SFN

Functionⁱ

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.1 Publication

p53-regulated inhibitor of G2/M progression.1 Publication

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 15778465
phosphoprotein binding Source: Ensembl
protein domain specific binding Source: InterPro
protein kinase binding Source: Ensembl
protein kinase C inhibitor activity
Source: ProtInc
Traceable author statementⁱ
- 8515476

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
establishment of skin barrier Source: UniProtKB
intrinsic apoptotic signaling pathway in response to DNA damage
Source: HGNC
Inferred from direct assayⁱ
- 11574543
keratinization Source: Ensembl
keratinocyte development Source: Ensembl
membrane organization Source: Reactome
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Source: HGNC
Inferred from direct assayⁱ
- 11574543
negative regulation of keratinocyte proliferation Source: Ensembl
negative regulation of protein kinase activity
Source: ProtInc
Traceable author statementⁱ
- 8515476
positive regulation of cell growth Source: Ensembl
positive regulation of epidermal cell differentiation Source: UniProtKB
positive regulation of protein export from nucleus Source: Ensembl
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
regulation of epidermal cell division Source: UniProtKB
release of cytochrome c from mitochondria
Source: HGNC
Inferred from direct assayⁱ
- 11574543
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 8515476

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-111447 Activation of BAD and translocation to mitochondria R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-5625740 RHO GTPases activate PKNs R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
SignaLinkⁱ	P31947
SIGNORⁱ	P31947

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 14-3-3 protein sigma Alternative name(s): Epithelial cell marker protein 1 Stratifin
Gene namesⁱ	Name:SFN Synonyms:HME1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000175793.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10773 SFN
MIMⁱ	601290 gene
neXtProtⁱ	NX_P31947

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2810
Open Targets More...OpenTargetsⁱ	ENSG00000175793
PharmGKBⁱ	PA177

Chemistry databases

ChEMBLⁱ	CHEMBL1909482

ChEMBLⁱ

CHEMBL1909482

Polymorphism and mutation databases

BioMutaⁱ	SFN
DMDMⁱ	398953

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000058643	1 – 248	14-3-3 protein sigmaAdd BLAST		248

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	5	PhosphoserineCombined sources	1
Modified residueⁱ	74	PhosphoserineCombined sources	1
Modified residueⁱ	248	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation.1 Publication

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P31947
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P31947
PaxDbⁱ	P31947
PeptideAtlas More...PeptideAtlasⁱ	P31947
PRIDEⁱ	P31947
TopDownProteomicsⁱ	P31947-1 [P31947-1] P31947-2 [P31947-2]

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P31947
SWISS-2DPAGEⁱ	P31947

PTM databases

iPTMnetⁱ	P31947
PhosphoSitePlusⁱ	P31947
SwissPalmⁱ	P31947

Expressionⁱ

Tissue specificityⁱ

Present mainly in tissues enriched in stratified squamous keratinizing epithelium.

Gene expression databases

Bgeeⁱ	ENSG00000175793 Expressed in 231 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_SFN
Genevisibleⁱ	P31947 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB006268 CAB040552 HPA011105

HPAⁱ

CAB006268
CAB040552
HPA011105

Interactionⁱ

Subunit structureⁱ

Homodimer. Interacts with KRT17 and SAMSN1 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29 and VPS35. Interacts with GAB2. Interacts with SRPK2. Interacts with COPS6. Interacts with COP1; this interaction leads to proteasomal degradation. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB (PubMed:23572552). Interacts with SLITRK1 (PubMed:19640509).By similarity9 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	56	Interaction with phosphoserine on interacting protein		1
Siteⁱ	129	Interaction with phosphoserine on interacting protein		1

