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Protein

Acyl-CoA-binding protein

Gene

ACB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.

Miscellaneous

Present with 8500 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51Acyl-CoABy similarity1
Binding sitei55Acyl-CoABy similarity1
Binding sitei74Acyl-CoABy similarity1

GO - Molecular functioni

  • fatty-acyl-CoA binding Source: SGD
  • lipid binding Source: UniProtKB-KW
  • long-chain fatty acyl-CoA binding Source: SGD

GO - Biological processi

  • chronological cell aging Source: SGD
  • very long-chain fatty acid biosynthetic process Source: SGD

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30758-MONOMER
ReactomeiR-SCE-390918 Peroxisomal lipid metabolism
R-SCE-77289 Mitochondrial Fatty Acid Beta-Oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding protein
Short name:
ACBP
Gene namesi
Name:ACB1
Synonyms:ACB
Ordered Locus Names:YGR037C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR037C
SGDiS000003269 ACB1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002140131 – 87Acyl-CoA-binding proteinAdd BLAST87

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki51Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Cross-linki72Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP31787
PaxDbiP31787
PRIDEiP31787

PTM databases

iPTMnetiP31787

Interactioni

Protein-protein interaction databases

BioGridi33282, 154 interactors
IntActiP31787, 24 interactors
MINTiP31787
STRINGi4932.YGR037C

Structurei

Secondary structure

187
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 13Combined sources11
Helixi22 – 37Combined sources16
Helixi50 – 60Combined sources11
Turni61 – 65Combined sources5
Helixi66 – 85Combined sources20

3D structure databases

ProteinModelPortaliP31787
SMRiP31787
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31787

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 87ACBPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 33Acyl-CoA bindingBy similarity5

Sequence similaritiesi

Belongs to the ACBP family.Curated

Phylogenomic databases

GeneTreeiENSGT00840000129776
HOGENOMiHOG000261845
InParanoidiP31787
OMAiRYKFEAW
OrthoDBiEOG092C5VJZ

Family and domain databases

Gene3Di1.20.80.10, 1 hit
InterProiView protein in InterPro
IPR022408 Acyl-CoA-binding_prot_CS
IPR000582 Acyl-CoA-binding_protein
IPR035984 Acyl-CoA-binding_sf
IPR014352 FERM/acyl-CoA-bd_prot_sf
PfamiView protein in Pfam
PF00887 ACBP, 1 hit
PRINTSiPR00689 ACOABINDINGP
SUPFAMiSSF47027 SSF47027, 1 hit
PROSITEiView protein in PROSITE
PS00880 ACB_1, 1 hit
PS51228 ACB_2, 1 hit

Sequencei

Sequence statusi: Complete.

P31787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSQLFEEKA KAVNELPTKP STDELLELYA LYKQATVGDN DKEKPGIFNM
60 70 80
KDRYKWEAWE NLKGKSQEDA EKEYIALVDQ LIAKYSS
Length:87
Mass (Da):10,061
Last modified:January 23, 2007 - v3
Checksum:i686B186195EA02FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99489 Genomic DNA Translation: AAA34384.1
Y08687 Genomic DNA Translation: CAA69944.1
Y08689 Genomic DNA Translation: CAA69947.1
DQ115390 Genomic DNA Translation: AAZ22453.1
Z72822 Genomic DNA Translation: CAA97025.1
BK006941 Genomic DNA Translation: DAA08135.1
PIRiS31247
RefSeqiNP_011551.3, NM_001181166.3

Genome annotation databases

EnsemblFungiiYGR037C; YGR037C; YGR037C
GeneIDi852925
KEGGisce:YGR037C

Similar proteinsi

Entry informationi

Entry nameiACBP_YEAST
AccessioniPrimary (citable) accession number: P31787
Secondary accession number(s): D6VUH4, Q45U46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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