UniProtKB - P31943 (HNRH1_HUMAN)

BLAST

>sp|P31943|HNRH1_HUMAN Heterogeneous nuclear ribonucleoprotein H OS=Homo sapiens OX=9606 GN=HNRNPH1 PE=1 SV=4
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVE
LESEDEVKLALKKDRETMGHRYVEVFKSNNVEMDWVLKHTGPNSPDTANDGFVRLRGLPF
GCSKEEIVQFFSGLEIVPNGITLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRY
IEIFKSSRAEVRTHYDPPRKLMAMQRPGPYDRPGAGRGYNSIGRGAGFERMRRGAYGGGY
GGYDDYNGYNDGYGFGSDRFGRDLNYCFSGMSDHRYGDGGSTFQSTTGHCVHMRGLPYRA
TENDIYNFFSPLNPVRVHIEIGPDGRVTGEADVEFATHEDAVAAMSKDKANMQHRYVELF
LNSTAGASGGAYEHRYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQLSGGY
GGGYGGQSSMSGYDQVLQENSSDFQSNIA

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History
Entry version 202 (10 Oct 2018)
Sequence version 4 (23 Jan 2007)
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Protein

Heterogeneous nuclear ribonucleoprotein H

Gene

HNRNPH1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).2 Publications

GO - Molecular functionⁱ

poly(U) RNA binding
Source: ProtInc
Traceable author statementⁱ
- 7499401
RNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16946708

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fibroblast growth factor receptor signaling pathway Source: Reactome
mRNA splicing, via spliceosome Source: Reactome
regulation of RNA splicing
Source: UniProtKB
Inferred from direct assayⁱ
- 16946708
RNA metabolic process Source: Reactome
RNA processing
Source: ProtInc
Traceable author statementⁱ
- 7499401

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, RNA-binding
Biological process	mRNA processing, mRNA splicing

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6803529 FGFR2 alternative splicing R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Reactomeⁱ

R-HSA-6803529 FGFR2 alternative splicing
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Heterogeneous nuclear ribonucleoprotein H Short name: hnRNP H Cleaved into the following chain: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed
Gene namesⁱ	Name:HNRNPH1 Synonyms:HNRPH, HNRPH1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000169045.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5041 HNRNPH1
MIMⁱ	601035 gene
neXtProtⁱ	NX_P31943

Keywords - Cellular componentⁱ

Nucleus, Spliceosome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3187
MalaCards human disease database More...MalaCardsⁱ	HNRNPH1
Open Targets More...OpenTargetsⁱ	ENSG00000169045
Orphanetⁱ	99861 Precursor T-cell acute lymphoblastic leukemia
PharmGKBⁱ	PA162391284

Chemistry databases

ChEMBLⁱ	CHEMBL3797013

ChEMBLⁱ

CHEMBL3797013

Polymorphism and mutation databases

BioMutaⁱ	HNRNPH1
DMDMⁱ	1710632

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000367119	1 – 449	Heterogeneous nuclear ribonucleoprotein HAdd BLAST	449
Initiator methionineⁱ		Removed; alternateCombined sources2 Publications
ChainⁱPRO_0000081857	2 – 449	Heterogeneous nuclear ribonucleoprotein H, N-terminally processedAdd BLAST	448

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H; alternateCombined sources1 Publication	1
Modified residueⁱ	2	N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H, N-terminally processedCombined sources1 Publication	1
Modified residueⁱ	23	PhosphoserineCombined sources	1
Cross-linkⁱ	35	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	54	PhosphoserineCombined sources	1
Modified residueⁱ	63	PhosphoserineCombined sources	1
Cross-linkⁱ	87	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	98	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	233	Dimethylated arginine; alternate1 Publication	1
Modified residueⁱ	233	Omega-N-methylarginine; alternateCombined sources1 Publication	1
Modified residueⁱ	246	PhosphotyrosineCombined sources	1
Modified residueⁱ	310	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P31943
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P31943
PaxDbⁱ	P31943
PeptideAtlas More...PeptideAtlasⁱ	P31943
PRIDEⁱ	P31943
ProteomicsDBⁱ	54814

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00013881 P31943

REPRODUCTION-2DPAGEⁱ

IPI00013881
P31943

PTM databases

iPTMnetⁱ	P31943
PhosphoSitePlusⁱ	P31943
SwissPalmⁱ	P31943

Expressionⁱ

Tissue specificityⁱ

Expressed ubiquitously.

Inductionⁱ

Up-regulated in myotonic dystrophy pathophysiology (DM).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000169045 Expressed in 239 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_HNRNPH1
ExpressionAtlasⁱ	P31943 baseline and differential
Genevisibleⁱ	P31943 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB032820 HPA000914 HPA001359 HPA016884

HPAⁱ

CAB032820
HPA000914
HPA001359
HPA016884

Interactionⁱ

Subunit structureⁱ

Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRNPH1. Identified in the spliceosome C complex. Interacts with IGF2BP1. Interacts with CUGBP1; the interaction is RNA-dependent. Interacts with MBNL1; the interaction in RNA-independent.4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PATZ1	Q9HBE1-4	4	EBI-351590,EBI-11022007
TEKT4	Q8WW24	4	EBI-351590,EBI-750487

Protein-protein interaction databases

BioGridⁱ	109428, 270 interactors
CORUMⁱ	P31943
IntActⁱ	P31943, 110 interactors
Molecular INTeraction database More...MINTⁱ	P31943
STRINGⁱ	9606.ENSP00000349168

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	9 – 17	Combined sources	9
Helixⁱ	24 – 30	Combined sources	7
Turnⁱ	31 – 33	Combined sources	3
Helixⁱ	39 – 41	Combined sources	3
Beta strandⁱ	42 – 47	Combined sources	6
Beta strandⁱ	51 – 62	Combined sources	12
Helixⁱ	64 – 71	Combined sources	8
Turnⁱ	72 – 75	Combined sources	4
Beta strandⁱ	84 – 88	Combined sources	5
Helixⁱ	90 – 98	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	P31943
SMRⁱ	P31943
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	11 – 90	RRM 1PROSITE-ProRule annotationAdd BLAST	80
Domainⁱ	111 – 188	RRM 2PROSITE-ProRule annotationAdd BLAST	78
Repeatⁱ	234 – 249	1-1Add BLAST	16
Domainⁱ	289 – 364	RRM 3PROSITE-ProRule annotationAdd BLAST	76
Repeatⁱ	354 – 372	2-1Add BLAST	19
Repeatⁱ	374 – 392	2-2Add BLAST	19
Repeatⁱ	418 – 433	1-2Add BLAST	16

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	234 – 433	2 X 16 AA Gly-rich approximate repeatsAdd BLAST		200
Regionⁱ	354 – 392	2 X 19 AA perfect repeatsAdd BLAST		39

Domainⁱ

Each quasi-RRM repeat bound poly(RG), while only the N-terminal QRRM bound poly(RC) and poly(RU). None of the repeats bound detectable amounts of poly(RA).

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG4211 Eukaryota ENOG410Z6M0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119102
HOGENOMⁱ	HOG000220896
HOVERGENⁱ	HBG055557
InParanoidⁱ	P31943
KEGG Orthology (KO) More...KOⁱ	K12898
PhylomeDBⁱ	P31943
TreeFamⁱ	TF316157

Family and domain databases

Gene3Dⁱ	3.30.70.330, 3 hits
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom IPR012996 Znf_CHHC
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 3 hits PF08080 zf-RNPHF, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 3 hits
SUPFAMⁱ	SSF54928 SSF54928, 3 hits
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 25 potential isoforms that are computationally mapped.Show all Align All

P31943-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MMLGTEGGEG FVVKVRGLPW SCSADEVQRF FSDCKIQNGA QGIRFIYTRE 
        60         70         80         90        100
GRPSGEAFVE LESEDEVKLA LKKDRETMGH RYVEVFKSNN VEMDWVLKHT 
       110        120        130        140        150
GPNSPDTAND GFVRLRGLPF GCSKEEIVQF FSGLEIVPNG ITLPVDFQGR 
       160        170        180        190        200
STGEAFVQFA SQEIAEKALK KHKERIGHRY IEIFKSSRAE VRTHYDPPRK 
       210        220        230        240        250
LMAMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY GGYDDYNGYN 
       260        270        280        290        300
DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG STFQSTTGHC VHMRGLPYRA 
       310        320        330        340        350
TENDIYNFFS PLNPVRVHIE IGPDGRVTGE ADVEFATHED AVAAMSKDKA 
       360        370        380        390        400
NMQHRYVELF LNSTAGASGG AYEHRYVELF LNSTAGASGG AYGSQMMGGM 
       410        420        430        440 
GLSNQSSYGG PASQQLSGGY GGGYGGQSSM SGYDQVLQEN SSDFQSNIA

Length:449

Mass (Da):49,229

Last modified:January 23, 2007 - v4

Checksum:ⁱ4ECF7A075C2526FF

Computationally mapped potential isoform sequencesⁱ

There are 25 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	G8JLB6	G8JLB6_HUMAN	Heterogeneous nuclear ribonucleopro... Heterogeneous nuclear ribonucleoprotein H	HNRNPH1	472	Annotation score:
	E9PCY7	E9PCY7_HUMAN	Heterogeneous nuclear ribonucleopro... Heterogeneous nuclear ribonucleoprotein H	HNRNPH1	429	Annotation score:
	D6RBM0	D6RBM0_HUMAN	Heterogeneous nuclear ribonucleopro... Heterogeneous nuclear ribonucleoprotein H	HNRNPH1	212	Annotation score:
	D6RIU0	D6RIU0_HUMAN	Heterogeneous nuclear ribonucleopro... Heterogeneous nuclear ribonucleoprotein H	HNRNPH1	168	Annotation score:
	D6RFM3	D6RFM3_HUMAN	Heterogeneous nuclear ribonucleopro... Heterogeneous nuclear ribonucleoprotein H	HNRNPH1	163	Annotation score:
	H0YBG7	H0YBG7_HUMAN	Heterogeneous nuclear ribonucleopro... Heterogeneous nuclear ribonucleoprotein H	HNRNPH1	185	Annotation score:
	H0YBK1	H0YBK1_HUMAN	Heterogeneous nuclear ribonucleopro... Heterogeneous nuclear ribonucleoprotein H	HNRNPH1	117	Annotation score:
	D6RIH9	D6RIH9_HUMAN	Heterogeneous nuclear ribonucleopro... Heterogeneous nuclear ribonucleoprotein H	HNRNPH1	184	Annotation score:
	D6RIT2	D6RIT2_HUMAN	Heterogeneous nuclear ribonucleopro... Heterogeneous nuclear ribonucleoprotein H	HNRNPH1	164	Annotation score:
	D6RDL0	D6RDL0_HUMAN	Heterogeneous nuclear ribonucleopro... Heterogeneous nuclear ribonucleoprotein H	HNRNPH1	84	Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	188	R → G in CAG33059 (Ref. 2) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L22009 mRNA Translation: AAA91346.1 CR456778 mRNA Translation: CAG33059.1 AK124530 mRNA Translation: BAG54048.1 CH471165 Genomic DNA Translation: EAW53807.1 CH471165 Genomic DNA Translation: EAW53808.1 BC001348 mRNA Translation: AAH01348.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4446.1
PIRⁱ	I39358
NCBI Reference Sequences More...RefSeqⁱ	NP_001244222.1, NM_001257293.1 NP_005511.1, NM_005520.2 XP_016864904.1, XM_017009415.1 XP_016864905.1, XM_017009416.1 XP_016864906.1, XM_017009417.1
UniGeneⁱ	Hs.604001

Genome annotation databases

Ensemblⁱ	ENST00000356731; ENSP00000349168; ENSG00000169045 ENST00000393432; ENSP00000377082; ENSG00000169045 ENST00000442819; ENSP00000397797; ENSG00000169045 ENST00000639490; ENSP00000492211; ENSG00000284254 ENST00000643274; ENSP00000496484; ENSG00000284254
GeneIDⁱ	3187
KEGGⁱ	hsa:3187
UCSC genome browser More...UCSCⁱ	uc003mke.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P31943	HNRNPH1 isoform 11		PANTR		449	UniRef100_P31943
Heterogeneous nuclear ribonucleoprotein H1		SAIBB		449
heterogeneous nuclear ribonucleoprotein H isoform X5		TURTR		449
Heterogeneous nuclear ribonucleoprotein H1		PIG		449
HNRNPH1 isoform 11		PONAB		449
+25

Protein	Similar proteins		Species	Score	Length	Source
P31943	Heterogeneous nuclear ribonucleoprotein H		MOUSE		449	UniRef90_P31943
Heterogeneous nuclear ribonucleoprotein H		RAT		449
Heterogeneous nuclear ribonucleoprotein H2		BOVIN		449
Heterogeneous nuclear ribonucleoprotein H2	)	HUMAN		449
Heterogeneous nuclear ribonucleoprotein H2		PONAB		449
+353

Protein	Similar proteins		Species	Score	Length	Source
P31943	Heterogeneous nuclear ribonucleoprotein H2		MOUSE		449	UniRef50_P31943
Heterogeneous nuclear ribonucleoprotein H2		RAT		449
Heterogeneous nuclear ribonucleoprotein H2		BOVIN		449
Heterogeneous nuclear ribonucleoprotein H2	)	HUMAN		449
Heterogeneous nuclear ribonucleoprotein H2		PONAB		449
+775

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L22009 mRNA Translation: AAA91346.1 CR456778 mRNA Translation: CAG33059.1 AK124530 mRNA Translation: BAG54048.1 CH471165 Genomic DNA Translation: EAW53807.1 CH471165 Genomic DNA Translation: EAW53808.1 BC001348 mRNA Translation: AAH01348.1
CCDSⁱ	CCDS4446.1
PIRⁱ	I39358
RefSeqⁱ	NP_001244222.1, NM_001257293.1 NP_005511.1, NM_005520.2 XP_016864904.1, XM_017009415.1 XP_016864905.1, XM_017009416.1 XP_016864906.1, XM_017009417.1
UniGeneⁱ	Hs.604001

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2LXU	NMR	-	A	7-111	[»]
ProteinModelPortalⁱ	P31943
SMRⁱ	P31943
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109428, 270 interactors
CORUMⁱ	P31943
IntActⁱ	P31943, 110 interactors
MINTⁱ	P31943
STRINGⁱ	9606.ENSP00000349168

Chemistry databases

ChEMBLⁱ	CHEMBL3797013

ChEMBLⁱ

CHEMBL3797013

PTM databases

iPTMnetⁱ	P31943
PhosphoSitePlusⁱ	P31943
SwissPalmⁱ	P31943

Polymorphism and mutation databases

BioMutaⁱ	HNRNPH1
DMDMⁱ	1710632

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00013881 P31943

REPRODUCTION-2DPAGEⁱ

IPI00013881
P31943

Proteomic databases

EPDⁱ	P31943
MaxQBⁱ	P31943
PaxDbⁱ	P31943
PeptideAtlasⁱ	P31943
PRIDEⁱ	P31943
ProteomicsDBⁱ	54814

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000356731; ENSP00000349168; ENSG00000169045 ENST00000393432; ENSP00000377082; ENSG00000169045 ENST00000442819; ENSP00000397797; ENSG00000169045 ENST00000639490; ENSP00000492211; ENSG00000284254 ENST00000643274; ENSP00000496484; ENSG00000284254
GeneIDⁱ	3187
KEGGⁱ	hsa:3187
UCSCⁱ	uc003mke.5 human

Organism-specific databases

CTDⁱ	3187
DisGeNETⁱ	3187
EuPathDBⁱ	HostDB:ENSG00000169045.17
GeneCardsⁱ	HNRNPH1
HGNCⁱ	HGNC:5041 HNRNPH1
HPAⁱ	CAB032820 HPA000914 HPA001359 HPA016884
MalaCardsⁱ	HNRNPH1
MIMⁱ	601035 gene
neXtProtⁱ	NX_P31943
OpenTargetsⁱ	ENSG00000169045
Orphanetⁱ	99861 Precursor T-cell acute lymphoblastic leukemia
PharmGKBⁱ	PA162391284
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4211 Eukaryota ENOG410Z6M0 LUCA
GeneTreeⁱ	ENSGT00760000119102
HOGENOMⁱ	HOG000220896
HOVERGENⁱ	HBG055557
InParanoidⁱ	P31943
KOⁱ	K12898
PhylomeDBⁱ	P31943
TreeFamⁱ	TF316157

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6803529 FGFR2 alternative splicing R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Reactomeⁱ

R-HSA-6803529 FGFR2 alternative splicing
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Miscellaneous databases

ChiTaRSⁱ	HNRNPH1 human
GeneWikiⁱ	HNRPH1
GenomeRNAiⁱ	3187
Protein Ontology More...PROⁱ	PR:P31943
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000169045 Expressed in 239 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_HNRNPH1
ExpressionAtlasⁱ	P31943 baseline and differential
Genevisibleⁱ	P31943 HS

Family and domain databases

Gene3Dⁱ	3.30.70.330, 3 hits
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom IPR012996 Znf_CHHC
Pfamⁱ	View protein in Pfam PF00076 RRM_1, 3 hits PF08080 zf-RNPHF, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 3 hits
SUPFAMⁱ	SSF54928 SSF54928, 3 hits
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HNRH1_HUMAN
Accessionⁱ	P31943Primary (citable) accession number: P31943 Secondary accession number(s): B3KW86, D3DWQ2, Q6IBM4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
	Last sequence update:	January 23, 2007
	Last modified:	October 10, 2018
	This is version 202 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P31943 (HNRH1_HUMAN)

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Heterogeneous nuclear ribonucleoprotein H

HNRNPH1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

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Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