chaA

Functionⁱ

Sodium exporter that functions mainly at alkaline pH. Can also function as a potassium/proton and calcium/proton antiporter at alkaline pH. Does not play a major role in calcium export.5 Publications

Activity regulationⁱ

Pronounced pH dependence. Inhibited by magnesium.1 Publication

GO - Molecular functionⁱ

potassium:proton antiporter activity
Source: EcoCyc
Inferred from direct assayⁱ
- 12460671
sodium:proton antiporter activity
Source: EcoCyc
Inferred from direct assayⁱ
- 8496184

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

sodium ion transport
Source: EcoCyc
Inferred from direct assayⁱ
- 8496184

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Antiport, Ion transport, Transport
Ligand	Calcium, Potassium, Sodium

Enzyme and pathway databases

BioCycⁱ	EcoCyc:CHAA-MONOMER MetaCyc:CHAA-MONOMER

BioCycⁱ

EcoCyc:CHAA-MONOMER
MetaCyc:CHAA-MONOMER

Protein family/group databases

TCDBⁱ	2.A.19.1.1 the ca(2+):cation antiporter (caca) family

TCDBⁱ

2.A.19.1.1 the ca(2+):cation antiporter (caca) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sodium-potassium/proton antiporter ChaACurated Alternative name(s): Na(+)/H(+) exchanger
Gene namesⁱ	Name:chaA Ordered Locus Names:b1216, JW1207
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG11753 chaA

EcoGeneⁱ

EG11753 chaA

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 16	CytoplasmicSequence analysisAdd BLAST	16
Transmembraneⁱ	17 – 37	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	38 – 58	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	59 – 74	CytoplasmicSequence analysisAdd BLAST	16
Transmembraneⁱ	75 – 95	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	96 – 106	PeriplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	107 – 127	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	128 – 143	CytoplasmicSequence analysisAdd BLAST	16
Transmembraneⁱ	144 – 164	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	165 – 167	PeriplasmicSequence analysis	3
Transmembraneⁱ	168 – 188	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	189 – 216	CytoplasmicSequence analysisAdd BLAST	28
Transmembraneⁱ	217 – 237	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	238 – 255	PeriplasmicSequence analysisAdd BLAST	18
Transmembraneⁱ	256 – 276	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	277 – 290	CytoplasmicSequence analysisAdd BLAST	14
Transmembraneⁱ	291 – 311	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	312 – 318	PeriplasmicSequence analysis	7
Transmembraneⁱ	319 – 339	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	340 – 345	CytoplasmicSequence analysis	6
Transmembraneⁱ	346 – 366	HelicalSequence analysisAdd BLAST	21

GO - Cellular componentⁱ

integral component of plasma membrane
Source: EcoliWiki
Inferred from direct assayⁱ
- 20196076
plasma membrane
Source: EcoCyc
Inferred from direct assayⁱ
- 15919996

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000209506	1 – 366	Sodium-potassium/proton antiporter ChaAAdd BLAST		366

Proteomic databases

PaxDbⁱ	P31801
PRIDEⁱ	P31801

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	4260120, 11 interactors
STRINGⁱ	316385.ECDH10B_1275

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P31801
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	200 – 209	Asp/Glu-rich (acidic)		10

Sequence similaritiesⁱ

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG4105EWV Bacteria COG0387 LUCA
HOGENOMⁱ	HOG000197726
InParanoidⁱ	P31801
KEGG Orthology (KO) More...KOⁱ	K07300
OMAⁱ	SNWLEGT
PhylomeDBⁱ	P31801

Family and domain databases

InterProⁱ	View protein in InterPro IPR004713 CaH_exchang IPR004837 NaCa_Exmemb
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01699 Na_Ca_ex, 2 hits
TIGRFAMsⁱ	TIGR00846 caca2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P31801-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSNAQEAVKT RHKETSLIFP VLALVVLFLW GSSQTLPVVI AINLLALIGI 
        60         70         80         90        100
LSSAFSVVRH ADVLAHRLGE PYGSLILSLS VVILEVSLIS ALMATGDAAP 
       110        120        130        140        150
TLMRDTLYSI IMIVTGGLVG FSLLLGGRKF ATQYMNLFGI KQYLIALFPL 
       160        170        180        190        200
AIIVLVFPMA LPAANFSTGQ ALLVALISAA MYGVFLLIQT KTHQSLFVYE 
       210        220        230        240        250
HEDDSDDDDP HHGKPSAHSS LWHAIWLIIH LIAVIAVTKM NASSLETLLD 
       260        270        280        290        300
SMNAPVAFTG FLVALLILSP EGLGALKAVL NNQVQRAMNL FFGSVLATIS 
       310        320        330        340        350
LTVPVVTLIA FMTGNELQFA LGAPEMVVMV ASLVLCHISF STGRTNVLNG 
       360 
AAHLALFAAY LMTIFA

