UniProtKB - P31948 (STIP1_HUMAN)
Stress-induced-phosphoprotein 1
STIP1
Functioni
GO - Molecular functioni
- chaperone binding Source: Ensembl
- Hsp70 protein binding Source: Ensembl
- Hsp90 protein binding Source: UniProtKB
- protein C-terminus binding Source: Ensembl
- RNA binding Source: UniProtKB
GO - Biological processi
- cellular response to interleukin-7 Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | P31948 |
Reactomei | R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) |
SIGNORi | P31948 |
Names & Taxonomyi
Protein namesi | Recommended name: Stress-induced-phosphoprotein 1Short name: STI1 Alternative name(s): Hsc70/Hsp90-organizing protein Short name: Hop Renal carcinoma antigen NY-REN-11 Transformation-sensitive protein IEF SSP 3521 |
Gene namesi | Name:STIP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000168439.16 |
HGNCi | HGNC:11387, STIP1 |
MIMi | 605063, gene |
neXtProti | NX_P31948 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Golgi apparatus
- Golgi apparatus Source: ProtInc
Nucleus
- nucleus Source: UniProtKB
Other locations
- chaperone complex Source: UniProtKB
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 10963 |
OpenTargetsi | ENSG00000168439 |
PharmGKBi | PA36196 |
Miscellaneous databases
Pharosi | P31948, Tbio |
Chemistry databases
DrugBanki | DB09130, Copper |
Polymorphism and mutation databases
BioMutai | STIP1 |
DMDMi | 400042 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000106372 | 1 – 543 | Stress-induced-phosphoprotein 1Add BLAST | 543 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources1 Publication | 1 | |
Modified residuei | 8 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 16 | PhosphoserineCombined sources | 1 | |
Cross-linki | 123 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 123 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 198 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 210 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 210 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 301 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 312 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 325 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 332 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 344 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 354 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 446 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 481 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P31948 |
jPOSTi | P31948 |
MassIVEi | P31948 |
PaxDbi | P31948 |
PeptideAtlasi | P31948 |
PRIDEi | P31948 |
ProteomicsDBi | 25436 33721 54820 [P31948-1] |
TopDownProteomicsi | P31948-1 [P31948-1] |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00013894 |
UCD-2DPAGEi | P31948 |
PTM databases
iPTMneti | P31948 |
MetOSitei | P31948 |
PhosphoSitePlusi | P31948 |
SwissPalmi | P31948 |
Expressioni
Gene expression databases
Bgeei | ENSG00000168439, Expressed in testis and 243 other tissues |
ExpressionAtlasi | P31948, baseline and differential |
Genevisiblei | P31948, HS |
Organism-specific databases
HPAi | ENSG00000168439, Tissue enhanced (vagina) |
Interactioni
Subunit structurei
Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (PubMed:29127155).
Forms a complex with HSPA8/HSC70, HSPCA/HSP-86 and HSPCB/HSP-84 (By similarity).
Interacts with PACRG (PubMed:14532270).
Interacts with METTL21B (PubMed:23349634).
Interacts with HSP90/HSP90AA1; the interaction dissociates the PPP5C:HSP90AA1 interaction (PubMed:9195923, PubMed:27353360).
Interacts with FLCN, FNIP1 and FNIP2 (PubMed:27353360).
Interacts with HSPA8/HSC70 (By similarity).
Interacts with HSP90AB1; upon SMYD2-dependent HSP90AB1 methylation (PubMed:24880080).
By similarity6 PublicationsBinary interactionsi
Hide detailsP31948
GO - Molecular functioni
- chaperone binding Source: Ensembl
- Hsp70 protein binding Source: Ensembl
- Hsp90 protein binding Source: UniProtKB
- protein C-terminus binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 116162, 242 interactors |
DIPi | DIP-41085N |
IntActi | P31948, 136 interactors |
MINTi | P31948 |
STRINGi | 9606.ENSP00000351646 |
Miscellaneous databases
RNActi | P31948, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P31948 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P31948 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 4 – 37 | TPR 1Add BLAST | 34 | |
Repeati | 38 – 71 | TPR 2Add BLAST | 34 | |
Repeati | 72 – 105 | TPR 3Add BLAST | 34 | |
Domaini | 130 – 169 | STI1 1Add BLAST | 40 | |
Repeati | 225 – 258 | TPR 4Add BLAST | 34 | |
Repeati | 259 – 292 | TPR 5Add BLAST | 34 | |
Repeati | 300 – 333 | TPR 6Add BLAST | 34 | |
Repeati | 360 – 393 | TPR 7Add BLAST | 34 | |
Repeati | 394 – 427 | TPR 8Add BLAST | 34 | |
Repeati | 428 – 461 | TPR 9Add BLAST | 34 | |
Domaini | 492 – 531 | STI1 2Add BLAST | 40 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 222 – 239 | Bipartite nuclear localization signalSequence analysisAdd BLAST | 18 |
Domaini
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG0548, Eukaryota |
GeneTreei | ENSGT00940000154911 |
HOGENOMi | CLU_000134_46_5_1 |
InParanoidi | P31948 |
OMAi | KDPAMRM |
OrthoDBi | 933764at2759 |
PhylomeDBi | P31948 |
TreeFami | TF300478 |
Family and domain databases
Gene3Di | 1.25.40.10, 3 hits |
IDEALi | IID00449 |
InterProi | View protein in InterPro IPR041243, STI1 IPR006636, STI1_HS-bd IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR013105, TPR_2 IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF17830, STI1, 2 hits PF07719, TPR_2, 1 hit PF13181, TPR_8, 1 hit |
SMARTi | View protein in SMART SM00727, STI1, 2 hits SM00028, TPR, 9 hits |
SUPFAMi | SSF48452, SSF48452, 3 hits |
PROSITEi | View protein in PROSITE PS50005, TPR, 9 hits PS50293, TPR_REGION, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEQVNELKEK GNKALSVGNI DDALQCYSEA IKLDPHNHVL YSNRSAAYAK
60 70 80 90 100
KGDYQKAYED GCKTVDLKPD WGKGYSRKAA ALEFLNRFEE AKRTYEEGLK
110 120 130 140 150
HEANNPQLKE GLQNMEARLA ERKFMNPFNM PNLYQKLESD PRTRTLLSDP
160 170 180 190 200
TYRELIEQLR NKPSDLGTKL QDPRIMTTLS VLLGVDLGSM DEEEEIATPP
210 220 230 240 250
PPPPPKKETK PEPMEEDLPE NKKQALKEKE LGNDAYKKKD FDTALKHYDK
260 270 280 290 300
AKELDPTNMT YITNQAAVYF EKGDYNKCRE LCEKAIEVGR ENREDYRQIA
310 320 330 340 350
KAYARIGNSY FKEEKYKDAI HFYNKSLAEH RTPDVLKKCQ QAEKILKEQE
360 370 380 390 400
RLAYINPDLA LEEKNKGNEC FQKGDYPQAM KHYTEAIKRN PKDAKLYSNR
410 420 430 440 450
AACYTKLLEF QLALKDCEEC IQLEPTFIKG YTRKAAALEA MKDYTKAMDV
460 470 480 490 500
YQKALDLDSS CKEAADGYQR CMMAQYNRHD SPEDVKRRAM ADPEVQQIMS
510 520 530 540
DPAMRLILEQ MQKDPQALSE HLKNPVIAQK IQKLMDVGLI AIR
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H783 | F5H783_HUMAN | Stress-induced-phosphoprotein 1 | STIP1 | 236 | Annotation score: | ||
H0YGI8 | H0YGI8_HUMAN | Stress-induced-phosphoprotein 1 | STIP1 | 137 | Annotation score: | ||
F5GXD8 | F5GXD8_HUMAN | Stress-induced-phosphoprotein 1 | STIP1 | 138 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 84 | F → L in AAH39299 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 364 | K → E in BAG59782 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 533 | K → R in BAG59782 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055034 | 1 – 3 | MEQ → MESGSPMGEVEISRTIRTNG RGQRGYDWQCKRPIRVAEVR SSLHSWSLRW in isoform 2. 1 Publication | 3 | |
Alternative sequenceiVSP_055035 | 74 – 97 | Missing in isoform 3. 1 PublicationAdd BLAST | 24 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M86752 mRNA Translation: AAA58682.1 BT020010 mRNA Translation: AAV38813.1 BT020011 mRNA Translation: AAV38814.1 CR536512 mRNA Translation: CAG38750.1 AK297319 mRNA Translation: BAG59782.1 AP005668 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74196.1 CH471076 Genomic DNA Translation: EAW74197.1 BC002987 mRNA Translation: AAH02987.1 BC039299 mRNA Translation: AAH39299.1 |
CCDSi | CCDS60827.1 [P31948-2] CCDS60828.1 [P31948-3] CCDS8058.1 [P31948-1] |
PIRi | A38093 |
RefSeqi | NP_001269581.1, NM_001282652.1 [P31948-2] NP_001269582.1, NM_001282653.1 [P31948-3] NP_006810.1, NM_006819.2 [P31948-1] |
Genome annotation databases
Ensembli | ENST00000305218; ENSP00000305958; ENSG00000168439 [P31948-1] ENST00000358794; ENSP00000351646; ENSG00000168439 [P31948-2] ENST00000538945; ENSP00000445957; ENSG00000168439 [P31948-3] |
GeneIDi | 10963 |
KEGGi | hsa:10963 |
UCSCi | uc010rnb.2, human [P31948-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M86752 mRNA Translation: AAA58682.1 BT020010 mRNA Translation: AAV38813.1 BT020011 mRNA Translation: AAV38814.1 CR536512 mRNA Translation: CAG38750.1 AK297319 mRNA Translation: BAG59782.1 AP005668 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74196.1 CH471076 Genomic DNA Translation: EAW74197.1 BC002987 mRNA Translation: AAH02987.1 BC039299 mRNA Translation: AAH39299.1 |
CCDSi | CCDS60827.1 [P31948-2] CCDS60828.1 [P31948-3] CCDS8058.1 [P31948-1] |
PIRi | A38093 |
RefSeqi | NP_001269581.1, NM_001282652.1 [P31948-2] NP_001269582.1, NM_001282653.1 [P31948-3] NP_006810.1, NM_006819.2 [P31948-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ELR | X-ray | 1.90 | A | 223-352 | [»] | |
1ELW | X-ray | 1.60 | A/B | 1-118 | [»] | |
2LNI | NMR | - | A | 356-477 | [»] | |
2NC9 | NMR | - | A | 220-350 | [»] | |
3ESK | X-ray | 2.05 | A | 223-350 | [»] | |
3FWV | X-ray | 2.20 | A/B | 223-349 | [»] | |
SMRi | P31948 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116162, 242 interactors |
DIPi | DIP-41085N |
IntActi | P31948, 136 interactors |
MINTi | P31948 |
STRINGi | 9606.ENSP00000351646 |
Chemistry databases
DrugBanki | DB09130, Copper |
PTM databases
iPTMneti | P31948 |
MetOSitei | P31948 |
PhosphoSitePlusi | P31948 |
SwissPalmi | P31948 |
Polymorphism and mutation databases
BioMutai | STIP1 |
DMDMi | 400042 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00013894 |
UCD-2DPAGEi | P31948 |
Proteomic databases
EPDi | P31948 |
jPOSTi | P31948 |
MassIVEi | P31948 |
PaxDbi | P31948 |
PeptideAtlasi | P31948 |
PRIDEi | P31948 |
ProteomicsDBi | 25436 33721 54820 [P31948-1] |
TopDownProteomicsi | P31948-1 [P31948-1] |
Protocols and materials databases
Antibodypediai | 15273, 413 antibodies |
DNASUi | 10963 |
Genome annotation databases
Ensembli | ENST00000305218; ENSP00000305958; ENSG00000168439 [P31948-1] ENST00000358794; ENSP00000351646; ENSG00000168439 [P31948-2] ENST00000538945; ENSP00000445957; ENSG00000168439 [P31948-3] |
GeneIDi | 10963 |
KEGGi | hsa:10963 |
UCSCi | uc010rnb.2, human [P31948-1] |
Organism-specific databases
CTDi | 10963 |
DisGeNETi | 10963 |
EuPathDBi | HostDB:ENSG00000168439.16 |
GeneCardsi | STIP1 |
HGNCi | HGNC:11387, STIP1 |
HPAi | ENSG00000168439, Tissue enhanced (vagina) |
MIMi | 605063, gene |
neXtProti | NX_P31948 |
OpenTargetsi | ENSG00000168439 |
PharmGKBi | PA36196 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0548, Eukaryota |
GeneTreei | ENSGT00940000154911 |
HOGENOMi | CLU_000134_46_5_1 |
InParanoidi | P31948 |
OMAi | KDPAMRM |
OrthoDBi | 933764at2759 |
PhylomeDBi | P31948 |
TreeFami | TF300478 |
Enzyme and pathway databases
PathwayCommonsi | P31948 |
Reactomei | R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) |
SIGNORi | P31948 |
Miscellaneous databases
BioGRID-ORCSi | 10963, 62 hits in 845 CRISPR screens |
ChiTaRSi | STIP1, human |
EvolutionaryTracei | P31948 |
GeneWikii | Hop_(protein) |
GenomeRNAii | 10963 |
Pharosi | P31948, Tbio |
PROi | PR:P31948 |
RNActi | P31948, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168439, Expressed in testis and 243 other tissues |
ExpressionAtlasi | P31948, baseline and differential |
Genevisiblei | P31948, HS |
Family and domain databases
Gene3Di | 1.25.40.10, 3 hits |
IDEALi | IID00449 |
InterProi | View protein in InterPro IPR041243, STI1 IPR006636, STI1_HS-bd IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR013105, TPR_2 IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF17830, STI1, 2 hits PF07719, TPR_2, 1 hit PF13181, TPR_8, 1 hit |
SMARTi | View protein in SMART SM00727, STI1, 2 hits SM00028, TPR, 9 hits |
SUPFAMi | SSF48452, SSF48452, 3 hits |
PROSITEi | View protein in PROSITE PS50005, TPR, 9 hits PS50293, TPR_REGION, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STIP1_HUMAN | |
Accessioni | P31948Primary (citable) accession number: P31948 Secondary accession number(s): B4DM70 Q5TZU9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | December 2, 2020 | |
This is version 215 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM