UniProtKB - P31802 (NARP_ECOLI)
Protein
Nitrate/nitrite response regulator protein NarP
Gene
narP
Organism
Escherichia coli (strain K12)
Status
Functioni
This protein activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal transmitted by either the NarX or NarQ proteins.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 171 – 190 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: EcoCyc
GO - Biological processi
- nitrate assimilation Source: UniProtKB-KW
- phosphorelay signal transduction system Source: UniProtKB-KW
- regulation of transcription, DNA-templated Source: EcoCyc
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Nitrate assimilation, Transcription, Transcription regulation, Two-component regulatory system |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:NARP-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Nitrate/nitrite response regulator protein NarP |
Gene namesi | Name:narP Ordered Locus Names:b2193, JW2181 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081149 | 1 – 215 | Nitrate/nitrite response regulator protein NarPAdd BLAST | 215 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 59 | 4-aspartylphosphatePROSITE-ProRule annotation | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | P31802 |
PaxDbi | P31802 |
PRIDEi | P31802 |
PTM databases
iPTMneti | P31802 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4263485, 18 interactors 853322, 3 interactors |
DIPi | DIP-10317N |
IntActi | P31802, 5 interactors |
STRINGi | 511145.b2193 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 124 | Response regulatoryPROSITE-ProRule annotationAdd BLAST | 117 | |
Domaini | 147 – 212 | HTH luxR-typePROSITE-ProRule annotationAdd BLAST | 66 |
Phylogenomic databases
eggNOGi | COG2197, Bacteria |
HOGENOMi | CLU_000445_90_10_6 |
InParanoidi | P31802 |
PhylomeDBi | P31802 |
Family and domain databases
CDDi | cd06170, LuxR_C_like, 1 hit |
InterProi | View protein in InterPro IPR011006, CheY-like_superfamily IPR016032, Sig_transdc_resp-reg_C-effctor IPR001789, Sig_transdc_resp-reg_receiver IPR000792, Tscrpt_reg_LuxR_C |
Pfami | View protein in Pfam PF00196, GerE, 1 hit PF00072, Response_reg, 1 hit |
PRINTSi | PR00038, HTHLUXR |
SMARTi | View protein in SMART SM00421, HTH_LUXR, 1 hit SM00448, REC, 1 hit |
SUPFAMi | SSF46894, SSF46894, 1 hit SSF52172, SSF52172, 1 hit |
PROSITEi | View protein in PROSITE PS00622, HTH_LUXR_1, 1 hit PS50043, HTH_LUXR_2, 1 hit PS50110, RESPONSE_REGULATORY, 1 hit |
i Sequence
Sequence statusi: Complete.
P31802-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPEATPFQVM IVDDHPLMRR GVRQLLELDP GSEVVAEAGD GASAIDLANR
60 70 80 90 100
LDIDVILLDL NMKGMSGLDT LNALRRDGVT AQIIILTVSD ASSDVFALID
110 120 130 140 150
AGADGYLLKD SDPEVLLEAI RAGAKGSKVF SERVNQYLRE REMFGAEEDP
160 170 180 190 200
FSVLTERELD VLHELAQGLS NKQIASVLNI SEQTVKVHIR NLLRKLNVRS
210
RVAATILFLQ QRGAQ
Sequence cautioni
The sequence AAA16411 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L11273 Genomic DNA Translation: AAA24200.1 U00008 Genomic DNA Translation: AAA16411.1 Different initiation. U00096 Genomic DNA Translation: AAC75253.1 AP009048 Genomic DNA Translation: BAE76656.1 |
PIRi | A40584 |
RefSeqi | NP_416697.1, NC_000913.3 WP_001113639.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75253; AAC75253; b2193 BAE76656; BAE76656; BAE76656 |
GeneIDi | 949081 |
KEGGi | ecj:JW2181 eco:b2193 |
PATRICi | fig|1411691.4.peg.43 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L11273 Genomic DNA Translation: AAA24200.1 U00008 Genomic DNA Translation: AAA16411.1 Different initiation. U00096 Genomic DNA Translation: AAC75253.1 AP009048 Genomic DNA Translation: BAE76656.1 |
PIRi | A40584 |
RefSeqi | NP_416697.1, NC_000913.3 WP_001113639.1, NZ_LN832404.1 |
3D structure databases
SMRi | P31802 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4263485, 18 interactors 853322, 3 interactors |
DIPi | DIP-10317N |
IntActi | P31802, 5 interactors |
STRINGi | 511145.b2193 |
PTM databases
iPTMneti | P31802 |
Proteomic databases
jPOSTi | P31802 |
PaxDbi | P31802 |
PRIDEi | P31802 |
Genome annotation databases
EnsemblBacteriai | AAC75253; AAC75253; b2193 BAE76656; BAE76656; BAE76656 |
GeneIDi | 949081 |
KEGGi | ecj:JW2181 eco:b2193 |
PATRICi | fig|1411691.4.peg.43 |
Organism-specific databases
EchoBASEi | EB1489 |
Phylogenomic databases
eggNOGi | COG2197, Bacteria |
HOGENOMi | CLU_000445_90_10_6 |
InParanoidi | P31802 |
PhylomeDBi | P31802 |
Enzyme and pathway databases
BioCyci | EcoCyc:NARP-MONOMER |
Miscellaneous databases
PROi | PR:P31802 |
Family and domain databases
CDDi | cd06170, LuxR_C_like, 1 hit |
InterProi | View protein in InterPro IPR011006, CheY-like_superfamily IPR016032, Sig_transdc_resp-reg_C-effctor IPR001789, Sig_transdc_resp-reg_receiver IPR000792, Tscrpt_reg_LuxR_C |
Pfami | View protein in Pfam PF00196, GerE, 1 hit PF00072, Response_reg, 1 hit |
PRINTSi | PR00038, HTHLUXR |
SMARTi | View protein in SMART SM00421, HTH_LUXR, 1 hit SM00448, REC, 1 hit |
SUPFAMi | SSF46894, SSF46894, 1 hit SSF52172, SSF52172, 1 hit |
PROSITEi | View protein in PROSITE PS00622, HTH_LUXR_1, 1 hit PS50043, HTH_LUXR_2, 1 hit PS50110, RESPONSE_REGULATORY, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NARP_ECOLI | |
Accessioni | P31802Primary (citable) accession number: P31802 Secondary accession number(s): Q2MAQ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | April 7, 2021 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |