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UniProtKB - P32043 (HXC5_MOUSE)
Protein
Homeobox protein Hox-C5
Gene
Hoxc5
Organism
Mus musculus (Mouse)
Status
Functioni
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 155 – 214 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- anterior/posterior pattern specification Source: MGI
- embryonic skeletal system development Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Hox-C5Alternative name(s): Homeobox protein Hox-3.4 Homeobox protein Hox-6.2 |
Gene namesi | Name:Hoxc5 Synonyms:Hox-3.4, Hoxc-5 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96196, Hoxc5 |
VEuPathDBi | HostDB:ENSMUSG00000022485 |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: GO_Central
Other locations
- cell junction Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200170 | 1 – 222 | Homeobox protein Hox-C5Add BLAST | 222 |
Proteomic databases
MaxQBi | P32043 |
PaxDbi | P32043 |
PRIDEi | P32043 |
ProteomicsDBi | 266934 |
PTM databases
PhosphoSitePlusi | P32043 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000022485, Expressed in mesonephros and 150 other tissues |
Genevisiblei | P32043, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 200387, 3 interactors |
IntActi | P32043, 3 interactors |
STRINGi | 10090.ENSMUSP00000001709 |
Miscellaneous databases
RNActi | P32043, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 68 – 141 | DisorderedSequence analysisAdd BLAST | 74 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 140 – 145 | Antp-type hexapeptide | 6 |
Sequence similaritiesi
Belongs to the Antp homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000161023 |
HOGENOMi | CLU_061398_2_1_1 |
InParanoidi | P32043 |
OMAi | DRPSCTV |
OrthoDBi | 1154159at2759 |
PhylomeDBi | P32043 |
TreeFami | TF316310 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017995, Homeobox_antennapedia IPR001827, Homeobox_Antennapedia_CS IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00025, ANTENNAPEDIA PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00032, ANTENNAPEDIA, 1 hit PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P32043-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSYVANSFY KQSPNIPAYN MQTCGNYGSA SEVQASRYCY GGLDLSITFP
60 70 80 90 100
PPAPSNSLHG VDMAANPRAH PDRPACSAAA APGHALGRDE AAPLNPGMYS
110 120 130 140 150
QKAARPALEE RAKSSGEIKE EQAQTGQPAG LSQPPAPPQI YPWMTKLHMS
160 170 180 190 200
HETDGKRSRT SYTRYQTLEL EKEFHFNRYL TRRRRIEIAN NLCLNERQIK
210 220
IWFQNRRMKW KKDSKMKSKE AL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 86 | L → P in AAA79876 (PubMed:8903739).Curated | 1 | |
Sequence conflicti | 125 | T → R in AAA79876 (PubMed:8903739).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28071 Genomic DNA Translation: AAA79876.1 AK078527 mRNA Translation: BAC37324.1 BC115551 mRNA Translation: AAI15552.1 BC115552 mRNA Translation: AAI15553.1 |
CCDSi | CCDS27896.1 |
PIRi | A60084 |
RefSeqi | NP_783857.1, NM_175730.5 |
Genome annotation databases
Ensembli | ENSMUST00000001709; ENSMUSP00000001709; ENSMUSG00000022485 |
GeneIDi | 15424 |
KEGGi | mmu:15424 |
UCSCi | uc007xxe.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28071 Genomic DNA Translation: AAA79876.1 AK078527 mRNA Translation: BAC37324.1 BC115551 mRNA Translation: AAI15552.1 BC115552 mRNA Translation: AAI15553.1 |
CCDSi | CCDS27896.1 |
PIRi | A60084 |
RefSeqi | NP_783857.1, NM_175730.5 |
3D structure databases
AlphaFoldDBi | P32043 |
SMRi | P32043 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200387, 3 interactors |
IntActi | P32043, 3 interactors |
STRINGi | 10090.ENSMUSP00000001709 |
PTM databases
PhosphoSitePlusi | P32043 |
Proteomic databases
MaxQBi | P32043 |
PaxDbi | P32043 |
PRIDEi | P32043 |
ProteomicsDBi | 266934 |
Protocols and materials databases
Antibodypediai | 27321, 129 antibodies from 19 providers |
DNASUi | 15424 |
Genome annotation databases
Ensembli | ENSMUST00000001709; ENSMUSP00000001709; ENSMUSG00000022485 |
GeneIDi | 15424 |
KEGGi | mmu:15424 |
UCSCi | uc007xxe.1, mouse |
Organism-specific databases
CTDi | 3222 |
MGIi | MGI:96196, Hoxc5 |
VEuPathDBi | HostDB:ENSMUSG00000022485 |
Phylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000161023 |
HOGENOMi | CLU_061398_2_1_1 |
InParanoidi | P32043 |
OMAi | DRPSCTV |
OrthoDBi | 1154159at2759 |
PhylomeDBi | P32043 |
TreeFami | TF316310 |
Miscellaneous databases
BioGRID-ORCSi | 15424, 2 hits in 72 CRISPR screens |
PROi | PR:P32043 |
RNActi | P32043, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022485, Expressed in mesonephros and 150 other tissues |
Genevisiblei | P32043, MM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017995, Homeobox_antennapedia IPR001827, Homeobox_Antennapedia_CS IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00025, ANTENNAPEDIA PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00032, ANTENNAPEDIA, 1 hit PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HXC5_MOUSE | |
Accessioni | P32043Primary (citable) accession number: P32043 Secondary accession number(s): Q8BJW4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | September 5, 2006 | |
Last modified: | May 25, 2022 | |
This is version 155 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families