UniProtKB - P32037 (GTR3_MOUSE)
Protein
Solute carrier family 2, facilitated glucose transporter member 3
Gene
Slc2a3
Organism
Mus musculus (Mouse)
Status
Functioni
Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.By similarity
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 315 | MonosaccharideBy similarity | 1 | |
Binding sitei | 378 | MonosaccharideBy similarity | 1 | |
Binding sitei | 386 | MonosaccharideBy similarity | 1 |
GO - Molecular functioni
- dehydroascorbic acid transmembrane transporter activity Source: UniProtKB
- D-glucose transmembrane transporter activity Source: UniProtKB
- galactoside binding Source: MGI
- glucose binding Source: UniProtKB
- glucose transmembrane transporter activity Source: MGI
- kinase binding Source: MGI
- monosaccharide transmembrane transporter activity Source: MGI
- xylose binding Source: MGI
GO - Biological processi
- dehydroascorbic acid transport Source: UniProtKB
- glucose import across plasma membrane Source: MGI
- glucose transmembrane transport Source: UniProtKB
- transport across blood-brain barrier Source: MGI
Keywordsi
Biological process | Sugar transport, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-189200, Cellular hexose transport R-MMU-196836, Vitamin C (ascorbate) metabolism R-MMU-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 2, facilitated glucose transporter member 3CuratedAlternative name(s): Glucose transporter type 3, brain1 Publication Short name: GLUT-31 Publication |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95757, Slc2a3 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein By similarity
Other locations
- Perikaryon By similarity
- Cell projection By similarity
Note: Localized to densely spaced patches along neuronal processes.By similarity
Plasma Membrane
- caveola Source: MGI
- integral component of plasma membrane Source: UniProtKB
- integral component of synaptic membrane Source: MGI
- plasma membrane Source: UniProtKB
Other locations
- acrosomal membrane Source: MGI
- cell projection Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB
- glutamatergic synapse Source: MGI
- integral component of membrane Source: UniProtKB
- perikaryon Source: UniProtKB-SubCell
- synaptic vesicle membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 10 | CytoplasmicBy similarity | 10 | |
Transmembranei | 11 – 32 | Helical; Name=1Sequence analysisBy similarityAdd BLAST | 22 | |
Topological domaini | 33 – 64 | ExtracellularBy similarityAdd BLAST | 32 | |
Transmembranei | 65 – 85 | Helical; Name=2Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 86 – 90 | CytoplasmicBy similarity | 5 | |
Transmembranei | 91 – 111 | Helical; Name=3By similarityAdd BLAST | 21 | |
Topological domaini | 112 – 118 | ExtracellularBy similarity | 7 | |
Transmembranei | 119 – 142 | Helical; Name=4Sequence analysisBy similarityAdd BLAST | 24 | |
Topological domaini | 143 – 153 | CytoplasmicBy similarityAdd BLAST | 11 | |
Transmembranei | 154 – 174 | Helical; Name=5Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 175 – 183 | ExtracellularBy similarity | 9 | |
Transmembranei | 184 – 204 | Helical; Name=6Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 205 – 269 | CytoplasmicBy similarityAdd BLAST | 65 | |
Transmembranei | 270 – 290 | Helical; Name=7Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 291 – 304 | ExtracellularBy similarityAdd BLAST | 14 | |
Transmembranei | 305 – 325 | Helical; Name=8Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 326 – 331 | CytoplasmicBy similarity | 6 | |
Transmembranei | 332 – 352 | Helical; Name=9Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 353 – 363 | ExtracellularBy similarityAdd BLAST | 11 | |
Transmembranei | 364 – 389 | Helical; Name=10Sequence analysisBy similarityAdd BLAST | 26 | |
Topological domaini | 390 – 399 | CytoplasmicBy similarity | 10 | |
Transmembranei | 400 – 420 | Helical; Name=11Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 421 – 429 | ExtracellularBy similarity | 9 | |
Transmembranei | 430 – 450 | Helical; Name=12Sequence analysisBy similarityAdd BLAST | 21 | |
Topological domaini | 451 – 493 | CytoplasmicBy similarityAdd BLAST | 43 |
Keywords - Cellular componenti
Cell membrane, Cell projection, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050354 | 1 – 493 | Solute carrier family 2, facilitated glucose transporter member 3Add BLAST | 493 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 43 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 232 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 471 | PhosphoserineCombined sources | 1 | |
Modified residuei | 482 | PhosphoserineBy similarity | 1 | |
Modified residuei | 489 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | P32037 |
PaxDbi | P32037 |
PeptideAtlasi | P32037 |
PRIDEi | P32037 |
PTM databases
GlyGeni | P32037, 1 site |
iPTMneti | P32037 |
PhosphoSitePlusi | P32037 |
Expressioni
Tissue specificityi
Detected in brain (at protein level). Highly expressed in brain.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000003153, Expressed in epiblast (generic) and 290 other tissues |
