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Protein

Low affinity immunoglobulin gamma Fc region receptor II-b

Gene

FCGR2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

Caution

Has sometimes been attributed to correspond to FcR-IIC.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • amyloid-beta binding Source: ARUK-UCL
  • IgG binding Source: ARUK-UCL
  • low-affinity IgG receptor activity Source: ARUK-UCL
  • protein-containing complex binding Source: ARUK-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIgG-binding protein, Receptor
Biological processHost-virus interaction

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P31994

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P31994

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I43.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Low affinity immunoglobulin gamma Fc region receptor II-b
Short name:
IgG Fc receptor II-b
Alternative name(s):
CDw32
Fc-gamma RII-b
Short name:
Fc-gamma-RIIb
Short name:
FcRII-b
CD_antigen: CD32
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FCGR2B
Synonyms:CD32, FCG2, IGFR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000072694.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3618 FCGR2B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604590 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P31994

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini43 – 217ExtracellularSequence analysisAdd BLAST175
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei218 – 240HelicalSequence analysisAdd BLAST23
Topological domaini241 – 310CytoplasmicSequence analysisAdd BLAST70

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Systemic lupus erythematosus (SLE)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
See also OMIM:152700

Keywords - Diseasei

Proto-oncogene, Systemic lupus erythematosus

Organism-specific databases

DisGeNET

More...
DisGeNETi
2213
9103

MalaCards human disease database

More...
MalaCardsi
FCGR2B
MIMi152700 phenotype
611162 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000072694

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
536 Systemic lupus erythematosus

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28064

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00054 Abciximab
DB00051 Adalimumab
DB00092 Alefacept
DB00087 Alemtuzumab
DB00098 Anti-thymocyte Globulin (Rabbit)
DB00074 Basiliximab
DB00112 Bevacizumab
DB00002 Cetuximab
DB00111 Daclizumab
DB00095 Efalizumab
DB00005 Etanercept
DB00056 Gemtuzumab ozogamicin
DB00078 Ibritumomab tiuxetan
DB00028 Immune Globulin Human
DB00075 Muromonab
DB00108 Natalizumab
DB00110 Palivizumab
DB00073 Rituximab
DB00081 Tositumomab
DB00072 Trastuzumab

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FCGR2B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
8039788

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 42Sequence analysisAdd BLAST42
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001514743 – 310Low affinity immunoglobulin gamma Fc region receptor II-bAdd BLAST268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi71 ↔ 113PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi152 ↔ 196PROSITE-ProRule annotation1 Publication
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei292Phosphotyrosine; by SRC-type Tyr-kinases1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by the SRC-type Tyr-kinases LYN and BLK.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P31994

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P31994

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P31994

PeptideAtlas

More...
PeptideAtlasi
P31994

PRoteomics IDEntifications database

More...
PRIDEi
P31994

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54822
54823 [P31994-2]
54824 [P31994-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P31994

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P31994

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000072694 Expressed in 177 organ(s), highest expression level in placenta

CleanEx database of gene expression profiles

More...
CleanExi
HS_FCGR2B

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P31994 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB007796
HPA014730

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with INPP5D/SHIP1. Interacts with FGR. Interacts with LYN.2 Publications
(Microbial infection) Isoform IIB1 interacts with measles virus protein N. Protein N is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108507, 5 interactors

Database of interacting proteins

More...
DIPi
DIP-36638N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P31994

Protein interaction database and analysis system

More...
IntActi
P31994, 15 interactors

Molecular INTeraction database

More...
MINTi
P31994

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000351497

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1310
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FCBX-ray1.74A46-217[»]
3WJJX-ray2.60C45-217[»]
5OCCX-ray2.50A43-218[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P31994

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P31994

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P31994

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini48 – 127Ig-like C2-type 1Add BLAST80
Domaini131 – 213Ig-like C2-type 2Add BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi290 – 295ITIM motif6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J9AP Eukaryota
ENOG410YXNK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153083

