UniProtKB - P31943 (HNRH1_HUMAN)
Protein
Heterogeneous nuclear ribonucleoprotein H
Gene
HNRNPH1
Organism
Homo sapiens (Human)
Status
Functioni
This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).2 Publications
GO - Molecular functioni
- identical protein binding Source: IntAct
- poly(U) RNA binding Source: ProtInc
- RNA binding Source: UniProtKB
GO - Biological processi
- fibroblast growth factor receptor signaling pathway Source: Reactome
- mRNA splicing, via spliceosome Source: Reactome
- regulation of RNA splicing Source: UniProtKB
- RNA metabolic process Source: Reactome
- RNA processing Source: ProtInc
Keywordsi
Molecular function | Ribonucleoprotein, RNA-binding |
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
PathwayCommonsi | P31943 |
Reactomei | R-HSA-6803529, FGFR2 alternative splicing R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72203, Processing of Capped Intron-Containing Pre-mRNA |
SIGNORi | P31943 |
Names & Taxonomyi
Protein namesi | Recommended name: Heterogeneous nuclear ribonucleoprotein HShort name: hnRNP H Cleaved into the following chain: |
Gene namesi | Name:HNRNPH1 Synonyms:HNRPH, HNRPH1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000169045.17 |
HGNCi | HGNC:5041, HNRNPH1 |
MIMi | 601035, gene |
neXtProti | NX_P31943 |
Subcellular locationi
Nucleus
Cytosol
- cytosol Source: HPA
Nucleus
- catalytic step 2 spliceosome Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- membrane Source: UniProtKB
- ribonucleoprotein complex Source: GO_Central
Keywords - Cellular componenti
Nucleus, SpliceosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 3187 |
MalaCardsi | HNRNPH1 |
OpenTargetsi | ENSG00000169045 |
Orphaneti | 99861, Precursor T-cell acute lymphoblastic leukemia |
PharmGKBi | PA162391284 |
Miscellaneous databases
Pharosi | P31943, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3797013 |
DrugBanki | DB09130, Copper |
Polymorphism and mutation databases
BioMutai | HNRNPH1 |
DMDMi | 1710632 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000367119 | 1 – 449 | Heterogeneous nuclear ribonucleoprotein HAdd BLAST | 449 | |
Initiator methioninei | Removed; alternateCombined sources2 Publications | |||
ChainiPRO_0000081857 | 2 – 449 | Heterogeneous nuclear ribonucleoprotein H, N-terminally processedAdd BLAST | 448 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H; alternateCombined sources1 Publication | 1 | |
Modified residuei | 2 | N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H, N-terminally processedCombined sources1 Publication | 1 | |
Modified residuei | 23 | PhosphoserineCombined sources | 1 | |
Cross-linki | 35 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 54 | PhosphoserineCombined sources | 1 | |
Modified residuei | 63 | PhosphoserineCombined sources | 1 | |
Cross-linki | 87 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 98 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 233 | Dimethylated arginine; alternate1 Publication | 1 | |
Modified residuei | 233 | Omega-N-methylarginine; alternateCombined sources1 Publication | 1 | |
Modified residuei | 246 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 310 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P31943 |
jPOSTi | P31943 |
MassIVEi | P31943 |
MaxQBi | P31943 |
PaxDbi | P31943 |
PeptideAtlasi | P31943 |
PRIDEi | P31943 |
ProteomicsDBi | 54814 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00013881 P31943 |
PTM databases
iPTMneti | P31943 |
MetOSitei | P31943 |
PhosphoSitePlusi | P31943 |
SwissPalmi | P31943 |
Expressioni
Tissue specificityi
Expressed ubiquitously.
Inductioni
Up-regulated in myotonic dystrophy pathophysiology (DM).1 Publication
Gene expression databases
Bgeei | ENSG00000169045, Expressed in left lobe of thyroid gland and 249 other tissues |
ExpressionAtlasi | P31943, baseline and differential |
Genevisiblei | P31943, HS |
Organism-specific databases
HPAi | ENSG00000169045, Low tissue specificity |
Interactioni
Subunit structurei
Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRNPH1. Identified in the spliceosome C complex.
Interacts with IGF2BP1.
Interacts with CUGBP1; the interaction is RNA-dependent.
Interacts with MBNL1; the interaction in RNA-independent.
4 PublicationsBinary interactionsi
Hide detailsP31943
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 109428, 379 interactors |
CORUMi | P31943 |
IntActi | P31943, 135 interactors |
MINTi | P31943 |
STRINGi | 9606.ENSP00000349168 |
Miscellaneous databases
RNActi | P31943, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P31943 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 90 | RRM 1PROSITE-ProRule annotationAdd BLAST | 80 | |
Domaini | 111 – 188 | RRM 2PROSITE-ProRule annotationAdd BLAST | 78 | |
Repeati | 234 – 249 | 1-1Add BLAST | 16 | |
Domaini | 289 – 364 | RRM 3PROSITE-ProRule annotationAdd BLAST | 76 | |
Repeati | 354 – 372 | 2-1Add BLAST | 19 | |
Repeati | 374 – 392 | 2-2Add BLAST | 19 | |
Repeati | 418 – 433 | 1-2Add BLAST | 16 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 234 – 433 | 2 X 16 AA Gly-rich approximate repeatsAdd BLAST | 200 | |
Regioni | 354 – 392 | 2 X 19 AA perfect repeatsAdd BLAST | 39 |
Domaini
Each quasi-RRM repeat bound poly(RG), while only the N-terminal QRRM bound poly(RC) and poly(RU). None of the repeats bound detectable amounts of poly(RA).
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4211, Eukaryota |
GeneTreei | ENSGT00940000153503 |
HOGENOMi | CLU_032003_1_0_1 |
InParanoidi | P31943 |
OrthoDBi | 603679at2759 |
PhylomeDBi | P31943 |
TreeFami | TF316157 |
Family and domain databases
Gene3Di | 3.30.70.330, 3 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR012996, Znf_CHHC |
Pfami | View protein in Pfam PF00076, RRM_1, 3 hits PF08080, zf-RNPHF, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 3 hits |
SUPFAMi | SSF54928, SSF54928, 3 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 25 potential isoforms that are computationally mapped.Show allAlign All
P31943-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMLGTEGGEG FVVKVRGLPW SCSADEVQRF FSDCKIQNGA QGIRFIYTRE
60 70 80 90 100
GRPSGEAFVE LESEDEVKLA LKKDRETMGH RYVEVFKSNN VEMDWVLKHT
110 120 130 140 150
GPNSPDTAND GFVRLRGLPF GCSKEEIVQF FSGLEIVPNG ITLPVDFQGR
160 170 180 190 200
STGEAFVQFA SQEIAEKALK KHKERIGHRY IEIFKSSRAE VRTHYDPPRK
210 220 230 240 250
LMAMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY GGYDDYNGYN
260 270 280 290 300
DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG STFQSTTGHC VHMRGLPYRA
310 320 330 340 350
TENDIYNFFS PLNPVRVHIE IGPDGRVTGE ADVEFATHED AVAAMSKDKA
360 370 380 390 400
NMQHRYVELF LNSTAGASGG AYEHRYVELF LNSTAGASGG AYGSQMMGGM
410 420 430 440
GLSNQSSYGG PASQQLSGGY GGGYGGQSSM SGYDQVLQEN SSDFQSNIA
Computationally mapped potential isoform sequencesi
There are 25 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG8JLB6 | G8JLB6_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPH1 | 472 | Annotation score: | ||
E9PCY7 | E9PCY7_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPH1 | 429 | Annotation score: | ||
D6RBM0 | D6RBM0_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPH1 | 212 | Annotation score: | ||
D6RFM3 | D6RFM3_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPH1 | 163 | Annotation score: | ||
D6RIU0 | D6RIU0_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPH1 | 168 | Annotation score: | ||
H0YBK1 | H0YBK1_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPH1 | 117 | Annotation score: | ||
H0YBG7 | H0YBG7_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPH1 | 185 | Annotation score: | ||
H0YBD7 | H0YBD7_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPH1 | 194 | Annotation score: | ||
D6RIT2 | D6RIT2_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPH1 | 164 | Annotation score: | ||
H0YB39 | H0YB39_HUMAN | Heterogeneous nuclear ribonucleopro... | HNRNPH1 | 277 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 188 | R → G in CAG33059 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L22009 mRNA Translation: AAA91346.1 CR456778 mRNA Translation: CAG33059.1 AK124530 mRNA Translation: BAG54048.1 CH471165 Genomic DNA Translation: EAW53807.1 CH471165 Genomic DNA Translation: EAW53808.1 BC001348 mRNA Translation: AAH01348.1 |
CCDSi | CCDS4446.1 |
PIRi | I39358 |
