SFN

Functionⁱ

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.

1 Publication

p53-regulated inhibitor of G2/M progression.

1 Publication

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

PathwayCommonsⁱ	P31947
Reactomeⁱ	R-HSA-111447, Activation of BAD and translocation to mitochondria R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-5625740, RHO GTPases activate PKNs R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-6804114, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-9614399, Regulation of localization of FOXO transcription factors
SignaLinkⁱ	P31947
SIGNORⁱ	P31947

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 14-3-3 protein sigma Alternative name(s): Epithelial cell marker protein 1 Stratifin
Gene namesⁱ	Name:SFN Synonyms:HME1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10773, SFN
MIMⁱ	601290, gene
neXtProtⁱ	NX_P31947
VEuPathDBⁱ	HostDB:ENSG00000175793.11

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2810
Open Targets More...OpenTargetsⁱ	ENSG00000175793
PharmGKBⁱ	PA177

Miscellaneous databases

Pharosⁱ	P31947, Tbio

Pharosⁱ

P31947, Tbio

Chemistry databases

ChEMBLⁱ	CHEMBL1909482

ChEMBLⁱ

CHEMBL1909482

Genetic variation databases

BioMutaⁱ	SFN
DMDMⁱ	398953

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000058643	1 – 248	14-3-3 protein sigmaAdd BLAST		248

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	5	PhosphoserineCombined sources	1
Modified residueⁱ	74	PhosphoserineCombined sources	1
Modified residueⁱ	248	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation.1 Publication

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P31947
jPOSTⁱ	P31947
MassIVEⁱ	P31947
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P31947
PaxDbⁱ	P31947
PeptideAtlas More...PeptideAtlasⁱ	P31947
PRIDEⁱ	P31947
ProteomicsDBⁱ	54818 54819 [P31947-2]
TopDownProteomicsⁱ	P31947-1 [P31947-1] P31947-2 [P31947-2]

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P31947
SWISS-2DPAGEⁱ	P31947

PTM databases

iPTMnetⁱ	P31947
MetOSiteⁱ	P31947
PhosphoSitePlusⁱ	P31947
SwissPalmⁱ	P31947

Expressionⁱ

Tissue specificityⁱ

Present mainly in tissues enriched in stratified squamous keratinizing epithelium.

Gene expression databases

Bgeeⁱ	ENSG00000175793, Expressed in amniotic fluid and 241 other tissues
Genevisibleⁱ	P31947, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000175793, Tissue enhanced (esophagus, lymphoid tissue, skin, tongue)

HPAⁱ

ENSG00000175793, Tissue enhanced (esophagus, lymphoid tissue, skin, tongue)

Interactionⁱ

Subunit structureⁱ

Homodimer (PubMed:28202711).

Interacts with KRT17 and SAMSN1 (By similarity).

Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29 and VPS35.

Interacts with GAB2.

Interacts with SRPK2.

Interacts with COPS6.

Interacts with COP1; this interaction leads to proteasomal degradation.

Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703).

Interacts with PI4KB (PubMed:23572552).

Interacts with SLITRK1 (PubMed:19640509).

Interacts with LRRK2; this interaction is dependent on LRRK2 phosphorylation (PubMed:28202711).

By similarity10 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	56	Interaction with phosphoserine on interacting protein		1
Siteⁱ	129	Interaction with phosphoserine on interacting protein		1

Binary interactionsⁱ

Hide details

P31947

With	#Exp.	IntAct
ABL1 [P00519]	2	EBI-476295,EBI-375543
AJUBA [Q96IF1]	2	EBI-476295,EBI-949782
ARAF [P10398]	3	EBI-476295,EBI-365961
BAD [Q92934]	6	EBI-476295,EBI-700771
BRAF [P15056]	3	EBI-476295,EBI-365980
CCDC102B [Q68D86]	3	EBI-476295,EBI-10171570
CCDC125 [Q86Z20]	3	EBI-476295,EBI-11977221
CCNH [P51946]	4	EBI-476295,EBI-741406
COP1 [Q8NHY2]	6	EBI-476295,EBI-1176214
COPS6 [Q7L5N1]	7	EBI-476295,EBI-486838
EGFR [P00533]	9	EBI-476295,EBI-297353
ERRFI1 [Q9UJM3]	3	EBI-476295,EBI-2941912
FAM53C [Q9NYF3]	3	EBI-476295,EBI-1644252
FAM9B [Q8IZU0]	3	EBI-476295,EBI-10175124
FOXO4 [P98177]	3	EBI-476295,EBI-4481939
GPRIN2 [O60269]	2	EBI-476295,EBI-740397
HDAC4 [P56524]	4	EBI-476295,EBI-308629
HDAC5 [Q9UQL6]	3	EBI-476295,EBI-715576
HDAC7 [Q8WUI4]	3	EBI-476295,EBI-1048378
HNRNPD - isoform 4 [Q14103-4]	7	EBI-476295,EBI-432545
LONRF1 [Q17RB8]	3	EBI-476295,EBI-2341787
LRRK2 [Q5S007]	5	EBI-476295,EBI-5323863
MAGEA1 [P43355]	3	EBI-476295,EBI-740978
MAP3K2 [Q9Y2U5]	2	EBI-476295,EBI-357393
MAPT - isoform Fetal-tau [P10636-2]	2	EBI-476295,EBI-7796412
MARK3 [P27448]	2	EBI-476295,EBI-707595
MKRN3 [Q13064]	3	EBI-476295,EBI-2340269
NTAQ1 [Q96HA8]	4	EBI-476295,EBI-741158
PAX9 [P55771]	3	EBI-476295,EBI-12111000
PLK4 [O00444]	2	EBI-476295,EBI-746202
RAB3IP [Q96QF0]	3	EBI-476295,EBI-747844
RAF1 [P04049]	5	EBI-476295,EBI-365996
itself	4	EBI-476295,EBI-476295
TNK1 [Q13470]	2	EBI-476295,EBI-1383444
TP53 [P04637]	4	EBI-476295,EBI-366083
YWHAG [P61981]	2	EBI-476295,EBI-359832
YWHAZ [P63104]	3	EBI-476295,EBI-347088
ZC2HC1C [Q53FD0]	3	EBI-476295,EBI-740767

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	109072, 300 interactors
Database of interacting proteins More...DIPⁱ	DIP-29861N
ELMⁱ	P31947
IntActⁱ	P31947, 189 interactors
Molecular INTeraction database More...MINTⁱ	P31947
STRINGⁱ	9606.ENSP00000340989

Chemistry databases

BindingDBⁱ

P31947

Miscellaneous databases

RNActⁱ	P31947, protein

RNActⁱ

P31947, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	3 – 15	Combined sources	13
Helixⁱ	19 – 31	Combined sources	13
Helixⁱ	38 – 69	Combined sources	32
Beta strandⁱ	72 – 75	Combined sources	4
Helixⁱ	80 – 104	Combined sources	25
Helixⁱ	107 – 110	Combined sources	4
Helixⁱ	114 – 134	Combined sources	21
Helixⁱ	137 – 139	Combined sources	3
Helixⁱ	140 – 161	Combined sources	22
Helixⁱ	167 – 182	Combined sources	16
Helixⁱ	187 – 204	Combined sources	18
Helixⁱ	205 – 207	Combined sources	3
Helixⁱ	210 – 230	Combined sources	21

Show more details

3D structure databases

SMRⁱ	P31947
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P31947

EvolutionaryTraceⁱ

P31947

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0841, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT01010000222256
HOGENOMⁱ	CLU_058290_1_0_1
InParanoidⁱ	P31947
OMAⁱ	GEAECRV
Database of Orthologous Groups More...OrthoDBⁱ	1176818at2759
PhylomeDBⁱ	P31947
TreeFamⁱ	TF102003

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10019, 14-3-3_sigma, 1 hit
Gene3Dⁱ	1.20.190.20, 1 hit
IDEALⁱ	IID00301
InterProⁱ	View protein in InterPro IPR000308, 14-3-3 IPR023409, 14-3-3_CS IPR036815, 14-3-3_dom_sf IPR023410, 14-3-3_domain IPR037435, 14-3-3_sigma
PANTHERⁱ	PTHR18860, PTHR18860, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00244, 14-3-3, 1 hit
PIRSFⁱ	PIRSF000868, 14-3-3, 1 hit
PRINTSⁱ	PR00305, 1433ZETA
SMARTⁱ	View protein in SMART SM00101, 14_3_3, 1 hit
SUPFAMⁱ	SSF48445, SSF48445, 1 hit
PROSITEⁱ	View protein in PROSITE PS00796, 1433_1, 1 hit PS00797, 1433_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P31947-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN 
        60         70         80         90        100
VVGGQRAAWR VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL 
       110        120        130        140        150
GLLDSHLIKE AGDAESRVFY LKMKGDYYRY LAEVATGDDK KRIIDSARSA 
       160        170        180        190        200
YQEAMDISKK EMPPTNPIRL GLALNFSVFH YEIANSPEEA ISLAKTTFDE 
       210        220        230        240 
AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG EAPQEPQS

Length:248

Mass (Da):27,774

Last modified:July 1, 1993 - v1

Checksum:ⁱ7F4B44E3AA59ECE6

GO

Isoform 2 (identifier: P31947-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
85-116: Missing.

« Hide

        10         20         30         40         50
MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN 
        60         70         80         90        100
VVGGQRAAWR VLSSIEQKSN EEGSEEKGPE VREYRVFYLK MKGDYYRYLA 
       110        120        130        140        150
EVATGDDKKR IIDSARSAYQ EAMDISKKEM PPTNPIRLGL ALNFSVFHYE 
       160        170        180        190        200
IANSPEEAIS LAKTTFDEAM ADLHTLSEDS YKDSTLIMQL LRDNLTLWTA 
       210 
DNAGEEGGEA PQEPQS

Show »

Length:216

Mass (Da):24,336

Checksum:ⁱ14CBC2F26014D926

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	77	K → M in CAG46703 (Ref. 4) Curated	1
Sequence conflictⁱ	120	Y → H in AAA59546 (PubMed:8515476).Curated	1
Sequence conflictⁱ	242	A → V in AAA59546 (PubMed:8515476).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_048095	155	M → I. Corresponds to variant dbSNP:rs11542705Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_021768	85 – 116	Missing in isoform 2. 1 PublicationAdd BLAST		32

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M93010 mRNA Translation: AAA59546.1 X57348 mRNA Translation: CAA40623.1 AF029081 Genomic DNA Translation: AAC52029.1 AF029082 mRNA Translation: AAC52030.1 CR541905 mRNA Translation: CAG46703.1 CR541926 mRNA Translation: CAG46724.1 AL034380 Genomic DNA No translation available. BC000329 mRNA Translation: AAH00329.1 BC000995 mRNA Translation: AAH00995.1 BC001550 mRNA Translation: AAH01550.1 BC002995 mRNA Translation: AAH02995.1 BC023552 mRNA Translation: AAH23552.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS288.1 [P31947-1]
PIRⁱ	S34753 S38956
NCBI Reference Sequences More...RefSeqⁱ	NP_006133.1, NM_006142.3 [P31947-1]

Genome annotation databases

Ensemblⁱ	ENST00000339276; ENSP00000340989; ENSG00000175793 [P31947-1]
GeneIDⁱ	2810
KEGGⁱ	hsa:2810
UCSC genome browser More...UCSCⁱ	uc001bnc.2, human [P31947-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P31947	Stratifin		PANTR		248	UniRef100_P31947
Stratifin		PANPA		248
14_3_3 domain-containing protein		NOMLE		248
Stratifin		GORGO		248
SFN isoform 1		PANTR		248
+6

Protein	Similar proteins		Species	Score	Length	Source
P31947	14-3-3 protein sigma		BOVIN		248	UniRef90_P31947
14-3-3 protein sigma		SHEEP		248
Stratifin		PANTR		248
Stratifin		PANPA		248
14_3_3 domain-containing protein		NOMLE		248
+136
P31947-2	14_3_3 domain-containing protein		MONDO		256	UniRef90_P31947-2
14-3-3 protein sigma		PHACI		254
Stratifin		SARHA		254
Stratifin		VOMUR		254
Stratifin		PROCO		248
+2

Protein	Similar proteins		Species	Score	Length	Source
P31947	14-3-3 protein sigma		BOVIN		248	UniRef50_P31947
14-3-3 protein sigma		SHEEP		248
14-3-3 protein theta	)	CHICK		245
14-3-3 protein sigma		MOUSE		248
14-3-3 protein zeta		XENTR		245
+1733
P31947-2	14-3-3-like protein		FUCVE		251	UniRef50_P31947-2
14_3_3 domain-containing protein		MONDO		256
Stratifin		SARHA		254
Stratifin		VOMUR		254
14-3-3 protein sigma		PHACI		254
+72

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M93010 mRNA Translation: AAA59546.1 X57348 mRNA Translation: CAA40623.1 AF029081 Genomic DNA Translation: AAC52029.1 AF029082 mRNA Translation: AAC52030.1 CR541905 mRNA Translation: CAG46703.1 CR541926 mRNA Translation: CAG46724.1 AL034380 Genomic DNA No translation available. BC000329 mRNA Translation: AAH00329.1 BC000995 mRNA Translation: AAH00995.1 BC001550 mRNA Translation: AAH01550.1 BC002995 mRNA Translation: AAH02995.1 BC023552 mRNA Translation: AAH23552.1
CCDSⁱ	CCDS288.1 [P31947-1]
PIRⁱ	S34753 S38956
RefSeqⁱ	NP_006133.1, NM_006142.3 [P31947-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1YWT	X-ray	2.40	A/B	1-248	[»]
	1YZ5	X-ray	2.80	A/B	1-248	[»]
	3IQJ	X-ray	1.15	A	1-231	[»]
	3IQU	X-ray	1.05	A	1-231	[»]
	3IQV	X-ray	1.20	A	1-231	[»]
	3LW1	X-ray	1.28	A	1-248	[»]
	3MHR	X-ray	1.15	A	1-231	[»]
	3O8I	X-ray	2.00	A	1-231	[»]
	3P1N	X-ray	1.40	A	1-231	[»]
	3P1O	X-ray	1.90	A	1-231	[»]
	3P1P	X-ray	1.95	A	1-231	[»]
	3P1Q	X-ray	1.70	A	1-231	[»]
	3P1R	X-ray	1.70	A	1-231	[»]
	3P1S	X-ray	1.65	A	1-231	[»]
	3SMK	X-ray	2.10	A	1-231	[»]
	3SML	X-ray	1.90	A	1-231	[»]
	3SMM	X-ray	2.00	A	1-231	[»]
	3SMN	X-ray	2.00	A	1-231	[»]
	3SMO	X-ray	1.80	A	1-231	[»]
	3SP5	X-ray	1.80	A	1-231	[»]
	3SPR	X-ray	1.99	A	1-231	[»]
	3T0L	X-ray	1.60	A	1-231	[»]
	3T0M	X-ray	1.62	A	1-231	[»]
	3U9X	X-ray	1.80	A	1-231	[»]
	3UX0	X-ray	1.75	A	1-231	[»]
	4DAT	X-ray	1.40	A	1-231	[»]
	4DAU	X-ray	2.00	A	1-231	[»]
	4DHM	X-ray	1.70	A	1-231	[»]
	4DHN	X-ray	1.80	A	1-231	[»]
	4DHO	X-ray	1.70	A	1-231	[»]
	4DHP	X-ray	1.75	A	1-231	[»]
	4DHQ	X-ray	1.75	A	1-231	[»]
	4DHR	X-ray	1.40	A	1-231	[»]
	4DHS	X-ray	1.74	A	1-231	[»]
