UniProtKB - P31946 (1433B_HUMAN)
14-3-3 protein beta/alpha
YWHAB
Functioni
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- enzyme binding Source: BHF-UCL
- histone deacetylase binding Source: BHF-UCL
- identical protein binding Source: IntAct
- phosphoprotein binding Source: BHF-UCL
- phosphoserine residue binding Source: BHF-UCL
- protein-containing complex binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
- protein domain specific binding Source: UniProtKB
GO - Biological processi
- cytoplasmic sequestering of protein Source: BHF-UCL
- hippo signaling Source: Reactome
- MAPK cascade Source: Reactome
- membrane organization Source: Reactome
- negative regulation of G protein-coupled receptor signaling pathway Source: UniProtKB
- negative regulation of protein dephosphorylation Source: BHF-UCL
- negative regulation of transcription, DNA-templated Source: Ensembl
- positive regulation of catalytic activity Source: BHF-UCL
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
- protein targeting Source: Ensembl
- regulation of mRNA stability Source: Reactome
- viral process Source: UniProtKB-KW
Keywordsi
Biological process | Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | P31946 |
Reactomei | R-HSA-111447, Activation of BAD and translocation to mitochondria R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-165159, MTOR signalling R-HSA-166208, mTORC1-mediated signalling R-HSA-170968, Frs2-mediated activation R-HSA-170984, ARMS-mediated activation R-HSA-2028269, Signaling by Hippo R-HSA-392517, Rap1 signalling R-HSA-450385, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450513, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-5625740, RHO GTPases activate PKNs R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-5673000, RAF activation R-HSA-5674135, MAP2K and MAPK activation R-HSA-5675221, Negative regulation of MAPK pathway R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-9614399, Regulation of localization of FOXO transcription factors R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants R-HSA-9660537, Signaling by MRAS-complex mutants |
SignaLinki | P31946 |
SIGNORi | P31946 |
Names & Taxonomyi
Protein namesi | Recommended name: 14-3-3 protein beta/alphaAlternative name(s): Protein 1054 Protein kinase C inhibitor protein 1 Short name: KCIP-1 Cleaved into the following chain: |
Gene namesi | Name:YWHAB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000166913.12 |
HGNCi | HGNC:12849, YWHAB |
MIMi | 601289, gene |
neXtProti | NX_P31946 |
Subcellular locationi
Other locations
- Cytoplasm 1 Publication
- Melanosome 1 Publication
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Other locations
- Vacuole membrane 1 Publication
Note: (Microbial infection) Upon infection with Chlamydia trachomatis, this protein is associated with the pathogen-containing vacuole membrane where it colocalizes with IncG.1 Publication
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Mitochondrion
- mitochondrion Source: GOC
Nucleus
- nucleus Source: Ensembl
Other locations
- cytoplasm Source: UniProtKB
- focal adhesion Source: UniProtKB
- melanosome Source: UniProtKB-SubCell
- membrane Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB
- transcription repressor complex Source: Ensembl
- vacuolar membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, Membrane, VacuolePathology & Biotechi
Organism-specific databases
DisGeNETi | 7529 |
OpenTargetsi | ENSG00000166913 |
PharmGKBi | PA37438 |
Miscellaneous databases
Pharosi | P31946, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3710403 |
DrugBanki | DB09130, Copper DB12695, Phenethyl Isothiocyanate |
Polymorphism and mutation databases
BioMutai | YWHAB |
DMDMi | 1345590 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000367900 | 1 – 246 | 14-3-3 protein beta/alphaAdd BLAST | 246 | |
Initiator methioninei | Removed; alternateCombined sources2 Publications | |||
ChainiPRO_0000000003 | 2 – 246 | 14-3-3 protein beta/alpha, N-terminally processedAdd BLAST | 245 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionine; in 14-3-3 protein beta/alpha; alternateCombined sources1 Publication | 1 | ||
Modified residuei | 2 | N-acetylthreonine; in 14-3-3 protein beta/alpha, N-terminally processedCombined sources2 Publications | 1 | ||
Modified residuei | 2 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 5 | N6-acetyllysineBy similarity | 1 | ||
Modified residuei | 51 | N6-acetyllysine; alternateBy similarity | 1 | ||
Cross-linki | 51 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | |||
Modified residuei | 60 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 70 | N6-acetyllysineCombined sources | 1 | ||
Modified residuei | 84 | 3'-nitrotyrosineBy similarity | 1 | ||
Modified residuei | 106 | 3'-nitrotyrosineBy similarity | 1 | ||
Modified residuei | 117 | N6-acetyllysineCombined sources | 1 | ||
Modified residuei | 186 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 232 | PhosphoserineCombined sources | 1 | ||
Isoform Short (identifier: P31946-2) | |||||
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Nitration, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-142 |
EPDi | P31946 |
jPOSTi | P31946 |
MassIVEi | P31946 |
PaxDbi | P31946 |
PeptideAtlasi | P31946 |
PRIDEi | P31946 |
ProteomicsDBi | 54816 54817 [P31946-2] |
TopDownProteomicsi | P31946-1 [P31946-1] P31946-2 [P31946-2] |
2D gel databases
OGPi | P31946 |
REPRODUCTION-2DPAGEi | IPI00216318 |
PTM databases
iPTMneti | P31946 |
MetOSitei | P31946 |
PhosphoSitePlusi | P31946 |
SwissPalmi | P31946 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166913, Expressed in endothelial cell and 259 other tissues |
ExpressionAtlasi | P31946, baseline and differential |
Genevisiblei | P31946, HS |
Organism-specific databases
HPAi | ENSG00000166913, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer (PubMed:17717073).
Interacts with SAMSN1 and PRKCE (By similarity).
Interacts with AKAP13 (PubMed:21224381).
Interacts with SSH1 and TORC2/CRTC2 (PubMed:15454081, PubMed:15159416).
Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis (PubMed:15696159).
Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues (PubMed:17717073).
Interacts with GAB2 (PubMed:19172738).
Interacts with YAP1 (phosphorylated form) (PubMed:17974916).
Interacts with the phosphorylated (by AKT1) form of SRPK2 (PubMed:19592491).
Interacts with PKA-phosphorylated AANAT (PubMed:11427721).
Interacts with MYO1C (PubMed:24636949).
Interacts with SIRT2 (PubMed:18249187).
Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703).
Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552).
Interacts with the 'Ser-1134' and 'Ser-1161' phosphorylated form of SOS1 (PubMed:22827337).
Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a protein kinase AKT1-dependent manner (PubMed:15538381).
Interacts with SLITRK1 (PubMed:19640509).
Interacts with SYNPO2 (phosphorylated form); YWHAB competes with ACTN2 for interaction with SYNPO2 (By similarity).
Interacts with RIPOR2 (via phosphorylated form) isoform 2; this interaction occurs in a chemokine-dependent manner and does not compete for binding of RIPOR2 with RHOA nor blocks inhibition of RIPOR2-mediated RHOA activity (PubMed:25588844).
Interacts with MARK2 and MARK3 (PubMed:16959763).
By similarity19 Publications(Microbial infection) Interacts with herpes simplex virus 1 protein UL46.
1 Publication(Microbial infection) Probably interacts with Chlamydia trachomatis protein IncG.
1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 58 | Interaction with phosphoserine on interacting proteinBy similarity | 1 | |
Sitei | 129 | Interaction with phosphoserine on interacting proteinBy similarity | 1 |
Binary interactionsi
Hide detailsP31946
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- enzyme binding Source: BHF-UCL
- histone deacetylase binding Source: BHF-UCL
- identical protein binding Source: IntAct
- phosphoprotein binding Source: BHF-UCL
- phosphoserine residue binding Source: BHF-UCL
- protein C-terminus binding Source: Ensembl
- protein domain specific binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 113361, 430 interactors |
CORUMi | P31946 |
DIPi | DIP-743N |
ELMi | P31946 |
IntActi | P31946, 457 interactors |
MINTi | P31946 |
STRINGi | 9606.ENSP00000361930 |
Chemistry databases
BindingDBi | P31946 |
Miscellaneous databases
RNActi | P31946, protein |
Structurei
Secondary structure
3D structure databases
SASBDBi | P31946 |
SMRi | P31946 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P31946 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0841, Eukaryota |
GeneTreei | ENSGT01000000214500 |
HOGENOMi | CLU_058290_1_0_1 |
InParanoidi | P31946 |
OMAi | KGCQLAR |
PhylomeDBi | P31946 |
TreeFami | TF102003 |
Family and domain databases
Gene3Di | 1.20.190.20, 1 hit |
IDEALi | IID00038 |
InterProi | View protein in InterPro IPR000308, 14-3-3 IPR023409, 14-3-3_CS IPR036815, 14-3-3_dom_sf IPR023410, 14-3-3_domain |
PANTHERi | PTHR18860, PTHR18860, 1 hit |
Pfami | View protein in Pfam PF00244, 14-3-3, 1 hit |
PIRSFi | PIRSF000868, 14-3-3, 1 hit |
PRINTSi | PR00305, 1433ZETA |
SMARTi | View protein in SMART SM00101, 14_3_3, 1 hit |
SUPFAMi | SSF48445, SSF48445, 1 hit |
PROSITEi | View protein in PROSITE PS00796, 1433_1, 1 hit PS00797, 1433_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative initiation. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTMDKSELVQ KAKLAEQAER YDDMAAAMKA VTEQGHELSN EERNLLSVAY
60 70 80 90 100
KNVVGARRSS WRVISSIEQK TERNEKKQQM GKEYREKIEA ELQDICNDVL
110 120 130 140 150
ELLDKYLIPN ATQPESKVFY LKMKGDYFRY LSEVASGDNK QTTVSNSQQA
160 170 180 190 200
YQEAFEISKK EMQPTHPIRL GLALNFSVFY YEILNSPEKA CSLAKTAFDE
210 220 230 240
AIAELDTLNE ESYKDSTLIM QLLRDNLTLW TSENQGDEGD AGEGEN
The sequence of this isoform differs from the canonical sequence as follows:
1-2: Missing.