RefSeqi | NP_001244222.1, NM_001257293.1 NP_005511.1, NM_005520.2 XP_016864904.1, XM_017009415.1 XP_016864905.1, XM_017009416.1 XP_016864906.1, XM_017009417.1 |
Genome annotation databases
Ensembli | ENST00000356731; ENSP00000349168; ENSG00000169045 ENST00000393432; ENSP00000377082; ENSG00000169045 ENST00000442819; ENSP00000397797; ENSG00000169045 ENST00000638505; ENSP00000492076; ENSG00000284254 ENST00000643310; ENSP00000495786; ENSG00000284254 |
GeneIDi | 3187 |
KEGGi | hsa:3187 |
UCSCi | uc003mke.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L22009 mRNA Translation: AAA91346.1 CR456778 mRNA Translation: CAG33059.1 AK124530 mRNA Translation: BAG54048.1 CH471165 Genomic DNA Translation: EAW53807.1 CH471165 Genomic DNA Translation: EAW53808.1 BC001348 mRNA Translation: AAH01348.1 |
CCDSi | CCDS4446.1 |
PIRi | I39358 |
RefSeqi | NP_001244222.1, NM_001257293.1 NP_005511.1, NM_005520.2 XP_016864904.1, XM_017009415.1 XP_016864905.1, XM_017009416.1 XP_016864906.1, XM_017009417.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2LXU | NMR | - | A | 7-111 | [»] | |
6DHS | X-ray | 3.50 | A/B/C/D | 10-194 | [»] | |
SMRi | P31943 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109428, 379 interactors |
CORUMi | P31943 |
IntActi | P31943, 135 interactors |
MINTi | P31943 |
STRINGi | 9606.ENSP00000349168 |
Chemistry databases
ChEMBLi | CHEMBL3797013 |
DrugBanki | DB09130, Copper |
PTM databases
iPTMneti | P31943 |
MetOSitei | P31943 |
PhosphoSitePlusi | P31943 |
SwissPalmi | P31943 |
Polymorphism and mutation databases
BioMutai | HNRNPH1 |
DMDMi | 1710632 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00013881 P31943 |
Proteomic databases
EPDi | P31943 |
jPOSTi | P31943 |
MassIVEi | P31943 |
MaxQBi | P31943 |
PaxDbi | P31943 |
PeptideAtlasi | P31943 |
PRIDEi | P31943 |
ProteomicsDBi | 54814 |
Protocols and materials databases
Antibodypediai | 17692, 290 antibodies |
Genome annotation databases
Ensembli | ENST00000356731; ENSP00000349168; ENSG00000169045 ENST00000393432; ENSP00000377082; ENSG00000169045 ENST00000442819; ENSP00000397797; ENSG00000169045 ENST00000638505; ENSP00000492076; ENSG00000284254 ENST00000643310; ENSP00000495786; ENSG00000284254 |
GeneIDi | 3187 |
KEGGi | hsa:3187 |
UCSCi | uc003mke.5, human |
Organism-specific databases
CTDi | 3187 |
DisGeNETi | 3187 |
EuPathDBi | HostDB:ENSG00000169045.17 |
GeneCardsi | HNRNPH1 |
HGNCi | HGNC:5041, HNRNPH1 |
HPAi | ENSG00000169045, Low tissue specificity |
MalaCardsi | HNRNPH1 |
MIMi | 601035, gene |
neXtProti | NX_P31943 |
OpenTargetsi | ENSG00000169045 |
Orphaneti | 99861, Precursor T-cell acute lymphoblastic leukemia |
PharmGKBi | PA162391284 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4211, Eukaryota |
GeneTreei | ENSGT00940000153503 |
HOGENOMi | CLU_032003_1_0_1 |
InParanoidi | P31943 |
OrthoDBi | 603679at2759 |
PhylomeDBi | P31943 |
TreeFami | TF316157 |
Enzyme and pathway databases
PathwayCommonsi | P31943 |
Reactomei | R-HSA-6803529, FGFR2 alternative splicing R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72203, Processing of Capped Intron-Containing Pre-mRNA |
SIGNORi | P31943 |
Miscellaneous databases
BioGRID-ORCSi | 3187, 641 hits in 859 CRISPR screens |
ChiTaRSi | HNRNPH1, human |
GeneWikii | HNRPH1 |
GenomeRNAii | 3187 |
Pharosi | P31943, Tbio |
PROi | PR:P31943 |
RNActi | P31943, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169045, Expressed in left lobe of thyroid gland and 249 other tissues |
ExpressionAtlasi | P31943, baseline and differential |
Genevisiblei | P31943, HS |
Family and domain databases
Gene3Di | 3.30.70.330, 3 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR012996, Znf_CHHC |
Pfami | View protein in Pfam PF00076, RRM_1, 3 hits PF08080, zf-RNPHF, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 3 hits |
SUPFAMi | SSF54928, SSF54928, 3 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HNRH1_HUMAN | |
Accessioni | P31943Primary (citable) accession number: P31943 Secondary accession number(s): B3KW86, D3DWQ2, Q6IBM4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 218 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references