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UniProtKB - P31947 (1433S_HUMAN)

Entry version 217 (07 Oct 2020)
Sequence version 1 (01 Jul 1993)
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Protein

14-3-3 protein sigma

Gene

SFN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.1 Publication
p53-regulated inhibitor of G2/M progression.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P31947

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-111447, Activation of BAD and translocation to mitochondria
R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-5625740, RHO GTPases activate PKNs
R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-6804114, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-HSA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-HSA-9614399, Regulation of localization of FOXO transcription factors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P31947

SIGNOR Signaling Network Open Resource

More...SIGNORi		P31947

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
14-3-3 protein sigma
Alternative name(s):
Epithelial cell marker protein 1
Stratifin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SFN
Synonyms:HME1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000175793.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:10773, SFN

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601290, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P31947

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		2810

Open Targets

More...OpenTargetsi		ENSG00000175793

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA177

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P31947, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1909482

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SFN

Domain mapping of disease mutations (DMDM)

More...DMDMi		398953

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000586431 – 24814-3-3 protein sigmaAdd BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei5PhosphoserineCombined sources1
Modified residuei74PhosphoserineCombined sources1
Modified residuei248PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P31947

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P31947

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P31947

MaxQB - The MaxQuant DataBase

More...MaxQBi		P31947

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P31947

PeptideAtlas

More...PeptideAtlasi		P31947

PRoteomics IDEntifications database

More...PRIDEi		P31947

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54818
54819 [P31947-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P31947-1 [P31947-1]
P31947-2 [P31947-2]

2D gel databases

USC-OGP 2-DE database

More...OGPi		P31947

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P31947

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P31947

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P31947

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P31947

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P31947

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present mainly in tissues enriched in stratified squamous keratinizing epithelium.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000175793, Expressed in amniotic fluid and 240 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P31947, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000175793, Tissue enhanced (esophagus, lymphoid tissue, skin, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:28202711).

Interacts with KRT17 and SAMSN1 (By similarity).

Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29 and VPS35.

Interacts with GAB2.

Interacts with SRPK2.

Interacts with COPS6.

Interacts with COP1; this interaction leads to proteasomal degradation.

Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703).

Interacts with PI4KB (PubMed:23572552).

Interacts with SLITRK1 (PubMed:19640509).

Interacts with LRRK2; this interaction is dependent on LRRK2 phosphorylation (PubMed:28202711).

By similarity10 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei56Interaction with phosphoserine on interacting protein1
Sitei129Interaction with phosphoserine on interacting protein1

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109072, 287 interactors

Database of interacting proteins

More...DIPi		DIP-29861N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P31947

Protein interaction database and analysis system

More...IntActi		P31947, 186 interactors

Molecular INTeraction database

More...MINTi		P31947

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000340989

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P31947

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P31947, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P31947

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P31947

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0841, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01000000214461

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_058290_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P31947

KEGG Orthology (KO)

More...KOi		K06644

Identification of Orthologs from Complete Genome Data

More...OMAi		GEAECRV

Database of Orthologous Groups

More...OrthoDBi		1176818at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P31947

TreeFam database of animal gene trees

More...TreeFami		TF102003

Family and domain databases

Conserved Domains Database

More...CDDi		cd10019, 14-3-3_sigma, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.190.20, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00301

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000308, 14-3-3
IPR023409, 14-3-3_CS
IPR036815, 14-3-3_dom_sf
IPR023410, 14-3-3_domain
IPR037435, 14-3-3_sigma

The PANTHER Classification System

More...PANTHERi		PTHR18860, PTHR18860, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00244, 14-3-3, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000868, 14-3-3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00305, 1433ZETA

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00101, 14_3_3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48445, SSF48445, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00796, 1433_1, 1 hit
PS00797, 1433_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P31947-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN 
        60         70         80         90        100
VVGGQRAAWR VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL 
       110        120        130        140        150
GLLDSHLIKE AGDAESRVFY LKMKGDYYRY LAEVATGDDK KRIIDSARSA 
       160        170        180        190        200
YQEAMDISKK EMPPTNPIRL GLALNFSVFH YEIANSPEEA ISLAKTTFDE 
       210        220        230        240 
AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG EAPQEPQS
Length:248
Mass (Da):27,774
Last modified:July 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7F4B44E3AA59ECE6
GO
Isoform 2 (identifier: P31947-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-116: Missing.

Show »
Length:216
Mass (Da):24,336
Checksum:i14CBC2F26014D926
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti77K → M in CAG46703 (Ref. 4) Curated1
Sequence conflicti120Y → H in AAA59546 (PubMed:8515476).Curated1
Sequence conflicti242A → V in AAA59546 (PubMed:8515476).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048095155M → I. Corresponds to variant dbSNP:rs11542705Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02176885 – 116Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M93010 mRNA Translation: AAA59546.1
X57348 mRNA Translation: CAA40623.1
AF029081 Genomic DNA Translation: AAC52029.1
AF029082 mRNA Translation: AAC52030.1
CR541905 mRNA Translation: CAG46703.1
CR541926 mRNA Translation: CAG46724.1
AL034380 Genomic DNA No translation available.
BC000329 mRNA Translation: AAH00329.1
BC000995 mRNA Translation: AAH00995.1
BC001550 mRNA Translation: AAH01550.1
BC002995 mRNA Translation: AAH02995.1
BC023552 mRNA Translation: AAH23552.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS288.1 [P31947-1]

Protein sequence database of the Protein Information Resource

More...PIRi		S34753
S38956

NCBI Reference Sequences

More...RefSeqi		NP_006133.1, NM_006142.3 [P31947-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000339276; ENSP00000340989; ENSG00000175793 [P31947-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2810

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2810

UCSC genome browser

More...UCSCi		uc001bnc.2, human [P31947-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93010 mRNA Translation: AAA59546.1
X57348 mRNA Translation: CAA40623.1
AF029081 Genomic DNA Translation: AAC52029.1
AF029082 mRNA Translation: AAC52030.1
CR541905 mRNA Translation: CAG46703.1
CR541926 mRNA Translation: CAG46724.1
AL034380 Genomic DNA No translation available.
BC000329 mRNA Translation: AAH00329.1
BC000995 mRNA Translation: AAH00995.1
BC001550 mRNA Translation: AAH01550.1
BC002995 mRNA Translation: AAH02995.1
BC023552 mRNA Translation: AAH23552.1
CCDSiCCDS288.1 [P31947-1]
PIRiS34753
S38956
RefSeqiNP_006133.1, NM_006142.3 [P31947-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YWTX-ray2.40A/B1-248[»]
1YZ5X-ray2.80A/B1-248[»]
3IQJX-ray1.15A1-231[»]
3IQUX-ray1.05A1-231[»]
3IQVX-ray1.20A1-231[»]
3LW1X-ray1.28A1-248[»]
3MHRX-ray1.15A1-231[»]
3O8IX-ray2.00A1-231[»]
3P1NX-ray1.40A1-231[»]
3P1OX-ray1.90A1-231[»]
3P1PX-ray1.95A1-231[»]
3P1QX-ray1.70A1-231[»]
3P1RX-ray1.70A1-231[»]
3P1SX-ray1.65A1-231[»]
3SMKX-ray2.10A1-231[»]
3SMLX-ray1.90A1-231[»]
3SMMX-ray2.00A1-231[»]
3SMNX-ray2.00A1-231[»]
3SMOX-ray1.80A1-231[»]
3SP5X-ray1.80A1-231[»]
3SPRX-ray1.99A1-231[»]
3T0LX-ray1.60A1-231[»]
3T0MX-ray1.62A1-231[»]
3U9XX-ray1.80A1-231[»]
3UX0X-ray1.75A1-231[»]
4DATX-ray1.40A1-231[»]
4DAUX-ray2.00A1-231[»]
4DHMX-ray1.70A1-231[»]
4DHNX-ray1.80A1-231[»]
4DHOX-ray1.70A1-231[»]
4DHPX-ray1.75A1-231[»]
4DHQX-ray1.75A1-231[»]
4DHRX-ray1.40A1-231[»]
4DHSX-ray1.74A1-231[»]
4DHTX-ray1.80A1-231[»]
4DHUX-ray1.67A1-231[»]
4FL5X-ray1.90A/B1-231[»]
4FR3X-ray1.90A1-231[»]
4IEAX-ray1.70A1-231[»]
4JC3X-ray2.05A1-231[»]
4JDDX-ray2.10A1-231[»]
4QLIX-ray1.45A1-231[»]
4Y32X-ray1.70A/B1-231[»]
4Y3BX-ray1.80A/B1-231[»]
4Y5IX-ray1.40A/B1-231[»]
5BTVX-ray1.70A1-231[»]
5HF3X-ray1.80A1-231[»]
5LTWX-ray4.50A/B/E/F/I/J1-231[»]
5LU1X-ray2.40A/B/E/F1-231[»]
5LU2X-ray2.50A/B1-231[»]
5MHCX-ray1.20A1-231[»]
5MOCX-ray1.80A1-231[»]
5MXOX-ray1.20A1-231[»]
5MY9X-ray1.33A1-231[»]
5MYCX-ray1.46A1-231[»]
5N5RX-ray1.80A1-231[»]
5N5TX-ray1.80A1-231[»]
5N5WX-ray1.37A1-231[»]
5N75X-ray1.80A1-231[»]
5OEGX-ray3.15A1-231[»]
5OEHX-ray2.35A1-231[»]
5OK9X-ray2.35A/B/E/F1-231[»]
5OKFX-ray3.20A/B/C/D1-231[»]
5OM0X-ray3.20A/B1-231[»]
5OMAX-ray3.90A/B/C/D1-231[»]
6FAUX-ray1.25A/C1-231[»]
6FAVX-ray1.40A/C1-231[»]
6FAWX-ray1.40A/C1-231[»]
6FBBX-ray1.30A1-231[»]
6FBWX-ray1.45A/C1-231[»]
6FBYX-ray1.50A/C1-231[»]
6FCPX-ray1.45A1-231[»]
6FI4X-ray2.00A1-231[»]
6FI5X-ray1.70A1-231[»]
6G6XX-ray1.13A1-231[»]
6G8IX-ray1.60A1-231[»]
6G8JX-ray1.47A1-231[»]
6G8KX-ray1.25A1-231[»]
6G8LX-ray1.37A1-231[»]
6G8PX-ray1.90A1-231[»]
6G8QX-ray1.85A1-231[»]
6GHPX-ray1.95A1-231[»]
6HHPX-ray1.80A1-231[»]
6HKBX-ray1.70A1-231[»]
6HKFX-ray1.80A1-231[»]
6HMTX-ray1.10A1-231[»]
6HMUX-ray1.20A1-231[»]
6HN2X-ray1.70A1-231[»]
6NV2X-ray1.13A1-231[»]
6QDRX-ray1.61A1-231[»]
6QDSX-ray1.72A1-231[»]
6QDTX-ray1.70A1-231[»]
6QDUX-ray1.63A1-231[»]
6QHLX-ray1.20A1-248[»]
6QHMX-ray1.25A1-248[»]
6QIUX-ray1.80A1-231[»]
6QZRX-ray2.30A/B/C/D/E/F/G/H1-248[»]
6QZSX-ray1.90A/B1-248[»]
6R5LX-ray1.88A1-231[»]
6RHCX-ray1.20A1-231[»]
6RJLX-ray1.28A1-248[»]
6RJQX-ray1.89A1-248[»]
6RJZX-ray1.58A1-248[»]
6RK8X-ray1.60A1-248[»]
6RKIX-ray1.88A1-248[»]
6RKKX-ray1.88A1-248[»]
6RKMX-ray1.88A1-248[»]
6RL3X-ray1.30A1-248[»]
6RL4X-ray1.60A1-248[»]
6RL6X-ray1.60A1-248[»]
6RM5X-ray1.88A1-248[»]
6RM7X-ray1.60A1-248[»]
6RP6X-ray1.89A1-231[»]
6RWHX-ray1.68A1-248[»]
6RWIX-ray1.65A1-248[»]
6RWSX-ray1.53A1-248[»]
6RWUX-ray1.46A1-248[»]
6RX2X-ray1.82A1-248[»]
6S39X-ray1.88A1-248[»]
6S3CX-ray2.00A1-248[»]
6S40X-ray1.90A1-248[»]
6S9QX-ray1.69A1-248[»]
6SINX-ray1.64A1-231[»]
6SIOX-ray1.60A1-231[»]
6SIPX-ray1.60A1-231[»]
6SIQX-ray1.60A1-231[»]
6SLVX-ray1.90A1-231[»]
6SLWX-ray2.00A1-248[»]
6SLXX-ray1.80A1-248[»]
6TCHX-ray1.80B1-231[»]
6TJMX-ray1.85A1-231[»]
6TL3X-ray2.46A1-231[»]
6TLFX-ray2.90A1-248[»]
6TLGX-ray2.40A1-248[»]
6TM7X-ray3.00A/B1-248[»]
6TWZX-ray2.80A/B/C/D1-231[»]
6W0LX-ray2.30A1-231[»]
6Y1JX-ray1.13A1-248[»]
SMRiP31947
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109072, 287 interactors
DIPiDIP-29861N
ELMiP31947
IntActiP31947, 186 interactors
MINTiP31947
STRINGi9606.ENSP00000340989

Chemistry databases

BindingDBiP31947
ChEMBLiCHEMBL1909482

PTM databases

iPTMnetiP31947
MetOSiteiP31947
PhosphoSitePlusiP31947
SwissPalmiP31947

Polymorphism and mutation databases

BioMutaiSFN
DMDMi398953

2D gel databases

OGPiP31947
SWISS-2DPAGEiP31947

Proteomic databases

EPDiP31947
jPOSTiP31947
MassIVEiP31947
MaxQBiP31947
PaxDbiP31947
PeptideAtlasiP31947
PRIDEiP31947
ProteomicsDBi54818
54819 [P31947-2]
TopDownProteomicsiP31947-1 [P31947-1]
P31947-2 [P31947-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1907, 736 antibodies

The CPTC Antibody Portal

More...CPTCi		P31947, 3 antibodies

The DNASU plasmid repository

More...DNASUi		2810

Genome annotation databases

EnsembliENST00000339276; ENSP00000340989; ENSG00000175793 [P31947-1]
GeneIDi2810
KEGGihsa:2810
UCSCiuc001bnc.2, human [P31947-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2810
DisGeNETi2810
EuPathDBiHostDB:ENSG00000175793.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		SFN
HGNCiHGNC:10773, SFN
HPAiENSG00000175793, Tissue enhanced (esophagus, lymphoid tissue, skin, tongue)
MIMi601290, gene
neXtProtiNX_P31947
OpenTargetsiENSG00000175793
PharmGKBiPA177

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0841, Eukaryota
GeneTreeiENSGT01000000214461
HOGENOMiCLU_058290_1_0_1
InParanoidiP31947
KOiK06644
OMAiGEAECRV
OrthoDBi1176818at2759
PhylomeDBiP31947
TreeFamiTF102003

Enzyme and pathway databases

PathwayCommonsiP31947
ReactomeiR-HSA-111447, Activation of BAD and translocation to mitochondria
R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-5625740, RHO GTPases activate PKNs
R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-6804114, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-HSA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-HSA-9614399, Regulation of localization of FOXO transcription factors
SignaLinkiP31947
SIGNORiP31947

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2810, 8 hits in 878 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SFN, human
EvolutionaryTraceiP31947

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Stratifin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2810
PharosiP31947, Tbio

Protein Ontology

More...PROi		PR:P31947
RNActiP31947, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000175793, Expressed in amniotic fluid and 240 other tissues
GenevisibleiP31947, HS

Family and domain databases

CDDicd10019, 14-3-3_sigma, 1 hit
Gene3Di1.20.190.20, 1 hit
IDEALiIID00301
InterProiView protein in InterPro
IPR000308, 14-3-3
IPR023409, 14-3-3_CS
IPR036815, 14-3-3_dom_sf
IPR023410, 14-3-3_domain
IPR037435, 14-3-3_sigma
PANTHERiPTHR18860, PTHR18860, 1 hit
PfamiView protein in Pfam
PF00244, 14-3-3, 1 hit
PIRSFiPIRSF000868, 14-3-3, 1 hit
PRINTSiPR00305, 1433ZETA
SMARTiView protein in SMART
SM00101, 14_3_3, 1 hit
SUPFAMiSSF48445, SSF48445, 1 hit
PROSITEiView protein in PROSITE
PS00796, 1433_1, 1 hit
PS00797, 1433_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei1433S_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31947
Secondary accession number(s): Q6FH30, Q6FH51, Q96DH0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 7, 2020
This is version 217 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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