UniProtKB - P31947 (1433S_HUMAN)
14-3-3 protein sigma
SFN
Functioni
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- identical protein binding Source: IntAct
- phosphoprotein binding Source: Ensembl
- protein kinase binding Source: Ensembl
- protein kinase C inhibitor activity Source: ProtInc
GO - Biological processi
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
- establishment of skin barrier Source: UniProtKB
- intrinsic apoptotic signaling pathway in response to DNA damage Source: HGNC-UCL
- keratinization Source: Ensembl
- keratinocyte development Source: Ensembl
- membrane organization Source: Reactome
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: HGNC-UCL
- negative regulation of keratinocyte proliferation Source: Ensembl
- negative regulation of protein kinase activity Source: ProtInc
- positive regulation of cell growth Source: Ensembl
- positive regulation of epidermal cell differentiation Source: UniProtKB
- positive regulation of protein export from nucleus Source: Ensembl
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
- regulation of epidermal cell division Source: UniProtKB
- release of cytochrome c from mitochondria Source: HGNC-UCL
- signal transduction Source: ProtInc
Enzyme and pathway databases
PathwayCommonsi | P31947 |
Reactomei | R-HSA-111447, Activation of BAD and translocation to mitochondria R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-5625740, RHO GTPases activate PKNs R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-6804114, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-9614399, Regulation of localization of FOXO transcription factors |
SignaLinki | P31947 |
SIGNORi | P31947 |
Names & Taxonomyi
Protein namesi | Recommended name: 14-3-3 protein sigmaAlternative name(s): Epithelial cell marker protein 1 Stratifin |
Gene namesi | Name:SFN Synonyms:HME1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000175793.11 |
HGNCi | HGNC:10773, SFN |
MIMi | 601290, gene |
neXtProti | NX_P31947 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular space Source: ProtInc
Mitochondrion
- mitochondrion Source: GOC
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, Nucleus, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 2810 |
OpenTargetsi | ENSG00000175793 |
PharmGKBi | PA177 |
Miscellaneous databases
Pharosi | P31947, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1909482 |
Polymorphism and mutation databases
BioMutai | SFN |
DMDMi | 398953 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058643 | 1 – 248 | 14-3-3 protein sigmaAdd BLAST | 248 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 5 | PhosphoserineCombined sources | 1 | |
Modified residuei | 74 | PhosphoserineCombined sources | 1 | |
Modified residuei | 248 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P31947 |
jPOSTi | P31947 |
MassIVEi | P31947 |
MaxQBi | P31947 |
PaxDbi | P31947 |
PeptideAtlasi | P31947 |
PRIDEi | P31947 |
ProteomicsDBi | 54818 54819 [P31947-2] |
TopDownProteomicsi | P31947-1 [P31947-1] P31947-2 [P31947-2] |
2D gel databases
OGPi | P31947 |
SWISS-2DPAGEi | P31947 |
PTM databases
iPTMneti | P31947 |
MetOSitei | P31947 |
PhosphoSitePlusi | P31947 |
SwissPalmi | P31947 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000175793, Expressed in amniotic fluid and 240 other tissues |
Genevisiblei | P31947, HS |
Organism-specific databases
HPAi | ENSG00000175793, Tissue enhanced (esophagus, lymphoid tissue, skin, tongue) |
Interactioni
Subunit structurei
Homodimer (PubMed:28202711).
Interacts with KRT17 and SAMSN1 (By similarity).
Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29 and VPS35.
Interacts with GAB2.
Interacts with SRPK2.
Interacts with COPS6.
Interacts with COP1; this interaction leads to proteasomal degradation.
Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703).
Interacts with PI4KB (PubMed:23572552).
Interacts with SLITRK1 (PubMed:19640509).
Interacts with LRRK2; this interaction is dependent on LRRK2 phosphorylation (PubMed:28202711).
By similarity10 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 56 | Interaction with phosphoserine on interacting protein | 1 | |
Sitei | 129 | Interaction with phosphoserine on interacting protein | 1 |
Binary interactionsi
Hide detailsP31947
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- identical protein binding Source: IntAct
- phosphoprotein binding Source: Ensembl
- protein kinase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 109072, 288 interactors |
DIPi | DIP-29861N |
ELMi | P31947 |
IntActi | P31947, 186 interactors |
MINTi | P31947 |
STRINGi | 9606.ENSP00000340989 |
Chemistry databases
BindingDBi | P31947 |
Miscellaneous databases
RNActi | P31947, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P31947 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P31947 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0841, Eukaryota |
GeneTreei | ENSGT01010000222256 |
HOGENOMi | CLU_058290_1_0_1 |
InParanoidi | P31947 |
OMAi | GEAECRV |
OrthoDBi | 1176818at2759 |
PhylomeDBi | P31947 |
TreeFami | TF102003 |
Family and domain databases
CDDi | cd10019, 14-3-3_sigma, 1 hit |
Gene3Di | 1.20.190.20, 1 hit |
IDEALi | IID00301 |
InterProi | View protein in InterPro IPR000308, 14-3-3 IPR023409, 14-3-3_CS IPR036815, 14-3-3_dom_sf IPR023410, 14-3-3_domain IPR037435, 14-3-3_sigma |
PANTHERi | PTHR18860, PTHR18860, 1 hit |
Pfami | View protein in Pfam PF00244, 14-3-3, 1 hit |
PIRSFi | PIRSF000868, 14-3-3, 1 hit |
PRINTSi | PR00305, 1433ZETA |
SMARTi | View protein in SMART SM00101, 14_3_3, 1 hit |
SUPFAMi | SSF48445, SSF48445, 1 hit |
PROSITEi | View protein in PROSITE PS00796, 1433_1, 1 hit PS00797, 1433_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN
60 70 80 90 100
VVGGQRAAWR VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL
110 120 130 140 150
GLLDSHLIKE AGDAESRVFY LKMKGDYYRY LAEVATGDDK KRIIDSARSA
160 170 180 190 200
YQEAMDISKK EMPPTNPIRL GLALNFSVFH YEIANSPEEA ISLAKTTFDE
210 220 230 240
AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG EAPQEPQS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 77 | K → M in CAG46703 (Ref. 4) Curated | 1 | |
Sequence conflicti | 120 | Y → H in AAA59546 (PubMed:8515476).Curated | 1 | |
Sequence conflicti | 242 | A → V in AAA59546 (PubMed:8515476).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048095 | 155 | M → I. Corresponds to variant dbSNP:rs11542705Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021768 | 85 – 116 | Missing in isoform 2. 1 PublicationAdd BLAST | 32 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M93010 mRNA Translation: AAA59546.1 X57348 mRNA Translation: CAA40623.1 AF029081 Genomic DNA Translation: AAC52029.1 AF029082 mRNA Translation: AAC52030.1 CR541905 mRNA Translation: CAG46703.1 CR541926 mRNA Translation: CAG46724.1 AL034380 Genomic DNA No translation available. BC000329 mRNA Translation: AAH00329.1 BC000995 mRNA Translation: AAH00995.1 BC001550 mRNA Translation: AAH01550.1 BC002995 mRNA Translation: AAH02995.1 BC023552 mRNA Translation: AAH23552.1 |
CCDSi | CCDS288.1 [P31947-1] |
PIRi | S34753 S38956 |
RefSeqi | NP_006133.1, NM_006142.3 [P31947-1] |
Genome annotation databases
Ensembli | ENST00000339276; ENSP00000340989; ENSG00000175793 [P31947-1] |
GeneIDi | 2810 |
KEGGi | hsa:2810 |
UCSCi | uc001bnc.2, human [P31947-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M93010 mRNA Translation: AAA59546.1 X57348 mRNA Translation: CAA40623.1 AF029081 Genomic DNA Translation: AAC52029.1 AF029082 mRNA Translation: AAC52030.1 CR541905 mRNA Translation: CAG46703.1 CR541926 mRNA Translation: CAG46724.1 AL034380 Genomic DNA No translation available. BC000329 mRNA Translation: AAH00329.1 BC000995 mRNA Translation: AAH00995.1 BC001550 mRNA Translation: AAH01550.1 BC002995 mRNA Translation: AAH02995.1 BC023552 mRNA Translation: AAH23552.1 |
CCDSi | CCDS288.1 [P31947-1] |
PIRi | S34753 S38956 |
RefSeqi | NP_006133.1, NM_006142.3 [P31947-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1YWT | X-ray | 2.40 | A/B | 1-248 | [»] | |
1YZ5 | X-ray | 2.80 | A/B | 1-248 | [»] | |
3IQJ | X-ray | 1.15 | A | 1-231 | [»] | |
3IQU | X-ray | 1.05 | A | 1-231 | [»] | |
3IQV | X-ray | 1.20 | A | 1-231 | [»] | |
3LW1 | X-ray | 1.28 | A | 1-248 | [»] | |
3MHR | X-ray | 1.15 | A | 1-231 | [»] | |
3O8I | X-ray | 2.00 | A | 1-231 | [»] | |
3P1N | X-ray | 1.40 | A | 1-231 | [»] | |
3P1O | X-ray | 1.90 | A | 1-231 | [»] | |
3P1P | X-ray | 1.95 | A | 1-231 | [»] | |
3P1Q | X-ray | 1.70 | A | 1-231 | [»] | |
3P1R | X-ray | 1.70 | A | 1-231 | [»] | |
3P1S | X-ray | 1.65 | A | 1-231 | [»] | |
3SMK | X-ray | 2.10 | A | 1-231 | [»] | |
3SML | X-ray | 1.90 | A | 1-231 | [»] | |
3SMM | X-ray | 2.00 | A | 1-231 | [»] | |
3SMN | X-ray | 2.00 | A | 1-231 | [»] | |
3SMO | X-ray | 1.80 | A | 1-231 | [»] | |
3SP5 | X-ray | 1.80 | A | 1-231 | [»] | |
3SPR | X-ray | 1.99 | A | 1-231 | [»] | |
3T0L | X-ray | 1.60 | A | 1-231 | [»] | |
3T0M | X-ray | 1.62 | A | 1-231 | [»] | |
3U9X | X-ray | 1.80 | A | 1-231 | [»] | |
3UX0 | X-ray | 1.75 | A | 1-231 | [»] | |
4DAT | X-ray | 1.40 | A | 1-231 | [»] | |
4DAU | X-ray | 2.00 | A | 1-231 | [»] | |
4DHM | X-ray | 1.70 | A | 1-231 | [»] | |
4DHN | X-ray | 1.80 | A | 1-231 | [»] | |
4DHO | X-ray | 1.70 | A | 1-231 | [»] | |
4DHP | X-ray | 1.75 | A | 1-231 | [»] | |
4DHQ | X-ray | 1.75 | A | 1-231 | [»] | |
