Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein Hox-C5

Gene

Hoxc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi155 – 214HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • embryonic skeletal system development Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C5
Alternative name(s):
Homeobox protein Hox-3.4
Homeobox protein Hox-6.2
Gene namesi
Name:Hoxc5
Synonyms:Hox-3.4, Hoxc-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96196 Hoxc5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001701 – 222Homeobox protein Hox-C5Add BLAST222

Proteomic databases

MaxQBiP32043
PaxDbiP32043
PRIDEiP32043

PTM databases

PhosphoSitePlusiP32043

Expressioni

Gene expression databases

BgeeiENSMUSG00000022485 Expressed in 128 organ(s), highest expression level in mesonephros
CleanExiMM_HOXC5
GenevisibleiP32043 MM

Interactioni

Protein-protein interaction databases

BioGridi200387, 3 interactors
STRINGi10090.ENSMUSP00000001709

Structurei

3D structure databases

ProteinModelPortaliP32043
SMRiP32043
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi140 – 145Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231178
HOVERGENiHBG016849
InParanoidiP32043
KOiK09305
OMAiNPGMYNQ
OrthoDBiEOG091G09XD
PhylomeDBiP32043
TreeFamiTF316310

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P32043-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSYVANSFY KQSPNIPAYN MQTCGNYGSA SEVQASRYCY GGLDLSITFP
60 70 80 90 100
PPAPSNSLHG VDMAANPRAH PDRPACSAAA APGHALGRDE AAPLNPGMYS
110 120 130 140 150
QKAARPALEE RAKSSGEIKE EQAQTGQPAG LSQPPAPPQI YPWMTKLHMS
160 170 180 190 200
HETDGKRSRT SYTRYQTLEL EKEFHFNRYL TRRRRIEIAN NLCLNERQIK
210 220
IWFQNRRMKW KKDSKMKSKE AL
Length:222
Mass (Da):24,992
Last modified:September 5, 2006 - v3
Checksum:i95D763BF5E4E7AC7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86L → P in AAA79876 (PubMed:8903739).Curated1
Sequence conflicti125T → R in AAA79876 (PubMed:8903739).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28071 Genomic DNA Translation: AAA79876.1
AK078527 mRNA Translation: BAC37324.1
BC115551 mRNA Translation: AAI15552.1
BC115552 mRNA Translation: AAI15553.1
CCDSiCCDS27896.1
PIRiA60084
RefSeqiNP_783857.1, NM_175730.5
UniGeneiMm.103825

Genome annotation databases

EnsembliENSMUST00000001709; ENSMUSP00000001709; ENSMUSG00000022485
GeneIDi15424
KEGGimmu:15424
UCSCiuc007xxe.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28071 Genomic DNA Translation: AAA79876.1
AK078527 mRNA Translation: BAC37324.1
BC115551 mRNA Translation: AAI15552.1
BC115552 mRNA Translation: AAI15553.1
CCDSiCCDS27896.1
PIRiA60084
RefSeqiNP_783857.1, NM_175730.5
UniGeneiMm.103825

3D structure databases

ProteinModelPortaliP32043
SMRiP32043
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200387, 3 interactors
STRINGi10090.ENSMUSP00000001709

PTM databases

PhosphoSitePlusiP32043

Proteomic databases

MaxQBiP32043
PaxDbiP32043
PRIDEiP32043

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001709; ENSMUSP00000001709; ENSMUSG00000022485
GeneIDi15424
KEGGimmu:15424
UCSCiuc007xxe.1 mouse

Organism-specific databases

CTDi3222
MGIiMGI:96196 Hoxc5

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231178
HOVERGENiHBG016849
InParanoidiP32043
KOiK09305
OMAiNPGMYNQ
OrthoDBiEOG091G09XD
PhylomeDBiP32043
TreeFamiTF316310

Miscellaneous databases

PROiPR:P32043
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022485 Expressed in 128 organ(s), highest expression level in mesonephros
CleanExiMM_HOXC5
GenevisibleiP32043 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXC5_MOUSE
AccessioniPrimary (citable) accession number: P32043
Secondary accession number(s): Q8BJW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: September 5, 2006
Last modified: November 7, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again