Length:366

Mass (Da):39,168

Last modified:July 1, 1993 - v1

Checksum:ⁱC16935AC6A6D811E

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L28709 Genomic DNA Translation: AAA20200.1 U00096 Genomic DNA Translation: AAC74300.1 AP009048 Genomic DNA Translation: BAA36074.1
PIRⁱ	A46716
NCBI Reference Sequences More...RefSeqⁱ	NP_415734.1, NC_000913.3 WP_000063607.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC74300; AAC74300; b1216 BAA36074; BAA36074; BAA36074
GeneIDⁱ	945790
KEGGⁱ	ecj:JW1207 eco:b1216
PATRICⁱ	fig\|1411691.4.peg.1066

Protein	Similar proteins		Species	Score	Length	Source
P31801	Calcium/sodium:proton antiporter		Escherichia coli B185		395	UniRef100_P31801
Calcium/proton antiporter		Escherichia coli H386		395
Calcium/proton antiporter		ECOLX		366
Sodium/proton antiporter ChaA		SHIBO		366
Calcium/proton antiporter		Escherichia coli 1-110-08_S3_C1		366
+10

Protein	Similar proteins		Species	Score	Length	Source
P31801	Calcium/sodium:proton antiporter		Escherichia coli B185		395	UniRef90_P31801
Calcium/proton antiporter		Escherichia coli H386		395
Calcium/proton antiporter		ECOLX		366
Sodium/proton antiporter ChaA		SHIBO		366
Calcium/proton antiporter		Escherichia coli 1-110-08_S3_C1		366
+1167

Protein	Similar proteins		Species	Score	Length	Source
P31801	Calcium/sodium:proton antiporter		Escherichia coli B185		395	UniRef50_P31801
Calcium/proton antiporter		Escherichia coli H386		395
Calcium/proton antiporter		ECOLX		366
Sodium/proton antiporter ChaA		SHIBO		366
Calcium/proton antiporter		Escherichia coli 1-110-08_S3_C1		366
+1639

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L28709 Genomic DNA Translation: AAA20200.1 U00096 Genomic DNA Translation: AAC74300.1 AP009048 Genomic DNA Translation: BAA36074.1
PIRⁱ	A46716
RefSeqⁱ	NP_415734.1, NC_000913.3 WP_000063607.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P31801
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4260120, 11 interactors
STRINGⁱ	316385.ECDH10B_1275

Protein family/group databases

TCDBⁱ	2.A.19.1.1 the ca(2+):cation antiporter (caca) family

TCDBⁱ

2.A.19.1.1 the ca(2+):cation antiporter (caca) family

Proteomic databases

PaxDbⁱ	P31801
PRIDEⁱ	P31801

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC74300; AAC74300; b1216 BAA36074; BAA36074; BAA36074
GeneIDⁱ	945790
KEGGⁱ	ecj:JW1207 eco:b1216
PATRICⁱ	fig\|1411691.4.peg.1066

Organism-specific databases

EchoBASEⁱ	EB1703
EcoGeneⁱ	EG11753 chaA

Phylogenomic databases

eggNOGⁱ	ENOG4105EWV Bacteria COG0387 LUCA
HOGENOMⁱ	HOG000197726
InParanoidⁱ	P31801
KOⁱ	K07300
OMAⁱ	SNWLEGT
PhylomeDBⁱ	P31801

Enzyme and pathway databases

BioCycⁱ	EcoCyc:CHAA-MONOMER MetaCyc:CHAA-MONOMER

BioCycⁱ

EcoCyc:CHAA-MONOMER
MetaCyc:CHAA-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P31801

PROⁱ

PR:P31801

Family and domain databases

InterProⁱ	View protein in InterPro IPR004713 CaH_exchang IPR004837 NaCa_Exmemb
Pfamⁱ	View protein in Pfam PF01699 Na_Ca_ex, 2 hits
TIGRFAMsⁱ	TIGR00846 caca2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CHAA_ECOLI
Accessionⁱ	P31801Primary (citable) accession number: P31801
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
	Last sequence update:	July 1, 1993
	Last modified:	September 12, 2018
	This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P31801 (CHAA_ECOLI)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Sodium-potassium/proton antiporter ChaA

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