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Entry version 229 (12 Aug 2020)
Sequence version 3 (23 Jan 2007)
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Protein

14-3-3 protein beta/alpha

Gene

YWHAB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P31946

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-111447, Activation of BAD and translocation to mitochondria
R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-165159, mTOR signalling
R-HSA-166208, mTORC1-mediated signalling
R-HSA-170968, Frs2-mediated activation
R-HSA-170984, ARMS-mediated activation
R-HSA-2028269, Signaling by Hippo
R-HSA-392517, Rap1 signalling
R-HSA-450385, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-HSA-450513, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
R-HSA-5625740, RHO GTPases activate PKNs
R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-5673000, RAF activation
R-HSA-5674135, MAP2K and MAPK activation
R-HSA-5675221, Negative regulation of MAPK pathway
R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948, Signaling by high-kinase activity BRAF mutants
R-HSA-6802952, Signaling by BRAF and RAF fusions
R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-HSA-9614399, Regulation of localization of FOXO transcription factors
R-HSA-9649948, Signaling downstream of RAS mutants

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P31946

SIGNOR Signaling Network Open Resource

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SIGNORi
P31946

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
14-3-3 protein beta/alpha
Alternative name(s):
Protein 1054
Protein kinase C inhibitor protein 1
Short name:
KCIP-1
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:YWHAB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000166913.12

Human Gene Nomenclature Database

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HGNCi
HGNC:12849, YWHAB

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601289, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P31946

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Vacuole

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
7529

Open Targets

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OpenTargetsi
ENSG00000166913

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA37438

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P31946, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3710403

Drug and drug target database

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DrugBanki
DB09130, Copper
DB12695, Phenethyl Isothiocyanate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
YWHAB

Domain mapping of disease mutations (DMDM)

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DMDMi
1345590

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003679001 – 24614-3-3 protein beta/alphaAdd BLAST246
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternateCombined sources2 Publications
ChainiPRO_00000000032 – 24614-3-3 protein beta/alpha, N-terminally processedAdd BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionine; in 14-3-3 protein beta/alpha; alternateCombined sources1 Publication1
Modified residuei2N-acetylthreonine; in 14-3-3 protein beta/alpha, N-terminally processedCombined sources2 Publications1
Modified residuei2PhosphothreonineCombined sources1
Modified residuei5N6-acetyllysineBy similarity1
Modified residuei51N6-acetyllysine; alternateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki51Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei60PhosphoserineBy similarity1
Modified residuei70N6-acetyllysineCombined sources1
Modified residuei843'-nitrotyrosineBy similarity1
Modified residuei1063'-nitrotyrosineBy similarity1
Modified residuei117N6-acetyllysineCombined sources1
Modified residuei186PhosphoserineBy similarity1
Modified residuei232PhosphoserineCombined sources1
Isoform Short (identifier: P31946-2)
Modified residuei1N-acetylmethionineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Nitration, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-142

Encyclopedia of Proteome Dynamics

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EPDi
P31946

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P31946

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P31946

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P31946

PeptideAtlas

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PeptideAtlasi
P31946

PRoteomics IDEntifications database

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PRIDEi
P31946

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
54816
54817 [P31946-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P31946-1 [P31946-1]
P31946-2 [P31946-2]

2D gel databases

USC-OGP 2-DE database

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OGPi
P31946

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
IPI00216318

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P31946

MetOSite database of methionine sulfoxide sites

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MetOSitei
P31946

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P31946

SwissPalm database of S-palmitoylation events

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SwissPalmi
P31946

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000166913, Expressed in endothelial cell and 259 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P31946, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P31946, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000166913, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:17717073).

Interacts with SAMSN1 and PRKCE (By similarity).

Interacts with AKAP13 (PubMed:21224381).

Interacts with SSH1 and TORC2/CRTC2 (PubMed:15454081, PubMed:15159416).

Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis (PubMed:15696159).

Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues (PubMed:17717073).

Interacts with GAB2 (PubMed:19172738).

Interacts with YAP1 (phosphorylated form) (PubMed:17974916).

Interacts with the phosphorylated (by AKT1) form of SRPK2 (PubMed:19592491).

Interacts with PKA-phosphorylated AANAT (PubMed:11427721).

Interacts with MYO1C (PubMed:24636949).

Interacts with SIRT2 (PubMed:18249187).

Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703).

Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552).

Interacts with the 'Ser-1134' and 'Ser-1161' phosphorylated form of SOS1 (PubMed:22827337).

Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a protein kinase AKT1-dependent manner (PubMed:15538381).

Interacts with SLITRK1 (PubMed:19640509).

Interacts with SYNPO2 (phosphorylated form); YWHAB competes with ACTN2 for interaction with SYNPO2 (By similarity).

Interacts with RIPOR2 (via phosphorylated form) isoform 2; this interaction occurs in a chemokine-dependent manner and does not compete for binding of RIPOR2 with RHOA nor blocks inhibition of RIPOR2-mediated RHOA activity (PubMed:25588844).

Interacts with MARK2 and MARK3 (PubMed:16959763).

By similarity19 Publications

(Microbial infection) Interacts with herpes simplex virus 1 protein UL46.

1 Publication

(Microbial infection) Probably interacts with Chlamydia trachomatis protein IncG.

1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei58Interaction with phosphoserine on interacting proteinBy similarity1
Sitei129Interaction with phosphoserine on interacting proteinBy similarity1

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
P31946
With#Exp.IntAct
ADAM22 - isoform 3 [Q9P0K1-3]2EBI-359815,EBI-1567267
BAD [Q92934]4EBI-359815,EBI-700771
BRAF [P15056]5EBI-359815,EBI-365980
CBL [P22681]3EBI-359815,EBI-518228
CBX4 [O00257]2EBI-359815,EBI-722425
CDC25A [P30304]10EBI-359815,EBI-747671
CDC25B [P30305]5EBI-359815,EBI-1051746
CDC25C [P30307]4EBI-359815,EBI-974439
CDK14 [O94921]5EBI-359815,EBI-1043945
DACT1 [Q9NYF0]4EBI-359815,EBI-3951744
DYRK1A - isoform 1 [Q13627-2]3EBI-359815,EBI-1053621
GAB2 [Q9UQC2]4EBI-359815,EBI-975200
GEM [P55040]4EBI-359815,EBI-744104
HDAC4 [P56524]3EBI-359815,EBI-308629
LRRK2 [Q5S007]5EBI-359815,EBI-5323863
MAP3K3 [Q99759]2EBI-359815,EBI-307281
MAP3K5 [Q99683]3EBI-359815,EBI-476263
MARK2 [Q7KZI7]3EBI-359815,EBI-516560
MARK3 [P27448]4EBI-359815,EBI-707595
PTPN3 [P26045]4EBI-359815,EBI-1047946
RAF1 [P04049]20EBI-359815,EBI-365996
RMDN3 [Q96TC7]5EBI-359815,EBI-1056589
RND3 [P61587]2EBI-359815,EBI-1111534
SRPK2 [P78362]2EBI-359815,EBI-593303
SSH1 [Q8WYL5]3EBI-359815,EBI-1222387
TSC2 [P49815]4EBI-359815,EBI-396587
YAP1 [P46937]6EBI-359815,EBI-1044059
itself3EBI-359815,EBI-359815
YWHAE [P62258]6EBI-359815,EBI-356498
YWHAG [P61981]3EBI-359815,EBI-359832
YWHAQ [P27348]3EBI-359815,EBI-359854
CSNK1A1 [P67828] from Oryctolagus cuniculus.3EBI-359815,EBI-7540603
Gem [P55041] from Mus musculus.3EBI-359815,EBI-7082069
let-756 [Q11184] from Caenorhabditis elegans.2EBI-359815,EBI-3843983
Rnd3 [P61588] from Mus musculus.5EBI-359815,EBI-6930266
Synpo2 [Q91YE8] from Mus musculus.3EBI-359815,EBI-7623057
tir [B7UM99] from Escherichia coli O127:H6 (strain E2348/69 / EPEC).2EBI-359815,EBI-2504426
Zfp36 [P22893] from Mus musculus.5EBI-359815,EBI-647803
Q76353 from Human immunodeficiency virus 1.3EBI-359815,EBI-6248077

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
113361, 425 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P31946

Database of interacting proteins

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DIPi
DIP-743N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P31946

Protein interaction database and analysis system

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IntActi
P31946, 457 interactors

Molecular INTeraction database

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MINTi
P31946

STRING: functional protein association networks

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STRINGi
9606.ENSP00000361930

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P31946

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P31946, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1246
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P31946

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P31946

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0841, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT01000000214500

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_058290_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P31946

KEGG Orthology (KO)

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KOi
K16197

Identification of Orthologs from Complete Genome Data

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OMAi
KGCQLAR

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P31946

TreeFam database of animal gene trees

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TreeFami
TF102003

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.190.20, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

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IDEALi
IID00038

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000308, 14-3-3
IPR023409, 14-3-3_CS
IPR036815, 14-3-3_dom_sf
IPR023410, 14-3-3_domain

The PANTHER Classification System

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PANTHERi
PTHR18860, PTHR18860, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00244, 14-3-3, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF000868, 14-3-3, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00305, 1433ZETA

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00101, 14_3_3, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48445, SSF48445, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00796, 1433_1, 1 hit
PS00797, 1433_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative initiation. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: P31946-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTMDKSELVQ KAKLAEQAER YDDMAAAMKA VTEQGHELSN EERNLLSVAY
60 70 80 90 100
KNVVGARRSS WRVISSIEQK TERNEKKQQM GKEYREKIEA ELQDICNDVL
110 120 130 140 150
ELLDKYLIPN ATQPESKVFY LKMKGDYFRY LSEVASGDNK QTTVSNSQQA
160 170 180 190 200
YQEAFEISKK EMQPTHPIRL GLALNFSVFY YEILNSPEKA CSLAKTAFDE
210 220 230 240
AIAELDTLNE ESYKDSTLIM QLLRDNLTLW TSENQGDEGD AGEGEN
Length:246
Mass (Da):28,082
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6BE1A9BF97468017
GO
Isoform Short (identifier: P31946-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: Missing.

Show »
Length:244
Mass (Da):27,850
Checksum:iCE0A59BF8C33FE2F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q4VY19Q4VY19_HUMAN
14-3-3 protein beta/alpha
YWHAB
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YWE8A0A0J9YWE8_HUMAN
14-3-3 protein beta/alpha
YWHAB
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YWZ2A0A0J9YWZ2_HUMAN
14-3-3 protein beta/alpha
YWHAB
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q4VY20Q4VY20_HUMAN
14-3-3 protein beta/alpha
YWHAB
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06476299V → I Found in a renal cell carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0186321 – 2Missing in isoform Short. Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X57346 mRNA Translation: CAA40621.1
AK292717 mRNA Translation: BAF85406.1
AL008725 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75893.1
CH471077 Genomic DNA Translation: EAW75894.1
CH471077 Genomic DNA Translation: EAW75896.1
BC001359 mRNA Translation: AAH01359.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13339.1 [P31946-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
S34755

NCBI Reference Sequences

More...
RefSeqi
NP_003395.1, NM_003404.4 [P31946-1]
NP_647539.1, NM_139323.3 [P31946-1]
XP_016883528.1, XM_017028039.1 [P31946-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000353703; ENSP00000300161; ENSG00000166913 [P31946-1]
ENST00000372839; ENSP00000361930; ENSG00000166913 [P31946-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7529

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7529

Keywords - Coding sequence diversityi

Alternative initiation, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57346 mRNA Translation: CAA40621.1
AK292717 mRNA Translation: BAF85406.1
AL008725 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75893.1
CH471077 Genomic DNA Translation: EAW75894.1
CH471077 Genomic DNA Translation: EAW75896.1
BC001359 mRNA Translation: AAH01359.1
CCDSiCCDS13339.1 [P31946-1]
PIRiS34755
RefSeqiNP_003395.1, NM_003404.4 [P31946-1]
NP_647539.1, NM_139323.3 [P31946-1]
XP_016883528.1, XM_017028039.1 [P31946-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BQ0X-ray2.50A/B2-239[»]
2C23X-ray2.65A2-239[»]
4DNKX-ray2.20A/B1-246[»]
5N10X-ray1.60A/B1-246[»]
6A5QX-ray2.00A/B/C1-246[»]
6BYKX-ray3.00A/B/C/D3-232[»]
6GN0X-ray3.24A/B/C/D1-239[»]
6GN8X-ray2.34A/B1-234[»]
6GNJX-ray3.24A/B1-234[»]
6GNKX-ray2.55A/B1-234[»]
6GNNX-ray3.79A1-239[»]
6HEPX-ray1.86A/B/C/D1-232[»]
SMRiP31946
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113361, 425 interactors
CORUMiP31946
DIPiDIP-743N
ELMiP31946
IntActiP31946, 457 interactors
MINTiP31946
STRINGi9606.ENSP00000361930

