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UniProtKB - P31942 (HNRH3_HUMAN)

Entry version 205 (07 Apr 2021)
Sequence version 2 (19 Sep 2002)
Previous versions | rss
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Protein

Heterogeneous nuclear ribonucleoprotein H3

Gene

HNRNPH3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P31942

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein H3
Short name:
hnRNP H3
Alternative name(s):
Heterogeneous nuclear ribonucleoprotein 2H9
Short name:
hnRNP 2H9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HNRNPH3
Synonyms:HNRPH3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5043, HNRNPH3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602324, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P31942

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000096746.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3189

Open Targets

More...OpenTargetsi		ENSG00000096746

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162391325

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P31942, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB09130, Copper

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HNRNPH3

Domain mapping of disease mutations (DMDM)

More...DMDMi		23503095

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000818611 – 346Heterogeneous nuclear ribonucleoprotein H3Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki6Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki67Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei121Asymmetric dimethylarginine1 Publication1
Modified residuei174Omega-N-methylarginineCombined sources1
Modified residuei216PhosphoserineCombined sources1
Modified residuei287Omega-N-methylarginine1 Publication1
Modified residuei296PhosphotyrosineCombined sources1
Modified residuei298PhosphoserineCombined sources1
Modified residuei314PhosphothreonineCombined sources1
Modified residuei323Omega-N-methylarginineCombined sources1
Modified residuei343Omega-N-methylarginineCombined sources1
Isoform 2 (identifier: P31942-2)
Modified residuei116Omega-N-methylarginineCombined sources1
Modified residuei121Omega-N-methylarginineCombined sources1
Modified residuei129Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P31942

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P31942

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P31942

MaxQB - The MaxQuant DataBase

More...MaxQBi		P31942

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P31942

PeptideAtlas

More...PeptideAtlasi		P31942

PRoteomics IDEntifications database

More...PRIDEi		P31942

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54808 [P31942-1]
54809 [P31942-2]
54810 [P31942-3]
54811 [P31942-4]
54812 [P31942-5]
54813 [P31942-6]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P31942-1 [P31942-1]
P31942-2 [P31942-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P31942

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P31942

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P31942

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P31942

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000096746, Expressed in tendon of biceps brachii and 246 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P31942, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P31942, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000096746, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109430, 232 interactors

Protein interaction database and analysis system

More...IntActi		P31942, 98 interactors

Molecular INTeraction database

More...MINTi		P31942

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000265866

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P31942, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P31942

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 93RRM 1PROSITE-ProRule annotationAdd BLAST78
Domaini195 – 270RRM 2PROSITE-ProRule annotationAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi108 – 344Gly-richAdd BLAST237

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4211, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157720

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_032003_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P31942

Identification of Orthologs from Complete Genome Data

More...OMAi		YGNEGFD

Database for complete collections of gene phylogenies

More...PhylomeDBi		P31942

TreeFam database of animal gene trees

More...TreeFami		TF316157

Family and domain databases

Conserved Domains Database

More...CDDi		cd12732, RRM2_hnRNPH3, 1 hit
cd12735, RRM3_hnRNPH3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR034970, hnRNPH3_RRM2
IPR034969, hnRNPH3_RRM3
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00076, RRM_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360, RRM, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102, RRM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P31942-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDWVMKHNGP NDASDGTVRL RGLPFGCSKE EIVQFFQGLE IVPNGITLTM 
        60         70         80         90        100
DYQGRSTGEA FVQFASKEIA ENALGKHKER IGHRYIEIFR SSRSEIKGFY 
       110        120        130        140        150
DPPRRLLGQR PGPYDRPIGG RGGYYGAGRG SMYDRMRRGG DGYDGGYGGF 
       160        170        180        190        200
DDYGGYNNYG YGNDGFDDRM RDGRGMGGHG YGGAGDASSG FHGGHFVHMR 
       210        220        230        240        250
GLPFRATEND IANFFSPLNP IRVHIDIGAD GRATGEADVE FVTHEDAVAA 
       260        270        280        290        300
MSKDKNNMQH RYIELFLNST PGGGSGMGGS GMGGYGRDGM DNQGGYGSVG 
       310        320        330        340 
RMGMGNNYSG GYGTPDGLGG YGRGGGGSGG YYGQGGMSGG GWRGMY
Length:346
Mass (Da):36,926
Last modified:September 19, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7D14C2947930E9E
GO
Isoform 2 (identifier: P31942-2) [UniParc]FASTAAdd to basket
Also known as: 2H9A

The sequence of this isoform differs from the canonical sequence as follows:
     132-146: Missing.

Show »
Length:331
Mass (Da):35,239
Checksum:iA3BA8D0F5FC07369
GO
Isoform 3 (identifier: P31942-3) [UniParc]FASTAAdd to basket
Also known as: 2H9B

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Show »
Length:297
Mass (Da):31,525
Checksum:iAAE63A29063E5153
GO
Isoform 4 (identifier: P31942-4) [UniParc]FASTAAdd to basket
Also known as: 2H9C

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: Missing.

Show »
Length:215
Mass (Da):22,322
Checksum:i969F8FE2710D2646
GO
Isoform 5 (identifier: P31942-5) [UniParc]FASTAAdd to basket
Also known as: 2H9D

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: Missing.
     259-276: QHRYIELFLNSTPGGGSG → RKWCLWHTILFPKREFIK
     277-346: Missing.

Show »
Length:145
Mass (Da):16,084
Checksum:i286234CBE7C9C996
GO
Isoform 6 (identifier: P31942-6) [UniParc]FASTAAdd to basket
Also known as: 2H9E

The sequence of this isoform differs from the canonical sequence as follows:
     1-137: Missing.
     138-145: RGGDGYDG → MCFSLNYT
     259-276: QHRYIELFLNSTPGGGSG → RKWCLWHTILFPKREFIK
     277-346: Missing.

Show »
Length:139
Mass (Da):15,413
Checksum:iF1E137E637675D93
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020333163N → S. Corresponds to variant dbSNP:rs2273903Ensembl.1
Natural variantiVAR_052226284G → A. Corresponds to variant dbSNP:rs16925347Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0058411 – 137Missing in isoform 6. 1 PublicationAdd BLAST137
Alternative sequenceiVSP_0058391 – 131Missing in isoform 4 and isoform 5. 3 PublicationsAdd BLAST131
Alternative sequenceiVSP_0058381 – 49Missing in isoform 3. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_005840132 – 146Missing in isoform 2. 3 PublicationsAdd BLAST15
Alternative sequenceiVSP_005842138 – 145RGGDGYDG → MCFSLNYT in isoform 6. 1 Publication8
Alternative sequenceiVSP_005843259 – 276QHRYI…GGGSG → RKWCLWHTILFPKREFIK in isoform 5 and isoform 6. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_005844277 – 346Missing in isoform 5 and isoform 6. 1 PublicationAdd BLAST70

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L32610 mRNA Translation: AAD45179.1
AF132360 Genomic DNA Translation: AAF68843.1
AF132360 Genomic DNA Translation: AAF68844.1
AF132360 Genomic DNA Translation: AAF68845.1
AF132360 Genomic DNA Translation: AAF68846.1
AF132360 Genomic DNA Translation: AAF68847.1
AF132360 Genomic DNA Translation: AAF68848.1
AF132361 mRNA Translation: AAF68849.1
AF132362 mRNA Translation: AAF68850.1
AF132363 mRNA Translation: AAF68851.1
AF132364 mRNA Translation: AAF68852.1
AK091411 mRNA Translation: BAG52353.1
AK291547 mRNA Translation: BAF84236.1
AL117395 mRNA Translation: CAB55897.1
CH471083 Genomic DNA Translation: EAW54281.1
CH471083 Genomic DNA Translation: EAW54282.1
BC004511 mRNA Translation: AAH04511.2
BC039824 mRNA Translation: AAH39824.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7278.1 [P31942-1]
CCDS7279.1 [P31942-2]

Protein sequence database of the Protein Information Resource

More...PIRi		T17207

NCBI Reference Sequences

More...RefSeqi		NP_001309363.1, NM_001322434.1 [P31942-1]
NP_001309365.1, NM_001322436.1 [P31942-1]
NP_001309366.1, NM_001322437.1 [P31942-1]
NP_001309367.1, NM_001322438.1 [P31942-2]
NP_001309368.1, NM_001322439.1 [P31942-2]
NP_001309369.1, NM_001322440.1 [P31942-2]
NP_001309370.1, NM_001322441.1 [P31942-2]
NP_001309374.1, NM_001322445.1 [P31942-4]
NP_001309375.1, NM_001322446.1 [P31942-4]
NP_001309376.1, NM_001322447.1 [P31942-4]
NP_001309377.1, NM_001322448.1 [P31942-4]
NP_001309378.1, NM_001322449.1 [P31942-4]
NP_036339.1, NM_012207.2 [P31942-1]
NP_067676.2, NM_021644.3 [P31942-2]
XP_016871657.1, XM_017016168.1
XP_016871658.1, XM_017016169.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000265866; ENSP00000265866; ENSG00000096746 [P31942-1]
ENST00000354695; ENSP00000346726; ENSG00000096746 [P31942-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3189

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3189

UCSC genome browser

More...UCSCi		uc001jnw.5, human [P31942-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32610 mRNA Translation: AAD45179.1
AF132360 Genomic DNA Translation: AAF68843.1
AF132360 Genomic DNA Translation: AAF68844.1
AF132360 Genomic DNA Translation: AAF68845.1
AF132360 Genomic DNA Translation: AAF68846.1
AF132360 Genomic DNA Translation: AAF68847.1
AF132360 Genomic DNA Translation: AAF68848.1
AF132361 mRNA Translation: AAF68849.1
AF132362 mRNA Translation: AAF68850.1
AF132363 mRNA Translation: AAF68851.1
AF132364 mRNA Translation: AAF68852.1
AK091411 mRNA Translation: BAG52353.1
AK291547 mRNA Translation: BAF84236.1
AL117395 mRNA Translation: CAB55897.1
CH471083 Genomic DNA Translation: EAW54281.1
CH471083 Genomic DNA Translation: EAW54282.1
BC004511 mRNA Translation: AAH04511.2
BC039824 mRNA Translation: AAH39824.1
CCDSiCCDS7278.1 [P31942-1]
CCDS7279.1 [P31942-2]
PIRiT17207
RefSeqiNP_001309363.1, NM_001322434.1 [P31942-1]
NP_001309365.1, NM_001322436.1 [P31942-1]
NP_001309366.1, NM_001322437.1 [P31942-1]
NP_001309367.1, NM_001322438.1 [P31942-2]
NP_001309368.1, NM_001322439.1 [P31942-2]
NP_001309369.1, NM_001322440.1 [P31942-2]
NP_001309370.1, NM_001322441.1 [P31942-2]
NP_001309374.1, NM_001322445.1 [P31942-4]
NP_001309375.1, NM_001322446.1 [P31942-4]
NP_001309376.1, NM_001322447.1 [P31942-4]
NP_001309377.1, NM_001322448.1 [P31942-4]
NP_001309378.1, NM_001322449.1 [P31942-4]
NP_036339.1, NM_012207.2 [P31942-1]
NP_067676.2, NM_021644.3 [P31942-2]
XP_016871657.1, XM_017016168.1
XP_016871658.1, XM_017016169.1

3D structure databases

SMRiP31942
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi109430, 232 interactors
IntActiP31942, 98 interactors
MINTiP31942
STRINGi9606.ENSP00000265866

Chemistry databases

DrugBankiDB09130, Copper

PTM databases

iPTMnetiP31942
MetOSiteiP31942
PhosphoSitePlusiP31942
SwissPalmiP31942

Genetic variation databases

BioMutaiHNRNPH3
DMDMi23503095

Proteomic databases

EPDiP31942
jPOSTiP31942
MassIVEiP31942
MaxQBiP31942
PaxDbiP31942
PeptideAtlasiP31942
PRIDEiP31942
ProteomicsDBi54808 [P31942-1]
54809 [P31942-2]
54810 [P31942-3]
54811 [P31942-4]
54812 [P31942-5]
54813 [P31942-6]
TopDownProteomicsiP31942-1 [P31942-1]
P31942-2 [P31942-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		14612, 102 antibodies

Genome annotation databases

EnsembliENST00000265866; ENSP00000265866; ENSG00000096746 [P31942-1]
ENST00000354695; ENSP00000346726; ENSG00000096746 [P31942-2]
GeneIDi3189
KEGGihsa:3189
UCSCiuc001jnw.5, human [P31942-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3189
DisGeNETi3189

GeneCards: human genes, protein and diseases

More...GeneCardsi		HNRNPH3
HGNCiHGNC:5043, HNRNPH3
HPAiENSG00000096746, Low tissue specificity
MIMi602324, gene
neXtProtiNX_P31942
OpenTargetsiENSG00000096746
PharmGKBiPA162391325
VEuPathDBiHostDB:ENSG00000096746.17

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4211, Eukaryota
GeneTreeiENSGT00940000157720
HOGENOMiCLU_032003_1_0_1
InParanoidiP31942
OMAiYGNEGFD
PhylomeDBiP31942
TreeFamiTF316157

Enzyme and pathway databases

PathwayCommonsiP31942

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3189, 37 hits in 1009 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HNRNPH3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HNRPH3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3189
PharosiP31942, Tbio

Protein Ontology

More...PROi		PR:P31942
RNActiP31942, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000096746, Expressed in tendon of biceps brachii and 246 other tissues
ExpressionAtlasiP31942, baseline and differential
GenevisibleiP31942, HS

Family and domain databases

CDDicd12732, RRM2_hnRNPH3, 1 hit
cd12735, RRM3_hnRNPH3, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR034970, hnRNPH3_RRM2
IPR034969, hnRNPH3_RRM3
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
PfamiView protein in Pfam
PF00076, RRM_1, 2 hits
SMARTiView protein in SMART
SM00360, RRM, 2 hits
SUPFAMiSSF54928, SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102, RRM, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHNRH3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31942
Secondary accession number(s): A8K682
, B3KRE1, Q9BSX1, Q9NP53, Q9NP96, Q9NPA7, Q9NPI4, Q9UFU4, Q9Y4J5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: September 19, 2002
Last modified: April 7, 2021
This is version 205 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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