UniProtKB - P31942 (HNRH3_HUMAN)
Protein
Heterogeneous nuclear ribonucleoprotein H3
Gene
HNRNPH3
Organism
Homo sapiens (Human)
Status
Functioni
Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction.
GO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- epithelial cell differentiation Source: UniProtKB
- mRNA splicing, via spliceosome Source: UniProtKB
- regulation of RNA splicing Source: GO_Central
- RNA processing Source: ProtInc
- RNA splicing Source: ProtInc
Keywordsi
Molecular function | Ribonucleoprotein, RNA-binding |
Biological process | mRNA processing |
Enzyme and pathway databases
PathwayCommonsi | P31942 |
Names & Taxonomyi
Protein namesi | Recommended name: Heterogeneous nuclear ribonucleoprotein H3Short name: hnRNP H3 Alternative name(s): Heterogeneous nuclear ribonucleoprotein 2H9 Short name: hnRNP 2H9 |
Gene namesi | Name:HNRNPH3 Synonyms:HNRPH3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5043, HNRNPH3 |
MIMi | 602324, gene |
neXtProti | NX_P31942 |
VEuPathDBi | HostDB:ENSG00000096746.17 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- spliceosomal complex Source: UniProtKB
Other locations
- ribonucleoprotein complex Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 3189 |
OpenTargetsi | ENSG00000096746 |
PharmGKBi | PA162391325 |
Miscellaneous databases
Pharosi | P31942, Tbio |
Chemistry databases
DrugBanki | DB09130, Copper |
Genetic variation databases
BioMutai | HNRNPH3 |
DMDMi | 23503095 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081861 | 1 – 346 | Heterogeneous nuclear ribonucleoprotein H3Add BLAST | 346 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionine1 Publication | 1 | ||
Cross-linki | 6 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Cross-linki | 67 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 121 | Asymmetric dimethylarginine1 Publication | 1 | ||
Modified residuei | 174 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 216 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 287 | Omega-N-methylarginine1 Publication | 1 | ||
Modified residuei | 296 | PhosphotyrosineCombined sources | 1 | ||
Modified residuei | 298 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 314 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 323 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 343 | Omega-N-methylarginineCombined sources | 1 | ||
Isoform 2 (identifier: P31942-2) | |||||
Modified residuei | 116 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 121 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 129 | Omega-N-methylarginineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P31942 |
jPOSTi | P31942 |
MassIVEi | P31942 |
MaxQBi | P31942 |
PaxDbi | P31942 |
PeptideAtlasi | P31942 |
PRIDEi | P31942 |
ProteomicsDBi | 54808 [P31942-1] 54809 [P31942-2] 54810 [P31942-3] 54811 [P31942-4] 54812 [P31942-5] 54813 [P31942-6] |
TopDownProteomicsi | P31942-1 [P31942-1] P31942-2 [P31942-2] |
PTM databases
iPTMneti | P31942 |
MetOSitei | P31942 |
PhosphoSitePlusi | P31942 |
SwissPalmi | P31942 |
Expressioni
Gene expression databases
Bgeei | ENSG00000096746, Expressed in tendon of biceps brachii and 246 other tissues |
ExpressionAtlasi | P31942, baseline and differential |
Genevisiblei | P31942, HS |
Organism-specific databases
HPAi | ENSG00000096746, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsP31942
With | #Exp. | IntAct |
---|---|---|
HNRNPA1 [P09651] | 3 | EBI-711437,EBI-352662 |
Isoform 2 [P31942-2]
With | #Exp. | IntAct |
---|---|---|
PSME3 [P61289] | 3 | EBI-16399628,EBI-355546 |
RFFL - isoform 3 [Q8WZ73-3] | 3 | EBI-16399628,EBI-25839575 |
SPATA46 [Q5T0L3] | 3 | EBI-16399628,EBI-750105 |
Protein-protein interaction databases
BioGRIDi | 109430, 232 interactors |
IntActi | P31942, 98 interactors |
MINTi | P31942 |
STRINGi | 9606.ENSP00000265866 |
Miscellaneous databases
RNActi | P31942, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 93 | RRM 1PROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 195 – 270 | RRM 2PROSITE-ProRule annotationAdd BLAST | 76 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 108 – 344 | Gly-richAdd BLAST | 237 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4211, Eukaryota |
GeneTreei | ENSGT00940000157720 |
HOGENOMi | CLU_032003_1_0_1 |
InParanoidi | P31942 |
OMAi | YGNEGFD |
PhylomeDBi | P31942 |
TreeFami | TF316157 |
Family and domain databases
CDDi | cd12732, RRM2_hnRNPH3, 1 hit cd12735, RRM3_hnRNPH3, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR034970, hnRNPH3_RRM2 IPR034969, hnRNPH3_RRM3 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
s (6)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: P31942-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDWVMKHNGP NDASDGTVRL RGLPFGCSKE EIVQFFQGLE IVPNGITLTM
60 70 80 90 100
DYQGRSTGEA FVQFASKEIA ENALGKHKER IGHRYIEIFR SSRSEIKGFY
110 120 130 140 150
DPPRRLLGQR PGPYDRPIGG RGGYYGAGRG SMYDRMRRGG DGYDGGYGGF
160 170 180 190 200
DDYGGYNNYG YGNDGFDDRM RDGRGMGGHG YGGAGDASSG FHGGHFVHMR
210 220 230 240 250
GLPFRATEND IANFFSPLNP IRVHIDIGAD GRATGEADVE FVTHEDAVAA
260 270 280 290 300
MSKDKNNMQH RYIELFLNST PGGGSGMGGS GMGGYGRDGM DNQGGYGSVG
310 320 330 340
RMGMGNNYSG GYGTPDGLGG YGRGGGGSGG YYGQGGMSGG GWRGMY
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020333 | 163 | N → S. Corresponds to variant dbSNP:rs2273903Ensembl. | 1 | |
Natural variantiVAR_052226 | 284 | G → A. Corresponds to variant dbSNP:rs16925347Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005841 | 1 – 137 | Missing in isoform 6. 1 PublicationAdd BLAST | 137 | |
Alternative sequenceiVSP_005839 | 1 – 131 | Missing in isoform 4 and isoform 5. 3 PublicationsAdd BLAST | 131 | |
Alternative sequenceiVSP_005838 | 1 – 49 | Missing in isoform 3. 1 PublicationAdd BLAST | 49 | |
Alternative sequenceiVSP_005840 | 132 – 146 | Missing in isoform 2. 3 PublicationsAdd BLAST | 15 | |
Alternative sequenceiVSP_005842 | 138 – 145 | RGGDGYDG → MCFSLNYT in isoform 6. 1 Publication | 8 | |
Alternative sequenceiVSP_005843 | 259 – 276 | QHRYI…GGGSG → RKWCLWHTILFPKREFIK in isoform 5 and isoform 6. 1 PublicationAdd BLAST | 18 | |
Alternative sequenceiVSP_005844 | 277 – 346 | Missing in isoform 5 and isoform 6. 1 PublicationAdd BLAST | 70 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000265866; ENSP00000265866; ENSG00000096746 [P31942-1] ENST00000354695; ENSP00000346726; ENSG00000096746 [P31942-2] |
GeneIDi | 3189 |
KEGGi | hsa:3189 |
UCSCi | uc001jnw.5, human [P31942-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | P31942 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109430, 232 interactors |
IntActi | P31942, 98 interactors |
MINTi | P31942 |
STRINGi | 9606.ENSP00000265866 |
Chemistry databases
DrugBanki | DB09130, Copper |
PTM databases
iPTMneti | P31942 |
MetOSitei | P31942 |
PhosphoSitePlusi | P31942 |
SwissPalmi | P31942 |
Genetic variation databases
BioMutai | HNRNPH3 |
DMDMi | 23503095 |
Proteomic databases
EPDi | P31942 |
jPOSTi | P31942 |
MassIVEi | P31942 |
MaxQBi | P31942 |
PaxDbi | P31942 |
PeptideAtlasi | P31942 |
PRIDEi | P31942 |
ProteomicsDBi | 54808 [P31942-1] 54809 [P31942-2] 54810 [P31942-3] 54811 [P31942-4] 54812 [P31942-5] 54813 [P31942-6] |
TopDownProteomicsi | P31942-1 [P31942-1] P31942-2 [P31942-2] |
Protocols and materials databases
Antibodypediai | 14612, 102 antibodies |
Genome annotation databases
Ensembli | ENST00000265866; ENSP00000265866; ENSG00000096746 [P31942-1] ENST00000354695; ENSP00000346726; ENSG00000096746 [P31942-2] |
GeneIDi | 3189 |
KEGGi | hsa:3189 |
UCSCi | uc001jnw.5, human [P31942-1] |
Organism-specific databases
CTDi | 3189 |
DisGeNETi | 3189 |
GeneCardsi | HNRNPH3 |
HGNCi | HGNC:5043, HNRNPH3 |
HPAi | ENSG00000096746, Low tissue specificity |
MIMi | 602324, gene |
neXtProti | NX_P31942 |
OpenTargetsi | ENSG00000096746 |
PharmGKBi | PA162391325 |
VEuPathDBi | HostDB:ENSG00000096746.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4211, Eukaryota |
GeneTreei | ENSGT00940000157720 |
HOGENOMi | CLU_032003_1_0_1 |
InParanoidi | P31942 |
OMAi | YGNEGFD |
PhylomeDBi | P31942 |
TreeFami | TF316157 |
Enzyme and pathway databases
PathwayCommonsi | P31942 |
Miscellaneous databases
BioGRID-ORCSi | 3189, 37 hits in 1009 CRISPR screens |
ChiTaRSi | HNRNPH3, human |
GeneWikii | HNRPH3 |
GenomeRNAii | 3189 |
Pharosi | P31942, Tbio |
PROi | PR:P31942 |
RNActi | P31942, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000096746, Expressed in tendon of biceps brachii and 246 other tissues |
ExpressionAtlasi | P31942, baseline and differential |
Genevisiblei | P31942, HS |
Family and domain databases
CDDi | cd12732, RRM2_hnRNPH3, 1 hit cd12735, RRM3_hnRNPH3, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR034970, hnRNPH3_RRM2 IPR034969, hnRNPH3_RRM3 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HNRH3_HUMAN | |
Accessioni | P31942Primary (citable) accession number: P31942 Secondary accession number(s): A8K682 Q9Y4J5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | September 19, 2002 | |
Last modified: | April 7, 2021 | |
This is version 205 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot