STIP1

Functionⁱ

Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).1 PublicationBy similarity

GO - Molecular functionⁱ

chaperone binding Source: Ensembl
Hsp70 protein binding Source: Ensembl
Hsp90 protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 29127155
protein C-terminus binding Source: Ensembl
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)

Reactomeⁱ

R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Stress-induced-phosphoprotein 1 Short name: STI1 Alternative name(s): Hsc70/Hsp90-organizing protein Short name: Hop Renal carcinoma antigen NY-REN-11 Transformation-sensitive protein IEF SSP 3521
Gene namesⁱ	Name:STIP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168439.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11387 STIP1
MIMⁱ	605063 gene
neXtProtⁱ	NX_P31948

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10963
Open Targets More...OpenTargetsⁱ	ENSG00000168439
PharmGKBⁱ	PA36196

Polymorphism and mutation databases

BioMutaⁱ	STIP1
DMDMⁱ	400042

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000106372	1 – 543	Stress-induced-phosphoprotein 1Add BLAST		543

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources1 Publication	1
Modified residueⁱ	8	N6-acetyllysineCombined sources	1
Modified residueⁱ	16	PhosphoserineCombined sources	1
Cross-linkⁱ	123	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linkⁱ	123	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	198	PhosphothreonineCombined sources	1
Cross-linkⁱ	210	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linkⁱ	210	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	301	N6-acetyllysineCombined sources	1
Modified residueⁱ	312	N6-acetyllysineCombined sources	1
Modified residueⁱ	325	N6-acetyllysineCombined sources	1
Modified residueⁱ	332	PhosphothreonineCombined sources	1
Modified residueⁱ	344	N6-acetyllysineCombined sources	1
Modified residueⁱ	354	PhosphotyrosineCombined sources	1
Modified residueⁱ	446	N6-acetyllysineCombined sources	1
Modified residueⁱ	481	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P31948
PaxDbⁱ	P31948
PeptideAtlas More...PeptideAtlasⁱ	P31948
PRIDEⁱ	P31948
ProteomicsDBⁱ	54820
TopDownProteomicsⁱ	P31948-1 [P31948-1]

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00013894
UCD-2DPAGEⁱ	P31948

PTM databases

iPTMnetⁱ	P31948
PhosphoSitePlusⁱ	P31948
SwissPalmⁱ	P31948

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000168439 Expressed in 231 organ(s), highest expression level in testis
CleanExⁱ	HS_STIP1
ExpressionAtlasⁱ	P31948 baseline and differential
Genevisibleⁱ	P31948 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB017448 HPA039291 HPA044062

HPAⁱ

CAB017448
HPA039291
HPA044062

Interactionⁱ

Subunit structureⁱ

Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (PubMed:29127155). Forms a complex with HSPA8/HSC70, HSPCA/HSP-86 and HSPCB/HSP-84 (By similarity). Interacts with PACRG (PubMed:14532270). Interacts with METTL21B (PubMed:23349634). Interacts with HSP90/HSP90AA1; the interaction dissociates the PPP5C:HSP90AA1 interaction (PubMed:9195923, PubMed:27353360). Interacts with FLCN, FNIP1 and FNIP2 (PubMed:27353360). Interacts with HSPA8/HSC70 (By similarity). Interacts with HSP90AB1; upon SMYD2-dependent HSP90AB1 methylation (PubMed:24880080).By similarity6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ACD	Q96AP0	2	EBI-1054052,EBI-717666
CCDC117	Q8IWD4	2	EBI-1054052,EBI-3387963
CDC37L1	Q7L3B6	2	EBI-1054052,EBI-2841876
EGFR	P00533	2	EBI-1054052,EBI-297353
HSP90AB1	P08238	3	EBI-1054052,EBI-352572
PPP5C	P53041	4	EBI-1054052,EBI-716663

GO - Molecular functionⁱ

chaperone binding Source: Ensembl
Hsp70 protein binding Source: Ensembl
Hsp90 protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 29127155
protein C-terminus binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116162, 190 interactors
Database of interacting proteins More...DIPⁱ	DIP-41085N
IntActⁱ	P31948, 109 interactors
Molecular INTeraction database More...MINTⁱ	P31948
STRINGⁱ	9606.ENSP00000305958

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	3 – 16	Combined sources	14
Helixⁱ	20 – 33	Combined sources	14
Helixⁱ	38 – 51	Combined sources	14
Helixⁱ	54 – 67	Combined sources	14
Helixⁱ	72 – 84	Combined sources	13
Helixⁱ	88 – 99	Combined sources	12
Helixⁱ	106 – 117	Combined sources	12
Helixⁱ	223 – 237	Combined sources	15
Helixⁱ	241 – 254	Combined sources	14
Helixⁱ	259 – 272	Combined sources	14
Helixⁱ	275 – 291	Combined sources	17
Helixⁱ	296 – 312	Combined sources	17
Helixⁱ	316 – 329	Combined sources	14
Helixⁱ	333 – 348	Combined sources	16
Helixⁱ	359 – 372	Combined sources	14
Helixⁱ	377 – 387	Combined sources	11
Helixⁱ	394 – 404	Combined sources	11
Turnⁱ	405 – 408	Combined sources	4
Helixⁱ	410 – 423	Combined sources	14
Helixⁱ	428 – 440	Combined sources	13
Helixⁱ	444 – 457	Combined sources	14
Helixⁱ	459 – 462	Combined sources	4
Helixⁱ	463 – 475	Combined sources	13

Show more details

3D structure databases

ProteinModelPortalⁱ	P31948
SMRⁱ	P31948
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P31948

EvolutionaryTraceⁱ

P31948

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	4 – 37	TPR 1Add BLAST	34
Repeatⁱ	38 – 71	TPR 2Add BLAST	34
Repeatⁱ	72 – 105	TPR 3Add BLAST	34
Domainⁱ	130 – 169	STI1 1Add BLAST	40
Repeatⁱ	225 – 258	TPR 4Add BLAST	34
Repeatⁱ	259 – 292	TPR 5Add BLAST	34
Repeatⁱ	300 – 333	TPR 6Add BLAST	34
Repeatⁱ	360 – 393	TPR 7Add BLAST	34
Repeatⁱ	394 – 427	TPR 8Add BLAST	34
Repeatⁱ	428 – 461	TPR 9Add BLAST	34
Domainⁱ	492 – 531	STI1 2Add BLAST	40

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	222 – 239	Bipartite nuclear localization signalSequence analysisAdd BLAST		18

Domainⁱ

The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90.

Keywords - Domainⁱ

Repeat, TPR repeat

Phylogenomic databases

eggNOGⁱ	KOG0548 Eukaryota ENOG410XTCJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140989
HOGENOMⁱ	HOG000186562
HOVERGENⁱ	HBG057820
InParanoidⁱ	P31948
KEGG Orthology (KO) More...KOⁱ	K09553
OMAⁱ	KDPAMRM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0E5W
PhylomeDBⁱ	P31948
TreeFamⁱ	TF300478

Family and domain databases

Gene3Dⁱ	1.25.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR006636 STI1_HS-bd IPR013026 TPR-contain_dom IPR011990 TPR-like_helical_dom_sf IPR013105 TPR_2 IPR019734 TPR_repeat
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07719 TPR_2, 1 hit PF13181 TPR_8, 1 hit
SMARTⁱ	View protein in SMART SM00727 STI1, 2 hits SM00028 TPR, 9 hits
SUPFAMⁱ	SSF48452 SSF48452, 3 hits
PROSITEⁱ	View protein in PROSITE PS50005 TPR, 9 hits PS50293 TPR_REGION, 2 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P31948-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQVNELKEK GNKALSVGNI DDALQCYSEA IKLDPHNHVL YSNRSAAYAK 
        60         70         80         90        100
KGDYQKAYED GCKTVDLKPD WGKGYSRKAA ALEFLNRFEE AKRTYEEGLK 
       110        120        130        140        150
HEANNPQLKE GLQNMEARLA ERKFMNPFNM PNLYQKLESD PRTRTLLSDP 
       160        170        180        190        200
TYRELIEQLR NKPSDLGTKL QDPRIMTTLS VLLGVDLGSM DEEEEIATPP 
       210        220        230        240        250
PPPPPKKETK PEPMEEDLPE NKKQALKEKE LGNDAYKKKD FDTALKHYDK 
       260        270        280        290        300
AKELDPTNMT YITNQAAVYF EKGDYNKCRE LCEKAIEVGR ENREDYRQIA 
       310        320        330        340        350
KAYARIGNSY FKEEKYKDAI HFYNKSLAEH RTPDVLKKCQ QAEKILKEQE 
       360        370        380        390        400
RLAYINPDLA LEEKNKGNEC FQKGDYPQAM KHYTEAIKRN PKDAKLYSNR 
       410        420        430        440        450
AACYTKLLEF QLALKDCEEC IQLEPTFIKG YTRKAAALEA MKDYTKAMDV 
       460        470        480        490        500
YQKALDLDSS CKEAADGYQR CMMAQYNRHD SPEDVKRRAM ADPEVQQIMS 
       510        520        530        540 
DPAMRLILEQ MQKDPQALSE HLKNPVIAQK IQKLMDVGLI AIR

Length:543

Mass (Da):62,639

Last modified:July 1, 1993 - v1

Checksum:ⁱ8E58ECA13825CB0E

GO

Isoform 2 (identifier: P31948-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-3: MEQ → MESGSPMGEVEISRTIRTNGRGQRGYDWQCKRPIRVAEVRSSLHSWSLRW

« Hide

        10         20         30         40         50
MESGSPMGEV EISRTIRTNG RGQRGYDWQC KRPIRVAEVR SSLHSWSLRW 
        60         70         80         90        100
VNELKEKGNK ALSVGNIDDA LQCYSEAIKL DPHNHVLYSN RSAAYAKKGD 
       110        120        130        140        150
YQKAYEDGCK TVDLKPDWGK GYSRKAAALE FLNRFEEAKR TYEEGLKHEA 
       160        170        180        190        200
NNPQLKEGLQ NMEARLAERK FMNPFNMPNL YQKLESDPRT RTLLSDPTYR 
       210        220        230        240        250
ELIEQLRNKP SDLGTKLQDP RIMTTLSVLL GVDLGSMDEE EEIATPPPPP 
       260        270        280        290        300
PPKKETKPEP MEEDLPENKK QALKEKELGN DAYKKKDFDT ALKHYDKAKE 
       310        320        330        340        350
LDPTNMTYIT NQAAVYFEKG DYNKCRELCE KAIEVGRENR EDYRQIAKAY 
       360        370        380        390        400
ARIGNSYFKE EKYKDAIHFY NKSLAEHRTP DVLKKCQQAE KILKEQERLA 
       410        420        430        440        450
YINPDLALEE KNKGNECFQK GDYPQAMKHY TEAIKRNPKD AKLYSNRAAC 
       460        470        480        490        500
YTKLLEFQLA LKDCEECIQL EPTFIKGYTR KAAALEAMKD YTKAMDVYQK 
       510        520        530        540        550
ALDLDSSCKE AADGYQRCMM AQYNRHDSPE DVKRRAMADP EVQQIMSDPA 
       560        570        580        590
MRLILEQMQK DPQALSEHLK NPVIAQKIQK LMDVGLIAIR

Show »

Length:590

Mass (Da):68,080

Checksum:ⁱ76F4C7A16BFCBCA0

GO

Isoform 3 (identifier: P31948-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
74-97: Missing.

« Hide

        10         20         30         40         50
MEQVNELKEK GNKALSVGNI DDALQCYSEA IKLDPHNHVL YSNRSAAYAK 
        60         70         80         90        100
KGDYQKAYED GCKTVDLKPD WGKGLKHEAN NPQLKEGLQN MEARLAERKF 
       110        120        130        140        150
MNPFNMPNLY QKLESDPRTR TLLSDPTYRE LIEQLRNKPS DLGTKLQDPR 
       160        170        180        190        200
IMTTLSVLLG VDLGSMDEEE EIATPPPPPP PKKETKPEPM EEDLPENKKQ 
       210        220        230        240        250
ALKEKELGND AYKKKDFDTA LKHYDKAKEL DPTNMTYITN QAAVYFEKGD 
       260        270        280        290        300
YNKCRELCEK AIEVGRENRE DYRQIAKAYA RIGNSYFKEE KYKDAIHFYN 
       310        320        330        340        350
KSLAEHRTPD VLKKCQQAEK ILKEQERLAY INPDLALEEK NKGNECFQKG 
       360        370        380        390        400
DYPQAMKHYT EAIKRNPKDA KLYSNRAACY TKLLEFQLAL KDCEECIQLE 
       410        420        430        440        450
PTFIKGYTRK AAALEAMKDY TKAMDVYQKA LDLDSSCKEA ADGYQRCMMA 
       460        470        480        490        500
QYNRHDSPED VKRRAMADPE VQQIMSDPAM RLILEQMQKD PQALSEHLKN 
       510 
PVIAQKIQKL MDVGLIAIR

Show »

