UniProtKB - P31828 (PQQL_ECOLI)
Protein
Probable zinc protease PqqL
Gene
pqqL
Organism
Escherichia coli (strain K12)
Status
Functioni
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 80 | ZincPROSITE-ProRule annotation | 1 | |
Active sitei | 83 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Metal bindingi | 84 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 160 | ZincPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- metallopeptidase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, Metalloprotease, Protease |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11744-MONOMER |
Protein family/group databases
MEROPSi | M16.A05 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pqqL Synonyms:yddC Ordered Locus Names:b1494, JW1489 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000074415 | 1 – 931 | Probable zinc protease PqqLAdd BLAST | 931 |
Proteomic databases
jPOSTi | P31828 |
PaxDbi | P31828 |
PRIDEi | P31828 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260787, 22 interactors 850420, 1 interactor |
DIPi | DIP-10556N |
IntActi | P31828, 12 interactors |
STRINGi | 511145.b1494 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SASBDBi | P31828 |
SMRi | P31828 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase M16 family.Curated
Phylogenomic databases
eggNOGi | COG0612, Bacteria |
HOGENOMi | CLU_008156_0_0_6 |
InParanoidi | P31828 |
PhylomeDBi | P31828 |
Family and domain databases
InterProi | View protein in InterPro IPR011249, Metalloenz_LuxS/M16 IPR011765, Pept_M16_N IPR001431, Pept_M16_Zn_BS IPR007863, Peptidase_M16_C |
Pfami | View protein in Pfam PF00675, Peptidase_M16, 1 hit PF05193, Peptidase_M16_C, 2 hits |
SUPFAMi | SSF63411, SSF63411, 4 hits |
PROSITEi | View protein in PROSITE PS00143, INSULINASE, 1 hit |
i Sequence
Sequence statusi: Complete.
P31828-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEIIMRNLCF LLTLVATLLL PGRLIAAALP QDEKLITGQL DNGLRYMIYP
60 70 80 90 100
HAHPKDQVNL WLQIHTGSLQ EEDNELGVAH FVEHMMFNGT KTWPGNKVIE
110 120 130 140 150
TFESMGLRFG RDVNAYTSYD ETVYQVSLPT TQKQNLQQVM AIFSEWSNAA
160 170 180 190 200
TFEKLEVDAE RGVITEEWRA HQDAKWRTSQ ARRPFLLANT RNLDREPIGL
210 220 230 240 250
MDTVATVTPA QLRQFYQRWY QPNNMTFIVV GDIDSKEALA LIKDNLSKLP
260 270 280 290 300
ANKAAENRVW PTKAENHLRF NIINDKENRV NGIALYYRLP MVQVNDEQSF
310 320 330 340 350
IEQAEWSMLV QLFNQRLQER IQSGELKTIS GGTARSVKIA PDYQSLFFRV
360 370 380 390 400
NARDDNMQDA ANALMAELAT IDQHGFSAEE LDDVKSTRLT WLKNAVDQQA
410 420 430 440 450
ERDLRMLTSR LASSSLNNTP FLSPEETYQL SKRLWQQITV QSLAEKWQQL
460 470 480 490 500
RKNQDAFWEQ MVNNEVAAKK ALSPAAILAL EKEYANKKLA AYVFPGRNLS
510 520 530 540 550
LTVDADPQAE ISSKETLAEN LTSLTLSNGA RVILAKSAGE EQKLQIIAVS
560 570 580 590 600
NKGDLSFPAQ QKSLIALANK AVSGSGVGEL SSSSLKRWSA ENSVTMSSKV
610 620 630 640 650
SGMNTLLSVS ARTNNPEPGF QLINQRITHS TINDNIWASL QNAQIQALKT
660 670 680 690 700
LDQRPAEKFA QQMYETRYAD DRTKLLQENQ IAQFTAADAL AADRQLFSSP
710 720 730 740 750
ADITFVIVGN VAEDKLVALI TRYLGSIKHS DSPLAAGKPL TRATDNASVT
760 770 780 790 800
VKEQNEPVAQ VSQWKRYDSR TPVNLPTRMA LDAFNVALAK DLRVNIREQA
810 820 830 840 850
SGAYSVSSRL SVDPQAKDIS HLLAFTCQPE RHDELLTLAN EVMVKRLAKG
860 870 880 890 900
ISEQELNEYQ QNVQRSLDIQ QRSVQQLANT IVNSLIQYDD PAAWTEQEQL
910 920 930
LKQMTVENVN TAVKQYLSHP VNTYTGVLLP K
Sequence cautioni
The sequence CAA50735 differs from that shown. Reason: Frameshift. Produces two separate ORFs.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 360 | A → V in CAA50734 (PubMed:9116051).Curated | 1 | |
Sequence conflicti | 867 | L → V in CAA50735 (PubMed:9116051).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71917 Genomic DNA Translation: CAA50734.1 Frameshift. X71917 Genomic DNA Translation: CAA50735.1 Frameshift. U00096 Genomic DNA Translation: AAC74567.1 AP009048 Genomic DNA Translation: BAA15164.2 |
PIRi | A64903 |
RefSeqi | NP_416011.1, NC_000913.3 WP_010723101.1, NZ_CP047127.1 |
Genome annotation databases
EnsemblBacteriai | AAC74567; AAC74567; b1494 BAA15164; BAA15164; BAA15164 |
GeneIDi | 946059 |
KEGGi | ecj:JW1489 eco:b1494 |
PATRICi | fig|511145.12.peg.1561 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71917 Genomic DNA Translation: CAA50734.1 Frameshift. X71917 Genomic DNA Translation: CAA50735.1 Frameshift. U00096 Genomic DNA Translation: AAC74567.1 AP009048 Genomic DNA Translation: BAA15164.2 |
PIRi | A64903 |
RefSeqi | NP_416011.1, NC_000913.3 WP_010723101.1, NZ_CP047127.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6OFS | X-ray | 2.60 | A | 27-931 | [»] | |
6OFT | X-ray | 2.00 | A/B | 27-497 | [»] | |
SASBDBi | P31828 | |||||
SMRi | P31828 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4260787, 22 interactors 850420, 1 interactor |
DIPi | DIP-10556N |
IntActi | P31828, 12 interactors |
STRINGi | 511145.b1494 |
Protein family/group databases
MEROPSi | M16.A05 |
Proteomic databases
jPOSTi | P31828 |
PaxDbi | P31828 |
PRIDEi | P31828 |
Genome annotation databases
EnsemblBacteriai | AAC74567; AAC74567; b1494 BAA15164; BAA15164; BAA15164 |
GeneIDi | 946059 |
KEGGi | ecj:JW1489 eco:b1494 |
PATRICi | fig|511145.12.peg.1561 |
Organism-specific databases
EchoBASEi | EB1695 |
Phylogenomic databases
eggNOGi | COG0612, Bacteria |
HOGENOMi | CLU_008156_0_0_6 |
InParanoidi | P31828 |
PhylomeDBi | P31828 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11744-MONOMER |
Miscellaneous databases
PROi | PR:P31828 |
Family and domain databases
InterProi | View protein in InterPro IPR011249, Metalloenz_LuxS/M16 IPR011765, Pept_M16_N IPR001431, Pept_M16_Zn_BS IPR007863, Peptidase_M16_C |
Pfami | View protein in Pfam PF00675, Peptidase_M16, 1 hit PF05193, Peptidase_M16_C, 2 hits |
SUPFAMi | SSF63411, SSF63411, 4 hits |
PROSITEi | View protein in PROSITE PS00143, INSULINASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PQQL_ECOLI | |
Accessioni | P31828Primary (citable) accession number: P31828 Secondary accession number(s): P31829, P76132, P78158 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | November 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 153 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families