4DHR | X-ray | 1.40 | A | 1-231 | [»] | |
4DHS | X-ray | 1.74 | A | 1-231 | [»] | |
4DHT | X-ray | 1.80 | A | 1-231 | [»] | |
4DHU | X-ray | 1.67 | A | 1-231 | [»] | |
4FL5 | X-ray | 1.90 | A/B | 1-231 | [»] | |
4FR3 | X-ray | 1.90 | A | 1-231 | [»] | |
4IEA | X-ray | 1.70 | A | 1-231 | [»] | |
4JC3 | X-ray | 2.05 | A | 1-231 | [»] | |
4JDD | X-ray | 2.10 | A | 1-231 | [»] | |
4QLI | X-ray | 1.45 | A | 1-231 | [»] | |
4Y32 | X-ray | 1.70 | A/B | 1-231 | [»] | |
4Y3B | X-ray | 1.80 | A/B | 1-231 | [»] | |
4Y5I | X-ray | 1.40 | A/B | 1-231 | [»] | |
5BTV | X-ray | 1.70 | A | 1-231 | [»] | |
5HF3 | X-ray | 1.80 | A | 1-231 | [»] | |
5LTW | X-ray | 4.50 | A/B/E/F/I/J | 1-231 | [»] | |
5LU1 | X-ray | 2.40 | A/B/E/F | 1-231 | [»] | |
5LU2 | X-ray | 2.50 | A/B | 1-231 | [»] | |
5MHC | X-ray | 1.20 | A | 1-231 | [»] | |
5MOC | X-ray | 1.80 | A | 1-231 | [»] | |
5MXO | X-ray | 1.20 | A | 1-231 | [»] | |
5MY9 | X-ray | 1.33 | A | 1-231 | [»] | |
5MYC | X-ray | 1.46 | A | 1-231 | [»] | |
5N5R | X-ray | 1.80 | A | 1-231 | [»] | |
5N5T | X-ray | 1.80 | A | 1-231 | [»] | |
5N5W | X-ray | 1.37 | A | 1-231 | [»] | |
5N75 | X-ray | 1.80 | A | 1-231 | [»] | |
5OEG | X-ray | 3.15 | A | 1-231 | [»] | |
5OEH | X-ray | 2.35 | A | 1-231 | [»] | |
5OK9 | X-ray | 2.35 | A/B/E/F | 1-231 | [»] | |
5OKF | X-ray | 3.20 | A/B/C/D | 1-231 | [»] | |
5OM0 | X-ray | 3.20 | A/B | 1-231 | [»] | |
5OMA | X-ray | 3.90 | A/B/C/D | 1-231 | [»] | |
6FAU | X-ray | 1.25 | A/C | 1-231 | [»] | |
6FAV | X-ray | 1.40 | A/C | 1-231 | [»] | |
6FAW | X-ray | 1.40 | A/C | 1-231 | [»] | |
6FBB | X-ray | 1.30 | A | 1-231 | [»] | |
6FBW | X-ray | 1.45 | A/C | 1-231 | [»] | |
6FBY | X-ray | 1.50 | A/C | 1-231 | [»] | |
6FCP | X-ray | 1.45 | A | 1-231 | [»] | |
6FI4 | X-ray | 2.00 | A | 1-231 | [»] | |
6FI5 | X-ray | 1.70 | A | 1-231 | [»] | |
6G6X | X-ray | 1.13 | A | 1-231 | [»] | |
6G8I | X-ray | 1.60 | A | 1-231 | [»] | |
6G8J | X-ray | 1.47 | A | 1-231 | [»] | |
6G8K | X-ray | 1.25 | A | 1-231 | [»] | |
6G8L | X-ray | 1.37 | A | 1-231 | [»] | |
6G8P | X-ray | 1.90 | A | 1-231 | [»] | |
6G8Q | X-ray | 1.85 | A | 1-231 | [»] | |
6GHP | X-ray | 1.95 | A | 1-231 | [»] | |
6HHP | X-ray | 1.80 | A | 1-231 | [»] | |
6HKB | X-ray | 1.70 | A | 1-231 | [»] | |
6HKF | X-ray | 1.80 | A | 1-231 | [»] | |
6HMT | X-ray | 1.10 | A | 1-231 | [»] | |
6HMU | X-ray | 1.20 | A | 1-231 | [»] | |
6HN2 | X-ray | 1.70 | A | 1-231 | [»] | |
6NV2 | X-ray | 1.13 | A | 1-231 | [»] | |
6QDR | X-ray | 1.61 | A | 1-231 | [»] | |
6QDS | X-ray | 1.72 | A | 1-231 | [»] | |
6QDT | X-ray | 1.70 | A | 1-231 | [»] | |
6QDU | X-ray | 1.63 | A | 1-231 | [»] | |
6QHL | X-ray | 1.20 | A | 1-248 | [»] | |
6QHM | X-ray | 1.25 | A | 1-248 | [»] | |
6QIU | X-ray | 1.80 | A | 1-231 | [»] | |
6QZR | X-ray | 2.30 | A/B/C/D/E/F/G/H | 1-248 | [»] | |
6QZS | X-ray | 1.90 | A/B | 1-248 | [»] | |
6R5L | X-ray | 1.88 | A | 1-231 | [»] | |
6RHC | X-ray | 1.20 | A | 1-231 | [»] | |
6RJL | X-ray | 1.28 | A | 1-248 | [»] | |
6RJQ | X-ray | 1.89 | A | 1-248 | [»] | |
6RJZ | X-ray | 1.58 | A | 1-248 | [»] | |
6RK8 | X-ray | 1.60 | A | 1-248 | [»] | |
6RKI | X-ray | 1.88 | A | 1-248 | [»] | |
6RKK | X-ray | 1.88 | A | 1-248 | [»] | |
6RKM | X-ray | 1.88 | A | 1-248 | [»] | |
6RL3 | X-ray | 1.30 | A | 1-248 | [»] | |
6RL4 | X-ray | 1.60 | A | 1-248 | [»] | |
6RL6 | X-ray | 1.60 | A | 1-248 | [»] | |
6RM5 | X-ray | 1.88 | A | 1-248 | [»] | |
6RM7 | X-ray | 1.60 | A | 1-248 | [»] | |
6RP6 | X-ray | 1.89 | A | 1-231 | [»] | |
6RWH | X-ray | 1.68 | A | 1-248 | [»] | |
6RWI | X-ray | 1.65 | A | 1-248 | [»] | |
6RWS | X-ray | 1.53 | A | 1-248 | [»] | |
6RWU | X-ray | 1.46 | A | 1-248 | [»] | |
6RX2 | X-ray | 1.82 | A | 1-248 | [»] | |
6S39 | X-ray | 1.88 | A | 1-248 | [»] | |
6S3C | X-ray | 2.00 | A | 1-248 | [»] | |
6S40 | X-ray | 1.90 | A | 1-248 | [»] | |
6S9Q | X-ray | 1.69 | A | 1-248 | [»] | |
6SIN | X-ray | 1.64 | A | 1-231 | [»] | |
6SIO | X-ray | 1.60 | A | 1-231 | [»] | |
6SIP | X-ray | 1.60 | A | 1-231 | [»] | |
6SIQ | X-ray | 1.60 | A | 1-231 | [»] | |
6SLV | X-ray | 1.90 | A | 1-231 | [»] | |
6SLW | X-ray | 2.00 | A | 1-248 | [»] | |
6SLX | X-ray | 1.80 | A | 1-248 | [»] | |
6TCH | X-ray | 1.80 | B | 1-231 | [»] | |
6TJM | X-ray | 1.85 | A | 1-231 | [»] | |
6TL3 | X-ray | 2.46 | A | 1-231 | [»] | |
6TLF | X-ray | 2.90 | A | 1-248 | [»] | |
6TLG | X-ray | 2.40 | A | 1-248 | [»] | |
6TM7 | X-ray | 3.00 | A/B | 1-248 | [»] | |
6TWZ | X-ray | 2.80 | A/B/C/D | 1-231 | [»] | |
6W0L | X-ray | 2.30 | A | 1-231 | [»] | |
6Y1J | X-ray | 1.13 | A | 1-248 | [»] | |
SMRi | P31947 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109072, 288 interactors |
DIPi | DIP-29861N |
ELMi | P31947 |
IntActi | P31947, 186 interactors |
MINTi | P31947 |
STRINGi | 9606.ENSP00000340989 |
Chemistry databases
BindingDBi | P31947 |
ChEMBLi | CHEMBL1909482 |
PTM databases
iPTMneti | P31947 |
MetOSitei | P31947 |
PhosphoSitePlusi | P31947 |
SwissPalmi | P31947 |
Polymorphism and mutation databases
BioMutai | SFN |
DMDMi | 398953 |
2D gel databases
OGPi | P31947 |
SWISS-2DPAGEi | P31947 |
Proteomic databases
EPDi | P31947 |
jPOSTi | P31947 |
MassIVEi | P31947 |
MaxQBi | P31947 |
PaxDbi | P31947 |
PeptideAtlasi | P31947 |
PRIDEi | P31947 |
ProteomicsDBi | 54818 54819 [P31947-2] |
TopDownProteomicsi | P31947-1 [P31947-1] P31947-2 [P31947-2] |
