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Protein

Carcinoembryonic antigen-related cell adhesion molecule 8

Gene

CEACAM8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner (PubMed:8776764, PubMed:2022629, PubMed:11590190). Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:8776764, PubMed:2022629, PubMed:11590190). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764).3 Publications

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB

GO - Biological processi

  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • immune response Source: ProtInc
  • leukocyte migration Source: Reactome
  • neutrophil degranulation Source: Reactome

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-1566977 Fibronectin matrix formation
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 8
Alternative name(s):
CD67 antigen
Carcinoembryonic antigen CGM6
Non-specific cross-reacting antigen NCA-95
CD_antigen: CD66b
Gene namesi
Name:CEACAM8
Synonyms:CGM6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000124469.10
HGNCiHGNC:1820 CEACAM8
MIMi615747 gene
neXtProtiNX_P31997

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi40 – 45AVPSNA → STPFNV: No effect on heterophilic cell adhesion. 1 Publication6
Mutagenesisi61 – 63DPR → NRI: No effect on heterophilic cell adhesion. 1 Publication3
Mutagenesisi66N → S: Inhibits heterophilic cell adhesion. 1 Publication1
Mutagenesisi72 – 75TVDA → RVDG: No effect on heterophilic cell adhesion. 1 Publication4
Mutagenesisi78R → A: Does not affect the monomeric structure. Loss of heterodimerization with CEACAM6. 1 Publication1
Mutagenesisi78R → Q: Inhibits heterophilic cell adhesion. 1 Publication1
Mutagenesisi85 – 89SNQQI → GTQQA: No effect on heterophilic cell adhesion. 1 Publication5
Mutagenesisi97N → G: No effect on heterophilic cell adhesion. 1 Publication1
Mutagenesisi123Q → A: Does not affect the monomeric structure. Decreases heterodimerization with CEACAM6. 1 Publication1
Mutagenesisi129L → A: Does not affect the monomeric structure. Loss of heterodimerization with CEACAM6. 1 Publication1

Organism-specific databases

DisGeNETi1088
OpenTargetsiENSG00000124469
PharmGKBiPA26364

Polymorphism and mutation databases

BioMutaiCEACAM8
DMDMi6166048

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Add BLAST34
ChainiPRO_000001457235 – 320Carcinoembryonic antigen-related cell adhesion molecule 8Add BLAST286
PropeptideiPRO_0000014573321 – 349Removed in mature formAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi104N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi111N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi115N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi152N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi167 ↔ 215PROSITE-ProRule annotation
Glycosylationi173N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi197N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi224N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi256N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi259 ↔ 299PROSITE-ProRule annotation
Glycosylationi274N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi288N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication1
Glycosylationi309N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Lipidationi320GPI-anchor amidated aspartate1 Publication1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP31997
PeptideAtlasiP31997
PRIDEiP31997
ProteomicsDBi54829

PTM databases

GlyConnecti1072
iPTMnetiP31997
PhosphoSitePlusiP31997

Expressioni

Tissue specificityi

Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.

Gene expression databases

BgeeiENSG00000124469 Expressed in 67 organ(s), highest expression level in bone marrow
CleanExiHS_CEACAM8
ExpressionAtlasiP31997 baseline and differential
GenevisibleiP31997 HS

Organism-specific databases

HPAiCAB033676

Interactioni

Subunit structurei

Monomer. Heterodimer with CEACAM6; heterodimerizes via its Ig-like V-type domain.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107514, 3 interactors
IntActiP31997, 3 interactors
STRINGi9606.ENSP00000244336

Structurei

Secondary structure

1349
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP31997
SMRiP31997
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31997

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 142Ig-like V-typeSequence analysis1 PublicationAdd BLAST108
Domaini145 – 232Ig-like C2-type 1PROSITE-ProRule annotationAdd BLAST88
Domaini237 – 319Ig-like C2-type 2PROSITE-ProRule annotationAdd BLAST83

Domaini

The N-terminus Ig-like V-type domain is necessary for heterophilic intercellular adhesion.1 Publication

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFE1 Eukaryota
ENOG410YR1P LUCA
GeneTreeiENSGT00760000119187
HOGENOMiHOG000233417
HOVERGENiHBG007922
InParanoidiP31997
KOiK06499
OMAiSYACHAT
OrthoDBiEOG091G0AMM
PhylomeDBiP31997
TreeFamiTF336859

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P31997-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPISAPSCR WRIPWQGLLL TASLFTFWNP PTTAQLTIEA VPSNAAEGKE
60 70 80 90 100
VLLLVHNLPQ DPRGYNWYKG ETVDANRRII GYVISNQQIT PGPAYSNRET
110 120 130 140 150
IYPNASLLMR NVTRNDTGSY TLQVIKLNLM SEEVTGQFSV HPETPKPSIS
160 170 180 190 200
SNNSNPVEDK DAVAFTCEPE TQNTTYLWWV NGQSLPVSPR LQLSNGNRTL
210 220 230 240 250
TLLSVTRNDV GPYECEIQNP ASANFSDPVT LNVLYGPDAP TISPSDTYYH
260 270 280 290 300
AGVNLNLSCH AASNPPSQYS WSVNGTFQQY TQKLFIPNIT TKNSGSYACH
310 320 330 340
TTNSATGRNR TTVRMITVSD ALVQGSSPGL SARATVSIMI GVLARVALI
Length:349
Mass (Da):38,154
Last modified:July 15, 1999 - v2
Checksum:iAACF74DA1AC839D8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R1X3M0R1X3_HUMAN
Carcinoembryonic antigen-related ce...
CEACAM8
51Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04984917G → V. Corresponds to variant dbSNP:rs28367882Ensembl.1
Natural variantiVAR_04985045A → V. Corresponds to variant dbSNP:rs35221575Ensembl.1
Natural variantiVAR_011721114R → K. Corresponds to variant dbSNP:rs1041997Ensembl.1
Natural variantiVAR_049851322L → V1 PublicationCorresponds to variant dbSNP:rs1126458Ensembl.1
Natural variantiVAR_049852340I → M. Corresponds to variant dbSNP:rs8103051Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52378 mRNA Translation: CAA36604.1
M33326 mRNA Translation: AAA59914.1
D90064 mRNA Translation: BAA14108.1
AC004558 Genomic DNA Translation: AAC13659.1
BC026263 mRNA Translation: AAH26263.1
Z95119 Genomic DNA Translation: CAB08298.1
CCDSiCCDS12610.1
PIRiS13524 A34815
RefSeqiNP_001807.2, NM_001816.3
XP_016881684.1, XM_017026195.1
UniGeneiHs.41

Genome annotation databases

EnsembliENST00000244336; ENSP00000244336; ENSG00000124469
GeneIDi1088
KEGGihsa:1088

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52378 mRNA Translation: CAA36604.1
M33326 mRNA Translation: AAA59914.1
D90064 mRNA Translation: BAA14108.1
AC004558 Genomic DNA Translation: AAC13659.1
BC026263 mRNA Translation: AAH26263.1
Z95119 Genomic DNA Translation: CAB08298.1
CCDSiCCDS12610.1
PIRiS13524 A34815
RefSeqiNP_001807.2, NM_001816.3
XP_016881684.1, XM_017026195.1
UniGeneiHs.41

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DKSNMR-A33-149[»]
4WTZX-ray2.52G/H/I/J/K/L34-141[»]
4Y88X-ray1.45A34-141[»]
4YIQX-ray1.85A/C34-141[»]
ProteinModelPortaliP31997
SMRiP31997
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107514, 3 interactors
IntActiP31997, 3 interactors
STRINGi9606.ENSP00000244336

PTM databases

GlyConnecti1072
iPTMnetiP31997
PhosphoSitePlusiP31997

Polymorphism and mutation databases

BioMutaiCEACAM8
DMDMi6166048

Proteomic databases

PaxDbiP31997
PeptideAtlasiP31997
PRIDEiP31997
ProteomicsDBi54829

Protocols and materials databases

DNASUi1088
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244336; ENSP00000244336; ENSG00000124469
GeneIDi1088
KEGGihsa:1088

Organism-specific databases

CTDi1088
DisGeNETi1088
EuPathDBiHostDB:ENSG00000124469.10
GeneCardsiCEACAM8
HGNCiHGNC:1820 CEACAM8
HPAiCAB033676
MIMi615747 gene
neXtProtiNX_P31997
OpenTargetsiENSG00000124469
PharmGKBiPA26364
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFE1 Eukaryota
ENOG410YR1P LUCA
GeneTreeiENSGT00760000119187
HOGENOMiHOG000233417
HOVERGENiHBG007922
InParanoidiP31997
KOiK06499
OMAiSYACHAT
OrthoDBiEOG091G0AMM
PhylomeDBiP31997
TreeFamiTF336859

Enzyme and pathway databases

ReactomeiR-HSA-1566977 Fibronectin matrix formation
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiCEACAM8 human
EvolutionaryTraceiP31997
GeneWikiiCEACAM8
GenomeRNAii1088
PROiPR:P31997
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124469 Expressed in 67 organ(s), highest expression level in bone marrow
CleanExiHS_CEACAM8
ExpressionAtlasiP31997 baseline and differential
GenevisibleiP31997 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCEAM8_HUMAN
AccessioniPrimary (citable) accession number: P31997
Secondary accession number(s): O60399, Q16574
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 15, 1999
Last modified: November 7, 2018
This is version 172 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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