ExpressionAtlasi | P32037, baseline and differential |
Genevisiblei | P32037, MM |
Interactioni
GO - Molecular functioni
- kinase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 203306, 6 interactors |
IntActi | P32037, 1 interactor |
STRINGi | 10090.ENSMUSP00000032476 |
Miscellaneous databases
RNActi | P32037, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 277 – 279 | Important for selectivity against fructoseBy similarity | 3 | |
Regioni | 280 – 286 | Monosaccharide bindingBy similarity | 7 |
Domaini
Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.By similarity
Sequence similaritiesi
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0569, Eukaryota |
GeneTreei | ENSGT00940000160313 |
HOGENOMi | CLU_001265_30_5_1 |
InParanoidi | P32037 |
OMAi | AACHFII |
OrthoDBi | 749998at2759 |
PhylomeDBi | P32037 |
TreeFami | TF313762 |
Family and domain databases
InterProi | View protein in InterPro IPR002945, Glc_transpt_3 IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR01192, GLUCTRSPORT3 PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
P32037-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGTTKVTPSL VFAVTVATIG SFQFGYNTGV INAPETILKD FLNYTLEERL
60 70 80 90 100
EDLPSEGLLT ALWSLCVAIF SVGGMIGSFS VGLFVNRFGR RNSMLLVNLL
110 120 130 140 150
AIIAGCLMGF AKIAESVEML ILGRLLIGIF CGLCTGFVPM YIGEVSPTAL
160 170 180 190 200
RGAFGTLNQL GIVVGILVAQ IFGLDFILGS EELWPGLLGL TIIPAILQSA
210 220 230 240 250
ALPFCPESPR FLLINKKEED QATEILQRLW GTSDVVQEIQ EMKDESVRMS
260 270 280 290 300
QEKQVTVLEL FRSPNYVQPL LISIVLQLSQ QLSGINAVFY YSTGIFKDAG
310 320 330 340 350
VQEPIYATIG AGVVNTIFTV VSLFLVERAG RRTLHMIGLG GMAVCSVFMT
360 370 380 390 400
ISLLLKDDYE AMSFVCIVAI LIYVAFFEIG PGPIPWFIVA ELFSQGPRPA
410 420 430 440 450
AIAVAGCCNW TSNFLVGMLF PSAAAYLGAY VFIIFAAFLI FFLIFTFFKV
460 470 480 490
PETKGRTFED IARAFEGQAH SGKGPAGVEL NSMQPVKETP GNA
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9Q2G7 | E9Q2G7_MOUSE | Solute carrier family 2, facilitate... | Slc2a3 | 163 | Annotation score: | ||
E9Q6T5 | E9Q6T5_MOUSE | Solute carrier family 2, facilitate... | Slc2a3 | 89 | Annotation score: | ||
E9Q4C4 | E9Q4C4_MOUSE | Solute carrier family 2, facilitate... | Slc2a3 | 70 | Annotation score: | ||
E9PZF2 | E9PZF2_MOUSE | Solute carrier family 2, facilitate... | Slc2a3 | 63 | Annotation score: | ||
E9PX20 | E9PX20_MOUSE | Solute carrier family 2, facilitate... | Slc2a3 | 39 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M75135 mRNA Translation: AAA37704.1 X61093 mRNA Translation: CAA43406.1 U11853 , U11844, U11845, U11846, U11848, U11849, U11850, U11851, U11852 Genomic DNA Translation: AAB60666.1 BC034122 mRNA Translation: AAH34122.1 BC058811 mRNA Translation: AAH58811.1 |
CCDSi | CCDS20502.1 |
PIRi | A41751 |
RefSeqi | NP_035531.3, NM_011401.4 |
Genome annotation databases
Ensembli | ENSMUST00000032476; ENSMUSP00000032476; ENSMUSG00000003153 |
GeneIDi | 20527 |
KEGGi | mmu:20527 |
UCSCi | uc009dpq.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M75135 mRNA Translation: AAA37704.1 X61093 mRNA Translation: CAA43406.1 U11853 , U11844, U11845, U11846, U11848, U11849, U11850, U11851, U11852 Genomic DNA Translation: AAB60666.1 BC034122 mRNA Translation: AAH34122.1 BC058811 mRNA Translation: AAH58811.1 |
CCDSi | CCDS20502.1 |
PIRi | A41751 |
RefSeqi | NP_035531.3, NM_011401.4 |
3D structure databases
SMRi | P32037 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203306, 6 interactors |
IntActi | P32037, 1 interactor |
STRINGi | 10090.ENSMUSP00000032476 |
PTM databases
GlyGeni | P32037, 1 site |
iPTMneti | P32037 |
PhosphoSitePlusi | P32037 |
Proteomic databases
EPDi | P32037 |
PaxDbi | P32037 |
PeptideAtlasi | P32037 |
PRIDEi | P32037 |
Genome annotation databases
Ensembli | ENSMUST00000032476; ENSMUSP00000032476; ENSMUSG00000003153 |
GeneIDi | 20527 |
KEGGi | mmu:20527 |
UCSCi | uc009dpq.2, mouse |
Organism-specific databases
CTDi | 6515 |
MGIi | MGI:95757, Slc2a3 |
Phylogenomic databases
eggNOGi | KOG0569, Eukaryota |
GeneTreei | ENSGT00940000160313 |
HOGENOMi | CLU_001265_30_5_1 |
InParanoidi | P32037 |
OMAi | AACHFII |
OrthoDBi | 749998at2759 |
PhylomeDBi | P32037 |
TreeFami | TF313762 |
Enzyme and pathway databases
Reactomei | R-MMU-189200, Cellular hexose transport R-MMU-196836, Vitamin C (ascorbate) metabolism R-MMU-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 20527, 1 hit in 17 CRISPR screens |
ChiTaRSi | Slc2a3, mouse |
PROi | PR:P32037 |
RNActi | P32037, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000003153, Expressed in epiblast (generic) and 290 other tissues |
ExpressionAtlasi | P32037, baseline and differential |
Genevisiblei | P32037, MM |
Family and domain databases
InterProi | View protein in InterPro IPR002945, Glc_transpt_3 IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR01192, GLUCTRSPORT3 PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GTR3_MOUSE | |
Accessioni | P32037Primary (citable) accession number: P32037 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | December 2, 2020 | |
This is version 172 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families