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UniProtKB - P31828 (PQQL_ECOLI)

Entry version 146 (13 Nov 2019)
Sequence version 2 (01 Nov 1997)
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Protein

Probable zinc protease PqqL

Gene

pqqL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi80ZincPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei83Proton acceptorPROSITE-ProRule annotation1
Metal bindingi84ZincPROSITE-ProRule annotation1
Metal bindingi160ZincPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:EG11744-MONOMER
ECOL316407:JW1489-MONOMER

Protein family/group databases

MEROPS protease database

More...MEROPSi		M16.A05

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable zinc protease PqqL (EC:3.4.24.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pqqL
Synonyms:yddC
Ordered Locus Names:b1494, JW1489
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Complete GO annotation on QuickGO ...

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000744151 – 931Probable zinc protease PqqLAdd BLAST931

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P31828

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P31828

PRoteomics IDEntifications database

More...PRIDEi		P31828

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		4260787, 22 interactors
850420, 1 interactor

Database of interacting proteins

More...DIPi		DIP-10556N

Protein interaction database and analysis system

More...IntActi		P31828, 12 interactors

STRING: functional protein association networks

More...STRINGi		511145.b1494

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P31828

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M16 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG4107RAN Bacteria
COG0612 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000120686

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P31828

KEGG Orthology (KO)

More...KOi		K07263

Database for complete collections of gene phylogenies

More...PhylomeDBi		P31828

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR011765 Pept_M16_N
IPR001431 Pept_M16_Zn_BS
IPR007863 Peptidase_M16_C

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF63411 SSF63411, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00143 INSULINASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P31828-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEIIMRNLCF LLTLVATLLL PGRLIAAALP QDEKLITGQL DNGLRYMIYP 
        60         70         80         90        100
HAHPKDQVNL WLQIHTGSLQ EEDNELGVAH FVEHMMFNGT KTWPGNKVIE 
       110        120        130        140        150
TFESMGLRFG RDVNAYTSYD ETVYQVSLPT TQKQNLQQVM AIFSEWSNAA 
       160        170        180        190        200
TFEKLEVDAE RGVITEEWRA HQDAKWRTSQ ARRPFLLANT RNLDREPIGL 
       210        220        230        240        250
MDTVATVTPA QLRQFYQRWY QPNNMTFIVV GDIDSKEALA LIKDNLSKLP 
       260        270        280        290        300
ANKAAENRVW PTKAENHLRF NIINDKENRV NGIALYYRLP MVQVNDEQSF 
       310        320        330        340        350
IEQAEWSMLV QLFNQRLQER IQSGELKTIS GGTARSVKIA PDYQSLFFRV 
       360        370        380        390        400
NARDDNMQDA ANALMAELAT IDQHGFSAEE LDDVKSTRLT WLKNAVDQQA 
       410        420        430        440        450
ERDLRMLTSR LASSSLNNTP FLSPEETYQL SKRLWQQITV QSLAEKWQQL 
       460        470        480        490        500
RKNQDAFWEQ MVNNEVAAKK ALSPAAILAL EKEYANKKLA AYVFPGRNLS 
       510        520        530        540        550
LTVDADPQAE ISSKETLAEN LTSLTLSNGA RVILAKSAGE EQKLQIIAVS 
       560        570        580        590        600
NKGDLSFPAQ QKSLIALANK AVSGSGVGEL SSSSLKRWSA ENSVTMSSKV 
       610        620        630        640        650
SGMNTLLSVS ARTNNPEPGF QLINQRITHS TINDNIWASL QNAQIQALKT 
       660        670        680        690        700
LDQRPAEKFA QQMYETRYAD DRTKLLQENQ IAQFTAADAL AADRQLFSSP 
       710        720        730        740        750
ADITFVIVGN VAEDKLVALI TRYLGSIKHS DSPLAAGKPL TRATDNASVT 
       760        770        780        790        800
VKEQNEPVAQ VSQWKRYDSR TPVNLPTRMA LDAFNVALAK DLRVNIREQA 
       810        820        830        840        850
SGAYSVSSRL SVDPQAKDIS HLLAFTCQPE RHDELLTLAN EVMVKRLAKG 
       860        870        880        890        900
ISEQELNEYQ QNVQRSLDIQ QRSVQQLANT IVNSLIQYDD PAAWTEQEQL 
       910        920        930 
LKQMTVENVN TAVKQYLSHP VNTYTGVLLP K
Length:931
Mass (Da):104,656
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i94A340CA83DB6D1E
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA50735 differs from that shown. Reason: Frameshift. Produces two separate ORFs.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti360A → V in CAA50734 (PubMed:9116051).Curated1
Sequence conflicti867L → V in CAA50735 (PubMed:9116051).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X71917 Genomic DNA Translation: CAA50734.1 Frameshift.
X71917 Genomic DNA Translation: CAA50735.1 Frameshift.
U00096 Genomic DNA Translation: AAC74567.1
AP009048 Genomic DNA Translation: BAA15164.2

Protein sequence database of the Protein Information Resource

More...PIRi		A64903

NCBI Reference Sequences

More...RefSeqi		NP_416011.1, NC_000913.3
WP_010723101.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC74567; AAC74567; b1494
BAA15164; BAA15164; BAA15164

Database of genes from NCBI RefSeq genomes

More...GeneIDi		946059

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW1489
eco:b1494

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|511145.12.peg.1561

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71917 Genomic DNA Translation: CAA50734.1 Frameshift.
X71917 Genomic DNA Translation: CAA50735.1 Frameshift.
U00096 Genomic DNA Translation: AAC74567.1
AP009048 Genomic DNA Translation: BAA15164.2
PIRiA64903
RefSeqiNP_416011.1, NC_000913.3
WP_010723101.1, NZ_LN832404.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6OFSX-ray2.60A27-931[»]
6OFTX-ray2.00A/B27-497[»]
SMRiP31828
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi4260787, 22 interactors
850420, 1 interactor
DIPiDIP-10556N
IntActiP31828, 12 interactors
STRINGi511145.b1494

Protein family/group databases

MEROPSiM16.A05

Proteomic databases

jPOSTiP31828
PaxDbiP31828
PRIDEiP31828

Genome annotation databases

EnsemblBacteriaiAAC74567; AAC74567; b1494
BAA15164; BAA15164; BAA15164
GeneIDi946059
KEGGiecj:JW1489
eco:b1494
PATRICifig|511145.12.peg.1561

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB1695

Phylogenomic databases

eggNOGiENOG4107RAN Bacteria
COG0612 LUCA
HOGENOMiHOG000120686
InParanoidiP31828
KOiK07263
PhylomeDBiP31828

Enzyme and pathway databases

BioCyciEcoCyc:EG11744-MONOMER
ECOL316407:JW1489-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P31828

Family and domain databases

InterProiView protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR011765 Pept_M16_N
IPR001431 Pept_M16_Zn_BS
IPR007863 Peptidase_M16_C
PfamiView protein in Pfam
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 2 hits
SUPFAMiSSF63411 SSF63411, 4 hits
PROSITEiView protein in PROSITE
PS00143 INSULINASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPQQL_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31828
Secondary accession number(s): P31829, P76132, P78158
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: November 13, 2019
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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