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		3	EBI-476295,EBI-476295
ABL1	P00519	2	EBI-476295,EBI-375543
AJUBA	Q96IF1	2	EBI-476295,EBI-949782
ARAF	P10398	2	EBI-476295,EBI-365961
BAD	Q92934	4	EBI-476295,EBI-700771
CCDC102B	Q68D86	3	EBI-476295,EBI-10171570
CCNH	P51946	3	EBI-476295,EBI-741406
COP1	Q8NHY2	6	EBI-476295,EBI-1176214
COPS6	Q7L5N1	7	EBI-476295,EBI-486838
EGFR	P00533	8	EBI-476295,EBI-297353
ERRFI1	Q9UJM3	3	EBI-476295,EBI-2941912
FAM53C	Q9NYF3	3	EBI-476295,EBI-1644252
FAM9B	Q8IZU0	3	EBI-476295,EBI-10175124
FOXO4	P98177	3	EBI-476295,EBI-4481939
GPRIN2	O60269	2	EBI-476295,EBI-740397
HDAC4	P56524	4	EBI-476295,EBI-308629
HDAC5	Q9UQL6	3	EBI-476295,EBI-715576
HDAC7	Q8WUI4	3	EBI-476295,EBI-1048378
HNRNPD	Q14103-4	7	EBI-476295,EBI-432545
LONRF1	Q17RB8	3	EBI-476295,EBI-2341787
MAGEA1	P43355	3	EBI-476295,EBI-740978
MAP3K2	Q9Y2U5	2	EBI-476295,EBI-357393
MARK3	P27448	2	EBI-476295,EBI-707595
MKRN3	Q13064	3	EBI-476295,EBI-2340269
PLK4	O00444	2	EBI-476295,EBI-746202
RAB3IP	Q96QF0	3	EBI-476295,EBI-747844
RAF1	P04049	3	EBI-476295,EBI-365996
REPS2	Q8NFH8-2	2	EBI-476295,EBI-8029141
TNK1	Q13470	2	EBI-476295,EBI-1383444
TP53	P04637	4	EBI-476295,EBI-366083
WDYHV1	Q96HA8	3	EBI-476295,EBI-741158
YWHAZ	P63104	2	EBI-476295,EBI-347088
ZC2HC1C	Q53FD0	3	EBI-476295,EBI-740767

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 15778465
phosphoprotein binding Source: Ensembl
protein domain specific binding Source: InterPro
protein kinase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109072, 262 interactors
Database of interacting proteins More...DIPⁱ	DIP-29861N
ELMⁱ	P31947
IntActⁱ	P31947, 170 interactors
Molecular INTeraction database More...MINTⁱ	P31947
STRINGⁱ	9606.ENSP00000340989

Chemistry databases

BindingDBⁱ

P31947

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	3 – 15	Combined sources	13
Helixⁱ	19 – 31	Combined sources	13
Helixⁱ	38 – 69	Combined sources	32
Helixⁱ	80 – 104	Combined sources	25
Helixⁱ	107 – 110	Combined sources	4
Helixⁱ	114 – 134	Combined sources	21
Beta strandⁱ	137 – 139	Combined sources	3
Helixⁱ	140 – 161	Combined sources	22
Helixⁱ	167 – 182	Combined sources	16
Helixⁱ	187 – 204	Combined sources	18
Helixⁱ	205 – 207	Combined sources	3
Helixⁱ	210 – 230	Combined sources	21

Show more details

3D structure databases

ProteinModelPortalⁱ	P31947
SMRⁱ	P31947
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P31947

EvolutionaryTraceⁱ

P31947

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0841 Eukaryota COG5040 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119116
HOGENOMⁱ	HOG000240379
HOVERGENⁱ	HBG050423
InParanoidⁱ	P31947
KEGG Orthology (KO) More...KOⁱ	K06644
OMAⁱ	SIEQKGN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0VKY
PhylomeDBⁱ	P31947
TreeFamⁱ	TF102003

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10019 14-3-3_sigma, 1 hit
Gene3Dⁱ	1.20.190.20, 1 hit
InterProⁱ	View protein in InterPro IPR000308 14-3-3 IPR023409 14-3-3_CS IPR036815 14-3-3_dom_sf IPR023410 14-3-3_domain IPR037435 14-3-3_sigma
PANTHERⁱ	PTHR18860 PTHR18860, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00244 14-3-3, 1 hit
PIRSFⁱ	PIRSF000868 14-3-3, 1 hit
PRINTSⁱ	PR00305 1433ZETA
SMARTⁱ	View protein in SMART SM00101 14_3_3, 1 hit
SUPFAMⁱ	SSF48445 SSF48445, 1 hit
PROSITEⁱ	View protein in PROSITE PS00796 1433_1, 1 hit PS00797 1433_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P31947-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN 
        60         70         80         90        100
VVGGQRAAWR VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL 
       110        120        130        140        150
GLLDSHLIKE AGDAESRVFY LKMKGDYYRY LAEVATGDDK KRIIDSARSA 
       160        170        180        190        200
YQEAMDISKK EMPPTNPIRL GLALNFSVFH YEIANSPEEA ISLAKTTFDE 
       210        220        230        240 
AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG EAPQEPQS

Length:248

Mass (Da):27,774

Last modified:July 1, 1993 - v1

Checksum:ⁱ7F4B44E3AA59ECE6

GO

Isoform 2 (identifier: P31947-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
85-116: Missing.

« Hide

        10         20         30         40         50
MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN 
        60         70         80         90        100
VVGGQRAAWR VLSSIEQKSN EEGSEEKGPE VREYRVFYLK MKGDYYRYLA 
       110        120        130        140        150
EVATGDDKKR IIDSARSAYQ EAMDISKKEM PPTNPIRLGL ALNFSVFHYE 
       160        170        180        190        200
IANSPEEAIS LAKTTFDEAM ADLHTLSEDS YKDSTLIMQL LRDNLTLWTA 
       210 
DNAGEEGGEA PQEPQS

Note: No experimental confirmation available.

Show »

Length:216

Mass (Da):24,336

Checksum:ⁱ14CBC2F26014D926

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	77	K → M in CAG46703 (Ref. 4) Curated	1
Sequence conflictⁱ	120	Y → H in AAA59546 (PubMed:8515476).Curated	1
Sequence conflictⁱ	242	A → V in AAA59546 (PubMed:8515476).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_048095	155	M → I. Corresponds to variant dbSNP:rs11542705Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_021768	85 – 116	Missing in isoform 2. 1 PublicationAdd BLAST		32

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M93010 mRNA Translation: AAA59546.1 X57348 mRNA Translation: CAA40623.1 AF029081 Genomic DNA Translation: AAC52029.1 AF029082 mRNA Translation: AAC52030.1 CR541905 mRNA Translation: CAG46703.1 CR541926 mRNA Translation: CAG46724.1 AL034380 Genomic DNA No translation available. BC000329 mRNA Translation: AAH00329.1 BC000995 mRNA Translation: AAH00995.1 BC001550 mRNA Translation: AAH01550.1 BC002995 mRNA Translation: AAH02995.1 BC023552 mRNA Translation: AAH23552.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS288.1 [P31947-1]
PIRⁱ	S34753 S38956
NCBI Reference Sequences More...RefSeqⁱ	NP_006133.1, NM_006142.3 [P31947-1]
UniGeneⁱ	Hs.523718

Genome annotation databases

Ensemblⁱ	ENST00000339276; ENSP00000340989; ENSG00000175793 [P31947-1]
GeneIDⁱ	2810
KEGGⁱ	hsa:2810
UCSC genome browser More...UCSCⁱ	uc001bnc.2 human [P31947-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P31947	SFN isoform 1		PANTR		248	UniRef100_P31947
Uncharacterized protein		PANPA		248
Uncharacterized protein		NOMLE		248
Stratifin		GORGO		248
UPI0001CC472E		HUMAN		253
+4

Protein	Similar proteins		Species	Score	Length	Source
P31947	14-3-3 protein sigma		BOVIN		248	UniRef90_P31947
14-3-3 protein sigma		SHEEP		248
14-3-3 protein sigma		MOUSE		248
SFN isoform 1		PANTR		248
Uncharacterized protein		PANPA		248
+101

Protein	Similar proteins		Species	Score	Length	Source
P31947	14-3-3 protein sigma		BOVIN		248	UniRef50_P31947
14-3-3 protein sigma		SHEEP		248
14-3-3 protein sigma		MOUSE		248
14-3-3 protein gamma-2		ONCMY		248
14-3-3 protein gamma-B		XENLA		247
+517
P31947-2	14-3-3 protein homolog 2 (Fragment)		SCHMA		214	UniRef50_P31947-2
Uncharacterized protein		RHIRO		210
Uncharacterized protein		Anopheles coluzzii		211
Uncharacterized protein		MONDO		246
14-3-3-like protein 2, variant 2		LOALO		211
+12

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M93010 mRNA Translation: AAA59546.1 X57348 mRNA Translation: CAA40623.1 AF029081 Genomic DNA Translation: AAC52029.1 AF029082 mRNA Translation: AAC52030.1 CR541905 mRNA Translation: CAG46703.1 CR541926 mRNA Translation: CAG46724.1 AL034380 Genomic DNA No translation available. BC000329 mRNA Translation: AAH00329.1 BC000995 mRNA Translation: AAH00995.1 BC001550 mRNA Translation: AAH01550.1 BC002995 mRNA Translation: AAH02995.1 BC023552 mRNA Translation: AAH23552.1
CCDSⁱ	CCDS288.1 [P31947-1]
PIRⁱ	S34753 S38956
RefSeqⁱ	NP_006133.1, NM_006142.3 [P31947-1]
UniGeneⁱ	Hs.523718

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1YWT	X-ray	2.40	A/B	1-248	[»]
	1YZ5	X-ray	2.80	A/B	1-248	[»]
	3IQJ	X-ray	1.15	A	1-231	[»]
	3IQU	X-ray	1.05	A	1-231	[»]
	3IQV	X-ray	1.20	A	1-231	[»]
	3LW1	X-ray	1.28	A	1-248	[»]
	3MHR	X-ray	1.15	A	1-231	[»]
	3O8I	X-ray	2.00	A	1-231	[»]
	3P1N	X-ray	1.40	A	1-231	[»]
	3P1O	X-ray	1.90	A	1-231	[»]
	3P1P	X-ray	1.95	A	1-231	[»]
	3P1Q	X-ray	1.70	A	1-231	[»]
	3P1R	X-ray	1.70	A	1-231	[»]
	3P1S	X-ray	1.65	A	1-231	[»]
	3SMK	X-ray	2.10	A	1-231	[»]
	3SML	X-ray	1.90	A	1-231	[»]
	3SMM	X-ray	2.00	A	1-231	[»]
	3SMN	X-ray	2.00	A	1-231	[»]
	3SMO	X-ray	1.80	A	1-231	[»]
	3SP5	X-ray	1.80	A	1-231	[»]
	3SPR	X-ray	1.99	A	1-231	[»]
	3T0L	X-ray	1.60	A	1-231	[»]
	3T0M	X-ray	1.62	A	1-231	[»]
	3U9X	X-ray	1.80	A	1-231	[»]
	3UX0	X-ray	1.75	A	1-231	[»]
	4DAT	X-ray	1.40	A	1-231	[»]
	4DAU	X-ray	2.00	A	1-231	[»]
	4DHM	X-ray	1.70	A	1-231	[»]
	4DHN	X-ray	1.80	A	1-231	[»]
	4DHO	X-ray	1.70	A	1-231	[»]
	4DHP	X-ray	1.75	A	1-231	[»]
	4DHQ	X-ray	1.75	A	1-231	[»]
	4DHR	X-ray	1.40	A	1-231	[»]
	4DHS	X-ray	1.74	A	1-231	[»]
	4DHT	X-ray	1.80	A	1-231	[»]
	4DHU	X-ray	1.67	A	1-231	[»]
	4FL5	X-ray	1.90	A/B	1-231	[»]
	4FR3	X-ray	1.90	A	1-231	[»]
	4IEA	X-ray	1.70	A	1-231	[»]
	4JC3	X-ray	2.05	A	1-231	[»]
	4JDD	X-ray	2.10	A	1-231	[»]
	4QLI	X-ray	1.45	A	1-231	[»]
	4Y32	X-ray	1.70	A/B	1-231	[»]
	4Y3B	X-ray	1.80	A/B	1-231	[»]
	4Y5I	X-ray	1.40	A/B	1-231	[»]
	5BTV	X-ray	1.70	A	1-231	[»]
	5HF3	X-ray	1.80	A	1-231	[»]
	5LTW	X-ray	4.50	A/B/E/F/I/J	1-231	[»]
	5LU1	X-ray	2.40	A/B/E/F	1-231	[»]
	5LU2	X-ray	2.50	A/B	1-231	[»]
	5MHC	X-ray	1.20	A	1-231	[»]
	5MOC	X-ray	1.80	A	1-231	[»]
	5MXO	X-ray	1.20	A	1-231	[»]
	5MY9	X-ray	1.33	A	1-231	[»]
	5MYC	X-ray	1.46	A	1-231	[»]
	5N5R	X-ray	1.80	A	1-231	[»]
	5N5T	X-ray	1.80	A	1-231	[»]
	5N5W	X-ray	1.37	A	1-231	[»]
	5N75	X-ray	1.80	A	1-231	[»]
	5OEG	X-ray	3.15	A	1-231	[»]
	5OEH	X-ray	2.35	A	1-231	[»]
	5OK9	X-ray	2.35	A/B/E/F	1-231	[»]
	5OKF	X-ray	3.20	A/B/C/D	1-231	[»]
5OM0	X-ray	3.20	A/B	1-231	[»]
5OMA	X-ray	3.90	A/B/C/D	1-231	[»]
6FAU	X-ray	1.25	A/C	1-231	[»]
6FAV	X-ray	1.40	A/C	1-231	[»]
6FAW	X-ray	1.40	A/C	1-231	[»]
6FBB	X-ray	1.30	A	1-231	[»]
6FBW	X-ray	1.45	A/C	1-231	[»]
6FBY	X-ray	1.50	A/C	1-231	[»]
6FCP	X-ray	1.45	A	1-231	[»]
6FI4	X-ray	2.00	A	1-231	[»]
6FI5	X-ray	1.70	A	1-231	[»]
6GHP	X-ray	1.95	A	1-231	[»]
ProteinModelPortalⁱ	P31947
SMRⁱ	P31947
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109072, 262 interactors
DIPⁱ	DIP-29861N
ELMⁱ	P31947
IntActⁱ	P31947, 170 interactors
MINTⁱ	P31947
STRINGⁱ	9606.ENSP00000340989

Chemistry databases

BindingDBⁱ	P31947
ChEMBLⁱ	CHEMBL1909482

PTM databases

iPTMnetⁱ	P31947
PhosphoSitePlusⁱ	P31947
SwissPalmⁱ	P31947

Polymorphism and mutation databases

BioMutaⁱ	SFN
DMDMⁱ	398953

2D gel databases

OGPⁱ	P31947
SWISS-2DPAGEⁱ	P31947

Proteomic databases

EPDⁱ	P31947
MaxQBⁱ	P31947
PaxDbⁱ	P31947
PeptideAtlasⁱ	P31947
PRIDEⁱ	P31947
TopDownProteomicsⁱ	P31947-1 [P31947-1] P31947-2 [P31947-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2810
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000339276; ENSP00000340989; ENSG00000175793 [P31947-1]
GeneIDⁱ	2810
KEGGⁱ	hsa:2810
UCSCⁱ	uc001bnc.2 human [P31947-1]

Organism-specific databases

CTDⁱ	2810
DisGeNETⁱ	2810
EuPathDBⁱ	HostDB:ENSG00000175793.11
GeneCardsⁱ	SFN
HGNCⁱ	HGNC:10773 SFN
HPAⁱ	CAB006268 CAB040552 HPA011105
MIMⁱ	601290 gene
neXtProtⁱ	NX_P31947
OpenTargetsⁱ	ENSG00000175793
PharmGKBⁱ	PA177
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0841 Eukaryota COG5040 LUCA
GeneTreeⁱ	ENSGT00760000119116
HOGENOMⁱ	HOG000240379
HOVERGENⁱ	HBG050423
InParanoidⁱ	P31947
KOⁱ	K06644
OMAⁱ	SIEQKGN
OrthoDBⁱ	EOG091G0VKY
PhylomeDBⁱ	P31947
TreeFamⁱ	TF102003

Enzyme and pathway databases

Reactomeⁱ	R-HSA-111447 Activation of BAD and translocation to mitochondria R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-5625740 RHO GTPases activate PKNs R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
SignaLinkⁱ	P31947
SIGNORⁱ	P31947

Miscellaneous databases

ChiTaRSⁱ	SFN human
EvolutionaryTraceⁱ	P31947
GeneWikiⁱ	Stratifin
GenomeRNAiⁱ	2810
Protein Ontology More...PROⁱ	PR:P31947
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000175793 Expressed in 231 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_SFN
Genevisibleⁱ	P31947 HS

Family and domain databases

CDDⁱ	cd10019 14-3-3_sigma, 1 hit
Gene3Dⁱ	1.20.190.20, 1 hit
InterProⁱ	View protein in InterPro IPR000308 14-3-3 IPR023409 14-3-3_CS IPR036815 14-3-3_dom_sf IPR023410 14-3-3_domain IPR037435 14-3-3_sigma
PANTHERⁱ	PTHR18860 PTHR18860, 1 hit
Pfamⁱ	View protein in Pfam PF00244 14-3-3, 1 hit
PIRSFⁱ	PIRSF000868 14-3-3, 1 hit
PRINTSⁱ	PR00305 1433ZETA
SMARTⁱ	View protein in SMART SM00101 14_3_3, 1 hit
SUPFAMⁱ	SSF48445 SSF48445, 1 hit
PROSITEⁱ	View protein in PROSITE PS00796 1433_1, 1 hit PS00797 1433_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	1433S_HUMAN
Accessionⁱ	P31947Primary (citable) accession number: P31947 Secondary accession number(s): Q6FH30, Q6FH51, Q96DH0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
	Last sequence update:	July 1, 1993
	Last modified:	October 10, 2018
	This is version 200 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P31947 (1433S_HUMAN)

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14-3-3 protein sigma

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

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Cytosol

Extracellular region or secreted

Mitochondrion

Nucleus

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Organism-specific databases

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Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

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GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

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Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

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Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