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000251632

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051602

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P31994

KEGG Orthology (KO)

More...
KOi
K12560

Identification of Orthologs from Complete Genome Data

More...
OMAi
LGDMLLW

Database of Orthologous Groups

More...
OrthoDBi
1246375at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P31994

TreeFam database of animal gene trees

More...
TreeFami
TF335097

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13895 Ig_2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform IIB11 Publication (identifier: P31994-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGILSFLPVL ATESDWADCK SPQPWGHMLL WTAVLFLAPV AGTPAAPPKA
60 70 80 90 100
VLKLEPQWIN VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR
110 120 130 140 150
FKANNNDSGE YTCQTGQTSL SDPVHLTVLS EWLVLQTPHL EFQEGETIVL
160 170 180 190 200
RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN FSIPQANHSH SGDYHCTGNI
210 220 230 240 250
GYTLYSSKPV TITVQAPSSS PMGIIVAVVT GIAVAAIVAA VVALIYCRKK
260 270 280 290 300
RISALPGYPE CREMGETLPE KPANPTNPDE ADKVGAENTI TYSLLMHPDA
310
LEEPDDQNRI
Length:310
Mass (Da):34,044
Last modified:May 30, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2186F8538FF01F36
GO
Isoform IIB21 Publication (identifier: P31994-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     254-272: Missing.

Show »
Length:291
Mass (Da):31,944
Checksum:i3B76609541B30962
GO
Isoform IIB31 Publication (identifier: P31994-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-45: Missing.

Show »
Length:303
Mass (Da):33,450
Checksum:iB84833348A175687
GO
Isoform 4 (identifier: P31994-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-46: Missing.

Show »
Length:309
Mass (Da):33,973
Checksum:i0D56C5FB9C0998C0
GO
Isoform 5 (identifier: P31994-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-46: Missing.
     254-272: Missing.

Show »
Length:290
Mass (Da):31,873
Checksum:i0D393C1EFDD6C0E4
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA35645 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti178D → I in CAA35644 (PubMed:2531080).Curated1
Sequence conflicti178D → I in CAA35645 (PubMed:2531080).Curated1
Sequence conflicti230T → I in CAA35644 (PubMed:2531080).Curated1
Sequence conflicti230T → I in CAA35645 (PubMed:2531080).Curated1
Sequence conflicti242V → G in CAA35644 (PubMed:2531080).Curated1
Sequence conflicti242V → G in CAA35645 (PubMed:2531080).Curated1
Sequence conflicti275P → S in CAA35644 (PubMed:2531080).Curated1
Sequence conflicti275P → S in CAA35645 (PubMed:2531080).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Note: FCGR2B polymorphisms can influence susceptibility or resistance to malaria [MIMi:611162].2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05943083Q → P. Corresponds to variant dbSNP:rs5017567Ensembl.1
Natural variantiVAR_027045205Y → F1 PublicationCorresponds to variant dbSNP:rs1050499Ensembl.1
Natural variantiVAR_015515232I → T Associated with susceptibility to SLE; associated with resistance to malaria; found at an increased frequency in African and Asian populations from areas where malaria is endemic; enhances phagocytosis of Plasmodium falciparum-infected erythrocytes in vitro. 4 PublicationsCorresponds to variant dbSNP:rs1050501EnsemblClinVar.1
Natural variantiVAR_008798258Y → D1 PublicationCorresponds to variant dbSNP:rs148534844Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00264239 – 45Missing in isoform IIB3. 1 Publication7
Alternative sequenceiVSP_05863546Missing in isoform 4 and isoform 5. 1 Publication1
Alternative sequenceiVSP_002643254 – 272Missing in isoform IIB2 and isoform 5. 6 PublicationsAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U87560 mRNA Translation: AAD00627.1
U87561 mRNA Translation: AAD00628.1
U87562 mRNA Translation: AAD00629.1
U87563 mRNA Translation: AAD00630.1
U87564 mRNA Translation: AAD00631.1
U87565 mRNA Translation: AAD00632.1
U87566 mRNA Translation: AAD00633.1
U87567 mRNA Translation: AAD00634.1
U87568 mRNA Translation: AAD00635.1
U87569 mRNA Translation: AAD00636.1
U87570 mRNA Translation: AAD00637.1
U87571 mRNA Translation: AAD00638.1
U87572 mRNA Translation: AAD00639.1
U87573 mRNA Translation: AAD00640.1
U87574 mRNA Translation: AAD00641.1
U87575 mRNA Translation: AAD00642.1
U87576 mRNA Translation: AAD00643.1
U87577 mRNA Translation: AAD00644.1
X17653 mRNA Translation: CAA35644.1
X17653 mRNA Translation: CAA35645.1 Different initiation.
M31933 mRNA Translation: AAA35841.1
M31934 mRNA Translation: AAA35842.1
M31935 mRNA Translation: AAA35843.1
X52473 mRNA Translation: CAA36713.1
CR407635 mRNA Translation: CAG28563.1
AL359541 Genomic DNA No translation available.
BC031992 mRNA Translation: AAH31992.1
BC146678 mRNA Translation: AAI46679.1
AB050934 mRNA Translation: BAB92093.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS30924.1 [P31994-1]
CCDS30925.1 [P31994-2]
CCDS53414.1 [P31994-3]

