UniProtKB - P31800 (QCR1_BOVIN)
Cytochrome b-c1 complex subunit 1, mitochondrial
UQCRC1
Functioni
GO - Molecular functioni
- metal ion binding Source: InterPro
Keywordsi
Biological process | Electron transport, Respiratory chain, Transport |
Protein family/group databases
MEROPSi | M16.973 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome b-c1 complex subunit 1, mitochondrialAlternative name(s): Complex III subunit 1 Core protein I Ubiquinol-cytochrome-c reductase complex core protein 1 |
Gene namesi | Name:UQCRC1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity
Mitochondrion
- mitochondrial inner membrane Source: AgBase
- mitochondrion Source: AgBase
Other locations
- respirasome Source: UniProtKB-KW
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 34 | Mitochondrion1 PublicationAdd BLAST | 34 | |
ChainiPRO_0000026785 | 35 – 480 | Cytochrome b-c1 complex subunit 1, mitochondrialAdd BLAST | 446 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 111 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 138 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 163 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 163 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 212 | PhosphoserineBy similarity | 1 | |
Modified residuei | 248 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | P31800 |
PeptideAtlasi | P31800 |
PRIDEi | P31800 |
Interactioni
Subunit structurei
Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (PubMed:9651245). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI1III2IV1 and megacomplex MCI2III2IV2) (PubMed:27830641).
Interacts with BRAWNIN (By similarity).
By similarity2 PublicationsProtein-protein interaction databases
CORUMi | P31800 |
DIPi | DIP-1105N |
IntActi | P31800, 3 interactors |
STRINGi | 9913.ENSBTAP00000025422 |
Structurei
Secondary structure
3D structure databases
SMRi | P31800 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P31800 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0960, Eukaryota |
InParanoidi | P31800 |
OrthoDBi | 638125at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR011249, Metalloenz_LuxS/M16 IPR011765, Pept_M16_N IPR007863, Peptidase_M16_C |
Pfami | View protein in Pfam PF00675, Peptidase_M16, 1 hit PF05193, Peptidase_M16_C, 1 hit |
SUPFAMi | SSF63411, SSF63411, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MAASAVCRAA GAGTRVLLRT RRSPALLRSS DLRGTATYAQ ALQSVPETQV
60 70 80 90 100
SQLDNGLRVA SEQSSQPTCT VGVWIDAGSR YESEKNNGAG YFVEHLAFKG
110 120 130 140 150
TKNRPGNALE KEVESMGAHL NAYSTREHTA YYIKALSKDL PKAVELLADI
160 170 180 190 200
VQNCSLEDSQ IEKERDVILQ ELQENDTSMR DVVFNYLHAT AFQGTPLAQS
210 220 230 240 250
VEGPSENVRK LSRADLTEYL SRHYKAPRMV LAAAGGLEHR QLLDLAQKHF
260 270 280 290 300
SGLSGTYDED AVPTLSPCRF TGSQICHRED GLPLAHVAIA VEGPGWAHPD
310 320 330 340 350
NVALQVANAI IGHYDCTYGG GAHLSSPLAS IAATNKLCQS FQTFNICYAD
360 370 380 390 400
TGLLGAHFVC DHMSIDDMMF VLQGQWMRLC TSATESEVLR GKNLLRNALV
410 420 430 440 450
SHLDGTTPVC EDIGRSLLTY GRRIPLAEWE SRIAEVDARV VREVCSKYFY
460 470 480
DQCPAVAGFG PIEQLPDYNR IRSGMFWLRF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59692 mRNA Translation: CAA42213.1 |
PIRi | S16220, ZPBOC1 |
RefSeqi | NP_777054.1, NM_174629.2 |
Genome annotation databases
GeneIDi | 282393 |
KEGGi | bta:282393 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59692 mRNA Translation: CAA42213.1 |
PIRi | S16220, ZPBOC1 |
RefSeqi | NP_777054.1, NM_174629.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BCC | X-ray | 3.16 | A | 35-480 | [»] | |
1BE3 | X-ray | 3.00 | A | 35-480 | [»] | |
1BGY | X-ray | 3.00 | A/M | 35-480 | [»] | |
1L0L | X-ray | 2.35 | A | 35-480 | [»] | |
1L0N | X-ray | 2.60 | A | 35-480 | [»] | |
1NTK | X-ray | 2.60 | A | 35-480 | [»] | |
1NTM | X-ray | 2.40 | A | 35-480 | [»] | |
1NTZ | X-ray | 2.60 | A | 35-480 | [»] | |
1NU1 | X-ray | 3.20 | A | 35-480 | [»] | |
1PP9 | X-ray | 2.10 | A/N | 35-480 | [»] | |
1PPJ | X-ray | 2.10 | A/N | 35-480 | [»] | |
1QCR | X-ray | 2.70 | A | 35-480 | [»] | |
1SQB | X-ray | 2.69 | A | 1-480 | [»] | |
1SQP | X-ray | 2.70 | A | 1-480 | [»] | |
1SQQ | X-ray | 3.00 | A | 35-480 | [»] | |
1SQV | X-ray | 2.85 | A | 35-480 | [»] | |
1SQX | X-ray | 2.60 | A | 35-480 | [»] | |
2A06 | X-ray | 2.10 | A/N | 35-480 | [»] | |
2BCC | X-ray | 3.50 | A | 35-480 | [»] | |
2FYU | X-ray | 2.26 | A | 35-480 | [»] | |
2YBB | electron microscopy | 19.00 | A/a | 35-480 | [»] | |
3BCC | X-ray | 3.70 | A | 35-480 | [»] | |
4D6T | X-ray | 3.57 | A/N | 1-480 | [»] | |
4D6U | X-ray | 4.09 | A | 1-480 | [»] | |
5GPN | electron microscopy | 5.40 | A/M | 35-480 | [»] | |
5KLV | X-ray | 2.65 | A | 35-480 | [»] | |
5LUF | electron microscopy | 9.10 | c/l | 35-480 | [»] | |
5NMI | X-ray | 3.50 | A/N | 36-479 | [»] | |
5OKD | X-ray | 3.10 | A | 1-480 | [»] | |
6FO0 | electron microscopy | 4.10 | A/N | 1-480 | [»] | |
6FO2 | electron microscopy | 4.40 | A/N | 1-480 | [»] | |
6FO6 | electron microscopy | 4.10 | A/N | 1-480 | [»] | |
6HAW | X-ray | 3.45 | A | 36-479 | [»] | |
6NHG | X-ray | 2.80 | A | 35-480 | [»] | |
6XVF | X-ray | 3.50 | A | 36-480 | [»] | |
SMRi | P31800 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
CORUMi | P31800 |
DIPi | DIP-1105N |
IntActi | P31800, 3 interactors |
STRINGi | 9913.ENSBTAP00000025422 |
Protein family/group databases
MEROPSi | M16.973 |
Proteomic databases
PaxDbi | P31800 |
PeptideAtlasi | P31800 |
PRIDEi | P31800 |
Genome annotation databases
GeneIDi | 282393 |
KEGGi | bta:282393 |
Organism-specific databases
CTDi | 7384 |
Phylogenomic databases
eggNOGi | KOG0960, Eukaryota |
InParanoidi | P31800 |
OrthoDBi | 638125at2759 |
Miscellaneous databases
EvolutionaryTracei | P31800 |
Family and domain databases
InterProi | View protein in InterPro IPR011249, Metalloenz_LuxS/M16 IPR011765, Pept_M16_N IPR007863, Peptidase_M16_C |
Pfami | View protein in Pfam PF00675, Peptidase_M16, 1 hit PF05193, Peptidase_M16_C, 1 hit |
SUPFAMi | SSF63411, SSF63411, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | QCR1_BOVIN | |
Accessioni | P31800Primary (citable) accession number: P31800 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | December 1, 2000 | |
Last modified: | April 7, 2021 | |
This is version 162 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families