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UniProtKB - P31943 (HNRH1_HUMAN)

Entry version 221 (02 Jun 2021)
Sequence version 4 (23 Jan 2007)
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Protein

Heterogeneous nuclear ribonucleoprotein H

Gene

HNRNPH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P31943

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6803529, FGFR2 alternative splicing
R-HSA-72163, mRNA Splicing - Major Pathway
R-HSA-72203, Processing of Capped Intron-Containing Pre-mRNA

SIGNOR Signaling Network Open Resource

More...SIGNORi		P31943

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein H
Short name:
hnRNP H
Cleaved into the following chain:
Heterogeneous nuclear ribonucleoprotein H, N-terminally processed
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HNRNPH1
Synonyms:HNRPH, HNRPH1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5041, HNRNPH1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601035, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P31943

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000169045.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3187

MalaCards human disease database

More...MalaCardsi		HNRNPH1

Open Targets

More...OpenTargetsi		ENSG00000169045

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		99861, Precursor T-cell acute lymphoblastic leukemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162391284

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P31943, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3797013

Drug and drug target database

More...DrugBanki		DB09130, Copper

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HNRNPH1

Domain mapping of disease mutations (DMDM)

More...DMDMi		1710632

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003671191 – 449Heterogeneous nuclear ribonucleoprotein HAdd BLAST449
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternateCombined sources2 Publications
ChainiPRO_00000818572 – 449Heterogeneous nuclear ribonucleoprotein H, N-terminally processedAdd BLAST448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H; alternateCombined sources1 Publication1
Modified residuei2N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H, N-terminally processedCombined sources1 Publication1
Modified residuei23PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki35Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei54PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Cross-linki87Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki98Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei233Dimethylated arginine; alternate1 Publication1
Modified residuei233Omega-N-methylarginine; alternateCombined sources1 Publication1
Modified residuei246PhosphotyrosineCombined sources1
Modified residuei310PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P31943

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P31943

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P31943

MaxQB - The MaxQuant DataBase

More...MaxQBi		P31943

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P31943

PeptideAtlas

More...PeptideAtlasi		P31943

PRoteomics IDEntifications database

More...PRIDEi		P31943

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54814

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00013881
P31943

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P31943

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P31943

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P31943

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P31943

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed ubiquitously.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in myotonic dystrophy pathophysiology (DM).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000169045, Expressed in left lobe of thyroid gland and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P31943, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P31943, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000169045, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRNPH1. Identified in the spliceosome C complex.

Interacts with IGF2BP1.

Interacts with CUGBP1; the interaction is RNA-dependent.

Interacts with MBNL1; the interaction in RNA-independent.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
P31943
With#Exp.IntAct
ARHGEF16 [Q5VV41]3EBI-351590,EBI-1057448
CATSPER1 [Q8NEC5]3EBI-351590,EBI-744545
CCDC120 [Q96HB5]3EBI-351590,EBI-744556
CCNK - isoform 2 [O75909-2]3EBI-351590,EBI-12010594
DDX17 [Q92841]3EBI-351590,EBI-746012
DZIP3 [Q86Y13]3EBI-351590,EBI-948630
ENKD1 [Q9H0I2]3EBI-351590,EBI-744099
GPANK1 [O95872]3EBI-351590,EBI-751540
GPS2 [Q13227]3EBI-351590,EBI-713355
HNRNPF [P52597]3EBI-351590,EBI-352986
itself3EBI-351590,EBI-351590
HNRNPM [P52272]3EBI-351590,EBI-486809
KRTAP13-2 [Q52LG2]3EBI-351590,EBI-11953846
LMO1 [P25800]3EBI-351590,EBI-8639312
LMO3 - isoform 4 [Q8TAP4-4]3EBI-351590,EBI-11742507
LNX1 [Q8TBB1]3EBI-351590,EBI-739832
MAGED1 [Q9Y5V3]3EBI-351590,EBI-716006
MBNL1 [Q9NR56]2EBI-351590,EBI-2805004
MRPL53 [Q96EL3]3EBI-351590,EBI-2513715
MSI2 [Q96DH6]3EBI-351590,EBI-2462339
MYPOP [Q86VE0]3EBI-351590,EBI-2858213
NFKBID [Q8NI38]3EBI-351590,EBI-10271199
NUDT16L1 [Q9BRJ7]3EBI-351590,EBI-2949792
OXER1 [Q8TDS5]3EBI-351590,EBI-12813389
PATZ1 - isoform 4 [Q9HBE1-4]6EBI-351590,EBI-11022007
PEX5 - isoform 3 [P50542-3]3EBI-351590,EBI-12181987
POLR1C [O15160]4EBI-351590,EBI-1055079
PPP1R32 - isoform 2 [Q7Z5V6-2]3EBI-351590,EBI-12000762
RAMAC [Q9BTL3]3EBI-351590,EBI-744023
RBFOX2 - isoform 10 [O43251-10]3EBI-351590,EBI-11963050
RBM38 [Q9H0Z9]3EBI-351590,EBI-2840723
RNF4 [P78317]3EBI-351590,EBI-2340927
SNRPB - isoform SM-B [P14678-2]3EBI-351590,EBI-372475
SNRPC [P09234]3EBI-351590,EBI-766589
SPG21 [Q9NZD8]3EBI-351590,EBI-742688
TARDBP [Q13148]6EBI-351590,EBI-372899
TEKT3 [Q9BXF9]3EBI-351590,EBI-8644516
TEKT4 [Q8WW24]3EBI-351590,EBI-750487
UBE2I [Q7KZS0]3EBI-351590,EBI-10180829

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109428, 1384 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P31943

Protein interaction database and analysis system

More...IntActi		P31943, 141 interactors

Molecular INTeraction database

More...MINTi		P31943

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000349168

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P31943, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1449
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P31943

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 90RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini111 – 188RRM 2PROSITE-ProRule annotationAdd BLAST78
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati234 – 2491-1Add BLAST16
Domaini289 – 364RRM 3PROSITE-ProRule annotationAdd BLAST76
Repeati354 – 3722-1Add BLAST19
Repeati374 – 3922-2Add BLAST19
Repeati418 – 4331-2Add BLAST16

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni234 – 4332 X 16 AA Gly-rich approximate repeatsAdd BLAST200
Regioni354 – 3922 X 19 AA perfect repeatsAdd BLAST39

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each quasi-RRM repeat bound poly(RG), while only the N-terminal QRRM bound poly(RC) and poly(RU). None of the repeats bound detectable amounts of poly(RA).

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4211, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153503

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_032003_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P31943

Identification of Orthologs from Complete Genome Data

More...OMAi		VEYYTIH

Database of Orthologous Groups

More...OrthoDBi		603679at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P31943

TreeFam database of animal gene trees

More...TreeFami		TF316157

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR012996, Znf_CHHC

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00076, RRM_1, 3 hits
PF08080, zf-RNPHF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360, RRM, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102, RRM, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 25 potential isoforms that are computationally mapped.Show allAlign All

P31943-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMLGTEGGEG FVVKVRGLPW SCSADEVQRF FSDCKIQNGA QGIRFIYTRE 
        60         70         80         90        100
GRPSGEAFVE LESEDEVKLA LKKDRETMGH RYVEVFKSNN VEMDWVLKHT 
       110        120        130        140        150
GPNSPDTAND GFVRLRGLPF GCSKEEIVQF FSGLEIVPNG ITLPVDFQGR 
       160        170        180        190        200
STGEAFVQFA SQEIAEKALK KHKERIGHRY IEIFKSSRAE VRTHYDPPRK 
       210        220        230        240        250
LMAMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY GGYDDYNGYN 
       260        270        280        290        300
DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG STFQSTTGHC VHMRGLPYRA 
       310        320        330        340        350
TENDIYNFFS PLNPVRVHIE IGPDGRVTGE ADVEFATHED AVAAMSKDKA 
       360        370        380        390        400
NMQHRYVELF LNSTAGASGG AYEHRYVELF LNSTAGASGG AYGSQMMGGM 
       410        420        430        440 
GLSNQSSYGG PASQQLSGGY GGGYGGQSSM SGYDQVLQEN SSDFQSNIA
Length:449
Mass (Da):49,229
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4ECF7A075C2526FF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 25 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G8JLB6G8JLB6_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPH1
472Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PCY7E9PCY7_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPH1
429Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBM0D6RBM0_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPH1
212Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RFM3D6RFM3_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPH1
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RIU0D6RIU0_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPH1
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBK1H0YBK1_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPH1
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBG7H0YBG7_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPH1
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBD7H0YBD7_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPH1
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RIT2D6RIT2_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPH1
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YB39H0YB39_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPH1
277Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti188R → G in CAG33059 (Ref. 2) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L22009 mRNA Translation: AAA91346.1
CR456778 mRNA Translation: CAG33059.1
AK124530 mRNA Translation: BAG54048.1
CH471165 Genomic DNA Translation: EAW53807.1
CH471165 Genomic DNA Translation: EAW53808.1
BC001348 mRNA Translation: AAH01348.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4446.1

Protein sequence database of the Protein Information Resource

More...PIRi		I39358

NCBI Reference Sequences

More...RefSeqi		NP_001244222.1, NM_001257293.1
NP_005511.1, NM_005520.2
XP_016864904.1, XM_017009415.1
XP_016864905.1, XM_017009416.1
XP_016864906.1, XM_017009417.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000356731; ENSP00000349168; ENSG00000169045
ENST00000393432; ENSP00000377082; ENSG00000169045
ENST00000442819; ENSP00000397797; ENSG00000169045
ENST00000638505; ENSP00000492076; ENSG00000284254
ENST00000643310; ENSP00000495786; ENSG00000284254

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3187

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3187

UCSC genome browser

More...UCSCi		uc003mke.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22009 mRNA Translation: AAA91346.1
CR456778 mRNA Translation: CAG33059.1
AK124530 mRNA Translation: BAG54048.1
CH471165 Genomic DNA Translation: EAW53807.1
CH471165 Genomic DNA Translation: EAW53808.1
BC001348 mRNA Translation: AAH01348.1
CCDSiCCDS4446.1
PIRiI39358
RefSeqiNP_001244222.1, NM_001257293.1
NP_005511.1, NM_005520.2
XP_016864904.1, XM_017009415.1
XP_016864905.1, XM_017009416.1
XP_016864906.1, XM_017009417.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LXUNMR-A7-111[»]
6DHSX-ray3.50A/B/C/D10-194[»]
SMRiP31943
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109428, 1384 interactors
CORUMiP31943
IntActiP31943, 141 interactors
MINTiP31943
STRINGi9606.ENSP00000349168

Chemistry databases

ChEMBLiCHEMBL3797013
DrugBankiDB09130, Copper

PTM databases

iPTMnetiP31943
MetOSiteiP31943
PhosphoSitePlusiP31943
SwissPalmiP31943

Genetic variation databases

BioMutaiHNRNPH1
DMDMi1710632

2D gel databases

REPRODUCTION-2DPAGEiIPI00013881
P31943

Proteomic databases

EPDiP31943
jPOSTiP31943
MassIVEiP31943
MaxQBiP31943
PaxDbiP31943
PeptideAtlasiP31943
PRIDEiP31943
ProteomicsDBi54814

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17692, 297 antibodies

The DNASU plasmid repository

More...DNASUi		3187

Genome annotation databases

EnsembliENST00000356731; ENSP00000349168; ENSG00000169045
ENST00000393432; ENSP00000377082; ENSG00000169045
ENST00000442819; ENSP00000397797; ENSG00000169045
ENST00000638505; ENSP00000492076; ENSG00000284254
ENST00000643310; ENSP00000495786; ENSG00000284254
GeneIDi3187
KEGGihsa:3187
UCSCiuc003mke.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3187
DisGeNETi3187

GeneCards: human genes, protein and diseases

More...GeneCardsi		HNRNPH1
HGNCiHGNC:5041, HNRNPH1
HPAiENSG00000169045, Low tissue specificity
MalaCardsiHNRNPH1
MIMi601035, gene
neXtProtiNX_P31943
OpenTargetsiENSG00000169045
Orphaneti99861, Precursor T-cell acute lymphoblastic leukemia
PharmGKBiPA162391284
VEuPathDBiHostDB:ENSG00000169045.17

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4211, Eukaryota
GeneTreeiENSGT00940000153503
HOGENOMiCLU_032003_1_0_1
InParanoidiP31943
OMAiVEYYTIH
OrthoDBi603679at2759
PhylomeDBiP31943
TreeFamiTF316157

Enzyme and pathway databases

PathwayCommonsiP31943
ReactomeiR-HSA-6803529, FGFR2 alternative splicing
R-HSA-72163, mRNA Splicing - Major Pathway
R-HSA-72203, Processing of Capped Intron-Containing Pre-mRNA
SIGNORiP31943

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3187, 660 hits in 1010 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HNRNPH1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HNRPH1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3187
PharosiP31943, Tbio

Protein Ontology

More...PROi		PR:P31943
RNActiP31943, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000169045, Expressed in left lobe of thyroid gland and 250 other tissues
ExpressionAtlasiP31943, baseline and differential
GenevisibleiP31943, HS

Family and domain databases

Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR012996, Znf_CHHC
PfamiView protein in Pfam
PF00076, RRM_1, 3 hits
PF08080, zf-RNPHF, 1 hit
SMARTiView protein in SMART
SM00360, RRM, 3 hits
SUPFAMiSSF54928, SSF54928, 3 hits
PROSITEiView protein in PROSITE
PS50102, RRM, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHNRH1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31943
Secondary accession number(s): B3KW86, D3DWQ2, Q6IBM4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: June 2, 2021
This is version 221 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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