Protocols and materials databases
Antibodypediai | 1907, 736 antibodies |
CPTCi | P31947, 3 antibodies |
DNASUi | 2810 |
Genome annotation databases
Ensembli | ENST00000339276; ENSP00000340989; ENSG00000175793 [P31947-1] |
GeneIDi | 2810 |
KEGGi | hsa:2810 |
UCSCi | uc001bnc.2, human [P31947-1] |
Organism-specific databases
CTDi | 2810 |
DisGeNETi | 2810 |
EuPathDBi | HostDB:ENSG00000175793.11 |
GeneCardsi | SFN |
HGNCi | HGNC:10773, SFN |
HPAi | ENSG00000175793, Tissue enhanced (esophagus, lymphoid tissue, skin, tongue) |
MIMi | 601290, gene |
neXtProti | NX_P31947 |
OpenTargetsi | ENSG00000175793 |
PharmGKBi | PA177 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0841, Eukaryota |
GeneTreei | ENSGT01010000222256 |
HOGENOMi | CLU_058290_1_0_1 |
InParanoidi | P31947 |
OMAi | GEAECRV |
OrthoDBi | 1176818at2759 |
PhylomeDBi | P31947 |
TreeFami | TF102003 |
Enzyme and pathway databases
PathwayCommonsi | P31947 |
Reactomei | R-HSA-111447, Activation of BAD and translocation to mitochondria R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-5625740, RHO GTPases activate PKNs R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-6804114, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-9614399, Regulation of localization of FOXO transcription factors |
SignaLinki | P31947 |
SIGNORi | P31947 |
Miscellaneous databases
BioGRID-ORCSi | 2810, 8 hits in 850 CRISPR screens |
ChiTaRSi | SFN, human |
EvolutionaryTracei | P31947 |
GeneWikii | Stratifin |
GenomeRNAii | 2810 |
Pharosi | P31947, Tbio |
PROi | PR:P31947 |
RNActi | P31947, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175793, Expressed in amniotic fluid and 240 other tissues |
Genevisiblei | P31947, HS |
Family and domain databases
CDDi | cd10019, 14-3-3_sigma, 1 hit |
Gene3Di | 1.20.190.20, 1 hit |
IDEALi | IID00301 |
InterProi | View protein in InterPro IPR000308, 14-3-3 IPR023409, 14-3-3_CS IPR036815, 14-3-3_dom_sf IPR023410, 14-3-3_domain IPR037435, 14-3-3_sigma |
PANTHERi | PTHR18860, PTHR18860, 1 hit |
Pfami | View protein in Pfam PF00244, 14-3-3, 1 hit |
PIRSFi | PIRSF000868, 14-3-3, 1 hit |
PRINTSi | PR00305, 1433ZETA |
SMARTi | View protein in SMART SM00101, 14_3_3, 1 hit |
SUPFAMi | SSF48445, SSF48445, 1 hit |
PROSITEi | View protein in PROSITE PS00796, 1433_1, 1 hit PS00797, 1433_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 1433S_HUMAN | |
Accessioni | P31947Primary (citable) accession number: P31947 Secondary accession number(s): Q6FH30, Q6FH51, Q96DH0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | December 2, 2020 | |
This is version 218 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations