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Protein

Neurogenic locus notch homolog protein 4

Gene

Notch4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May regulate branching morphogenesis in the developing vascular system.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • Notch binding Source: MGI
  • signaling receptor activity Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, Receptor
Biological processDifferentiation, Notch signaling pathway, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neurogenic locus notch homolog protein 4
Short name:
Notch 4
Cleaved into the following 3 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Notch4
Synonyms:Int-3, Int3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:107471 Notch4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 1443ExtracellularSequence analysisAdd BLAST1423
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1444 – 1464HelicalSequence analysisAdd BLAST21
Topological domaini1465 – 1964CytoplasmicSequence analysisAdd BLAST500

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Loss of the extracellular domain causes constitutive activation of the Notch protein, which leads to hyperproliferation of glandular epithelial tissues and development of mammary carcinomas.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1463V → L: NICD processing severely reduced. 1 Publication1

Keywords - Diseasei

Proto-oncogene

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000770421 – 1964Neurogenic locus notch homolog protein 4Add BLAST1944
ChainiPRO_00000077051411 – 1964Transforming protein Int-3Add BLAST554
ChainiPRO_00000077061428 – 1964Notch 4 extracellular truncationAdd BLAST537
ChainiPRO_00000077071463 – 1964Notch 4 intracellular domainAdd BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi25 ↔ 38By similarity
Disulfide bondi32 ↔ 48By similarity
Disulfide bondi50 ↔ 59By similarity
Disulfide bondi65 ↔ 77By similarity
Disulfide bondi71 ↔ 100By similarity
Disulfide bondi102 ↔ 111By similarity
Disulfide bondi119 ↔ 130By similarity
Disulfide bondi124 ↔ 140By similarity
Disulfide bondi142 ↔ 151By similarity
Disulfide bondi157 ↔ 168By similarity
Disulfide bondi162 ↔ 177By similarity
Disulfide bondi179 ↔ 188By similarity
Disulfide bondi195 ↔ 208By similarity
Disulfide bondi202 ↔ 217By similarity
Disulfide bondi219 ↔ 228By similarity
Disulfide bondi235 ↔ 246By similarity
Disulfide bondi240 ↔ 259By similarity
Disulfide bondi261 ↔ 270By similarity
Disulfide bondi277 ↔ 288By similarity
Disulfide bondi282 ↔ 297By similarity
Disulfide bondi299 ↔ 308By similarity
Disulfide bondi315 ↔ 329By similarity
Disulfide bondi323 ↔ 338By similarity
Disulfide bondi340 ↔ 349By similarity
Disulfide bondi356 ↔ 367By similarity
Disulfide bondi361 ↔ 376By similarity
Disulfide bondi378 ↔ 387By similarity
Disulfide bondi393 ↔ 404By similarity
Disulfide bondi398 ↔ 415By similarity
Disulfide bondi417 ↔ 426By similarity
Disulfide bondi433 ↔ 449By similarity
Disulfide bondi443 ↔ 458By similarity
Disulfide bondi460 ↔ 469By similarity
Disulfide bondi476 ↔ 487By similarity
Disulfide bondi481 ↔ 496By similarity
Disulfide bondi498 ↔ 507By similarity
Disulfide bondi514 ↔ 525By similarity
Disulfide bondi519 ↔ 534By similarity
Disulfide bondi536 ↔ 545By similarity
Disulfide bondi552 ↔ 563By similarity
Disulfide bondi557 ↔ 572By similarity
Disulfide bondi574 ↔ 583By similarity
Disulfide bondi590 ↔ 601By similarity
Disulfide bondi595 ↔ 610By similarity
Disulfide bondi612 ↔ 621By similarity
Disulfide bondi626 ↔ 637By similarity
Disulfide bondi631 ↔ 646By similarity
Disulfide bondi648 ↔ 655By similarity
Disulfide bondi662 ↔ 669By similarity
Disulfide bondi664 ↔ 674By similarity
Disulfide bondi676 ↔ 685By similarity
Disulfide bondi692 ↔ 703By similarity
Disulfide bondi697 ↔ 712By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi711N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi714 ↔ 723By similarity
Disulfide bondi730 ↔ 741By similarity
Disulfide bondi735 ↔ 750By similarity
Disulfide bondi752 ↔ 761By similarity
Disulfide bondi768 ↔ 779By similarity
Disulfide bondi773 ↔ 788By similarity
Disulfide bondi790 ↔ 799By similarity
Disulfide bondi807 ↔ 818By similarity
Disulfide bondi812 ↔ 827By similarity
Disulfide bondi829 ↔ 838By similarity
Disulfide bondi845 ↔ 856By similarity
Disulfide bondi850 ↔ 865By similarity
Disulfide bondi867 ↔ 876By similarity
Disulfide bondi882 ↔ 903By similarity
Disulfide bondi897 ↔ 912By similarity
Disulfide bondi914 ↔ 923By similarity
Disulfide bondi930 ↔ 941By similarity
Disulfide bondi935 ↔ 950By similarity
Disulfide bondi952 ↔ 961By similarity
Glycosylationi960N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi968 ↔ 979By similarity
Disulfide bondi973 ↔ 988By similarity
Disulfide bondi990 ↔ 999By similarity
Disulfide bondi1006 ↔ 1019By similarity
Disulfide bondi1011 ↔ 1028By similarity
Disulfide bondi1030 ↔ 1039By similarity
Disulfide bondi1046 ↔ 1057By similarity
Disulfide bondi1051 ↔ 1069By similarity
Disulfide bondi1071 ↔ 1080By similarity
Disulfide bondi1087 ↔ 1098By similarity
Disulfide bondi1092 ↔ 1110By similarity
Disulfide bondi1112 ↔ 1121By similarity
Disulfide bondi1130 ↔ 1142By similarity
Disulfide bondi1136 ↔ 1155By similarity
Glycosylationi1139N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1157 ↔ 1166By similarity
Disulfide bondi1174 ↔ 1187By similarity
Disulfide bondi1183 ↔ 1199By similarity
Disulfide bondi1210 ↔ 1234By similarity
Disulfide bondi1216 ↔ 1229By similarity
Disulfide bondi1225 ↔ 1241By similarity
Disulfide bondi1247 ↔ 1273By similarity
Disulfide bondi1255 ↔ 1268By similarity
Disulfide bondi1264 ↔ 1280By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane.2 Publications
Phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P31695

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P31695

PRoteomics IDEntifications database

More...
PRIDEi
P31695

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P31695

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P31695

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in lung, moderately in heart kidney, and at lower levels in the ovary and skeletal muscle. A very low expression is seen in the brain, intestine, liver and testis.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed in endothelial cells during embryonic development from 9.0 dpc.

Gene expression databases

CleanEx database of gene expression profiles

More...
CleanExi
MM_NOTCH4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH4.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
sel-10Q937942EBI-643670,EBI-323098From Caenorhabditis elegans.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
201812, 6 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P31695

Protein interaction database and analysis system

More...
IntActi
P31695, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000015612

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P31695

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P31695

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 60EGF-like 1PROSITE-ProRule annotationAdd BLAST40
Domaini61 – 112EGF-like 2PROSITE-ProRule annotationAdd BLAST52
Domaini115 – 152EGF-like 3PROSITE-ProRule annotationAdd BLAST38
Domaini153 – 189EGF-like 4PROSITE-ProRule annotationAdd BLAST37
Domaini191 – 229EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini231 – 271EGF-like 6PROSITE-ProRule annotationAdd BLAST41
Domaini273 – 309EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini311 – 350EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini352 – 388EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini389 – 427EGF-like 10PROSITE-ProRule annotationAdd BLAST39
Domaini429 – 470EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini472 – 508EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini510 – 546EGF-like 13; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini548 – 584EGF-like 14; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini586 – 622EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini623 – 656EGF-like 16PROSITE-ProRule annotationAdd BLAST34
Domaini658 – 686EGF-like 17PROSITE-ProRule annotationAdd BLAST29
Domaini688 – 724EGF-like 18PROSITE-ProRule annotationAdd BLAST37
Domaini726 – 762EGF-like 19PROSITE-ProRule annotationAdd BLAST37
Domaini764 – 800EGF-like 20PROSITE-ProRule annotationAdd BLAST37
Domaini803 – 839EGF-like 21PROSITE-ProRule annotationAdd BLAST37
Domaini841 – 877EGF-like 22PROSITE-ProRule annotationAdd BLAST37
Domaini878 – 924EGF-like 23PROSITE-ProRule annotationAdd BLAST47
Domaini926 – 962EGF-like 24PROSITE-ProRule annotationAdd BLAST37
Domaini964 – 1000EGF-like 25PROSITE-ProRule annotationAdd BLAST37
Domaini1002 – 1040EGF-like 26PROSITE-ProRule annotationAdd BLAST39
Domaini1042 – 1081EGF-like 27PROSITE-ProRule annotationAdd BLAST40
Domaini1083 – 1122EGF-like 28PROSITE-ProRule annotationAdd BLAST40
Domaini1126 – 1167EGF-like 29PROSITE-ProRule annotationAdd BLAST42
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1166 – 1209LNR 1Add BLAST44
Repeati1210 – 1241LNR 2Add BLAST32
Repeati1247 – 1287LNR 3Add BLAST41
Repeati1628 – 1657ANK 1Add BLAST30
Repeati1661 – 1691ANK 2Add BLAST31
Repeati1695 – 1724ANK 3Add BLAST30
Repeati1728 – 1757ANK 4Add BLAST30
Repeati1761 – 1790ANK 5Add BLAST30

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NOTCH family.Curated

Keywords - Domaini

ANK repeat, EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR7G Eukaryota
COG0666 LUCA

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052650

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P31695

KEGG Orthology (KO)

More...
KOi
K20996

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P31695

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR008297 Notch
IPR035993 Notch-like_dom_sf
IPR022355 Notch_4
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF00008 EGF, 17 hits
PF07645 EGF_CA, 3 hits
PF12661 hEGF, 3 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002279 Notch, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01452 LNOTCHREPEAT
PR01987 NOTCH4

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 6 hits
SM00181 EGF, 28 hits
SM00179 EGF_CA, 21 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 4 hits
SSF90193 SSF90193, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS00010 ASX_HYDROXYL, 11 hits
PS00022 EGF_1, 28 hits
PS01186 EGF_2, 21 hits
PS50026 EGF_3, 27 hits
PS01187 EGF_CA, 9 hits
PS50258 LNR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P31695-1 [UniParc]FASTAAdd to basket
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MQPQLLLLLL LPLNFPVILT RELLCGGSPE PCANGGTCLR LSQGQGICQC
60 70 80 90 100
APGFLGETCQ FPDPCRDTQL CKNGGSCQAL LPTPPSSRSP TSPLTPHFSC
110 120 130 140 150
TCPSGFTGDR CQTHLEELCP PSFCSNGGHC YVQASGRPQC SCEPGWTGEQ
160 170 180 190 200
CQLRDFCSAN PCANGGVCLA TYPQIQCRCP PGFEGHTCER DINECFLEPG
210 220 230 240 250
PCPQGTSCHN TLGSYQCLCP VGQEGPQCKL RKGACPPGSC LNGGTCQLVP
260 270 280 290 300
EGHSTFHLCL CPPGFTGLDC EMNPDDCVRH QCQNGATCLD GLDTYTCLCP
310 320 330 340 350
KTWKGWDCSE DIDECEARGP PRCRNGGTCQ NTAGSFHCVC VSGWGGAGCE
360 370 380 390 400
ENLDDCAAAT CAPGSTCIDR VGSFSCLCPP GRTGLLCHLE DMCLSQPCHV
410 420 430 440 450
NAQCSTNPLT GSTLCICQPG YSGSTCHQDL DECQMAQQGP SPCEHGGSCI
460 470 480 490 500
NTPGSFNCLC LPGYTGSRCE ADHNECLSQP CHPGSTCLDL LATFHCLCPP
510 520 530 540 550
GLEGRLCEVE VNECTSNPCL NQAACHDLLN GFQCLCLPGF TGARCEKDMD
560 570 580 590 600
ECSSTPCANG GRCRDQPGAF YCECLPGFEG PHCEKEVDEC LSDPCPVGAS
610 620 630 640 650
CLDLPGAFFC LCRPGFTGQL CEVPLCTPNM CQPGQQCQGQ EHRAPCLCPD
660 670 680 690 700
GSPGCVPAED NCPCHHGHCQ RSLCVCDEGW TGPECETELG GCISTPCAHG
710 720 730 740 750
GTCHPQPSGY NCTCPAGYMG LTCSEEVTAC HSGPCLNGGS CSIRPEGYSC
760 770 780 790 800
TCLPSHTGRH CQTAVDHCVS ASCLNGGTCV NKPGTFFCLC ATGFQGLHCE
810 820 830 840 850
EKTNPSCADS PCRNKATCQD TPRGARCLCS PGYTGSSCQT LIDLCARKPC
860 870 880 890 900
PHTARCLQSG PSFQCLCLQG WTGALCDFPL SCQMAAMSQG IEISGLCQNG
910 920 930 940 950
GLCIDTGSSY FCRCPPGFQG KLCQDNMNPC EPNPCHHGST CVPQPSGYVC
960 970 980 990 1000
QCAPGYEGQN CSKVLEACQS QPCHNHGTCT SRPGGFHCAC PPGFVGLRCE
1010 1020 1030 1040 1050
GDVDECLDRP CHPSGTAACH SLANAFYCQC LPGHTGQRCE VEMDLCQSQP
1060 1070 1080 1090 1100
CSNGGSCEIT TGPPPGFTCH CPKGFEGPTC SHKALSCGIH HCHNGGLCLP
1110 1120 1130 1140 1150
SPKPGSPPLC ACLSGFGGPD CLTPPAPPGC GPPSPCLHNG TCTETPGLGN
1160 1170 1180 1190 1200
PGFQCTCPPD SPGPRCQRPG ASGCEGRGGD GTCDAGCSGP GGDWDGGDCS
1210 1220 1230 1240 1250
LGVPDPWKGC PPHSQCWLLF RDGRCHPQCD SEECLFDGYD CEIPLTCIPA
1260 1270 1280 1290 1300
YDQYCRDHFH NGHCEKGCNN AECGWDGGDC RPEGEDSEGR PSLALLVVLR
1310 1320 1330 1340 1350
PPALDQQLLA LARVLSLTLR VGLWVRKDSE GRNMVFPYPG TRAKEELSGA
1360 1370 1380 1390 1400
RDSSSWERQA PPTQPLGKET ESLGAGFVVV MGVDLSRCGP EHPASRCPWD
1410 1420 1430 1440 1450
SGLLLRFLAA MAAVGALEPL LPGPLLAAHP QAGTRPPANQ LPWPILCSPV
1460 1470 1480 1490 1500
VGVLLLALGA LLVLQLIRRR RREHGALWLP PGFIRRPQAQ QAPHRRRPPL
1510 1520 1530 1540 1550
GEDNIGLKAL KPEAEVDEDG VAMCSGPEEG EAEETASASR CQLWPLNSSC
1560 1570 1580 1590 1600
GELPQAAMLT PPQECESEVL DVDTCGPDGV TPLMSAVFCG GVQSTTGASP
1610 1620 1630 1640 1650
QRLGLGNLEP WEPLLDRGAC PQAHTVGTGE TPLHLAARFS RPTAARRLLE
1660 1670 1680 1690 1700
AGANPNQPDR AGRTPLHTAV AADAREVCQL LLASRQTSVD ARTEDGTTPL
1710 1720 1730 1740 1750
MLAARLAVED LVEELIAARA DVGARDKRGK TALHWAAAVN NARAARSLLQ
1760 1770 1780 1790 1800
AGADKDAQDS REQTPLFLAA REGAVEVAQL LLELGAARGL RDQAGLAPGD
1810 1820 1830 1840 1850
VARQRSHWDL LTLLEGAGPT TQEARAHART TPGGGAAARC RTLSAGARPR
1860 1870 1880 1890 1900
GGGACLQART WSVDLGARGG KVYARCRSRS GSCGGPTTRG RRFSAGSRGR
1910 1920 1930 1940 1950
RGARASQDDW PRDWVALEAC GSACSAPIPP PSLTPSPERG SPQVAWGLPV
1960
HQEIPLNSVV RNLN
Length:1,964
Mass (Da):206,693
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i213B65D11BF489BE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2CG28A2CG28_MOUSE
Neurogenic locus notch homolog prot...
Notch4 RP23-24A13.10-001
1,964Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UX69G3UX69_MOUSE
Neurogenic locus notch homolog prot...
Notch4
978Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UZH3G3UZH3_MOUSE
Neurogenic locus notch homolog prot...
Notch4
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA32281 differs from that shown.Curated
The sequence BAA32283 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA32284 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti43Q → R in AAC52630 (PubMed:8681805).Curated1
Sequence conflicti43Q → R in AAB82004 (PubMed:14656967).Curated1
Sequence conflicti298L → P in AAC52630 (PubMed:8681805).Curated1
Sequence conflicti884M → K in AAC52630 (PubMed:8681805).Curated1
Sequence conflicti884M → K in AAB82004 (PubMed:14656967).Curated1
Sequence conflicti927M → V in AAC52630 (PubMed:8681805).Curated1
Sequence conflicti927M → V in AAB82004 (PubMed:14656967).Curated1
Sequence conflicti966E → D in AAC52630 (PubMed:8681805).Curated1
Sequence conflicti966E → D in AAB82004 (PubMed:14656967).Curated1
Sequence conflicti1245L → P in AAC52630 (PubMed:8681805).Curated1
Sequence conflicti1437P → S in AAB82004 (PubMed:14656967).Curated1
Sequence conflicti1469R → Q in BAA32283 (PubMed:10233982).Curated1
Sequence conflicti1469R → Q in BAA32284 (PubMed:10233982).Curated1
Sequence conflicti1489A → T in AAC52630 (PubMed:8681805).Curated1
Sequence conflicti1489A → T in AAC52631 (PubMed:8681805).Curated1
Sequence conflicti1489A → T in AAB82004 (PubMed:14656967).Curated1
Sequence conflicti1489A → T in BAA32283 (PubMed:10233982).Curated1
Sequence conflicti1489A → T in BAA32284 (PubMed:10233982).Curated1
Sequence conflicti1549S → G in AAC52630 (PubMed:8681805).Curated1
Sequence conflicti1549S → G in AAC52631 (PubMed:8681805).Curated1
Sequence conflicti1549S → G in AAB82004 (PubMed:14656967).Curated1
Sequence conflicti1549S → G in BAA32283 (PubMed:10233982).Curated1
Sequence conflicti1549S → G in BAA32284 (PubMed:10233982).Curated1
Sequence conflicti1549S → G in BAA32285 (PubMed:10233982).Curated1
Sequence conflicti1688S → T in AAC52630 (PubMed:8681805).Curated1
Sequence conflicti1688S → T in AAC52631 (PubMed:8681805).Curated1
Sequence conflicti1688S → T in AAB82004 (PubMed:14656967).Curated1
Sequence conflicti1836A → S in AAC52630 (PubMed:8681805).Curated1
Sequence conflicti1836A → S in AAC52631 (PubMed:8681805).Curated1
Sequence conflicti1838A → P in AAC52630 (PubMed:8681805).Curated1
Sequence conflicti1838A → P in AAC52631 (PubMed:8681805).Curated1
Sequence conflicti1838A → P in AAB82004 (PubMed:14656967).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M80456 mRNA Translation: AAB38377.1
U43691 mRNA Translation: AAC52630.1
U43691 mRNA Translation: AAC52631.1
AF030001 Genomic DNA Translation: AAB82004.1
AB016771 Genomic DNA Translation: BAA32281.1 Sequence problems.
AB016772 mRNA Translation: BAA32283.1 Different initiation.
AB016773 mRNA Translation: BAA32284.1 Different initiation.
AB016774 mRNA Translation: BAA32285.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS28647.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A38072 TVMVT3
T09059

NCBI Reference Sequences

More...
RefSeqi
NP_035059.2, NM_010929.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.173813

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
18132

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:18132

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80456 mRNA Translation: AAB38377.1
U43691 mRNA Translation: AAC52630.1
U43691 mRNA Translation: AAC52631.1
AF030001 Genomic DNA Translation: AAB82004.1
AB016771 Genomic DNA Translation: BAA32281.1 Sequence problems.
AB016772 mRNA Translation: BAA32283.1 Different initiation.
AB016773 mRNA Translation: BAA32284.1 Different initiation.
AB016774 mRNA Translation: BAA32285.1
CCDSiCCDS28647.1
PIRiA38072 TVMVT3
T09059
RefSeqiNP_035059.2, NM_010929.2
UniGeneiMm.173813

3D structure databases

ProteinModelPortaliP31695
SMRiP31695
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201812, 6 interactors
CORUMiP31695
IntActiP31695, 2 interactors
STRINGi10090.ENSMUSP00000015612

PTM databases

iPTMnetiP31695
PhosphoSitePlusiP31695

Proteomic databases

MaxQBiP31695
PaxDbiP31695
PRIDEiP31695

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi18132
KEGGimmu:18132

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4855
MGIiMGI:107471 Notch4

Phylogenomic databases

eggNOGiENOG410IR7G Eukaryota
COG0666 LUCA
HOVERGENiHBG052650
InParanoidiP31695
KOiK20996
PhylomeDBiP31695

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Notch4 mouse

Protein Ontology

More...
PROi
PR:P31695

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

CleanExiMM_NOTCH4

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR008297 Notch
IPR035993 Notch-like_dom_sf
IPR022355 Notch_4
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00008 EGF, 17 hits
PF07645 EGF_CA, 3 hits
PF12661 hEGF, 3 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits
PIRSFiPIRSF002279 Notch, 1 hit
PRINTSiPR01452 LNOTCHREPEAT
PR01987 NOTCH4
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00181 EGF, 28 hits
SM00179 EGF_CA, 21 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 4 hits
SSF90193 SSF90193, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS00010 ASX_HYDROXYL, 11 hits
PS00022 EGF_1, 28 hits
PS01186 EGF_2, 21 hits
PS50026 EGF_3, 27 hits
PS01187 EGF_CA, 9 hits
PS50258 LNR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOTC4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31695
Secondary accession number(s): O35442
, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: December 5, 2018
This is version 185 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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