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UniProtKB - P31950 (S10AB_PIG)
Protein
Protein S100-A11
Gene
S100A11
Organism
Sus scrofa (Pig)
Status
Functioni
Facilitates the differentiation and the cornification of keratinocytes.
By similarityMiscellaneous
Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 29 | Calcium 1; low affinityCurated | 1 | |
Metal bindingi | 31 | Calcium 1; low affinityCurated | 1 | |
Metal bindingi | 36 | Calcium 1; low affinityCurated | 1 | |
Metal bindingi | 66 | Calcium 2; high affinityPROSITE-ProRule annotation | 1 | |
Metal bindingi | 68 | Calcium 2; high affinityPROSITE-ProRule annotation | 1 | |
Metal bindingi | 70 | Calcium 2; high affinityPROSITE-ProRule annotation | 1 | |
Metal bindingi | 72 | Calcium 2; high affinityPROSITE-ProRule annotation | 1 | |
Metal bindingi | 77 | Calcium 2; high affinityPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- calcium-dependent protein binding Source: GO_Central
- calcium ion binding Source: GO_Central
- S100 protein binding Source: GO_Central
GO - Biological processi
- regulation of cell population proliferation Source: InterPro
Keywordsi
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
Reactomei | R-SSC-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Protein S100-A11Alternative name(s): Calgizzarin Protein S100-C S100 calcium-binding protein A11 |
Gene namesi | Name:S100A11 Synonyms:S100C |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:92537, S100A11 |
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: GO_Central
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144011 | 1 – 99 | Protein S100-A11Add BLAST | 99 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionine1 Publication | 1 | |
Modified residuei | 8 | PhosphothreonineBy similarity | 1 | |
Disulfide bondi | 11 | InterchainBy similarity |
Post-translational modificationi
Phosphorylation at Thr-8 significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.By similarity
Keywords - PTMi
Acetylation, Disulfide bond, PhosphoproteinProteomic databases
PaxDbi | P31950 |
PeptideAtlasi | P31950 |
PRIDEi | P31950 |
PTM databases
iPTMneti | P31950 |
Expressioni
Gene expression databases
Bgeei | ENSSSCG00000006610, Expressed in hindlimb bud and 50 other tissues |
ExpressionAtlasi | P31950, baseline and differential |
Genevisiblei | P31950, SS |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
By similarityGO - Molecular functioni
- calcium-dependent protein binding Source: GO_Central
- S100 protein binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000021681 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P31950 |
SMRi | P31950 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P31950 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 47 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 53 – 88 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the S-100 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502SS6H, Eukaryota |
GeneTreei | ENSGT00940000154172 |
HOGENOMi | CLU_138624_1_0_1 |
InParanoidi | P31950 |
OMAi | MACEKCY |
OrthoDBi | 1549220at2759 |
TreeFami | TF332727 |
Family and domain databases
IDEALi | IID50073 |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR001751, S100/CaBP7/8-like_CS IPR013787, S100_Ca-bd_sub IPR028482, S100A11 |
PANTHERi | PTHR11639:SF60, PTHR11639:SF60, 1 hit |
Pfami | View protein in Pfam PF00036, EF-hand_1, 1 hit PF01023, S_100, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 1 hit SM01394, S_100, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits PS00303, S100_CABP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P31950-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKRPTETER CIESLIAIFQ KHAGRDGNNT KISKTEFLIF MNTELAAFTQ
60 70 80 90
NQKDPGVLDR MMKKLDLDSD GQLDFQEFLN LIGGLAIACH DSFIKSTQK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5G2QR31 | A0A5G2QR31_PIG | Protein S100 | S100A11 | 130 | Annotation score: | ||
A0A5G2QQA2 | A0A5G2QQA2_PIG | Protein S100 | S100A11 | 111 | Annotation score: | ||
A0A5G2QTA1 | A0A5G2QTA1_PIG | Protein S100 | S100A11 | 100 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB004800 mRNA Translation: BAA20521.1 AB003363 Genomic DNA Translation: BAA25189.1 |
PIRi | S20342 |
RefSeqi | NP_001004045.1, NM_001004045.1 XP_003361619.1, XM_003361571.2 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB004800 mRNA Translation: BAA20521.1 AB003363 Genomic DNA Translation: BAA25189.1 |
PIRi | S20342 |
RefSeqi | NP_001004045.1, NM_001004045.1 XP_003361619.1, XM_003361571.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1QLS | X-ray | 2.30 | A | 1-99 | [»] | |
AlphaFoldDBi | P31950 | |||||
SMRi | P31950 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000021681 |
PTM databases
iPTMneti | P31950 |
Proteomic databases
PaxDbi | P31950 |
PeptideAtlasi | P31950 |
PRIDEi | P31950 |
Genome annotation databases
Organism-specific databases
CTDi | 6282 |
VGNCi | VGNC:92537, S100A11 |
Phylogenomic databases
eggNOGi | ENOG502SS6H, Eukaryota |
GeneTreei | ENSGT00940000154172 |
HOGENOMi | CLU_138624_1_0_1 |
InParanoidi | P31950 |
OMAi | MACEKCY |
OrthoDBi | 1549220at2759 |
TreeFami | TF332727 |
Enzyme and pathway databases
Reactomei | R-SSC-6798695, Neutrophil degranulation |
Miscellaneous databases
EvolutionaryTracei | P31950 |
Gene expression databases
Bgeei | ENSSSCG00000006610, Expressed in hindlimb bud and 50 other tissues |
ExpressionAtlasi | P31950, baseline and differential |
Genevisiblei | P31950, SS |
Family and domain databases
IDEALi | IID50073 |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR001751, S100/CaBP7/8-like_CS IPR013787, S100_Ca-bd_sub IPR028482, S100A11 |
PANTHERi | PTHR11639:SF60, PTHR11639:SF60, 1 hit |
Pfami | View protein in Pfam PF00036, EF-hand_1, 1 hit PF01023, S_100, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 1 hit SM01394, S_100, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits PS00303, S100_CABP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S10AB_PIG | |
Accessioni | P31950Primary (citable) accession number: P31950 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | May 25, 2022 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families