UniProtKB - P31808 (YCIK_ECOLI)

BLAST

>sp|P31808|YCIK_ECOLI Uncharacterized oxidoreductase YciK OS=Escherichia coli (strain K12) OX=83333 GN=yciK PE=1 SV=3
MHYQPKQDLLNDRIILVTGASDGIGREAAMTYARYGATVILLGRNEEKLRQVASHINEET
GRQPQWFILDLLTCTSENCQQLAQRIAVNYPRLDGVLHNAGLLGDVCPMSEQNPQVWQDV
MQVNVNATFMLTQALLPLLLKSDAGSLVFTSSSVGRQGRANWGAYAASKFATEGMMQVLA
DEYQQRLRVNCINPGGTRTAMRASAFPTEDPQKLKTPADIMPLYLWLMGDDSRRKTGMTF
DAQPGRKPGISQ

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History
Entry version 132 (07 Nov 2018)
Sequence version 3 (01 Nov 1997)
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Protein

Uncharacterized oxidoreductase YciK

Gene

yciK

Organism

Escherichia coli (strain K12)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	152	SubstrateBy similarity		1
Active siteⁱ	165	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	16 – 40	NADPBy similarityAdd BLAST		25

GO - Molecular functionⁱ

oxidoreductase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase

Molecular function

Oxidoreductase

Enzyme and pathway databases

BioCycⁱ	EcoCyc:EG11759-MONOMER

BioCycⁱ

EcoCyc:EG11759-MONOMER

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Uncharacterized oxidoreductase YciK (EC:1.-.-.-)
Gene namesⁱ	Name:yciK Ordered Locus Names:b1271, JW1263
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG11759 yciK

EcoGeneⁱ

EG11759 yciK

Subcellular locationⁱ

GO - Cellular componentⁱ

intracellular
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000054824	1 – 252	Uncharacterized oxidoreductase YciKAdd BLAST		252

Proteomic databases

EPDⁱ	P31808
PaxDbⁱ	P31808
PRIDEⁱ	P31808

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	4259576, 48 interactors
IntActⁱ	P31808, 6 interactors
STRINGⁱ	316385.ECDH10B_1386

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	7 – 12	Combined sources	6
Beta strandⁱ	14 – 19	Combined sources	6
Helixⁱ	23 – 34	Combined sources	12
Beta strandⁱ	38 – 44	Combined sources	7
Helixⁱ	46 – 60	Combined sources	15
Beta strandⁱ	65 – 68	Combined sources	4
Turnⁱ	71 – 73	Combined sources	3
Helixⁱ	76 – 89	Combined sources	14
Beta strandⁱ	94 – 98	Combined sources	5
Turnⁱ	109 – 111	Combined sources	3
Helixⁱ	114 – 124	Combined sources	11
Helixⁱ	126 – 140	Combined sources	15
Beta strandⁱ	142 – 144	Combined sources	3
Beta strandⁱ	146 – 150	Combined sources	5
Helixⁱ	153 – 155	Combined sources	3
Helixⁱ	163 – 182	Combined sources	20
Turnⁱ	183 – 186	Combined sources	4
Beta strandⁱ	188 – 193	Combined sources	6
Beta strandⁱ	196 – 199	Combined sources	4
Helixⁱ	200 – 205	Combined sources	6
Beta strandⁱ	207 – 209	Combined sources	3
Helixⁱ	211 – 213	Combined sources	3
Helixⁱ	218 – 220	Combined sources	3
Helixⁱ	221 – 228	Combined sources	8
Helixⁱ	230 – 232	Combined sources	3
Beta strandⁱ	239 – 243	Combined sources	5
Beta strandⁱ	248 – 250	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P31808
SMRⁱ	P31808
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P31808

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG4105UBK Bacteria COG1028 LUCA
InParanoidⁱ	P31808
PhylomeDBⁱ	P31808

Family and domain databases

InterProⁱ	View protein in InterPro IPR036291 NAD(P)-bd_dom_sf IPR020904 Sc_DH/Rdtase_CS IPR002347 SDR_fam
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00106 adh_short, 1 hit
PRINTSⁱ	PR00081 GDHRDH
SUPFAMⁱ	SSF51735 SSF51735, 1 hit
PROSITEⁱ	View protein in PROSITE PS00061 ADH_SHORT, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P31808-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MHYQPKQDLL NDRIILVTGA SDGIGREAAM TYARYGATVI LLGRNEEKLR 
        60         70         80         90        100
QVASHINEET GRQPQWFILD LLTCTSENCQ QLAQRIAVNY PRLDGVLHNA 
       110        120        130        140        150
GLLGDVCPMS EQNPQVWQDV MQVNVNATFM LTQALLPLLL KSDAGSLVFT 
       160        170        180        190        200
SSSVGRQGRA NWGAYAASKF ATEGMMQVLA DEYQQRLRVN CINPGGTRTA 
       210        220        230        240        250
MRASAFPTED PQKLKTPADI MPLYLWLMGD DSRRKTGMTF DAQPGRKPGI 

SQ

Length:252

Mass (Da):27,933

Last modified:November 1, 1997 - v3

Checksum:ⁱ4F7D860BF8840F7A

Sequence cautionⁱ

The sequence AAB59991 differs from that shown. Reason: Frameshift at position 115.Curated

The sequence AAB59992 differs from that shown. Reason: Frameshift at position 115.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	63	Q → P (PubMed:1885549).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U00096 Genomic DNA Translation: AAC74353.1 AP009048 Genomic DNA Translation: BAA14808.1 U17433 Genomic DNA Translation: AAB59992.1 Frameshift. U17433 Genomic DNA Translation: AAB59991.1 Frameshift. M73320 Genomic DNA No translation available.
PIRⁱ	B64875
NCBI Reference Sequences More...RefSeqⁱ	NP_415787.1, NC_000913.3 WP_000559286.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC74353; AAC74353; b1271 BAA14808; BAA14808; BAA14808
GeneIDⁱ	945838
KEGGⁱ	ecj:JW1263 eco:b1271
PATRICⁱ	fig\|1411691.4.peg.1013

Protein	Similar proteins		Species	Score	Length	Source
P31808	NAD(P)-dependent oxidoreductase		Shigella sp.		252	UniRef100_P31808
Putative oxidoreductase		Klebsiella pneumoniae IS22		252
3-oxoacyl-ACP reductase		ECOLX		252
Short chain dehydrogenase		Escherichia coli M114		252
NAD(P)-dependent oxidoreductase		SHIBO		252
+17

Protein	Similar proteins		Species	Score	Length	Source
P31808	NAD(P)-dependent oxidoreductase		Shigella sp.		252	UniRef90_P31808
Putative oxidoreductase		Klebsiella pneumoniae IS22		252
3-oxoacyl-ACP reductase		ECOLX		252
Short chain dehydrogenase		Escherichia coli M114		252
NAD(P)-dependent oxidoreductase		SHIBO		252
+573

Protein	Similar proteins		Species	Score	Length	Source
P31808	NAD(P)-dependent oxidoreductase		Shigella sp.		252	UniRef50_P31808
Putative oxidoreductase		Klebsiella pneumoniae IS22		252
3-oxoacyl-ACP reductase		ECOLX		252
Short chain dehydrogenase		Escherichia coli M114		252
NAD(P)-dependent oxidoreductase		SHIBO		252
+1561

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U00096 Genomic DNA Translation: AAC74353.1 AP009048 Genomic DNA Translation: BAA14808.1 U17433 Genomic DNA Translation: AAB59992.1 Frameshift. U17433 Genomic DNA Translation: AAB59991.1 Frameshift. M73320 Genomic DNA No translation available.
PIRⁱ	B64875
RefSeqⁱ	NP_415787.1, NC_000913.3 WP_000559286.1, NZ_LN832404.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3E9Q	X-ray	1.70	A/B	1-252	[»]
	3F1K	X-ray	2.60	A	1-252	[»]
	3F1L	X-ray	0.95	A/B	1-252	[»]
ProteinModelPortalⁱ	P31808
SMRⁱ	P31808
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4259576, 48 interactors
IntActⁱ	P31808, 6 interactors
STRINGⁱ	316385.ECDH10B_1386

Proteomic databases

EPDⁱ	P31808
PaxDbⁱ	P31808
PRIDEⁱ	P31808

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC74353; AAC74353; b1271 BAA14808; BAA14808; BAA14808
GeneIDⁱ	945838
KEGGⁱ	ecj:JW1263 eco:b1271
PATRICⁱ	fig\|1411691.4.peg.1013

Organism-specific databases

EchoBASEⁱ	EB1709
EcoGeneⁱ	EG11759 yciK

Phylogenomic databases

eggNOGⁱ	ENOG4105UBK Bacteria COG1028 LUCA
InParanoidⁱ	P31808
PhylomeDBⁱ	P31808

Enzyme and pathway databases

BioCycⁱ	EcoCyc:EG11759-MONOMER

BioCycⁱ

EcoCyc:EG11759-MONOMER

Miscellaneous databases

EvolutionaryTraceⁱ	P31808
Protein Ontology More...PROⁱ	PR:P31808

Family and domain databases

InterProⁱ	View protein in InterPro IPR036291 NAD(P)-bd_dom_sf IPR020904 Sc_DH/Rdtase_CS IPR002347 SDR_fam
Pfamⁱ	View protein in Pfam PF00106 adh_short, 1 hit
PRINTSⁱ	PR00081 GDHRDH
SUPFAMⁱ	SSF51735 SSF51735, 1 hit
PROSITEⁱ	View protein in PROSITE PS00061 ADH_SHORT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	YCIK_ECOLI
Accessionⁱ	P31808Primary (citable) accession number: P31808 Secondary accession number(s): P77516
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
	Last sequence update:	November 1, 1997
	Last modified:	November 7, 2018
	This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P31808 (YCIK_ECOLI)

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Uncharacterized oxidoreductase YciK

yciK

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