	4DHT	X-ray	1.80	A	1-231	[»]
	4DHU	X-ray	1.67	A	1-231	[»]
	4FL5	X-ray	1.90	A/B	1-231	[»]
	4FR3	X-ray	1.90	A	1-231	[»]
	4IEA	X-ray	1.70	A	1-231	[»]
	4JC3	X-ray	2.05	A	1-231	[»]
	4JDD	X-ray	2.10	A	1-231	[»]
	4QLI	X-ray	1.45	A	1-231	[»]
	4Y32	X-ray	1.70	A/B	1-231	[»]
	4Y3B	X-ray	1.80	A/B	1-231	[»]
	4Y5I	X-ray	1.40	A/B	1-231	[»]
	5BTV	X-ray	1.70	A	1-231	[»]
	5HF3	X-ray	1.80	A	1-231	[»]
	5LTW	X-ray	4.50	A/B/E/F/I/J	1-231	[»]
	5LU1	X-ray	2.40	A/B/E/F	1-231	[»]
	5LU2	X-ray	2.50	A/B	1-231	[»]
	5MHC	X-ray	1.20	A	1-231	[»]
	5MOC	X-ray	1.80	A	1-231	[»]
	5MXO	X-ray	1.20	A	1-231	[»]
	5MY9	X-ray	1.33	A	1-231	[»]
	5MYC	X-ray	1.46	A	1-231	[»]
	5N5R	X-ray	1.80	A	1-231	[»]
	5N5T	X-ray	1.80	A	1-231	[»]
	5N5W	X-ray	1.37	A	1-231	[»]
	5N75	X-ray	1.80	A	1-231	[»]
	5OEG	X-ray	3.15	A	1-231	[»]
	5OEH	X-ray	2.35	A	1-231	[»]
	5OK9	X-ray	2.35	A/B/E/F	1-231	[»]
	5OKF	X-ray	3.20	A/B/C/D	1-231	[»]
5OM0	X-ray	3.20	A/B	1-231	[»]
5OMA	X-ray	3.90	A/B/C/D	1-231	[»]
6FAU	X-ray	1.25	A/C	1-231	[»]
6FAV	X-ray	1.40	A/C	1-231	[»]
6FAW	X-ray	1.40	A/C	1-231	[»]
6FBB	X-ray	1.30	A	1-231	[»]
6FBW	X-ray	1.45	A/C	1-231	[»]
6FBY	X-ray	1.50	A/C	1-231	[»]
6FCP	X-ray	1.45	A	1-231	[»]
6FI4	X-ray	2.00	A	1-231	[»]
6FI5	X-ray	1.70	A	1-231	[»]
6G6X	X-ray	1.13	A	1-231	[»]
6G8I	X-ray	1.60	A	1-231	[»]
6G8J	X-ray	1.47	A	1-231	[»]
6G8K	X-ray	1.25	A	1-231	[»]
6G8L	X-ray	1.37	A	1-231	[»]
6G8P	X-ray	1.90	A	1-231	[»]
6G8Q	X-ray	1.85	A	1-231	[»]
6GHP	X-ray	1.95	A	1-231	[»]
6HHP	X-ray	1.80	A	1-231	[»]
6HKB	X-ray	1.70	A	1-231	[»]
6HKF	X-ray	1.80	A	1-231	[»]
6HMT	X-ray	1.10	A	1-231	[»]
6HMU	X-ray	1.20	A	1-231	[»]
6HN2	X-ray	1.70	A	1-231	[»]
6NV2	X-ray	1.13	A	1-231	[»]
6QDR	X-ray	1.61	A	1-231	[»]
6QDS	X-ray	1.72	A	1-231	[»]
6QDT	X-ray	1.70	A	1-231	[»]
6QDU	X-ray	1.63	A	1-231	[»]
6QHL	X-ray	1.20	A	1-248	[»]
6QHM	X-ray	1.25	A	1-248	[»]
6QIU	X-ray	1.80	A	1-231	[»]
6QZR	X-ray	2.30	A/B/C/D/E/F/G/H	1-248	[»]
6QZS	X-ray	1.90	A/B	1-248	[»]
6R5L	X-ray	1.88	A	1-231	[»]
6RHC	X-ray	1.20	A	1-231	[»]
6RJL	X-ray	1.28	A	1-248	[»]
6RJQ	X-ray	1.89	A	1-248	[»]
6RJZ	X-ray	1.58	A	1-248	[»]
6RK8	X-ray	1.60	A	1-248	[»]
6RKI	X-ray	1.88	A	1-248	[»]
6RKK	X-ray	1.88	A	1-248	[»]
6RKM	X-ray	1.88	A	1-248	[»]
6RL3	X-ray	1.30	A	1-248	[»]
6RL4	X-ray	1.60	A	1-248	[»]
6RL6	X-ray	1.60	A	1-248	[»]
6RM5	X-ray	1.88	A	1-248	[»]
6RM7	X-ray	1.60	A	1-248	[»]
6RP6	X-ray	1.89	A	1-231	[»]
6RWH	X-ray	1.68	A	1-248	[»]
6RWI	X-ray	1.65	A	1-248	[»]
6RWS	X-ray	1.53	A	1-248	[»]
6RWU	X-ray	1.46	A	1-248	[»]
6RX2	X-ray	1.82	A	1-248	[»]
6S39	X-ray	1.88	A	1-248	[»]
6S3C	X-ray	2.00	A	1-248	[»]
6S40	X-ray	1.90	A	1-248	[»]
6S9Q	X-ray	1.69	A	1-248	[»]
6SIN	X-ray	1.64	A	1-231	[»]
6SIO	X-ray	1.60	A	1-231	[»]
6SIP	X-ray	1.60	A	1-231	[»]
6SIQ	X-ray	1.60	A	1-231	[»]
6SLV	X-ray	1.90	A	1-231	[»]
6SLW	X-ray	2.00	A	1-248	[»]
6SLX	X-ray	1.80	A	1-248	[»]
6T5F	X-ray	2.63	A/B/C/D	1-231	[»]
6T5H	X-ray	2.04	A/B	1-231	[»]
6T80	X-ray	2.99	A/B/C/D	1-231	[»]
6TCH	X-ray	1.80	B	1-231	[»]
6TJM	X-ray	1.85	A	1-231	[»]
6TL3	X-ray	2.46	A	1-231	[»]
6TLF	X-ray	2.90	A	1-248	[»]
6TLG	X-ray	2.40	A	1-248	[»]
6TM7	X-ray	3.00	A/B	1-248	[»]
6TWZ	X-ray	2.80	A/B/C/D	1-231	[»]
6W0L	X-ray	2.30	A	1-231	[»]
6XWD	X-ray	1.60	A	1-231	[»]
6XXC	X-ray	1.30	A	1-231	[»]
6XY5	X-ray	1.30	A	1-231	[»]
6Y18	X-ray	1.30	A	1-231	[»]
6Y1D	X-ray	1.38	A	1-231	[»]
6Y1J	X-ray	1.13	A	1-248	[»]
6Y3M	X-ray	1.50	A	1-248	[»]
6Y3O	X-ray	1.50	A	1-248	[»]
6Y3R	X-ray	1.50	A	1-248	[»]
6Y3S	X-ray	1.95	A	1-248	[»]
6Y3V	X-ray	1.50	A	1-248	[»]
6Y3W	X-ray	1.34	A	1-231	[»]
6Y40	X-ray	1.75	A	1-248	[»]
6Y44	X-ray	1.71	A	1-248	[»]
6Y58	X-ray	1.90	A	1-231	[»]
6Y8A	X-ray	1.50	A	1-248	[»]
6Y8B	X-ray	1.54	A	1-248	[»]
6Y8D	X-ray	1.51	A	1-248	[»]
6Y8E	X-ray	1.42	A	1-248	[»]
6YLU	X-ray	1.88	A	1-231	[»]
6YOW	X-ray	1.23	A	1-231	[»]
6YOX	X-ray	2.05	A	1-248	[»]
6YOY	X-ray	1.80	A	1-231	[»]
6YP2	X-ray	1.80	A	1-231	[»]
6YP3	X-ray	1.80	A	1-231	[»]
6YP8	X-ray	1.80	A	1-231	[»]
6YPL	X-ray	1.80	A	1-231	[»]
6YPY	X-ray	1.40	A	1-231	[»]
6YQ2	X-ray	1.40	A	1-231	[»]
6ZCJ	X-ray	1.53	A	1-231	[»]
7AEW	X-ray	1.20	AAA	1-231	[»]
7NFW	X-ray	1.19	A	1-248	[»]
SMRⁱ	P31947
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	109072, 300 interactors
DIPⁱ	DIP-29861N
ELMⁱ	P31947
IntActⁱ	P31947, 189 interactors
MINTⁱ	P31947
STRINGⁱ	9606.ENSP00000340989

Chemistry databases

BindingDBⁱ	P31947
ChEMBLⁱ	CHEMBL1909482

PTM databases

iPTMnetⁱ	P31947
MetOSiteⁱ	P31947
PhosphoSitePlusⁱ	P31947
SwissPalmⁱ	P31947

Genetic variation databases

BioMutaⁱ	SFN
DMDMⁱ	398953

2D gel databases

OGPⁱ	P31947
SWISS-2DPAGEⁱ	P31947

Proteomic databases

EPDⁱ	P31947
jPOSTⁱ	P31947
MassIVEⁱ	P31947
MaxQBⁱ	P31947
PaxDbⁱ	P31947
PeptideAtlasⁱ	P31947
PRIDEⁱ	P31947
ProteomicsDBⁱ	54818 54819 [P31947-2]
TopDownProteomicsⁱ	P31947-1 [P31947-1] P31947-2 [P31947-2]

Protocols and materials databases

Antibodypediaⁱ	1907, 753 antibodies
The CPTC Antibody Portal More...CPTCⁱ	P31947, 3 antibodies
The DNASU plasmid repository More...DNASUⁱ	2810

Genome annotation databases

Ensemblⁱ	ENST00000339276; ENSP00000340989; ENSG00000175793 [P31947-1]
GeneIDⁱ	2810
KEGGⁱ	hsa:2810
UCSCⁱ	uc001bnc.2, human [P31947-1]

Organism-specific databases

CTDⁱ	2810
DisGeNETⁱ	2810
GeneCardsⁱ	SFN
HGNCⁱ	HGNC:10773, SFN
HPAⁱ	ENSG00000175793, Tissue enhanced (esophagus, lymphoid tissue, skin, tongue)
MIMⁱ	601290, gene
neXtProtⁱ	NX_P31947
OpenTargetsⁱ	ENSG00000175793
PharmGKBⁱ	PA177
VEuPathDBⁱ	HostDB:ENSG00000175793.11
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0841, Eukaryota
GeneTreeⁱ	ENSGT01010000222256
HOGENOMⁱ	CLU_058290_1_0_1
InParanoidⁱ	P31947
OMAⁱ	GEAECRV
OrthoDBⁱ	1176818at2759
PhylomeDBⁱ	P31947
TreeFamⁱ	TF102003

Enzyme and pathway databases

PathwayCommonsⁱ	P31947
Reactomeⁱ	R-HSA-111447, Activation of BAD and translocation to mitochondria R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-5625740, RHO GTPases activate PKNs R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-6804114, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-9614399, Regulation of localization of FOXO transcription factors
SignaLinkⁱ	P31947
SIGNORⁱ	P31947

Miscellaneous databases

BioGRID-ORCSⁱ	2810, 11 hits in 993 CRISPR screens
ChiTaRSⁱ	SFN, human
EvolutionaryTraceⁱ	P31947
GeneWikiⁱ	Stratifin
GenomeRNAiⁱ	2810
Pharosⁱ	P31947, Tbio
Protein Ontology More...PROⁱ	PR:P31947
RNActⁱ	P31947, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000175793, Expressed in amniotic fluid and 241 other tissues
Genevisibleⁱ	P31947, HS

Family and domain databases

CDDⁱ	cd10019, 14-3-3_sigma, 1 hit
Gene3Dⁱ	1.20.190.20, 1 hit
IDEALⁱ	IID00301
InterProⁱ	View protein in InterPro IPR000308, 14-3-3 IPR023409, 14-3-3_CS IPR036815, 14-3-3_dom_sf IPR023410, 14-3-3_domain IPR037435, 14-3-3_sigma
PANTHERⁱ	PTHR18860, PTHR18860, 1 hit
Pfamⁱ	View protein in Pfam PF00244, 14-3-3, 1 hit
PIRSFⁱ	PIRSF000868, 14-3-3, 1 hit
PRINTSⁱ	PR00305, 1433ZETA
SMARTⁱ	View protein in SMART SM00101, 14_3_3, 1 hit
SUPFAMⁱ	SSF48445, SSF48445, 1 hit
PROSITEⁱ	View protein in PROSITE PS00796, 1433_1, 1 hit PS00797, 1433_2, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	1433S_HUMAN
Accessionⁱ	P31947Primary (citable) accession number: P31947 Secondary accession number(s): Q6FH30, Q6FH51, Q96DH0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
	Last sequence update:	July 1, 1993
	Last modified:	June 2, 2021
	This is version 221 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

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UniRef

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Supporting data

UniProtKB - P31947 (1433S_HUMAN)

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14-3-3 protein sigma

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Cytoplasm and Cytosol

Nucleus

Cytosol

Extracellular region or secreted

Mitochondrion

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

P31947

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Genetic variation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