UniProtKB - P31785 (IL2RG_HUMAN)
Cytokine receptor common subunit gamma
IL2RG
Functioni
Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770).
1 PublicationGO - Molecular functioni
- cytokine binding Source: GO_Central
- cytokine receptor activity Source: GO_Central
- interleukin-15 receptor activity Source: UniProtKB
- interleukin-2 binding Source: UniProtKB
GO - Biological processi
- cytokine-mediated signaling pathway Source: GO_Central
- immune response Source: ProtInc
- interleukin-15-mediated signaling pathway Source: UniProtKB
- interleukin-2-mediated signaling pathway Source: GOC
- interleukin-4-mediated signaling pathway Source: GOC
- interleukin-7-mediated signaling pathway Source: GOC
- positive regulation of phagocytosis Source: UniProtKB
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Receptor |
Biological process | Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | P31785 |
Reactomei | R-HSA-1266695, Interleukin-7 signaling R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-8983432, Interleukin-15 signaling R-HSA-8985947, Interleukin-9 signaling R-HSA-9020558, Interleukin-2 signaling R-HSA-9020958, Interleukin-21 signaling R-HSA-912526, Interleukin receptor SHC signaling R-HSA-9701898, STAT3 nuclear events downstream of ALK signaling |
SignaLinki | P31785 |
SIGNORi | P31785 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytokine receptor common subunit gammaAlternative name(s): Interleukin-2 receptor subunit gamma Short name: IL-2 receptor subunit gamma Short name: IL-2R subunit gamma Short name: IL-2RG gammaC p64 CD_antigen: CD132 |
Gene namesi | Name:IL2RG |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6010, IL2RG |
MIMi | 308380, gene |
neXtProti | NX_P31785 |
VEuPathDBi | HostDB:ENSG00000147168 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Sequence analysis
Other locations
- Cell surface 1 Publication
Cytosol
- cytosol Source: Reactome
Endosome
- endosome Source: Reactome
Plasma Membrane
- external side of plasma membrane Source: UniProtKB
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Other locations
- cell surface Source: UniProtKB
- membrane Source: UniProtKB
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 262 | ExtracellularSequence analysisAdd BLAST | 240 | |
Transmembranei | 263 – 283 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 284 – 369 | CytoplasmicSequence analysisAdd BLAST | 86 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID)11 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_002668 | 39 | D → N in XSCID. 1 Publication | 1 | |
Natural variantiVAR_002669 | 62 | C → G in XSCID. | 1 | |
Natural variantiVAR_002670 | 68 | E → G in XSCID. | 1 | |
Natural variantiVAR_002671 | 68 | E → K in XSCID. 1 PublicationCorresponds to variant dbSNP:rs1057520644EnsemblClinVar. | 1 | |
Natural variantiVAR_002672 | 84 | N → K in XSCID. | 1 | |
Natural variantiVAR_002673 | 89 | Y → C in XSCID. | 1 | |
Natural variantiVAR_002674 | 105 | Y → C in XSCID. Corresponds to variant dbSNP:rs193922347EnsemblClinVar. | 1 | |
Natural variantiVAR_002675 | 114 | G → D in XSCID. 1 PublicationCorresponds to variant dbSNP:rs111033620EnsemblClinVar. | 1 | |
Natural variantiVAR_002676 | 115 | C → F in XSCID. 1 Publication | 1 | |
Natural variantiVAR_002677 | 115 | C → R in XSCID; atypical. 1 PublicationCorresponds to variant dbSNP:rs111033622EnsemblClinVar. | 1 | |
Natural variantiVAR_002678 | 123 | H → P in XSCID. | 1 | |
Natural variantiVAR_002679 | 125 | Y → N in XSCID. | 1 | |
Natural variantiVAR_002680 | 144 | Q → P in XSCID. | 1 | |
Natural variantiVAR_002681 | 153 | I → N in XSCID. 1 PublicationCorresponds to variant dbSNP:rs111033621EnsemblClinVar. | 1 | |
Natural variantiVAR_002682 | 156 | A → V in XSCID. Corresponds to variant dbSNP:rs1057521062EnsemblClinVar. | 1 | |
Natural variantiVAR_002683 | 162 | L → H in XSCID. 1 Publication | 1 | |
Natural variantiVAR_002684 | 172 | L → P in XSCID. | 1 | |
Natural variantiVAR_002685 | 172 | L → Q in XSCID. | 1 | |
Natural variantiVAR_002686 | 182 | C → R in XSCID. | 1 | |
Natural variantiVAR_002687 | 183 | L → S in XSCID. 1 Publication | 1 | |
Natural variantiVAR_002689 | 224 | R → W in XSCID. 1 PublicationCorresponds to variant dbSNP:rs869320658EnsemblClinVar. | 1 | |
Natural variantiVAR_002690 | 226 | R → C in XSCID. 1 PublicationCorresponds to variant dbSNP:rs869320659EnsemblClinVar. | 1 | |
Natural variantiVAR_002691 | 226 | R → H in XSCID. 1 PublicationCorresponds to variant dbSNP:rs869320660EnsemblClinVar. | 1 | |
Natural variantiVAR_002692 | 227 | F → C in XSCID. | 1 | |
Natural variantiVAR_002693 | 230 | L → P in XSCID. | 1 | |
Natural variantiVAR_002694 | 231 | C → Y in XSCID. | 1 | |
Natural variantiVAR_002695 | 232 | G → R in XSCID. Corresponds to variant dbSNP:rs1569479909EnsemblClinVar. | 1 | |
Natural variantiVAR_002696 | 237 | W → WQHW in XSCID. 1 Publication | 1 | |
Natural variantiVAR_002697 | 240 | W → C in XSCID. 1 Publication | 1 | |
Natural variantiVAR_002698 | 241 | S → I in XSCID. 1 Publication | 1 | |
Natural variantiVAR_002699 | 270 | M → R in XSCID. | 1 | |
Natural variantiVAR_002701 | 285 | R → Q in XSCID. 1 PublicationCorresponds to variant dbSNP:rs111033617EnsemblClinVar. | 1 |
X-linked combined immunodeficiency (XCID)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_002688 | 222 | R → C in XCID. 1 PublicationCorresponds to variant dbSNP:rs111033618EnsemblClinVar. | 1 | |
Natural variantiVAR_002702 | 293 | L → Q in XCID. 1 PublicationCorresponds to variant dbSNP:rs137852510EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, SCIDOrganism-specific databases
DisGeNETi | 3561 |
GeneReviewsi | IL2RG |
MalaCardsi | IL2RG |
MIMi | 300400, phenotype 312863, phenotype |
OpenTargetsi | ENSG00000147168 |
Orphaneti | 39041, Omenn syndrome 276, T-B+ severe combined immunodeficiency due to gamma chain deficiency |
PharmGKBi | PA196 |
Miscellaneous databases
Pharosi | P31785, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2364167 |
DrugBanki | DB00041, Aldesleukin DB00004, Denileukin diftitox DB05943, Resatorvid |
DrugCentrali | P31785 |
GuidetoPHARMACOLOGYi | 2303 |
Genetic variation databases
BioMutai | IL2RG |
DMDMi | 400048 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Add BLAST | 22 | |
ChainiPRO_0000010866 | 23 – 369 | Cytokine receptor common subunit gammaAdd BLAST | 347 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 24 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 62 ↔ 72 | |||
Glycosylationi | 71 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 75 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 84 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Disulfide bondi | 102 ↔ 115 | |||
Glycosylationi | 159 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Disulfide bondi | 182 ↔ 231 | |||
Glycosylationi | 249 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 292 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | P31785 |
MassIVEi | P31785 |
MaxQBi | P31785 |
PaxDbi | P31785 |
PeptideAtlasi | P31785 |
PRIDEi | P31785 |
ProteomicsDBi | 54802 [P31785-1] 62802 |
PTM databases
GlyGeni | P31785, 8 sites |
iPTMneti | P31785 |
PhosphoSitePlusi | P31785 |
Expressioni
Gene expression databases
Bgeei | ENSG00000147168, Expressed in granulocyte and 189 other tissues |
ExpressionAtlasi | P31785, baseline and differential |
Genevisiblei | P31785, HS |
Organism-specific databases
HPAi | ENSG00000147168, Tissue enhanced (intestine, lymphoid tissue) |
Interactioni
Subunit structurei
The gamma subunit is common to the IL2, IL4, IL7, IL15, IL21 and probably also the IL13 receptors.
Interacts with SHB upon interleukin stimulation.
3 Publications(Microbial infection) Interacts with HTLV-1 accessory protein p12I.
1 PublicationBinary interactionsi
P31785
With | #Exp. | IntAct |
---|---|---|
IL7 [P13232] | 2 | EBI-80475,EBI-80516 |
KRTAP10-8 [P60410] | 3 | EBI-80475,EBI-10171774 |
KRTAP5-7 [Q6L8G8] | 3 | EBI-80475,EBI-11987425 |
NOTCH2NLA [Q7Z3S9] | 4 | EBI-80475,EBI-945833 |
GO - Molecular functioni
- cytokine binding Source: GO_Central
- interleukin-2 binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109776, 26 interactors |
CORUMi | P31785 |
DIPi | DIP-173N |
IntActi | P31785, 18 interactors |
STRINGi | 9606.ENSP00000363318 |
Miscellaneous databases
RNActi | P31785, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P31785 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P31785 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 156 – 253 | Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST | 98 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 237 – 241 | WSXWS motif | 5 | |
Motifi | 286 – 294 | Box 1 motif | 9 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S289, Eukaryota |
GeneTreei | ENSGT00510000048979 |
HOGENOMi | CLU_060544_1_0_1 |
InParanoidi | P31785 |
OMAi | MPRIPNP |
OrthoDBi | 753404at2759 |
PhylomeDBi | P31785 |
TreeFami | TF333657 |
Family and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003531, Hempt_rcpt_S_F1_CS IPR013783, Ig-like_fold IPR015321, TypeI_recpt_CBD |
Pfami | View protein in Pfam PF09240, IL6Ra-bind, 1 hit |
SUPFAMi | SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 1 hit PS01355, HEMATOPO_REC_S_F1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLKPSLPFTS LLFLQLPLLG VGLNTTILTP NGNEDTTADF FLTTMPTDSL
60 70 80 90 100
SVSTLPLPEV QCFVFNVEYM NCTWNSSSEP QPTNLTLHYW YKNSDNDKVQ
110 120 130 140 150
KCSHYLFSEE ITSGCQLQKK EIHLYQTFVV QLQDPREPRR QATQMLKLQN
160 170 180 190 200
LVIPWAPENL TLHKLSESQL ELNWNNRFLN HCLEHLVQYR TDWDHSWTEQ
210 220 230 240 250
SVDYRHKFSL PSVDGQKRYT FRVRSRFNPL CGSAQHWSEW SHPIHWGSNT
260 270 280 290 300
SKENPFLFAL EAVVISVGSM GLIISLLCVY FWLERTMPRI PTLKNLEDLV
310 320 330 340 350
TEYHGNFSAW SGVSKGLAES LQPDYSERLC LVSEIPPKGG ALGEGPGASP
360
CNQHSPYWAP PCYTLKPET
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RDW9 | D6RDW9_HUMAN | Cytokine receptor common subunit ga... | IL2RG | 219 | Annotation score: | ||
H0Y8J6 | H0Y8J6_HUMAN | Cytokine receptor common subunit ga... | IL2RG | 65 | Annotation score: | ||
D6R964 | D6R964_HUMAN | Cytokine receptor common subunit ga... | IL2RG | 99 | Annotation score: | ||
Q5FC10 | Q5FC10_HUMAN | Cytokine receptor common subunit ga... | IL2RG | 98 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_002668 | 39 | D → N in XSCID. 1 Publication | 1 | |
Natural variantiVAR_059301 | 44 | T → S. Corresponds to variant dbSNP:rs7885041Ensembl. | 1 | |
Natural variantiVAR_002669 | 62 | C → G in XSCID. | 1 | |
Natural variantiVAR_002670 | 68 | E → G in XSCID. | 1 | |
Natural variantiVAR_002671 | 68 | E → K in XSCID. 1 PublicationCorresponds to variant dbSNP:rs1057520644EnsemblClinVar. | 1 | |
Natural variantiVAR_002672 | 84 | N → K in XSCID. | 1 | |
Natural variantiVAR_002673 | 89 | Y → C in XSCID. | 1 | |
Natural variantiVAR_002674 | 105 | Y → C in XSCID. Corresponds to variant dbSNP:rs193922347EnsemblClinVar. | 1 | |
Natural variantiVAR_020611 | 109 | E → K1 PublicationCorresponds to variant dbSNP:rs17875899EnsemblClinVar. | 1 | |
Natural variantiVAR_002675 | 114 | G → D in XSCID. 1 PublicationCorresponds to variant dbSNP:rs111033620EnsemblClinVar. | 1 | |
Natural variantiVAR_002676 | 115 | C → F in XSCID. 1 Publication | 1 | |
Natural variantiVAR_002677 | 115 | C → R in XSCID; atypical. 1 PublicationCorresponds to variant dbSNP:rs111033622EnsemblClinVar. | 1 | |
Natural variantiVAR_002678 | 123 | H → P in XSCID. | 1 | |
Natural variantiVAR_002679 | 125 | Y → N in XSCID. | 1 | |
Natural variantiVAR_002680 | 144 | Q → P in XSCID. | 1 | |
Natural variantiVAR_002681 | 153 | I → N in XSCID. 1 PublicationCorresponds to variant dbSNP:rs111033621EnsemblClinVar. | 1 | |
Natural variantiVAR_002682 | 156 | A → V in XSCID. Corresponds to variant dbSNP:rs1057521062EnsemblClinVar. | 1 | |
Natural variantiVAR_002683 | 162 | L → H in XSCID. 1 Publication | 1 | |
Natural variantiVAR_002684 | 172 | L → P in XSCID. | 1 | |
Natural variantiVAR_002685 | 172 | L → Q in XSCID. | 1 | |
Natural variantiVAR_002686 | 182 | C → R in XSCID. | 1 | |
Natural variantiVAR_002687 | 183 | L → S in XSCID. 1 Publication | 1 | |
Natural variantiVAR_002688 | 222 | R → C in XCID. 1 PublicationCorresponds to variant dbSNP:rs111033618EnsemblClinVar. | 1 | |
Natural variantiVAR_002689 | 224 | R → W in XSCID. 1 PublicationCorresponds to variant dbSNP:rs869320658EnsemblClinVar. | 1 | |
Natural variantiVAR_002690 | 226 | R → C in XSCID. 1 PublicationCorresponds to variant dbSNP:rs869320659EnsemblClinVar. | 1 | |
Natural variantiVAR_002691 | 226 | R → H in XSCID. 1 PublicationCorresponds to variant dbSNP:rs869320660EnsemblClinVar. | 1 | |
Natural variantiVAR_002692 | 227 | F → C in XSCID. | 1 | |
Natural variantiVAR_002693 | 230 | L → P in XSCID. | 1 | |
Natural variantiVAR_002694 | 231 | C → Y in XSCID. | 1 | |
Natural variantiVAR_002695 | 232 | G → R in XSCID. Corresponds to variant dbSNP:rs1569479909EnsemblClinVar. | 1 | |
Natural variantiVAR_002696 | 237 | W → WQHW in XSCID. 1 Publication | 1 | |
Natural variantiVAR_002697 | 240 | W → C in XSCID. 1 Publication | 1 | |
Natural variantiVAR_002698 | 241 | S → I in XSCID. 1 Publication | 1 | |
Natural variantiVAR_002699 | 270 | M → R in XSCID. | 1 | |
Natural variantiVAR_002701 | 285 | R → Q in XSCID. 1 PublicationCorresponds to variant dbSNP:rs111033617EnsemblClinVar. | 1 | |
Natural variantiVAR_002702 | 293 | L → Q in XCID. 1 PublicationCorresponds to variant dbSNP:rs137852510EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047581 | 1 – 8 | MLKPSLPF → MGMKTPQL in isoform 2. 1 Publication | 8 | |
Alternative sequenceiVSP_047582 | 9 – 198 | Missing in isoform 2. 1 PublicationAdd BLAST | 190 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D11086 mRNA Translation: BAA01857.1 L12183 , L12178, L12176, L12177, L12179, L12180, L12181, L12182 Genomic DNA Translation: AAA59145.1 L19546 Genomic DNA Translation: AAC37524.1 AB102794 mRNA Translation: BAD89385.1 AY692262 Genomic DNA Translation: AAT85803.1 AL590764 Genomic DNA No translation available. BC014972 mRNA Translation: AAH14972.1 |
CCDSi | CCDS14406.1 [P31785-1] |
PIRi | A42565 |
RefSeqi | NP_000197.1, NM_000206.2 [P31785-1] |
Genome annotation databases
Ensembli | ENST00000374202; ENSP00000363318; ENSG00000147168 ENST00000456850; ENSP00000388967; ENSG00000147168 [P31785-2] |
GeneIDi | 3561 |
KEGGi | hsa:3561 |
MANE-Selecti | ENST00000374202.7; ENSP00000363318.3; NM_000206.3; NP_000197.1 |
UCSCi | uc004dyw.4, human [P31785-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
IL2RGbase X-linked SCID mutation database |
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D11086 mRNA Translation: BAA01857.1 L12183 , L12178, L12176, L12177, L12179, L12180, L12181, L12182 Genomic DNA Translation: AAA59145.1 L19546 Genomic DNA Translation: AAC37524.1 AB102794 mRNA Translation: BAD89385.1 AY692262 Genomic DNA Translation: AAT85803.1 AL590764 Genomic DNA No translation available. BC014972 mRNA Translation: AAH14972.1 |
CCDSi | CCDS14406.1 [P31785-1] |
PIRi | A42565 |
RefSeqi | NP_000197.1, NM_000206.2 [P31785-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2B5I | X-ray | 2.30 | C | 56-254 | [»] | |
2ERJ | X-ray | 3.00 | C/G | 23-255 | [»] | |
3BPL | X-ray | 2.93 | C | 56-254 | [»] | |
3QAZ | X-ray | 3.80 | C/F/I/L/O/R/U/X/a/d/g/j | 56-254 | [»] | |
3QB7 | X-ray | 3.24 | C/D | 55-254 | [»] | |
4GS7 | X-ray | 2.35 | C | 55-254 | [»] | |
5M5E | X-ray | 2.30 | C | 23-262 | [»] | |
6OEL | X-ray | 3.10 | C | 61-249 | [»] | |
SMRi | P31785 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109776, 26 interactors |
CORUMi | P31785 |
DIPi | DIP-173N |
IntActi | P31785, 18 interactors |
STRINGi | 9606.ENSP00000363318 |
Chemistry databases
ChEMBLi | CHEMBL2364167 |
DrugBanki | DB00041, Aldesleukin DB00004, Denileukin diftitox DB05943, Resatorvid |
DrugCentrali | P31785 |
GuidetoPHARMACOLOGYi | 2303 |
PTM databases
GlyGeni | P31785, 8 sites |
iPTMneti | P31785 |
PhosphoSitePlusi | P31785 |
Genetic variation databases
BioMutai | IL2RG |
DMDMi | 400048 |
Proteomic databases
EPDi | P31785 |
MassIVEi | P31785 |
MaxQBi | P31785 |
PaxDbi | P31785 |
PeptideAtlasi | P31785 |
PRIDEi | P31785 |
ProteomicsDBi | 54802 [P31785-1] 62802 |
Protocols and materials databases
ABCDi | P31785, 1 sequenced antibody |
Antibodypediai | 27479, 640 antibodies from 36 providers |
CPTCi | P31785, 1 antibody |
DNASUi | 3561 |
Genome annotation databases
Ensembli | ENST00000374202; ENSP00000363318; ENSG00000147168 ENST00000456850; ENSP00000388967; ENSG00000147168 [P31785-2] |
GeneIDi | 3561 |
KEGGi | hsa:3561 |
MANE-Selecti | ENST00000374202.7; ENSP00000363318.3; NM_000206.3; NP_000197.1 |
UCSCi | uc004dyw.4, human [P31785-1] |
Organism-specific databases
CTDi | 3561 |
DisGeNETi | 3561 |
GeneCardsi | IL2RG |
GeneReviewsi | IL2RG |
HGNCi | HGNC:6010, IL2RG |
HPAi | ENSG00000147168, Tissue enhanced (intestine, lymphoid tissue) |
MalaCardsi | IL2RG |
MIMi | 300400, phenotype 308380, gene 312863, phenotype |
neXtProti | NX_P31785 |
OpenTargetsi | ENSG00000147168 |
Orphaneti | 39041, Omenn syndrome 276, T-B+ severe combined immunodeficiency due to gamma chain deficiency |
PharmGKBi | PA196 |
VEuPathDBi | HostDB:ENSG00000147168 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S289, Eukaryota |
GeneTreei | ENSGT00510000048979 |
HOGENOMi | CLU_060544_1_0_1 |
InParanoidi | P31785 |
OMAi | MPRIPNP |
OrthoDBi | 753404at2759 |
PhylomeDBi | P31785 |
TreeFami | TF333657 |
Enzyme and pathway databases
PathwayCommonsi | P31785 |
Reactomei | R-HSA-1266695, Interleukin-7 signaling R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-8983432, Interleukin-15 signaling R-HSA-8985947, Interleukin-9 signaling R-HSA-9020558, Interleukin-2 signaling R-HSA-9020958, Interleukin-21 signaling R-HSA-912526, Interleukin receptor SHC signaling R-HSA-9701898, STAT3 nuclear events downstream of ALK signaling |
SignaLinki | P31785 |
SIGNORi | P31785 |
Miscellaneous databases
BioGRID-ORCSi | 3561, 7 hits in 673 CRISPR screens |
ChiTaRSi | IL2RG, human |
EvolutionaryTracei | P31785 |
GeneWikii | Common_gamma_chain |
GenomeRNAii | 3561 |
Pharosi | P31785, Tclin |
PROi | PR:P31785 |
RNActi | P31785, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000147168, Expressed in granulocyte and 189 other tissues |
ExpressionAtlasi | P31785, baseline and differential |
Genevisiblei | P31785, HS |
Family and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003531, Hempt_rcpt_S_F1_CS IPR013783, Ig-like_fold IPR015321, TypeI_recpt_CBD |
Pfami | View protein in Pfam PF09240, IL6Ra-bind, 1 hit |
SUPFAMi | SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 1 hit PS01355, HEMATOPO_REC_S_F1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IL2RG_HUMAN | |
Accessioni | P31785Primary (citable) accession number: P31785 Secondary accession number(s): Q5FC12 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | February 23, 2022 | |
This is version 231 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families