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Protein

Cytochrome b-c1 complex subunit 1, mitochondrial

Gene

UQCRC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

Caution

Does not seem to have a protease activity as it lack the zinc-binding site.Curated

GO - Molecular functioni

  • metal ion binding Source: InterPro
  • metalloendopeptidase activity Source: GO_Central
  • protein-containing complex binding Source: Ensembl
  • ubiquinol-cytochrome-c reductase activity Source: ProtInc
  • ubiquitin protein ligase binding Source: ParkinsonsUK-UCL

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport
SignaLinkiP31930

Protein family/group databases

MEROPSiM16.973

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 1, mitochondrial
Alternative name(s):
Complex III subunit 1
Core protein I
Ubiquinol-cytochrome-c reductase complex core protein 1
Gene namesi
Name:UQCRC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000010256.10
HGNCiHGNC:12585 UQCRC1
MIMi191328 gene
neXtProtiNX_P31930

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7384
OpenTargetsiENSG00000010256
PharmGKBiPA37216

Chemistry databases

DrugBankiDB08453 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE
DB07778 FAMOXADONE
DB07401 METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE
DB08330 METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
DB04741 Myxothiazol
DB08690 UBIQUINONE-2

Polymorphism and mutation databases

BioMutaiUQCRC1
DMDMi92090651

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34MitochondrionCombined sources1 PublicationAdd BLAST34
ChainiPRO_000002678635 – 480Cytochrome b-c1 complex subunit 1, mitochondrialAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei111N6-acetyllysineCombined sources1
Modified residuei138N6-acetyllysineBy similarity1
Modified residuei163N6-acetyllysine; alternateBy similarity1
Modified residuei163N6-succinyllysine; alternateBy similarity1
Modified residuei212PhosphoserineBy similarity1
Modified residuei248N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP31930
MaxQBiP31930
PaxDbiP31930
PeptideAtlasiP31930
PRIDEiP31930
ProteomicsDBi54803

2D gel databases

OGPiP31930
REPRODUCTION-2DPAGEiIPI00013847
SWISS-2DPAGEiP31930
UCD-2DPAGEiP31930

PTM databases

iPTMnetiP31930
PhosphoSitePlusiP31930
SwissPalmiP31930

Expressioni

Gene expression databases

BgeeiENSG00000010256 Expressed in 233 organ(s), highest expression level in apex of heart
CleanExiHS_UQCRC1
ExpressionAtlasiP31930 baseline and differential
GenevisibleiP31930 HS

Organism-specific databases

HPAiCAB033782
HPA002815
HPA003525

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113230, 66 interactors
ComplexPortaliCPX-560 Mitochondrial respiratory chain complex III
IntActiP31930, 37 interactors
MINTiP31930
STRINGi9606.ENSP00000203407

Structurei

Secondary structure

1480
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP31930
SMRiP31930
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0960 Eukaryota
COG0612 LUCA
GeneTreeiENSGT00550000074701
HOGENOMiHOG000242450
HOVERGENiHBG006393
InParanoidiP31930
KOiK00414
OMAiSRHYKAP
OrthoDBiEOG091G05W9
PhylomeDBiP31930
TreeFamiTF105032

Family and domain databases

InterProiView protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR011765 Pept_M16_N
IPR007863 Peptidase_M16_C
PfamiView protein in Pfam
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 1 hit
SUPFAMiSSF63411 SSF63411, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P31930-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASVVCRAA TAGAQVLLRA RRSPALLRTP ALRSTATFAQ ALQFVPETQV
60 70 80 90 100
SLLDNGLRVA SEQSSQPTCT VGVWIDVGSR FETEKNNGAG YFLEHLAFKG
110 120 130 140 150
TKNRPGSALE KEVESMGAHL NAYSTREHTA YYIKALSKDL PKAVELLGDI
160 170 180 190 200
VQNCSLEDSQ IEKERDVILR EMQENDASMR DVVFNYLHAT AFQGTPLAQA
210 220 230 240 250
VEGPSENVRK LSRADLTEYL STHYKAPRMV LAAAGGVEHQ QLLDLAQKHL
260 270 280 290 300
GGIPWTYAED AVPTLTPCRF TGSEIRHRDD ALPFAHVAIA VEGPGWASPD
310 320 330 340 350
NVALQVANAI IGHYDCTYGG GVHLSSPLAS GAVANKLCQS FQTFSICYAE
360 370 380 390 400
TGLLGAHFVC DRMKIDDMMF VLQGQWMRLC TSATESEVAR GKNILRNALV
410 420 430 440 450
SHLDGTTPVC EDIGRSLLTY GRRIPLAEWE SRIAEVDASV VREICSKYIY
460 470 480
DQCPAVAGYG PIEQLPDYNR IRSGMFWLRF
Length:480
Mass (Da):52,646
Last modified:April 4, 2006 - v3
Checksum:iE76B082166CAF48F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WER5F8WER5_HUMAN
Cytochrome b-c1 complex subunit 1, ...
UQCRC1
121Annotation score:
F8WEF1F8WEF1_HUMAN
Cytochrome b-c1 complex subunit 1, ...
UQCRC1
68Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034581215D → H. Corresponds to variant dbSNP:rs17080284Ensembl.1
Natural variantiVAR_013629301N → S2 PublicationsCorresponds to variant dbSNP:rs144710790Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16842 mRNA Translation: AAA20046.1
D26485 mRNA Translation: BAA05495.1
AK313090 mRNA Translation: BAG35915.1
CH471055 Genomic DNA Translation: EAW64898.1
BC009586 mRNA Translation: AAH09586.1
CCDSiCCDS2774.1
PIRiA48043
RefSeqiNP_003356.2, NM_003365.2
UniGeneiHs.119251

Genome annotation databases

EnsembliENST00000203407; ENSP00000203407; ENSG00000010256
GeneIDi7384
KEGGihsa:7384
UCSCiuc003cub.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16842 mRNA Translation: AAA20046.1
D26485 mRNA Translation: BAA05495.1
AK313090 mRNA Translation: BAG35915.1
CH471055 Genomic DNA Translation: EAW64898.1
BC009586 mRNA Translation: AAH09586.1
CCDSiCCDS2774.1
PIRiA48043
RefSeqiNP_003356.2, NM_003365.2
UniGeneiHs.119251

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTEelectron microscopy3.40L/Y35-480[»]
5XTHelectron microscopy3.90AL/AY35-480[»]
5XTIelectron microscopy17.40AL/AY35-480[»]
ProteinModelPortaliP31930
SMRiP31930
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113230, 66 interactors
ComplexPortaliCPX-560 Mitochondrial respiratory chain complex III
IntActiP31930, 37 interactors
MINTiP31930
STRINGi9606.ENSP00000203407

Chemistry databases

DrugBankiDB08453 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE
DB07778 FAMOXADONE
DB07401 METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE
DB08330 METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
DB04741 Myxothiazol
DB08690 UBIQUINONE-2

Protein family/group databases

MEROPSiM16.973

PTM databases

iPTMnetiP31930
PhosphoSitePlusiP31930
SwissPalmiP31930

Polymorphism and mutation databases

BioMutaiUQCRC1
DMDMi92090651

2D gel databases

OGPiP31930
REPRODUCTION-2DPAGEiIPI00013847
SWISS-2DPAGEiP31930
UCD-2DPAGEiP31930

Proteomic databases

EPDiP31930
MaxQBiP31930
PaxDbiP31930
PeptideAtlasiP31930
PRIDEiP31930
ProteomicsDBi54803

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000203407; ENSP00000203407; ENSG00000010256
GeneIDi7384
KEGGihsa:7384
UCSCiuc003cub.2 human

Organism-specific databases

CTDi7384
DisGeNETi7384
EuPathDBiHostDB:ENSG00000010256.10
GeneCardsiUQCRC1
HGNCiHGNC:12585 UQCRC1
HPAiCAB033782
HPA002815
HPA003525
MIMi191328 gene
neXtProtiNX_P31930
OpenTargetsiENSG00000010256
PharmGKBiPA37216
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0960 Eukaryota
COG0612 LUCA
GeneTreeiENSGT00550000074701
HOGENOMiHOG000242450
HOVERGENiHBG006393
InParanoidiP31930
KOiK00414
OMAiSRHYKAP
OrthoDBiEOG091G05W9
PhylomeDBiP31930
TreeFamiTF105032

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport
SignaLinkiP31930

Miscellaneous databases

ChiTaRSiUQCRC1 human
GeneWikiiUQCRC1
GenomeRNAii7384
PROiPR:P31930
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000010256 Expressed in 233 organ(s), highest expression level in apex of heart
CleanExiHS_UQCRC1
ExpressionAtlasiP31930 baseline and differential
GenevisibleiP31930 HS

Family and domain databases

InterProiView protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR011765 Pept_M16_N
IPR007863 Peptidase_M16_C
PfamiView protein in Pfam
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 1 hit
SUPFAMiSSF63411 SSF63411, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQCR1_HUMAN
AccessioniPrimary (citable) accession number: P31930
Secondary accession number(s): B2R7R8, Q96DD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: April 4, 2006
Last modified: November 7, 2018
This is version 189 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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