Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acyl-CoA-binding protein

Gene

Dbi

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14Acyl-CoABy similarity1
Binding sitei51Acyl-CoABy similarity1
Binding sitei55Acyl-CoABy similarity1
Binding sitei74Acyl-CoABy similarity1

GO - Molecular functioni

GO - Biological processi

  • behavioral fear response Source: MGI
  • glial cell proliferation Source: MGI
  • hair follicle development Source: MGI
  • lateral ventricle development Source: MGI
  • learning or memory Source: MGI
  • long-term synaptic potentiation Source: MGI
  • negative regulation of fatty acid beta-oxidation Source: MGI
  • phosphatidylcholine acyl-chain remodeling Source: MGI
  • positive regulation of lipid biosynthetic process Source: MGI
  • positive regulation of release of sequestered calcium ion into cytosol Source: MGI
  • regulation of synaptic transmission, GABAergic Source: MGI
  • skin development Source: MGI
  • triglyceride metabolic process Source: MGI

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-77289 Mitochondrial Fatty Acid Beta-Oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding protein
Short name:
ACBP
Alternative name(s):
Diazepam-binding inhibitor
Short name:
DBI
Endozepine
Short name:
EP
Gene namesi
Name:Dbi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:94865 Dbi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002140052 – 87Acyl-CoA-binding proteinAdd BLAST86

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei8N6-acetyllysine; alternateBy similarity1
Modified residuei8N6-succinyllysine; alternateCombined sources1
Modified residuei17N6-succinyllysineCombined sources1
Modified residuei29PhosphotyrosineCombined sources1
Modified residuei51N6-acetyllysineCombined sources1
Modified residuei55N6-acetyllysine; alternateCombined sources1
Modified residuei55N6-malonyllysine; alternateBy similarity1
Modified residuei55N6-succinyllysine; alternateCombined sources1
Modified residuei61N6-succinyllysineCombined sources1
Modified residuei77N6-acetyllysine; alternateBy similarity1
Modified residuei77N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP31786
PaxDbiP31786
PeptideAtlasiP31786
PRIDEiP31786
TopDownProteomicsiP31786

2D gel databases

SWISS-2DPAGEiP31786

PTM databases

iPTMnetiP31786
PhosphoSitePlusiP31786

Expressioni

Gene expression databases

BgeeiENSMUSG00000026385
CleanExiMM_DBI
ExpressionAtlasiP31786 baseline and differential
GenevisibleiP31786 MM

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP31786, 3 interactors
MINTiP31786
STRINGi10090.ENSMUSP00000114705

Structurei

3D structure databases

ProteinModelPortaliP31786
SMRiP31786
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 87ACBPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 33Acyl-CoA bindingBy similarity5

Sequence similaritiesi

Belongs to the ACBP family.Curated

Phylogenomic databases

eggNOGiKOG0817 Eukaryota
COG4281 LUCA
GeneTreeiENSGT00840000129776
HOGENOMiHOG000261845
HOVERGENiHBG000398
InParanoidiP31786
KOiK08762
TreeFamiTF335802

Family and domain databases

Gene3Di1.20.80.10, 1 hit
InterProiView protein in InterPro
IPR022408 Acyl-CoA-binding_prot_CS
IPR000582 Acyl-CoA-binding_protein
IPR035984 Acyl-CoA-binding_sf
IPR014352 FERM/acyl-CoA-bd_prot_sf
PfamiView protein in Pfam
PF00887 ACBP, 1 hit
PRINTSiPR00689 ACOABINDINGP
SUPFAMiSSF47027 SSF47027, 1 hit
PROSITEiView protein in PROSITE
PS00880 ACB_1, 1 hit
PS51228 ACB_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31786-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQAEFDKAA EEVKRLKTQP TDEEMLFIYS HFKQATVGDV NTDRPGLLDL
60 70 80
KGKAKWDSWN KLKGTSKESA MKTYVEKVDE LKKKYGI
Length:87
Mass (Da):10,000
Last modified:January 23, 2007 - v2
Checksum:i86F725C998785675
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61431 mRNA Translation: CAA43673.1
AK018720 mRNA Translation: BAB31366.1
AK027906 mRNA Translation: BAC25658.1
BC028874 mRNA Translation: AAH28874.1
CCDSiCCDS15230.1
PIRiA60059
RefSeqiNP_031856.1, NM_007830.4
UniGeneiMm.2785

Genome annotation databases

EnsembliENSMUST00000027634; ENSMUSP00000027634; ENSMUSG00000026385
GeneIDi13167
KEGGimmu:13167
UCSCiuc007cjf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiACBP_MOUSE
AccessioniPrimary (citable) accession number: P31786
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health