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UniProtKB - P31955 (AREG_MOUSE)
Protein
Amphiregulin
Gene
Areg
Organism
Mus musculus (Mouse)
Status
Functioni
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- epidermal growth factor receptor binding Source: MGI
- growth factor activity Source: MGI
GO - Biological processi
- dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis Source: MGI
- epidermal growth factor receptor signaling pathway Source: MGI
- epithelial cell proliferation involved in mammary gland duct elongation Source: MGI
- glial cell proliferation Source: MGI
- G protein-coupled receptor signaling pathway Source: MGI
- mammary gland alveolus development Source: MGI
- mammary gland branching involved in thelarche Source: MGI
- negative regulation of osteoblast differentiation Source: MGI
- neuron projection development Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of epidermal growth factor-activated receptor activity Source: GO_Central
- positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
- positive regulation of phosphorylation Source: MGI
- response to cAMP Source: Ensembl
- response to estradiol Source: MGI
- response to glucocorticoid Source: MGI
- response to hydrogen peroxide Source: Ensembl
- response to peptide hormone Source: Ensembl
Keywordsi
Molecular function | Cytokine, Growth factor |
Enzyme and pathway databases
Reactomei | R-MMU-1257604, PIP3 activates AKT signaling R-MMU-177929, Signaling by EGFR R-MMU-179812, GRB2 events in EGFR signaling R-MMU-180292, GAB1 signalosome R-MMU-180336, SHC1 events in EGFR signaling R-MMU-182971, EGFR downregulation R-MMU-204005, COPII-mediated vesicle transport R-MMU-212718, EGFR interacts with phospholipase C-gamma R-MMU-5673001, RAF/MAP kinase cascade R-MMU-5694530, Cargo concentration in the ER R-MMU-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-MMU-8856825, Cargo recognition for clathrin-mediated endocytosis R-MMU-8856828, Clathrin-mediated endocytosis R-MMU-9009391, Extra-nuclear estrogen signaling |
Names & Taxonomyi
Protein namesi | Recommended name: AmphiregulinShort name: AR Alternative name(s): Schwannoma-derived growth factor Short name: SDGF |
Gene namesi | Name:Areg Synonyms:Sdgf |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88068, Areg |
VEuPathDBi | HostDB:ENSMUSG00000029378 |
Subcellular locationi
Other locations
Extracellular region or secreted
- extracellular space Source: MGI
Nucleus
- nucleus Source: MGI
Other locations
- cell surface Source: MGI
- cytoplasm Source: MGI
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 192 – 215 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
PropeptideiPRO_0000007476 | 27 – 99 | Add BLAST | 73 | |
ChainiPRO_0000007477 | 100 – 248 | AmphiregulinAdd BLAST | 149 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 106 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 139 ↔ 152 | PROSITE-ProRule annotation | ||
Disulfide bondi | 147 ↔ 163 | PROSITE-ProRule annotation | ||
Disulfide bondi | 165 ↔ 174 | PROSITE-ProRule annotation | ||
Glycosylationi | 241 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P31955 |
PRIDEi | P31955 |
ProteomicsDBi | 277271 |
PTM databases
GlyGeni | P31955, 2 sites |
iPTMneti | P31955 |
PhosphoSitePlusi | P31955 |
Expressioni
Inductioni
Androgen-dependent.
Gene expression databases
Bgeei | ENSMUSG00000029378, Expressed in inguinal mammary gland and 80 other tissues |
Genevisiblei | P31955, MM |
Interactioni
Subunit structurei
The immature precursor interacts with CNIH.
By similarityGO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- epidermal growth factor receptor binding Source: MGI
- growth factor activity Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000031325 |
Miscellaneous databases
RNActi | P31955, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 135 – 175 | EGF-likePROSITE-ProRule annotationAdd BLAST | 41 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 29 – 48 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 57 – 77 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 100 – 136 | DisorderedSequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 58 – 72 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 100 – 117 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 118 – 136 | Basic residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the amphiregulin family.Curated
Keywords - Domaini
EGF-like domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S0KA, Eukaryota |
GeneTreei | ENSGT00940000160696 |
HOGENOMi | CLU_096527_1_0_1 |
InParanoidi | P31955 |
OMAi | CHHDYFG |
OrthoDBi | 1444868at2759 |
PhylomeDBi | P31955 |
TreeFami | TF332773 |
Family and domain databases
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR015497, EGF_rcpt_ligand |
PANTHERi | PTHR10740, PTHR10740, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 1 hit PS50026, EGF_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P31955-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRTPLLPLAR SVLLLLVLGS GHYAAALELN DPSSGKGESL SGDHSAGGLE
60 70 80 90 100
LSVGREVSTI SEMPSGSELS TGDYDYSEEY DNEPQISGYI IDDSVRVEQV
110 120 130 140 150
IKPKKNKTEG EKSTEKPKRK KKGGKNGKGR RNKKKKNPCT AKFQNFCIHG
160 170 180 190 200
ECRYIENLEV VTCNCHQDYF GERCGEKSMK THSEDDKDLS KIAVVAVTIF
210 220 230 240
VSAIILAAIG IGIVITVHLW KRYFREYEGE TEERRRLRQE NGTVHAIA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D12648 mRNA Translation: BAA02169.1 L41352 Genomic DNA Translation: AAB00472.1 AK018590 mRNA Translation: BAB31296.1 BC009138 mRNA Translation: AAH09138.1 |
CCDSi | CCDS19421.1 |
PIRi | JH0612 |
RefSeqi | NP_033834.1, NM_009704.4 |
Genome annotation databases
Ensembli | ENSMUST00000031325; ENSMUSP00000031325; ENSMUSG00000029378 |
GeneIDi | 11839 |
KEGGi | mmu:11839 |
UCSCi | uc008ybt.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D12648 mRNA Translation: BAA02169.1 L41352 Genomic DNA Translation: AAB00472.1 AK018590 mRNA Translation: BAB31296.1 BC009138 mRNA Translation: AAH09138.1 |
CCDSi | CCDS19421.1 |
PIRi | JH0612 |
RefSeqi | NP_033834.1, NM_009704.4 |
3D structure databases
SMRi | P31955 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000031325 |
PTM databases
GlyGeni | P31955, 2 sites |
iPTMneti | P31955 |
PhosphoSitePlusi | P31955 |
Proteomic databases
PaxDbi | P31955 |
PRIDEi | P31955 |
ProteomicsDBi | 277271 |
Protocols and materials databases
Antibodypediai | 1919, 577 antibodies from 35 providers |
DNASUi | 11839 |
Genome annotation databases
Ensembli | ENSMUST00000031325; ENSMUSP00000031325; ENSMUSG00000029378 |
GeneIDi | 11839 |
KEGGi | mmu:11839 |
UCSCi | uc008ybt.1, mouse |
Organism-specific databases
CTDi | 374 |
MGIi | MGI:88068, Areg |
VEuPathDBi | HostDB:ENSMUSG00000029378 |
Phylogenomic databases
eggNOGi | ENOG502S0KA, Eukaryota |
GeneTreei | ENSGT00940000160696 |
HOGENOMi | CLU_096527_1_0_1 |
InParanoidi | P31955 |
OMAi | CHHDYFG |
OrthoDBi | 1444868at2759 |
PhylomeDBi | P31955 |
TreeFami | TF332773 |
Enzyme and pathway databases
Reactomei | R-MMU-1257604, PIP3 activates AKT signaling R-MMU-177929, Signaling by EGFR R-MMU-179812, GRB2 events in EGFR signaling R-MMU-180292, GAB1 signalosome R-MMU-180336, SHC1 events in EGFR signaling R-MMU-182971, EGFR downregulation R-MMU-204005, COPII-mediated vesicle transport R-MMU-212718, EGFR interacts with phospholipase C-gamma R-MMU-5673001, RAF/MAP kinase cascade R-MMU-5694530, Cargo concentration in the ER R-MMU-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-MMU-8856825, Cargo recognition for clathrin-mediated endocytosis R-MMU-8856828, Clathrin-mediated endocytosis R-MMU-9009391, Extra-nuclear estrogen signaling |
Miscellaneous databases
BioGRID-ORCSi | 11839, 2 hits in 66 CRISPR screens |
ChiTaRSi | Areg, mouse |
PROi | PR:P31955 |
RNActi | P31955, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029378, Expressed in inguinal mammary gland and 80 other tissues |
Genevisiblei | P31955, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR015497, EGF_rcpt_ligand |
PANTHERi | PTHR10740, PTHR10740, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 1 hit PS50026, EGF_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AREG_MOUSE | |
Accessioni | P31955Primary (citable) accession number: P31955 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | February 23, 2022 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families