1
PIRⁱ	A60084
NCBI Reference Sequences More...RefSeqⁱ	NP_783857.1, NM_175730.5
UniGeneⁱ	Mm.103825

Genome annotation databases

Ensemblⁱ	ENSMUST00000001709; ENSMUSP00000001709; ENSMUSG00000022485
GeneIDⁱ	15424
KEGGⁱ	mmu:15424
UCSC genome browser More...UCSCⁱ	uc007xxe.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P32043	HOXC5 isoform 1		PONAB		222	UniRef100_P32043
Homeobox protein Hox-3D		MACMU		222
Uncharacterized protein		COLAP		222
Uncharacterized protein		MUSPF		222
homeobox protein Hox-C5		DELLE		222
+30

Protein	Similar proteins		Species	Score	Length	Source
P32043	Homeobox protein Hox-C5		HUMAN		222	UniRef90_Q00444
HOXC5 isoform 1		PANTR		222
Uncharacterized protein		PANPA		222
Homeobox C5		LOXAF		230
Homeobox protein Hox-C5-like protein		CAMFR		225
+96

Protein	Similar proteins		Species	Score	Length	Source
P32043	Homeobox protein Hox-C5		HUMAN		222	UniRef50_Q00444
HOXC5 isoform 1		PANTR		222
Uncharacterized protein		PANPA		222
Homeobox C5		LOXAF		230
Homeobox protein Hox-C5-like protein		CAMFR		225
+105

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U28071 Genomic DNA Translation: AAA79876.1 AK078527 mRNA Translation: BAC37324.1 BC115551 mRNA Translation: AAI15552.1 BC115552 mRNA Translation: AAI15553.1
CCDSⁱ	CCDS27896.1
PIRⁱ	A60084
RefSeqⁱ	NP_783857.1, NM_175730.5
UniGeneⁱ	Mm.103825

3D structure databases

ProteinModelPortalⁱ	P32043
SMRⁱ	P32043
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	200387, 3 interactors
STRINGⁱ	10090.ENSMUSP00000001709

PTM databases

PhosphoSitePlusⁱ	P32043

PhosphoSitePlusⁱ

P32043

Proteomic databases

MaxQBⁱ	P32043
PaxDbⁱ	P32043
PRIDEⁱ	P32043

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000001709; ENSMUSP00000001709; ENSMUSG00000022485
GeneIDⁱ	15424
KEGGⁱ	mmu:15424
UCSCⁱ	uc007xxe.1 mouse

Organism-specific databases

CTDⁱ	3222
MGIⁱ	MGI:96196 Hoxc5

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
GeneTreeⁱ	ENSGT00910000143983
HOGENOMⁱ	HOG000231178
HOVERGENⁱ	HBG016849
InParanoidⁱ	P32043
KOⁱ	K09305
OMAⁱ	NPGMYNQ
OrthoDBⁱ	EOG091G09XD
PhylomeDBⁱ	P32043
TreeFamⁱ	TF316310

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P32043
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000022485 Expressed in 128 organ(s), highest expression level in mesonephros
CleanExⁱ	MM_HOXC5
Genevisibleⁱ	P32043 MM

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017995 Homeobox_antennapedia IPR001827 Homeobox_Antennapedia_CS IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00025 ANTENNAPEDIA PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00032 ANTENNAPEDIA, 1 hit PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HXC5_MOUSE
Accessionⁱ	P32043Primary (citable) accession number: P32043 Secondary accession number(s): Q8BJW4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
	Last sequence update:	September 5, 2006
	Last modified:	November 7, 2018
	This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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Supporting data

UniProtKB - P32043 (HXC5_MOUSE)

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Homeobox protein Hox-C5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