Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Low affinity immunoglobulin gamma Fc region receptor II-b

Gene

FCGR2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

Caution

Has sometimes been attributed to correspond to FcR-IIC.Curated

GO - Molecular functioni

  • amyloid-beta binding Source: ARUK-UCL
  • IgG binding Source: ARUK-UCL
  • low-affinity IgG receptor activity Source: ARUK-UCL
  • protein-containing complex binding Source: ARUK-UCL

GO - Biological processi

  • antigen processing and presentation of exogenous peptide antigen via MHC class II Source: ARUK-UCL
  • cellular response to amyloid-beta Source: ARUK-UCL
  • cellular response to molecule of bacterial origin Source: ARUK-UCL
  • cerebellum development Source: BHF-UCL
  • defense response Source: ARUK-UCL
  • Fc-gamma receptor signaling pathway involved in phagocytosis Source: ARUK-UCL
  • follicular B cell differentiation Source: ARUK-UCL
  • follicular dendritic cell activation Source: ARUK-UCL
  • immune complex clearance by monocytes and macrophages Source: ARUK-UCL
  • immune response Source: ProtInc
  • immunoglobulin mediated immune response Source: ARUK-UCL
  • inflammatory response Source: ARUK-UCL
  • mature B cell differentiation involved in immune response Source: ARUK-UCL
  • negative regulation of acute inflammatory response to antigenic stimulus Source: ARUK-UCL
  • negative regulation of antibody-dependent cellular cytotoxicity Source: ARUK-UCL
  • negative regulation of B cell activation Source: ARUK-UCL
  • negative regulation of B cell proliferation Source: ARUK-UCL
  • negative regulation of cytokine secretion Source: ARUK-UCL
  • negative regulation of cytotoxic T cell degranulation Source: ARUK-UCL
  • negative regulation of dendritic cell antigen processing and presentation Source: ARUK-UCL
  • negative regulation of dendritic cell differentiation Source: ARUK-UCL
  • negative regulation of humoral immune response mediated by circulating immunoglobulin Source: ARUK-UCL
  • negative regulation of immune response Source: ARUK-UCL
  • negative regulation of immunoglobulin production Source: ARUK-UCL
  • negative regulation of interleukin-10 production Source: ARUK-UCL
  • negative regulation of macrophage activation Source: ARUK-UCL
  • negative regulation of neutrophil activation Source: ARUK-UCL
  • negative regulation of phagocytosis Source: ARUK-UCL
  • negative regulation of type I hypersensitivity Source: ARUK-UCL
  • phagocytosis, engulfment Source: ARUK-UCL
  • positive regulation of humoral immune response Source: ARUK-UCL
  • positive regulation of JNK cascade Source: ARUK-UCL
  • positive regulation of neuron death Source: ARUK-UCL
  • positive regulation of phagocytosis Source: ARUK-UCL
  • positive regulation of response to endoplasmic reticulum stress Source: ARUK-UCL
  • receptor-mediated endocytosis Source: ARUK-UCL
  • regulation of adaptive immune response Source: ARUK-UCL
  • regulation of B cell antigen processing and presentation Source: ARUK-UCL
  • regulation of dendritic spine maintenance Source: ARUK-UCL
  • regulation of immune complex clearance by monocytes and macrophages Source: ARUK-UCL
  • regulation of immune response Source: Reactome
  • regulation of innate immune response Source: ARUK-UCL
  • regulation of signaling receptor activity Source: ARUK-UCL
  • response to bacterium Source: ARUK-UCL
  • signal transduction Source: ProtInc
  • viral process Source: UniProtKB-KW

Keywordsi

Molecular functionIgG-binding protein, Receptor
Biological processHost-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
SignaLinkiP31994
SIGNORiP31994

Protein family/group databases

MEROPSiI43.001

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity immunoglobulin gamma Fc region receptor II-b
Short name:
IgG Fc receptor II-b
Alternative name(s):
CDw32
Fc-gamma RII-b
Short name:
Fc-gamma-RIIb
Short name:
FcRII-b
CD_antigen: CD32
Gene namesi
Name:FCGR2B
Synonyms:CD32, FCG2, IGFR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000072694.19
HGNCiHGNC:3618 FCGR2B
MIMi604590 gene
neXtProtiNX_P31994

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini43 – 217ExtracellularSequence analysisAdd BLAST175
Transmembranei218 – 240HelicalSequence analysisAdd BLAST23
Topological domaini241 – 310CytoplasmicSequence analysisAdd BLAST70

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Systemic lupus erythematosus (SLE)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
See also OMIM:152700

Keywords - Diseasei

Proto-oncogene, Systemic lupus erythematosus

Organism-specific databases

DisGeNETi2213
9103
MalaCardsiFCGR2B
MIMi152700 phenotype
611162 phenotype
OpenTargetsiENSG00000072694
Orphaneti536 Systemic lupus erythematosus
PharmGKBiPA28064

Chemistry databases

DrugBankiDB00054 Abciximab
DB00051 Adalimumab
DB00092 Alefacept
DB00087 Alemtuzumab
DB00098 Anti-thymocyte Globulin (Rabbit)
DB00074 Basiliximab
DB00112 Bevacizumab
DB00002 Cetuximab
DB00111 Daclizumab
DB00095 Efalizumab
DB00005 Etanercept
DB00056 Gemtuzumab ozogamicin
DB00078 Ibritumomab tiuxetan
DB00028 Immune Globulin Human
DB00075 Muromonab
DB00108 Natalizumab
DB00110 Palivizumab
DB00073 Rituximab
DB00081 Tositumomab
DB00072 Trastuzumab

Polymorphism and mutation databases

BioMutaiFCGR2B
DMDMi8039788

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 42Sequence analysisAdd BLAST42
ChainiPRO_000001514743 – 310Low affinity immunoglobulin gamma Fc region receptor II-bAdd BLAST268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi71 ↔ 113PROSITE-ProRule annotation1 Publication
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi152 ↔ 196PROSITE-ProRule annotation1 Publication
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei292Phosphotyrosine; by SRC-type Tyr-kinases1 Publication1

Post-translational modificationi

Phosphorylated by the SRC-type Tyr-kinases LYN and BLK.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP31994
PaxDbiP31994
PeptideAtlasiP31994
PRIDEiP31994
ProteomicsDBi54822
54823 [P31994-2]
54824 [P31994-3]

PTM databases

iPTMnetiP31994
PhosphoSitePlusiP31994

Expressioni

Tissue specificityi

Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.

Gene expression databases

BgeeiENSG00000072694
CleanExiHS_FCGR2B
GenevisibleiP31994 HS

Organism-specific databases

HPAiCAB007796
HPA014730

Interactioni

Subunit structurei

Interacts with INPP5D/SHIP1. Interacts with FGR. Interacts with LYN.2 Publications
(Microbial infection) Isoform IIB1 interacts with measles virus protein N. Protein N is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi108507, 5 interactors
DIPiDIP-36638N
ELMiP31994
IntActiP31994, 15 interactors
MINTiP31994
STRINGi9606.ENSP00000351497

Structurei

Secondary structure

1310
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi51 – 56Combined sources6
Beta strandi59 – 62Combined sources4
Beta strandi66 – 72Combined sources7
Beta strandi83 – 86Combined sources4
Beta strandi96 – 102Combined sources7
Helixi105 – 107Combined sources3
Beta strandi109 – 114Combined sources6
Beta strandi116 – 118Combined sources3
Beta strandi124 – 129Combined sources6
Beta strandi131 – 136Combined sources6
Beta strandi140 – 142Combined sources3
Beta strandi148 – 154Combined sources7
Helixi155 – 157Combined sources3
Beta strandi161 – 167Combined sources7
Beta strandi170 – 177Combined sources8
Beta strandi180 – 183Combined sources4
Helixi188 – 190Combined sources3
Beta strandi192 – 200Combined sources9
Beta strandi203 – 206Combined sources4
Beta strandi210 – 214Combined sources5

3D structure databases

ProteinModelPortaliP31994
SMRiP31994
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31994

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 127Ig-like C2-type 1Add BLAST80
Domaini131 – 213Ig-like C2-type 2Add BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi290 – 295ITIM motif6

Domaini

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9AP Eukaryota
ENOG410YXNK LUCA
GeneTreeiENSGT00760000119130
HOGENOMiHOG000251632
HOVERGENiHBG051602
InParanoidiP31994
KOiK12560
OMAiXAENTIT
OrthoDBiEOG091G0JSA
PhylomeDBiP31994
TreeFamiTF335097

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform IIB11 Publication (identifier: P31994-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGILSFLPVL ATESDWADCK SPQPWGHMLL WTAVLFLAPV AGTPAAPPKA
60 70 80 90 100
VLKLEPQWIN VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR
110 120 130 140 150
FKANNNDSGE YTCQTGQTSL SDPVHLTVLS EWLVLQTPHL EFQEGETIVL
160 170 180 190 200
RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN FSIPQANHSH SGDYHCTGNI
210 220 230 240 250
GYTLYSSKPV TITVQAPSSS PMGIIVAVVT GIAVAAIVAA VVALIYCRKK
260 270 280 290 300
RISALPGYPE CREMGETLPE KPANPTNPDE ADKVGAENTI TYSLLMHPDA
310
LEEPDDQNRI
Length:310
Mass (Da):34,044
Last modified:May 30, 2000 - v2
Checksum:i2186F8538FF01F36
GO
Isoform IIB21 Publication (identifier: P31994-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     254-272: Missing.

Show »
Length:291
Mass (Da):31,944
Checksum:i3B76609541B30962
GO
Isoform IIB31 Publication (identifier: P31994-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-45: Missing.

Show »
Length:303
Mass (Da):33,450
Checksum:iB84833348A175687
GO
Isoform 4 (identifier: P31994-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-46: Missing.

Show »
Length:309
Mass (Da):33,973
Checksum:i0D56C5FB9C0998C0
GO
Isoform 5 (identifier: P31994-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-46: Missing.
     254-272: Missing.

Show »
Length:290
Mass (Da):31,873
Checksum:i0D393C1EFDD6C0E4
GO

Sequence cautioni

The sequence CAA35645 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti178D → I in CAA35644 (PubMed:2531080).Curated1
Sequence conflicti178D → I in CAA35645 (PubMed:2531080).Curated1
Sequence conflicti230T → I in CAA35644 (PubMed:2531080).Curated1
Sequence conflicti230T → I in CAA35645 (PubMed:2531080).Curated1
Sequence conflicti242V → G in CAA35644 (PubMed:2531080).Curated1
Sequence conflicti242V → G in CAA35645 (PubMed:2531080).Curated1
Sequence conflicti275P → S in CAA35644 (PubMed:2531080).Curated1
Sequence conflicti275P → S in CAA35645 (PubMed:2531080).Curated1

Polymorphismi

Note: FCGR2B polymorphisms can influence susceptibility or resistance to malaria [MIMi:611162].2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05943083Q → P. Corresponds to variant dbSNP:rs5017567Ensembl.1
Natural variantiVAR_027045205Y → F1 PublicationCorresponds to variant dbSNP:rs1050499Ensembl.1
Natural variantiVAR_015515232I → T Associated with susceptibility to SLE; associated with resistance to malaria; found at an increased frequency in African and Asian populations from areas where malaria is endemic; enhances phagocytosis of Plasmodium falciparum-infected erythrocytes in vitro. 4 PublicationsCorresponds to variant dbSNP:rs1050501EnsemblClinVar.1
Natural variantiVAR_008798258Y → D1 PublicationCorresponds to variant dbSNP:rs148534844Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00264239 – 45Missing in isoform IIB3. 1 Publication7
Alternative sequenceiVSP_05863546Missing in isoform 4 and isoform 5. 1 Publication1
Alternative sequenceiVSP_002643254 – 272Missing in isoform IIB2 and isoform 5. 6 PublicationsAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87560 mRNA Translation: AAD00627.1
U87561 mRNA Translation: AAD00628.1
U87562 mRNA Translation: AAD00629.1
U87563 mRNA Translation: AAD00630.1
U87564 mRNA Translation: AAD00631.1
U87565 mRNA Translation: AAD00632.1
U87566 mRNA Translation: AAD00633.1
U87567 mRNA Translation: AAD00634.1
U87568 mRNA Translation: AAD00635.1
U87569 mRNA Translation: AAD00636.1
U87570 mRNA Translation: AAD00637.1
U87571 mRNA Translation: AAD00638.1
U87572 mRNA Translation: AAD00639.1
U87573 mRNA Translation: AAD00640.1
U87574 mRNA Translation: AAD00641.1
U87575 mRNA Translation: AAD00642.1
U87576 mRNA Translation: AAD00643.1
U87577 mRNA Translation: AAD00644.1
X17653 mRNA Translation: CAA35644.1
X17653 mRNA Translation: CAA35645.1 Different initiation.
M31933 mRNA Translation: AAA35841.1
M31934 mRNA Translation: AAA35842.1
M31935 mRNA Translation: AAA35843.1
X52473 mRNA Translation: CAA36713.1
CR407635 mRNA Translation: CAG28563.1
AL359541 Genomic DNA No translation available.
BC031992 mRNA Translation: AAH31992.1
BC146678 mRNA Translation: AAI46679.1
AB050934 mRNA Translation: BAB92093.1
CCDSiCCDS30924.1 [P31994-1]
CCDS30925.1 [P31994-2]
CCDS53414.1 [P31994-3]
PIRiJL0119
RefSeqiNP_001002273.1, NM_001002273.2 [P31994-5]
NP_001002274.1, NM_001002274.2 [P31994-2]
NP_001002275.1, NM_001002275.2 [P31994-4]
NP_001177757.1, NM_001190828.1 [P31994-3]
NP_003992.3, NM_004001.4 [P31994-1]
XP_016856160.1, XM_017000671.1 [P31994-1]
XP_016856161.1, XM_017000672.1 [P31994-2]
UniGeneiHs.654395

Genome annotation databases

EnsembliENST00000236937; ENSP00000236937; ENSG00000072694 [P31994-2]
ENST00000358671; ENSP00000351497; ENSG00000072694 [P31994-1]
ENST00000367961; ENSP00000356938; ENSG00000072694 [P31994-3]
GeneIDi2213
KEGGihsa:2213
UCSCiuc001gaz.3 human [P31994-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFCG2B_HUMAN
AccessioniPrimary (citable) accession number: P31994
Secondary accession number(s): A6H8N3
, O95649, Q53X85, Q5VXA9, Q8NIA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: May 30, 2000
Last modified: June 20, 2018
This is version 204 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health