Length:519

Mass (Da):59,778

Checksum:ⁱ0D7C993B4B4E230E

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5H783	F5H783_HUMAN	Stress-induced-phosphoprotein 1 Stress-induced-phosphoprotein 1	STIP1	236	Annotation score:
H0YGI8	H0YGI8_HUMAN	Stress-induced-phosphoprotein 1 Stress-induced-phosphoprotein 1	STIP1	137	Annotation score:
F5GXD8	F5GXD8_HUMAN	Stress-induced-phosphoprotein 1 Stress-induced-phosphoprotein 1	STIP1	138	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	84	F → L in AAH39299 (PubMed:15489334).Curated	1
Sequence conflictⁱ	364	K → E in BAG59782 (PubMed:14702039).Curated	1
Sequence conflictⁱ	533	K → R in BAG59782 (PubMed:14702039).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055034	1 – 3	MEQ → MESGSPMGEVEISRTIRTNG RGQRGYDWQCKRPIRVAEVR SSLHSWSLRW in isoform 2. 1 Publication		3
Alternative sequenceⁱVSP_055035	74 – 97	Missing in isoform 3. 1 PublicationAdd BLAST		24

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M86752 mRNA Translation: AAA58682.1 BT020010 mRNA Translation: AAV38813.1 BT020011 mRNA Translation: AAV38814.1 CR536512 mRNA Translation: CAG38750.1 AK297319 mRNA Translation: BAG59782.1 AP005668 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74196.1 CH471076 Genomic DNA Translation: EAW74197.1 BC002987 mRNA Translation: AAH02987.1 BC039299 mRNA Translation: AAH39299.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS60827.1 [P31948-2] CCDS60828.1 [P31948-3] CCDS8058.1 [P31948-1]
PIRⁱ	A38093
NCBI Reference Sequences More...RefSeqⁱ	NP_001269581.1, NM_001282652.1 [P31948-2] NP_001269582.1, NM_001282653.1 [P31948-3] NP_006810.1, NM_006819.2 [P31948-1]
UniGeneⁱ	Hs.337295

Genome annotation databases

Ensemblⁱ	ENST00000305218; ENSP00000305958; ENSG00000168439 [P31948-1] ENST00000358794; ENSP00000351646; ENSG00000168439 [P31948-2] ENST00000538945; ENSP00000445957; ENSG00000168439 [P31948-3]
GeneIDⁱ	10963
KEGGⁱ	hsa:10963
UCSC genome browser More...UCSCⁱ	uc010rnb.2 human [P31948-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P31948	Epididymis secretory sperm binding protein Li 94n		HUMAN		543	UniRef100_P31948
STIP1 isoform 1		PANTR		543
UPI0000111355		HUMAN		118
P31948-2	STIP1 isoform 2		PANTR		590	UniRef100_A0A2I3RDJ4
UPI0009B4EBF8		HUMAN		131

Protein	Similar proteins		Species	Score	Length	Source
P31948	Stress-induced-phosphoprotein 1		MACFA		543	UniRef90_P31948
Stress-induced-phosphoprotein 1		CRIGR		543
Stress-induced-phosphoprotein 1		MOUSE		543
Stress-induced-phosphoprotein 1		BOVIN		543
Stress-induced-phosphoprotein 1		RAT		543
+141
P31948-2	Uncharacterized protein		MYOLU		590	UniRef90_G1P864
Stress-induced-phosphoprotein 1		MACFA		649
Stress-induced-phosphoprotein 1 (Fragment)		wild yak		595
Uncharacterized protein		SHEEP		592
Stress induced phosphoprotein 1		CHLSB		591
+31
P31948-3	stress-induced-phosphoprotein 1 isoform X2		ODORO		519	UniRef90_P31948-3
stress-induced-phosphoprotein 1		Enhydra lutris kenyoni		519
STIP1 isoform 4		PONAB		519
UPI0003F17386		CHRAS		519
UPI00046BB350		EPTFU		519
+3

Protein	Similar proteins		Species	Score	Length	Source
P31948	Stress-induced-phosphoprotein 1		MOUSE		543	UniRef50_P31948
Stress-induced-phosphoprotein 1		RAT		543
Stress-induced-phosphoprotein 1		MACFA		543
Stress-induced-phosphoprotein 1		CRIGR		543
Stress-induced-phosphoprotein 1		BOVIN		543
+253
P31948-3	stress-induced-phosphoprotein 1		Enhydra lutris kenyoni		519	UniRef50_P31948-3
stress-induced-phosphoprotein 1 isoform X2		ODORO		519
STIP1 isoform 4		PONAB		519
Stress induced phosphoprotein 1		GASAC		542
Uncharacterized protein		HYDTA		551
+45

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M86752 mRNA Translation: AAA58682.1 BT020010 mRNA Translation: AAV38813.1 BT020011 mRNA Translation: AAV38814.1 CR536512 mRNA Translation: CAG38750.1 AK297319 mRNA Translation: BAG59782.1 AP005668 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74196.1 CH471076 Genomic DNA Translation: EAW74197.1 BC002987 mRNA Translation: AAH02987.1 BC039299 mRNA Translation: AAH39299.1
CCDSⁱ	CCDS60827.1 [P31948-2] CCDS60828.1 [P31948-3] CCDS8058.1 [P31948-1]
PIRⁱ	A38093
RefSeqⁱ	NP_001269581.1, NM_001282652.1 [P31948-2] NP_001269582.1, NM_001282653.1 [P31948-3] NP_006810.1, NM_006819.2 [P31948-1]
UniGeneⁱ	Hs.337295

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1ELR	X-ray	1.90	A	223-352	[»]
	1ELW	X-ray	1.60	A/B	1-118	[»]
	2LNI	NMR	-	A	356-477	[»]
	2NC9	NMR	-	A	220-350	[»]
	3ESK	X-ray	2.05	A	223-350	[»]
	3FWV	X-ray	2.20	A/B	223-349	[»]
ProteinModelPortalⁱ	P31948
SMRⁱ	P31948
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116162, 190 interactors
DIPⁱ	DIP-41085N
IntActⁱ	P31948, 109 interactors
MINTⁱ	P31948
STRINGⁱ	9606.ENSP00000305958

PTM databases

iPTMnetⁱ	P31948
PhosphoSitePlusⁱ	P31948
SwissPalmⁱ	P31948

Polymorphism and mutation databases

BioMutaⁱ	STIP1
DMDMⁱ	400042

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00013894
UCD-2DPAGEⁱ	P31948

Proteomic databases

EPDⁱ	P31948
PaxDbⁱ	P31948
PeptideAtlasⁱ	P31948
PRIDEⁱ	P31948
ProteomicsDBⁱ	54820
TopDownProteomicsⁱ	P31948-1 [P31948-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10963
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000305218; ENSP00000305958; ENSG00000168439 [P31948-1] ENST00000358794; ENSP00000351646; ENSG00000168439 [P31948-2] ENST00000538945; ENSP00000445957; ENSG00000168439 [P31948-3]
GeneIDⁱ	10963
KEGGⁱ	hsa:10963
UCSCⁱ	uc010rnb.2 human [P31948-1]

Organism-specific databases

CTDⁱ	10963
DisGeNETⁱ	10963
EuPathDBⁱ	HostDB:ENSG00000168439.16
GeneCardsⁱ	STIP1
HGNCⁱ	HGNC:11387 STIP1
HPAⁱ	CAB017448 HPA039291 HPA044062
MIMⁱ	605063 gene
neXtProtⁱ	NX_P31948
OpenTargetsⁱ	ENSG00000168439
PharmGKBⁱ	PA36196
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0548 Eukaryota ENOG410XTCJ LUCA
GeneTreeⁱ	ENSGT00900000140989
HOGENOMⁱ	HOG000186562
HOVERGENⁱ	HBG057820
InParanoidⁱ	P31948
KOⁱ	K09553
OMAⁱ	KDPAMRM
OrthoDBⁱ	EOG091G0E5W
PhylomeDBⁱ	P31948
TreeFamⁱ	TF300478

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)

Reactomeⁱ

R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)

Miscellaneous databases

ChiTaRSⁱ	STIP1 human
EvolutionaryTraceⁱ	P31948
GeneWikiⁱ	Hop_(protein)
GenomeRNAiⁱ	10963
Protein Ontology More...PROⁱ	PR:P31948
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000168439 Expressed in 231 organ(s), highest expression level in testis
CleanExⁱ	HS_STIP1
ExpressionAtlasⁱ	P31948 baseline and differential
Genevisibleⁱ	P31948 HS

Family and domain databases

Gene3Dⁱ	1.25.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR006636 STI1_HS-bd IPR013026 TPR-contain_dom IPR011990 TPR-like_helical_dom_sf IPR013105 TPR_2 IPR019734 TPR_repeat
Pfamⁱ	View protein in Pfam PF07719 TPR_2, 1 hit PF13181 TPR_8, 1 hit
SMARTⁱ	View protein in SMART SM00727 STI1, 2 hits SM00028 TPR, 9 hits
SUPFAMⁱ	SSF48452 SSF48452, 3 hits
PROSITEⁱ	View protein in PROSITE PS50005 TPR, 9 hits PS50293 TPR_REGION, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STIP1_HUMAN
Accessionⁱ	P31948Primary (citable) accession number: P31948 Secondary accession number(s): B4DM70 , F5H0T1, G3XAD8, Q3ZCU9, Q5TZU9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
	Last sequence update:	July 1, 1993
	Last modified:	September 12, 2018
	This is version 199 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P31948 (STIP1_HUMAN)

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Stress-induced-phosphoprotein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Gene expression databases

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

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Miscellaneousⁱ

Keywords - Technical termⁱ