Protein sequence database of the Protein Information Resource

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PIRi
JL0119

NCBI Reference Sequences

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RefSeqi
NP_001002273.1, NM_001002273.2 [P31994-5]
NP_001002274.1, NM_001002274.2 [P31994-2]
NP_001002275.1, NM_001002275.2 [P31994-4]
NP_001177757.1, NM_001190828.1 [P31994-3]
NP_003992.3, NM_004001.4 [P31994-1]
XP_016856160.1, XM_017000671.1
XP_016856161.1, XM_017000672.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.654395

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000236937; ENSP00000236937; ENSG00000072694 [P31994-2]
ENST00000358671; ENSP00000351497; ENSG00000072694 [P31994-1]
ENST00000367961; ENSP00000356938; ENSG00000072694 [P31994-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2213

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2213

UCSC genome browser

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UCSCi
uc001gaz.3 human [P31994-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87560 mRNA Translation: AAD00627.1
U87561 mRNA Translation: AAD00628.1
U87562 mRNA Translation: AAD00629.1
U87563 mRNA Translation: AAD00630.1
U87564 mRNA Translation: AAD00631.1
U87565 mRNA Translation: AAD00632.1
U87566 mRNA Translation: AAD00633.1
U87567 mRNA Translation: AAD00634.1
U87568 mRNA Translation: AAD00635.1
U87569 mRNA Translation: AAD00636.1
U87570 mRNA Translation: AAD00637.1
U87571 mRNA Translation: AAD00638.1
U87572 mRNA Translation: AAD00639.1
U87573 mRNA Translation: AAD00640.1
U87574 mRNA Translation: AAD00641.1
U87575 mRNA Translation: AAD00642.1
U87576 mRNA Translation: AAD00643.1
U87577 mRNA Translation: AAD00644.1
X17653 mRNA Translation: CAA35644.1
X17653 mRNA Translation: CAA35645.1 Different initiation.
M31933 mRNA Translation: AAA35841.1
M31934 mRNA Translation: AAA35842.1
M31935 mRNA Translation: AAA35843.1
X52473 mRNA Translation: CAA36713.1
CR407635 mRNA Translation: CAG28563.1
AL359541 Genomic DNA No translation available.
BC031992 mRNA Translation: AAH31992.1
BC146678 mRNA Translation: AAI46679.1
AB050934 mRNA Translation: BAB92093.1
CCDSiCCDS30924.1 [P31994-1]
CCDS30925.1 [P31994-2]
CCDS53414.1 [P31994-3]
PIRiJL0119
RefSeqiNP_001002273.1, NM_001002273.2 [P31994-5]
NP_001002274.1, NM_001002274.2 [P31994-2]
NP_001002275.1, NM_001002275.2 [P31994-4]
NP_001177757.1, NM_001190828.1 [P31994-3]
NP_003992.3, NM_004001.4 [P31994-1]
XP_016856160.1, XM_017000671.1
XP_016856161.1, XM_017000672.1
UniGeneiHs.654395

