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UniProtKB - P31941 (ABC3A_HUMAN)

Entry version 181 (02 Jun 2021)
Sequence version 3 (11 Jan 2001)
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Protein

DNA dC->dU-editing enzyme APOBEC-3A

Gene

APOBEC3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.

12 Publications

Miscellaneous

It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi70Zinc; catalyticBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei72Proton donorBy similarity1
Metal bindingi101Zinc; catalyticBy similarity1
Metal bindingi106Zinc; catalyticBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processAntiviral defense, Immunity, Innate immunity
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.5.4.38, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P31941

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-72200, mRNA Editing: C to U Conversion
R-HSA-75094, Formation of the Editosome

SIGNOR Signaling Network Open Resource

More...SIGNORi		P31941

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA dC->dU-editing enzyme APOBEC-3A (EC:3.5.4.384 Publications)
Short name:
A3A
Alternative name(s):
Phorbolin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APOBEC3A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17343, APOBEC3A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607109, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P31941

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000128383.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi28R → E: No effect on deaminase activity despite an altered restriction activity towards genetic invaders. 1 Publication1
Mutagenesisi29H → A: Altered deaminase activity and restriction activity towards genetic invaders. 1 Publication1
Mutagenesisi30K → F: Altered deaminase activity and restriction activity towards genetic invaders. 1 Publication1
Mutagenesisi57N → A: Altered deaminase activity and restriction activity towards genetic invaders. 1 Publication1
Mutagenesisi60K → A: Altered deaminase activity and restriction activity towards genetic invaders. 1 Publication1
Mutagenesisi69R → A: Altered deaminase activity and restriction activity towards genetic invaders. 1 Publication1
Mutagenesisi70H → R: Altered deaminase activity. 1 Publication1
Mutagenesisi72E → Q: Altered deaminase activity and restriction activity towards genetic invaders. 2 Publications1
Mutagenesisi98W → L: Altered deaminase activity and restriction activity towards genetic invaders. 1 Publication1
Mutagenesisi106C → S: Altered deaminase activity. 1 Publication1
Mutagenesisi128R → A: Altered deaminase activity and restriction activity towards genetic invaders. 1 Publication1
Mutagenesisi130Y → A: Altered deaminase activity and restriction activity towards genetic invaders. 1 Publication1
Mutagenesisi131D → N: No effect on deaminase activity despite an altered restriction activity towards genetic invaders. 1 Publication1
Mutagenesisi133D → N: Altered deaminase activity and restriction activity towards genetic invaders. 1 Publication1
Mutagenesisi136Y → A: Altered deaminase activity and restriction activity towards genetic invaders. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		100913187
200315

Open Targets

More...OpenTargetsi		ENSG00000128383

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24891

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P31941, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1741179

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		APOBEC3A

Domain mapping of disease mutations (DMDM)

More...DMDMi		12644206

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001717521 – 199DNA dC->dU-editing enzyme APOBEC-3AAdd BLAST199

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P31941

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P31941

MaxQB - The MaxQuant DataBase

More...MaxQBi		P31941

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P31941

PeptideAtlas

More...PeptideAtlasi		P31941

PRoteomics IDEntifications database

More...PRIDEi		P31941

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54806 [P31941-1]
54807 [P31941-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P31941

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P31941

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non-lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia.4 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by interferon and CpG single-stranded DNA (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000128383, Expressed in blood and 159 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P31941, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P31941, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000128383, Tissue enhanced (blood, bone marrow, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AGO2.

Interacts with TRIB3 (via N-terminus).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		128318, 8 interactors

Database of interacting proteins

More...DIPi		DIP-61365N

Protein interaction database and analysis system

More...IntActi		P31941, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000384359

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P31941

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P31941, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P31941

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P31941

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 143CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST117

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytidine and deoxycytidylate deaminase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4075, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000164701

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_080056_2_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		HYRLTCF

Database for complete collections of gene phylogenies

More...PhylomeDBi		P31941

TreeFam database of animal gene trees

More...TreeFami		TF331356

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016192, APOBEC/CMP_deaminase_Zn-bd
IPR002125, CMP_dCMP_dom
IPR016193, Cytidine_deaminase-like

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53927, SSF53927, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00903, CYT_DCMP_DEAMINASES_1, 1 hit
PS51747, CYT_DCMP_DEAMINASES_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative initiation. AlignAdd to basket
Isoform 1 (identifier: P31941-1) [UniParc]FASTAAdd to basket
Also known as: Phorbolin-1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEASPASGPR HLMDPHIFTS NFNNGIGRHK TYLCYEVERL DNGTSVKMDQ 
        60         70         80         90        100
HRGFLHNQAK NLLCGFYGRH AELRFLDLVP SLQLDPAQIY RVTWFISWSP 
       110        120        130        140        150
CFSWGCAGEV RAFLQENTHV RLRIFAARIY DYDPLYKEAL QMLRDAGAQV 
       160        170        180        190 
SIMTYDEFKH CWDTFVDHQG CPFQPWDGLD EHSQALSGRL RAILQNQGN
Note: Enzymatically active.
Length:199
Mass (Da):23,012
Last modified:January 11, 2001 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42E99E0D7DF7AA14
GO
Isoform 2 (identifier: P31941-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.

Note: Enzymatically active.Curated
Show »
Length:187
Mass (Da):21,778
Checksum:iC7901DFD6A693D9D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04872119T → A. Corresponds to variant dbSNP:rs17000556Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0417231 – 12Missing in isoform 2. CuratedAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U03891 mRNA Translation: AAA03706.2
CR456393 mRNA Translation: CAG30279.1
AL022318 Genomic DNA No translation available.
BC126416 mRNA Translation: AAI26417.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13981.1 [P31941-1]

Protein sequence database of the Protein Information Resource

More...PIRi		G01233

NCBI Reference Sequences

More...RefSeqi		NP_001180218.1, NM_001193289.1 [P31941-1]
NP_663745.1, NM_145699.3 [P31941-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000249116; ENSP00000249116; ENSG00000128383 [P31941-1]
ENST00000402255; ENSP00000384359; ENSG00000128383 [P31941-1]
ENST00000570508; ENSP00000461288; ENSG00000262156 [P31941-1]
ENST00000618553; ENSP00000481904; ENSG00000128383 [P31941-1]
ENST00000623492; ENSP00000485234; ENSG00000262156 [P31941-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100913187
200315

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:100913187
hsa:200315

UCSC genome browser

More...UCSCi		uc003awn.2, human [P31941-1]

Keywords - Coding sequence diversityi

Alternative initiation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03891 mRNA Translation: AAA03706.2
CR456393 mRNA Translation: CAG30279.1
AL022318 Genomic DNA No translation available.
BC126416 mRNA Translation: AAI26417.1
CCDSiCCDS13981.1 [P31941-1]
PIRiG01233
RefSeqiNP_001180218.1, NM_001193289.1 [P31941-1]
NP_663745.1, NM_145699.3 [P31941-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M65NMR-A1-199[»]
4XXOX-ray2.84A/B1-199[»]
5KEGX-ray2.20A1-199[»]
5SWWX-ray3.15A/B/C/D1-196[»]
BMRBiP31941
SMRiP31941
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi128318, 8 interactors
DIPiDIP-61365N
IntActiP31941, 5 interactors
STRINGi9606.ENSP00000384359

Chemistry databases

BindingDBiP31941
ChEMBLiCHEMBL1741179

PTM databases

iPTMnetiP31941
PhosphoSitePlusiP31941

Genetic variation databases

BioMutaiAPOBEC3A
DMDMi12644206

Proteomic databases

jPOSTiP31941
MassIVEiP31941
MaxQBiP31941
PaxDbiP31941
PeptideAtlasiP31941
PRIDEiP31941
ProteomicsDBi54806 [P31941-1]
54807 [P31941-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26513, 246 antibodies

The DNASU plasmid repository

More...DNASUi		200315

Genome annotation databases

EnsembliENST00000249116; ENSP00000249116; ENSG00000128383 [P31941-1]
ENST00000402255; ENSP00000384359; ENSG00000128383 [P31941-1]
ENST00000570508; ENSP00000461288; ENSG00000262156 [P31941-1]
ENST00000618553; ENSP00000481904; ENSG00000128383 [P31941-1]
ENST00000623492; ENSP00000485234; ENSG00000262156 [P31941-1]
GeneIDi100913187
200315
KEGGihsa:100913187
hsa:200315
UCSCiuc003awn.2, human [P31941-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		100913187
200315
DisGeNETi100913187
200315

GeneCards: human genes, protein and diseases

More...GeneCardsi		APOBEC3A
HGNCiHGNC:17343, APOBEC3A
HPAiENSG00000128383, Tissue enhanced (blood, bone marrow, lymphoid tissue)
MIMi607109, gene
neXtProtiNX_P31941
OpenTargetsiENSG00000128383
PharmGKBiPA24891
VEuPathDBiHostDB:ENSG00000128383.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4075, Eukaryota
GeneTreeiENSGT00940000164701
HOGENOMiCLU_080056_2_0_1
OMAiHYRLTCF
PhylomeDBiP31941
TreeFamiTF331356

Enzyme and pathway databases

BRENDAi3.5.4.38, 2681
PathwayCommonsiP31941
ReactomeiR-HSA-72200, mRNA Editing: C to U Conversion
R-HSA-75094, Formation of the Editosome
SIGNORiP31941

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		100913187, 0 hits in 41 CRISPR screens
200315, 4 hits in 986 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		APOBEC3A, human
PharosiP31941, Tbio

Protein Ontology

More...PROi		PR:P31941
RNActiP31941, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000128383, Expressed in blood and 159 other tissues
ExpressionAtlasiP31941, baseline and differential
GenevisibleiP31941, HS

Family and domain databases

InterProiView protein in InterPro
IPR016192, APOBEC/CMP_deaminase_Zn-bd
IPR002125, CMP_dCMP_dom
IPR016193, Cytidine_deaminase-like
SUPFAMiSSF53927, SSF53927, 1 hit
PROSITEiView protein in PROSITE
PS00903, CYT_DCMP_DEAMINASES_1, 1 hit
PS51747, CYT_DCMP_DEAMINASES_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABC3A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31941
Secondary accession number(s): A0AVM1
, Q12807, Q5JZ93, Q9UH18
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 11, 2001
Last modified: June 2, 2021
This is version 181 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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