Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome b-c1 complex subunit 1, mitochondrial

Gene

UQCRC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

Caution

Does not seem to have a protease activity as it lack the zinc-binding site.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Protein family/group databases

MEROPSiM16.973

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 1, mitochondrial
Alternative name(s):
Complex III subunit 1
Core protein I
Ubiquinol-cytochrome-c reductase complex core protein 1
Gene namesi
Name:UQCRC1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34Mitochondrion1 PublicationAdd BLAST34
ChainiPRO_000002678535 – 480Cytochrome b-c1 complex subunit 1, mitochondrialAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei111N6-acetyllysineBy similarity1
Modified residuei138N6-acetyllysineBy similarity1
Modified residuei163N6-acetyllysine; alternateBy similarity1
Modified residuei163N6-succinyllysine; alternateBy similarity1
Modified residuei212PhosphoserineBy similarity1
Modified residuei248N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP31800
PeptideAtlasiP31800
PRIDEiP31800

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

CORUMiP31800
DIPiDIP-1105N
IntActiP31800, 3 interactors
STRINGi9913.ENSBTAP00000025422

Structurei

Secondary structure

1480
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi38 – 42Combined sources5
Beta strandi49 – 52Combined sources4
Beta strandi54 – 56Combined sources3
Beta strandi58 – 63Combined sources6
Beta strandi67 – 76Combined sources10
Helixi79 – 81Combined sources3
Turni84 – 88Combined sources5
Helixi89 – 96Combined sources8
Beta strandi97 – 99Combined sources3
Beta strandi101 – 104Combined sources4
Turni105 – 107Combined sources3
Helixi108 – 115Combined sources8
Beta strandi119 – 124Combined sources6
Beta strandi129 – 136Combined sources8
Helixi137 – 139Combined sources3
Helixi140 – 153Combined sources14
Helixi158 – 175Combined sources18
Helixi179 – 191Combined sources13
Turni192 – 194Combined sources3
Helixi196 – 198Combined sources3
Helixi205 – 210Combined sources6
Helixi213 – 223Combined sources11
Helixi226 – 228Combined sources3
Beta strandi229 – 236Combined sources8
Helixi239 – 250Combined sources12
Beta strandi252 – 256Combined sources5
Beta strandi259 – 261Combined sources3
Beta strandi273 – 279Combined sources7
Beta strandi282 – 293Combined sources12
Helixi301 – 311Combined sources11
Beta strandi313 – 315Combined sources3
Helixi321 – 323Combined sources3
Helixi327 – 335Combined sources9
Beta strandi339 – 347Combined sources9
Beta strandi352 – 360Combined sources9
Helixi362 – 364Combined sources3
Helixi365 – 382Combined sources18
Helixi385 – 402Combined sources18
Helixi406 – 419Combined sources14
Beta strandi420 – 422Combined sources3
Helixi426 – 434Combined sources9
Helixi438 – 448Combined sources11
Turni449 – 451Combined sources3
Beta strandi455 – 461Combined sources7
Beta strandi463 – 465Combined sources3
Helixi468 – 473Combined sources6

3D structure databases

ProteinModelPortaliP31800
SMRiP31800
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31800

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0960 Eukaryota
COG0612 LUCA
HOGENOMiHOG000242450
HOVERGENiHBG006393
InParanoidiP31800
KOiK00414

Family and domain databases

InterProiView protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR011765 Pept_M16_N
IPR007863 Peptidase_M16_C
PfamiView protein in Pfam
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 1 hit
SUPFAMiSSF63411 SSF63411, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASAVCRAA GAGTRVLLRT RRSPALLRSS DLRGTATYAQ ALQSVPETQV
60 70 80 90 100
SQLDNGLRVA SEQSSQPTCT VGVWIDAGSR YESEKNNGAG YFVEHLAFKG
110 120 130 140 150
TKNRPGNALE KEVESMGAHL NAYSTREHTA YYIKALSKDL PKAVELLADI
160 170 180 190 200
VQNCSLEDSQ IEKERDVILQ ELQENDTSMR DVVFNYLHAT AFQGTPLAQS
210 220 230 240 250
VEGPSENVRK LSRADLTEYL SRHYKAPRMV LAAAGGLEHR QLLDLAQKHF
260 270 280 290 300
SGLSGTYDED AVPTLSPCRF TGSQICHRED GLPLAHVAIA VEGPGWAHPD
310 320 330 340 350
NVALQVANAI IGHYDCTYGG GAHLSSPLAS IAATNKLCQS FQTFNICYAD
360 370 380 390 400
TGLLGAHFVC DHMSIDDMMF VLQGQWMRLC TSATESEVLR GKNLLRNALV
410 420 430 440 450
SHLDGTTPVC EDIGRSLLTY GRRIPLAEWE SRIAEVDARV VREVCSKYFY
460 470 480
DQCPAVAGFG PIEQLPDYNR IRSGMFWLRF
Length:480
Mass (Da):52,736
Last modified:December 1, 2000 - v2
Checksum:i4E54DD28C1905392
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59692 mRNA Translation: CAA42213.1
PIRiS16220 ZPBOC1
RefSeqiNP_777054.1, NM_174629.2
UniGeneiBt.23164

Genome annotation databases

GeneIDi282393
KEGGibta:282393

Similar proteinsi

Entry informationi

Entry nameiQCR1_BOVIN
AccessioniPrimary (citable) accession number: P31800
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health