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FCBX-ray1.74A46-217[»]
3WJJX-ray2.60C45-217[»]
5OCCX-ray2.50A43-218[»]
ProteinModelPortaliP31994
SMRiP31994
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108507, 5 interactors
DIPiDIP-36638N
ELMiP31994
IntActiP31994, 15 interactors
MINTiP31994
STRINGi9606.ENSP00000351497

Chemistry databases

DrugBankiDB00054 Abciximab
DB00051 Adalimumab
DB00092 Alefacept
DB00087 Alemtuzumab
DB00098 Anti-thymocyte Globulin (Rabbit)
DB00074 Basiliximab
DB00112 Bevacizumab
DB00002 Cetuximab
DB00111 Daclizumab
DB00095 Efalizumab
DB00005 Etanercept
DB00056 Gemtuzumab ozogamicin
DB00078 Ibritumomab tiuxetan
DB00028 Immune Globulin Human
DB00075 Muromonab
DB00108 Natalizumab
DB00110 Palivizumab
DB00073 Rituximab
DB00081 Tositumomab
DB00072 Trastuzumab

Protein family/group databases

MEROPSiI43.001

PTM databases

iPTMnetiP31994
PhosphoSitePlusiP31994

Polymorphism and mutation databases

BioMutaiFCGR2B
DMDMi8039788

Proteomic databases

jPOSTiP31994
MaxQBiP31994
PaxDbiP31994
PeptideAtlasiP31994
PRIDEiP31994
ProteomicsDBi54822
54823 [P31994-2]
54824 [P31994-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000236937; ENSP00000236937; ENSG00000072694 [P31994-2]
ENST00000358671; ENSP00000351497; ENSG00000072694 [P31994-1]
ENST00000367961; ENSP00000356938; ENSG00000072694 [P31994-3]
GeneIDi2213
KEGGihsa:2213
UCSCiuc001gaz.3 human [P31994-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2213
DisGeNETi2213
9103
EuPathDBiHostDB:ENSG00000072694.19

GeneCards: human genes, protein and diseases

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GeneCardsi
FCGR2B
HGNCiHGNC:3618 FCGR2B
HPAiCAB007796
HPA014730
MalaCardsiFCGR2B
MIMi152700 phenotype
604590 gene
611162 phenotype
neXtProtiNX_P31994
OpenTargetsiENSG00000072694
Orphaneti536 Systemic lupus erythematosus
PharmGKBiPA28064

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J9AP Eukaryota
ENOG410YXNK LUCA
GeneTreeiENSGT00940000153083
HOGENOMiHOG000251632
HOVERGENiHBG051602
InParanoidiP31994
KOiK12560
OMAiLGDMLLW
OrthoDBi1246375at2759
PhylomeDBiP31994
TreeFamiTF335097

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
SignaLinkiP31994
SIGNORiP31994

Miscellaneous databases

EvolutionaryTraceiP31994

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FCGR2B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2213

Protein Ontology

More...
PROi
PR:P31994

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000072694 Expressed in 177 organ(s), highest expression level in placenta
CleanExiHS_FCGR2B
GenevisibleiP31994 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFCG2B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31994
Secondary accession number(s): A6H8N3
, O95649, Q53X85, Q5VXA9, Q8NIA1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: May 30, 2000
Last modified: January 16, 2019
This is version 209 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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