Chemistry databases

BindingDBiP31946
ChEMBLiCHEMBL3710403
DrugBankiDB09130, Copper
DB12695, Phenethyl Isothiocyanate

PTM databases

iPTMnetiP31946
MetOSiteiP31946
PhosphoSitePlusiP31946
SwissPalmiP31946

Polymorphism and mutation databases

BioMutaiYWHAB
DMDMi1345590

2D gel databases

OGPiP31946
REPRODUCTION-2DPAGEiIPI00216318

Proteomic databases

CPTACiCPTAC-142
EPDiP31946
jPOSTiP31946
MassIVEiP31946
PaxDbiP31946
PeptideAtlasiP31946
PRIDEiP31946
ProteomicsDBi54816
54817 [P31946-2]
TopDownProteomicsiP31946-1 [P31946-1]
P31946-2 [P31946-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1906, 692 antibodies

The DNASU plasmid repository

More...
DNASUi
7529

Genome annotation databases

EnsembliENST00000353703; ENSP00000300161; ENSG00000166913 [P31946-1]
ENST00000372839; ENSP00000361930; ENSG00000166913 [P31946-1]
GeneIDi7529
KEGGihsa:7529

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7529
DisGeNETi7529
EuPathDBiHostDB:ENSG00000166913.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
YWHAB
HGNCiHGNC:12849, YWHAB
HPAiENSG00000166913, Low tissue specificity
MIMi601289, gene
neXtProtiNX_P31946
OpenTargetsiENSG00000166913
PharmGKBiPA37438

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0841, Eukaryota
GeneTreeiENSGT01000000214500
HOGENOMiCLU_058290_1_0_1
InParanoidiP31946
KOiK16197
OMAiKGCQLAR
PhylomeDBiP31946
TreeFamiTF102003

Enzyme and pathway databases

PathwayCommonsiP31946
ReactomeiR-HSA-111447, Activation of BAD and translocation to mitochondria
R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-165159, mTOR signalling
R-HSA-166208, mTORC1-mediated signalling
R-HSA-170968, Frs2-mediated activation
R-HSA-170984, ARMS-mediated activation
R-HSA-2028269, Signaling by Hippo
R-HSA-392517, Rap1 signalling
R-HSA-450385, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-HSA-450513, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
R-HSA-5625740, RHO GTPases activate PKNs
R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-5673000, RAF activation
R-HSA-5674135, MAP2K and MAPK activation
R-HSA-5675221, Negative regulation of MAPK pathway
R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948, Signaling by high-kinase activity BRAF mutants
R-HSA-6802952, Signaling by BRAF and RAF fusions
R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-HSA-9614399, Regulation of localization of FOXO transcription factors
R-HSA-9649948, Signaling downstream of RAS mutants
SignaLinkiP31946
SIGNORiP31946

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
7529, 12 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
YWHAB, human
EvolutionaryTraceiP31946

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
YWHAB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7529
PharosiP31946, Tchem

Protein Ontology

More...
PROi
PR:P31946
RNActiP31946, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166913, Expressed in endothelial cell and 259 other tissues
ExpressionAtlasiP31946, baseline and differential
GenevisibleiP31946, HS

Family and domain databases

Gene3Di1.20.190.20, 1 hit
IDEALiIID00038
InterProiView protein in InterPro
IPR000308, 14-3-3
IPR023409, 14-3-3_CS
IPR036815, 14-3-3_dom_sf
IPR023410, 14-3-3_domain
PANTHERiPTHR18860, PTHR18860, 1 hit
PfamiView protein in Pfam
PF00244, 14-3-3, 1 hit
PIRSFiPIRSF000868, 14-3-3, 1 hit
PRINTSiPR00305, 1433ZETA
SMARTiView protein in SMART
SM00101, 14_3_3, 1 hit
SUPFAMiSSF48445, SSF48445, 1 hit
PROSITEiView protein in PROSITE
PS00796, 1433_1, 1 hit
PS00797, 1433_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei1433B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31946
Secondary accession number(s): A8K9K2, E1P616
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: August 12, 2020
This is version 229 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. UniProtKB entry view manual
    User manual for the UniProtKB entry view
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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