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UniProtKB - P31939 (PUR9_HUMAN)

Entry version 210 (02 Jun 2021)
Sequence version 3 (10 Oct 2002)
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Protein

Bifunctional purine biosynthesis protein ATIC

Gene

ATIC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554).

Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:9378707, PubMed:11948179, PubMed:10985775).

Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775).

Also catalyzes the cyclization of FAICAR to IMP (PubMed:11948179, PubMed:14756554).

Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775).

Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571).

5 Publications

Miscellaneous

The de novo purine synthesis pathway includes 10 sequential steps, beginning with phosphoribosyl pyrophosphate and ending with inositol monophosphate (IMP), the first purin compound of the pathway.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

AMP and XMP inhibit AICAR formyltransferase activity (PubMed:10985775). AICAR formyltransferase activity is inhibited by N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5- [(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), which acts as a tumor suppression in cancer cell lines (PubMed:29072452).2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 3.7 sec(-1) for AICAR formyltransferase activity with (6S)-10-formyltetrahydrofolate as substrate (PubMed:10985775). kcat is 4.1 sec(-1) for AICAR formyltransferase activity with 10-formyldihydrofolate as substrate (PubMed:10985775). kcat is 2.9 sec(-1) for AICAR formyltransferase activity with (6S)-10-formyltetrahydrofolate as substrate (PubMed:11948179). kcat is 6.0 sec(-1) for FAICAR cyclization activity (PubMed:11948179). kcat is 8.6 sec(-1) for FAICAR cyclization activity (PubMed:14756554).3 Publications
  1. KM=10 µM for 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide (with (6S)-10-formyltetrahydrofolate as cosubstrate)1 Publication
  2. KM=1.5 µM for 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide (with 10-formyldihydrofolate as cosubstrate)1 Publication
  3. KM=1.9 µM for 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide (with (6S)-10-formyltetrahydrofolate as cosubstrate)1 Publication
  4. KM=110 µM for (6S)-10-formyltetrahydrofolate1 Publication
  5. KM=100 µM for (6S)-10-formyltetrahydrofolate1 Publication
  6. KM=39 µM for (6S)-10-formyltetrahydrofolate1 Publication
  7. KM=11 µM for 10-formyldihydrofolate1 Publication
  8. KM=1.4 µM for 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide1 Publication
  9. KM=0.9 µM for 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: IMP biosynthesis via de novo pathway

    This protein is involved in step 1 of the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route).1 Publication This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

    Pathwayi: IMP biosynthesis via de novo pathway

    This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.1 Publication This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei137Proton donor/acceptor; for FAICAR cyclization activity1 Publication1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei266Transition state stabilizer1 Publication1
    Active sitei267Proton acceptor; for AICAR formyltransferase activity1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei267AICARCombined sources2 Publications1
    Binding sitei316AICAR; via carbonyl oxygenCombined sources2 Publications1
    Binding sitei339AICARCombined sources2 Publications1
    Binding sitei431AICAR; shared with dimeric partnerCombined sources2 Publications1
    Binding sitei451AICAR; shared with dimeric partnerCombined sources2 Publications1
    Binding sitei45210-formyltetrahydrofolate; via amide nitrogenBy similarity1
    Binding sitei541AICAR; via carbonyl oxygen; shared with dimeric partnerCombined sources2 Publications1
    Binding sitei54610-formyltetrahydrofolateBy similarity1
    Binding sitei588AICAR; shared with dimeric partnerCombined sources2 Publications1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi12 – 14IMPCombined sources2 Publications3
    Nucleotide bindingi34 – 37IMPCombined sources2 Publications4
    Nucleotide bindingi64 – 67IMPCombined sources2 Publications4
    Nucleotide bindingi101 – 102IMPCombined sources2 Publications2
    Nucleotide bindingi125 – 126IMPCombined sources2 Publications2

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Multifunctional enzyme, Transferase
    Biological processPurine biosynthesis

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...    BioCyci    		MetaCyc:HS06490-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		2.1.2.3, 2681
    3.5.4.10, 2681

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		P31939

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-73817, Purine ribonucleoside monophosphate biosynthesis

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		P31939

    SIGNOR Signaling Network Open Resource

    More...    SIGNORi    		P31939

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...    UniPathwayi    		UPA00074;UER00133
    UPA00074;UER00135

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein ATIC
    Alternative name(s):
    AICAR transformylase/inosine monophosphate cyclohydrolase
    Short name:
    ATIC
    Cleaved into the following chain:
    Bifunctional purine biosynthesis protein ATIC, N-terminally processed
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.33 Publications)
    Alternative name(s):
    5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase1 Publication
    Short name:
    AICAR formyltransferase1 Publication
    AICAR transformylase
    Inosine 5'-monophosphate cyclohydrolase1 Publication (EC:3.5.4.102 Publications)
    Short name:
    IMP cyclohydrolase1 Publication
    Alternative name(s):
    IMP synthase
    Inosinicase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ATICImported
    Synonyms:PURH
    ORF Names:OK/SW-cl.86
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:794, ATIC

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		601731, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_P31939

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...    VEuPathDBi    		HostDB:ENSG00000138363.14

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    AICAR transformylase/IMP cyclohydrolase deficiency (AICAR)1 Publication
    The disease is caused by variants affecting the gene represented in this entry.
    Disease descriptionA neurologically devastating inborn error of purine biosynthesis. Patients excrete massive amounts of AICA-riboside in the urine and accumulate AICA-ribotide and its derivatives in erythrocytes and fibroblasts. AICAR causes profound mental retardation, epilepsy, dysmorphic features and congenital blindness.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019307426K → R in AICAR; loss of transformylase activity. 1 PublicationCorresponds to variant dbSNP:rs121434478EnsemblClinVar.1

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi66K → A: Decreased affinity to FAICAR; no change in FAICAR cyclization activity. 1 Publication1
    Mutagenesisi104Y → A or F: Decreased FAICAR cyclization activity; no change in affinity to FAICAR. 1 Publication1
    Mutagenesisi125D → A, E or N: Decreased FAICAR cyclization activity; no change in affinity to FAICAR. 1 Publication1
    Mutagenesisi137K → A: Decreased affinity to FAICAR; no change in FAICAR cyclization activity. 1 Publication1
    Mutagenesisi137K → R: Decreased FAICAR cyclization activity; no change in affinity to FAICAR. 1 Publication1
    Mutagenesisi213H → A: Loss of AICAR transformylase activity. 1 Publication1
    Mutagenesisi267H → A: Loss of AICAR transformylase activity. 1 Publication1

    Keywords - Diseasei

    Disease variant, Epilepsy

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		471

    MalaCards human disease database

    More...    MalaCardsi    		ATIC
    MIMi608688, phenotype

    Open Targets

    More...    OpenTargetsi    		ENSG00000138363

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...    Orphaneti    		250977, AICA-ribosiduria

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA25094

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		P31939, Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL2518

    Drug and drug target database

    More...    DrugBanki    		DB02309, 5-monophosphate-9-beta-D-ribofuranosyl xanthine
    DB03442, Acid yellow 54 free acid
    DB01700, AICA ribonucleotide
    DB01972, Guanosine-5'-Monophosphate
    DB00563, Methotrexate
    DB04057, N-[4-([(2-Amino-4-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-6-yl)methyl]{(2E)-3-[4-carbamoyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-5-yl]-2-propenoyl}amino)benzoyl]-L-glutamic acid
    DB00642, Pemetrexed
    DB00116, Tetrahydrofolic acid

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		ATIC

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		23831360

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001921561 – 592Bifunctional purine biosynthesis protein ATICAdd BLAST592
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternateCombined sources
    ChainiPRO_00004343762 – 592Bifunctional purine biosynthesis protein ATIC, N-terminally processed1 PublicationAdd BLAST591

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
    Modified residuei199N6-acetyllysineCombined sources1

    Keywords - PTMi

    Acetylation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		P31939

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		P31939

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		P31939

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		P31939

    PeptideAtlas

    More...    PeptideAtlasi    		P31939

    PRoteomics IDEntifications database

    More...    PRIDEi    		P31939

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		19298
    54805 [P31939-1]

    2D gel databases

    REPRODUCTION-2DPAGE

    More...    REPRODUCTION-2DPAGEi    		IPI00289499

    University College Dublin 2-DE Proteome Database

    More...    UCD-2DPAGEi    		P31939

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		P31939

    MetOSite database of methionine sulfoxide sites

    More...    MetOSitei    		P31939

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		P31939

    SwissPalm database of S-palmitoylation events

    More...    SwissPalmi    		P31939

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Present in the heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000138363, Expressed in adrenal gland and 241 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		P31939, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		P31939, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000138363, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer (PubMed:14756553, PubMed:14966129). Associates with internalized INSR complexes on Golgi/endosomal membranes (PubMed:25687571).

    Interacts with INSR; ATIC together with PRKAA2/AMPK2 and HACD3/PTPLAD1 is proposed to be part of a signaling network regulating INSR autophosphorylation and endocytosis (PubMed:25687571).

    3 Publications

    GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		106961, 103 interactors

    Protein interaction database and analysis system

    More...    IntActi    		P31939, 15 interactors

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000236959

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		P31939

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		P31939, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1592
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		P31939

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...    EvolutionaryTracei    		P31939

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 146MGS-likePROSITE-ProRule annotationAdd BLAST145

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 198IMP cyclohydrolaseBy similarityAdd BLAST197
    Regioni199 – 592AICAR formyltransferaseBy similarityAdd BLAST394
    Regioni207 – 208AICAR bindingCombined sources1 Publication2
    Regioni565 – 56610-formyltetrahydrofolate bindingBy similarity2

    <p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the PurH family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG2555, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00390000004553

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_016316_3_2_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		P31939

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		WRVAKFV

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		P31939

    TreeFam database of animal gene trees

    More...    TreeFami    		TF105642

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		1.10.287.440, 1 hit
    3.40.140.20, 2 hits
    3.40.50.1380, 1 hit

    HAMAP database of protein families

    More...    HAMAPi    		MF_00139, PurH, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR024051, AICAR_Tfase_dup_dom_sf
    IPR024050, AICAR_Tfase_insert_dom_sf
    IPR016193, Cytidine_deaminase-like
    IPR011607, MGS-like_dom
    IPR036914, MGS-like_dom_sf
    IPR002695, PurH-like

    The PANTHER Classification System

    More...    PANTHERi    		PTHR11692, PTHR11692, 1 hit

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF01808, AICARFT_IMPCHas, 1 hit
    PF02142, MGS, 1 hit

    PIRSF; a whole-protein classification database

    More...    PIRSFi    		PIRSF000414, AICARFT_IMPCHas, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...    SMARTi    		View protein in SMART
    SM00798, AICARFT_IMPCHas, 1 hit
    SM00851, MGS, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF52335, SSF52335, 1 hit
    SSF53927, SSF53927, 1 hit

    TIGRFAMs; a protein family database

    More...    TIGRFAMsi    		TIGR00355, purH, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS51855, MGS, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P31939-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAPGQLALFS VSDKTGLVEF ARNLTALGLN LVASGGTAKA LRDAGLAVRD 
            60         70         80         90        100
    VSELTGFPEM LGGRVKTLHP AVHAGILARN IPEDNADMAR LDFNLIRVVA 
           110        120        130        140        150
    CNLYPFVKTV ASPGVTVEEA VEQIDIGGVT LLRAAAKNHA RVTVVCEPED 
           160        170        180        190        200
    YVVVSTEMQS SESKDTSLET RRQLALKAFT HTAQYDEAIS DYFRKQYSKG 
           210        220        230        240        250
    VSQMPLRYGM NPHQTPAQLY TLQPKLPITV LNGAPGFINL CDALNAWQLV 
           260        270        280        290        300
    KELKEALGIP AAASFKHVSP AGAAVGIPLS EDEAKVCMVY DLYKTLTPIS 
           310        320        330        340        350
    AAYARARGAD RMSSFGDFVA LSDVCDVPTA KIISREVSDG IIAPGYEEEA 
           360        370        380        390        400
    LTILSKKKNG NYCVLQMDQS YKPDENEVRT LFGLHLSQKR NNGVVDKSLF 
           410        420        430        440        450
    SNVVTKNKDL PESALRDLIV ATIAVKYTQS NSVCYAKNGQ VIGIGAGQQS 
           460        470        480        490        500
    RIHCTRLAGD KANYWWLRHH PQVLSMKFKT GVKRAEISNA IDQYVTGTIG 
           510        520        530        540        550
    EDEDLIKWKA LFEEVPELLT EAEKKEWVEK LTEVSISSDA FFPFRDNVDR 
           560        570        580        590 
    AKRSGVAYIA APSGSAADKV VIEACDELGI ILAHTNLRLF HH
    Length:592
    Mass (Da):64,616
    Last modified:October 10, 2002 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD778892021F0888
    GO
    Isoform 2 (identifier: P31939-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-6: MAPGQL → MSSLS

    Show »
    Length:591
    Mass (Da):64,524
    Checksum:i372861CF93D74887
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    C9JLK0C9JLK0_HUMAN
    AICAR transformylase/inosine monoph...
    ATIC
    		170Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8WEF0F8WEF0_HUMAN
    AICAR transformylase/inosine monoph...
    ATIC
    		84Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H7C1S2H7C1S2_HUMAN
    Bifunctional purine biosynthesis pr...
    ATIC
    		231Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F2Z3E8F2Z3E8_HUMAN
    Bifunctional purine biosynthesis pr...
    ATIC
    		43Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti165D → G in AAA97405 (PubMed:8567683).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_019306116T → S2 PublicationsCorresponds to variant dbSNP:rs2372536EnsemblClinVar.1
    Natural variantiVAR_019307426K → R in AICAR; loss of transformylase activity. 1 PublicationCorresponds to variant dbSNP:rs121434478EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0534951 – 6MAPGQL → MSSLS in isoform 2. 2 Publications6

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		U37436 mRNA Translation: AAA97405.1
    D82348 mRNA Translation: BAA11559.1
    D89976 mRNA Translation: BAA21762.1
    AB062403 mRNA Translation: BAB93490.1
    AK290067 mRNA Translation: BAF82756.1
    AC073284 Genomic DNA Translation: AAY24062.1
    CH471063 Genomic DNA Translation: EAW70529.1
    BC008879 mRNA Translation: AAH08879.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS2398.1 [P31939-1]

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		JC4642

    NCBI Reference Sequences

    More...    RefSeqi    		NP_004035.2, NM_004044.6 [P31939-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000236959; ENSP00000236959; ENSG00000138363 [P31939-1]
    ENST00000435675; ENSP00000415935; ENSG00000138363 [P31939-2]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		471

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:471

    UCSC genome browser

    More...    UCSCi    		uc002vey.5, human [P31939-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		U37436 mRNA Translation: AAA97405.1
    D82348 mRNA Translation: BAA11559.1
    D89976 mRNA Translation: BAA21762.1
    AB062403 mRNA Translation: BAB93490.1
    AK290067 mRNA Translation: BAF82756.1
    AC073284 Genomic DNA Translation: AAY24062.1
    CH471063 Genomic DNA Translation: EAW70529.1
    BC008879 mRNA Translation: AAH08879.1
    CCDSiCCDS2398.1 [P31939-1]
    PIRiJC4642
    RefSeqiNP_004035.2, NM_004044.6 [P31939-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1P4RX-ray2.55A/B1-592[»]
    1PKXX-ray1.90A/B/C/D1-592[»]
    1PL0X-ray2.60A/B/C/D1-592[»]
    5UY8X-ray2.39A/B/C/D2-592[»]
    5UZ0X-ray1.79A/B/C/D2-592[»]
    SMRiP31939
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi106961, 103 interactors
    IntActiP31939, 15 interactors
    STRINGi9606.ENSP00000236959

    Chemistry databases

    BindingDBiP31939
    ChEMBLiCHEMBL2518
    DrugBankiDB02309, 5-monophosphate-9-beta-D-ribofuranosyl xanthine
    DB03442, Acid yellow 54 free acid
    DB01700, AICA ribonucleotide
    DB01972, Guanosine-5'-Monophosphate
    DB00563, Methotrexate
    DB04057, N-[4-([(2-Amino-4-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-6-yl)methyl]{(2E)-3-[4-carbamoyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-5-yl]-2-propenoyl}amino)benzoyl]-L-glutamic acid
    DB00642, Pemetrexed
    DB00116, Tetrahydrofolic acid

    PTM databases

    iPTMnetiP31939
    MetOSiteiP31939
    PhosphoSitePlusiP31939
    SwissPalmiP31939

    Genetic variation databases

    BioMutaiATIC
    DMDMi23831360

    2D gel databases

    REPRODUCTION-2DPAGEiIPI00289499
    UCD-2DPAGEiP31939

    Proteomic databases

    EPDiP31939
    jPOSTiP31939
    MassIVEiP31939
    PaxDbiP31939
    PeptideAtlasiP31939
    PRIDEiP31939
    ProteomicsDBi19298
    54805 [P31939-1]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		4601, 398 antibodies

    The DNASU plasmid repository

    More...    DNASUi    		471

    Genome annotation databases

    EnsembliENST00000236959; ENSP00000236959; ENSG00000138363 [P31939-1]
    ENST00000435675; ENSP00000415935; ENSG00000138363 [P31939-2]
    GeneIDi471
    KEGGihsa:471
    UCSCiuc002vey.5, human [P31939-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		471
    DisGeNETi471

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		ATIC
    HGNCiHGNC:794, ATIC
    HPAiENSG00000138363, Low tissue specificity
    MalaCardsiATIC
    MIMi601731, gene
    608688, phenotype
    neXtProtiNX_P31939
    OpenTargetsiENSG00000138363
    Orphaneti250977, AICA-ribosiduria
    PharmGKBiPA25094
    VEuPathDBiHostDB:ENSG00000138363.14

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG2555, Eukaryota
    GeneTreeiENSGT00390000004553
    HOGENOMiCLU_016316_3_2_1
    InParanoidiP31939
    OMAiWRVAKFV
    PhylomeDBiP31939
    TreeFamiTF105642

    Enzyme and pathway databases

    UniPathwayiUPA00074;UER00133
    UPA00074;UER00135
    BioCyciMetaCyc:HS06490-MONOMER
    BRENDAi2.1.2.3, 2681
    3.5.4.10, 2681
    PathwayCommonsiP31939
    ReactomeiR-HSA-73817, Purine ribonucleoside monophosphate biosynthesis
    SABIO-RKiP31939
    SIGNORiP31939

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		471, 188 hits in 1002 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		ATIC, human
    EvolutionaryTraceiP31939

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		Inosine_monophosphate_synthase

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		471
    PharosiP31939, Tchem

    Protein Ontology

    More...    PROi    		PR:P31939
    RNActiP31939, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000138363, Expressed in adrenal gland and 241 other tissues
    ExpressionAtlasiP31939, baseline and differential
    GenevisibleiP31939, HS

    Family and domain databases

    Gene3Di1.10.287.440, 1 hit
    3.40.140.20, 2 hits
    3.40.50.1380, 1 hit
    HAMAPiMF_00139, PurH, 1 hit
    InterProiView protein in InterPro
    IPR024051, AICAR_Tfase_dup_dom_sf
    IPR024050, AICAR_Tfase_insert_dom_sf
    IPR016193, Cytidine_deaminase-like
    IPR011607, MGS-like_dom
    IPR036914, MGS-like_dom_sf
    IPR002695, PurH-like
    PANTHERiPTHR11692, PTHR11692, 1 hit
    PfamiView protein in Pfam
    PF01808, AICARFT_IMPCHas, 1 hit
    PF02142, MGS, 1 hit
    PIRSFiPIRSF000414, AICARFT_IMPCHas, 1 hit
    SMARTiView protein in SMART
    SM00798, AICARFT_IMPCHas, 1 hit
    SM00851, MGS, 1 hit
    SUPFAMiSSF52335, SSF52335, 1 hit
    SSF53927, SSF53927, 1 hit
    TIGRFAMsiTIGR00355, purH, 1 hit
    PROSITEiView protein in PROSITE
    PS51855, MGS, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPUR9_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31939
    Secondary accession number(s): A8K202
    , E9PBU3, Q13856, Q53S28
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: October 10, 2002
    Last modified: June 2, 2021
    This is version 210 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with genetic variants
      List of human entries with genetic variants
    3. Human variants curated from literature reports
      Index of human variants curated from literature reports
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families
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