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ4VY19 | Q4VY19_HUMAN | 14-3-3 protein beta/alpha | YWHAB | 100 | Annotation score: | ||
A0A0J9YWE8 | A0A0J9YWE8_HUMAN | 14-3-3 protein beta/alpha | YWHAB | 149 | Annotation score: | ||
A0A0J9YWZ2 | A0A0J9YWZ2_HUMAN | 14-3-3 protein beta/alpha | YWHAB | 81 | Annotation score: | ||
Q4VY20 | Q4VY20_HUMAN | 14-3-3 protein beta/alpha | YWHAB | 74 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_064762 | 99 | V → I Found in a renal cell carcinoma sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018632 | 1 – 2 | Missing in isoform Short. Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X57346 mRNA Translation: CAA40621.1 AK292717 mRNA Translation: BAF85406.1 AL008725 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75893.1 CH471077 Genomic DNA Translation: EAW75894.1 CH471077 Genomic DNA Translation: EAW75896.1 BC001359 mRNA Translation: AAH01359.1 |
CCDSi | CCDS13339.1 [P31946-1] |
PIRi | S34755 |
RefSeqi | NP_003395.1, NM_003404.4 [P31946-1] NP_647539.1, NM_139323.3 [P31946-1] XP_016883528.1, XM_017028039.1 [P31946-1] |
Genome annotation databases
Ensembli | ENST00000353703; ENSP00000300161; ENSG00000166913 [P31946-1] ENST00000372839; ENSP00000361930; ENSG00000166913 [P31946-1] |
GeneIDi | 7529 |
KEGGi | hsa:7529 |
Keywords - Coding sequence diversityi
Alternative initiation, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X57346 mRNA Translation: CAA40621.1 AK292717 mRNA Translation: BAF85406.1 AL008725 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75893.1 CH471077 Genomic DNA Translation: EAW75894.1 CH471077 Genomic DNA Translation: EAW75896.1 BC001359 mRNA Translation: AAH01359.1 |
CCDSi | CCDS13339.1 [P31946-1] |
PIRi | S34755 |
RefSeqi | NP_003395.1, NM_003404.4 [P31946-1] NP_647539.1, NM_139323.3 [P31946-1] XP_016883528.1, XM_017028039.1 [P31946-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2BQ0 | X-ray | 2.50 | A/B | 2-239 | [»] | |
2C23 | X-ray | 2.65 | A | 2-239 | [»] | |
4DNK | X-ray | 2.20 | A/B | 1-246 | [»] | |
5N10 | X-ray | 1.60 | A/B | 1-246 | [»] | |
6A5Q | X-ray | 2.00 | A/B/C | 1-246 | [»] | |
6BYK | X-ray | 3.00 | A/B/C/D | 3-232 | [»] | |
6GN0 | X-ray | 3.24 | A/B/C/D | 1-239 | [»] | |
6GN8 | X-ray | 2.34 | A/B | 1-234 | [»] | |
6GNJ | X-ray | 3.24 | A/B | 1-234 | [»] | |
6GNK | X-ray | 2.55 | A/B | 1-234 | [»] | |
6GNN | X-ray | 3.79 | A | 1-239 | [»] | |
6HEP | X-ray | 1.86 | A/B/C/D | 1-232 | [»] | |
SASBDBi | P31946 | |||||
SMRi | P31946 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113361, 430 interactors |
CORUMi | P31946 |
DIPi | DIP-743N |
ELMi | P31946 |
IntActi | P31946, 457 interactors |
MINTi | P31946 |
STRINGi | 9606.ENSP00000361930 |
Chemistry databases
BindingDBi | P31946 |
ChEMBLi | CHEMBL3710403 |
DrugBanki | DB09130, Copper DB12695, Phenethyl Isothiocyanate |
PTM databases
iPTMneti | P31946 |
MetOSitei | P31946 |
PhosphoSitePlusi | P31946 |
SwissPalmi | P31946 |
Polymorphism and mutation databases
BioMutai | YWHAB |
DMDMi | 1345590 |
2D gel databases
OGPi | P31946 |
REPRODUCTION-2DPAGEi | IPI00216318 |
Proteomic databases
CPTACi | CPTAC-142 |
EPDi | P31946 |
jPOSTi | P31946 |
MassIVEi | P31946 |
PaxDbi | P31946 |
PeptideAtlasi | P31946 |
PRIDEi | P31946 |
ProteomicsDBi | 54816 54817 [P31946-2] |
TopDownProteomicsi | P31946-1 [P31946-1] P31946-2 [P31946-2] |
Protocols and materials databases
Antibodypediai | 1906, 692 antibodies |
CPTCi | P31946, 3 antibodies |
DNASUi | 7529 |
Genome annotation databases
Ensembli | ENST00000353703; ENSP00000300161; ENSG00000166913 [P31946-1] ENST00000372839; ENSP00000361930; ENSG00000166913 [P31946-1] |
GeneIDi | 7529 |
KEGGi | hsa:7529 |
Organism-specific databases
CTDi | 7529 |
DisGeNETi | 7529 |
EuPathDBi | HostDB:ENSG00000166913.12 |
GeneCardsi | YWHAB |
HGNCi | HGNC:12849, YWHAB |
HPAi | ENSG00000166913, Low tissue specificity |
MIMi | 601289, gene |
neXtProti | NX_P31946 |
OpenTargetsi | ENSG00000166913 |
PharmGKBi | PA37438 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0841, Eukaryota |
GeneTreei | ENSGT01000000214500 |
HOGENOMi | CLU_058290_1_0_1 |
InParanoidi | P31946 |
OMAi | KGCQLAR |
PhylomeDBi | P31946 |
TreeFami | TF102003 |
Enzyme and pathway databases
PathwayCommonsi | P31946 |
Reactomei | R-HSA-111447, Activation of BAD and translocation to mitochondria R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-165159, MTOR signalling R-HSA-166208, mTORC1-mediated signalling R-HSA-170968, Frs2-mediated activation R-HSA-170984, ARMS-mediated activation R-HSA-2028269, Signaling by Hippo R-HSA-392517, Rap1 signalling R-HSA-450385, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450513, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-5625740, RHO GTPases activate PKNs R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-5673000, RAF activation R-HSA-5674135, MAP2K and MAPK activation R-HSA-5675221, Negative regulation of MAPK pathway R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-9614399, Regulation of localization of FOXO transcription factors R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants R-HSA-9660537, Signaling by MRAS-complex mutants |
SignaLinki | P31946 |
SIGNORi | P31946 |
Miscellaneous databases
BioGRID-ORCSi | 7529, 11 hits in 845 CRISPR screens |
ChiTaRSi | YWHAB, human |
EvolutionaryTracei | P31946 |
GeneWikii | YWHAB |
GenomeRNAii | 7529 |
Pharosi | P31946, Tchem |
PROi | PR:P31946 |
RNActi | P31946, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166913, Expressed in endothelial cell and 259 other tissues |
ExpressionAtlasi | P31946, baseline and differential |
Genevisiblei | P31946, HS |
Family and domain databases
Gene3Di | 1.20.190.20, 1 hit |
IDEALi | IID00038 |
InterProi | View protein in InterPro IPR000308, 14-3-3 IPR023409, 14-3-3_CS IPR036815, 14-3-3_dom_sf IPR023410, 14-3-3_domain |
PANTHERi | PTHR18860, PTHR18860, 1 hit |
Pfami | View protein in Pfam PF00244, 14-3-3, 1 hit |
PIRSFi | PIRSF000868, 14-3-3, 1 hit |
PRINTSi | PR00305, 1433ZETA |
SMARTi | View protein in SMART SM00101, 14_3_3, 1 hit |
SUPFAMi | SSF48445, SSF48445, 1 hit |
PROSITEi | View protein in PROSITE PS00796, 1433_1, 1 hit PS00797, 1433_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 1433B_HUMAN | |
Accessioni | P31946Primary (citable) accession number: P31946 Secondary accession number(s): A8K9K2, E1P616 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 231 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - UniProtKB entry view manual
User manual for the UniProtKB entry view - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations