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UniProtKB - P31695 (NOTC4_MOUSE)

Entry version 204 (25 May 2022)
Sequence version 3 (10 Apr 2019)
Previous versions | rss
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Protein

Neurogenic locus notch homolog protein 4

Gene

Notch4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).

May regulate branching morphogenesis in the developing vascular system.

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, Receptor
Biological processDifferentiation, Notch signaling pathway, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-1912420, Pre-NOTCH Processing in Golgi
R-MMU-350054, Notch-HLH transcription pathway
R-MMU-9013700, NOTCH4 Activation and Transmission of Signal to the Nucleus
R-MMU-9604323, Negative regulation of NOTCH4 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neurogenic locus notch homolog protein 4By similarity
Short name:
Notch 4
Cleaved into the following 3 chains:
Transforming protein Int-3
Notch 4 extracellular truncation
Notch 4 intracellular domain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Notch4Imported
Synonyms:Int-3, Int3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:107471, Notch4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000015468

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 1443ExtracellularSequence analysisAdd BLAST1423
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1444 – 1464HelicalSequence analysisAdd BLAST21
Topological domaini1465 – 1964CytoplasmicSequence analysisAdd BLAST500

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Loss of the extracellular domain causes constitutive activation of the Notch protein, which leads to hyperproliferation of glandular epithelial tissues and development of mammary carcinomas.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1463V → L: NICD processing severely reduced. 1 Publication1

Keywords - Diseasei

Proto-oncogene

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000770421 – 1964Neurogenic locus notch homolog protein 4Add BLAST1944
ChainiPRO_00000077051411 – 1964Transforming protein Int-3Add BLAST554
ChainiPRO_00000077061428 – 1964Notch 4 extracellular truncationAdd BLAST537
ChainiPRO_00000077071463 – 1964Notch 4 intracellular domainAdd BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi25 ↔ 38By similarity
Disulfide bondi32 ↔ 48By similarity
Disulfide bondi50 ↔ 59By similarity
Disulfide bondi65 ↔ 77By similarity
Disulfide bondi71 ↔ 100By similarity
Disulfide bondi102 ↔ 111By similarity
Disulfide bondi119 ↔ 130By similarity
Disulfide bondi124 ↔ 140By similarity
Disulfide bondi142 ↔ 151By similarity
Disulfide bondi157 ↔ 168By similarity
Disulfide bondi162 ↔ 177By similarity
Disulfide bondi179 ↔ 188By similarity
Disulfide bondi195 ↔ 208By similarity
Disulfide bondi202 ↔ 217By similarity
Disulfide bondi219 ↔ 228By similarity
Disulfide bondi235 ↔ 246By similarity
Disulfide bondi240 ↔ 259By similarity
Disulfide bondi261 ↔ 270By similarity
Disulfide bondi277 ↔ 288By similarity
Disulfide bondi282 ↔ 297By similarity
Disulfide bondi299 ↔ 308By similarity
Disulfide bondi315 ↔ 329By similarity
Disulfide bondi323 ↔ 338By similarity
Disulfide bondi340 ↔ 349By similarity
Disulfide bondi356 ↔ 367By similarity
Disulfide bondi361 ↔ 376By similarity
Disulfide bondi378 ↔ 387By similarity
Disulfide bondi393 ↔ 404By similarity
Disulfide bondi398 ↔ 415By similarity
Disulfide bondi417 ↔ 426By similarity
Disulfide bondi433 ↔ 449By similarity
Disulfide bondi443 ↔ 458By similarity
Disulfide bondi460 ↔ 469By similarity
Disulfide bondi476 ↔ 487By similarity
Disulfide bondi481 ↔ 496By similarity
Disulfide bondi498 ↔ 507By similarity
Disulfide bondi514 ↔ 525By similarity
Disulfide bondi519 ↔ 534By similarity
Disulfide bondi536 ↔ 545By similarity
Disulfide bondi552 ↔ 563By similarity
Disulfide bondi557 ↔ 572By similarity
Disulfide bondi574 ↔ 583By similarity
Disulfide bondi590 ↔ 601By similarity
Disulfide bondi595 ↔ 610By similarity
Disulfide bondi612 ↔ 621By similarity
Disulfide bondi626 ↔ 637By similarity
Disulfide bondi631 ↔ 646By similarity
Disulfide bondi648 ↔ 655By similarity
Disulfide bondi662 ↔ 669By similarity
Disulfide bondi664 ↔ 674By similarity
Disulfide bondi676 ↔ 685By similarity
Disulfide bondi692 ↔ 703By similarity
Disulfide bondi697 ↔ 712By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi711N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi714 ↔ 723By similarity
Disulfide bondi730 ↔ 741By similarity
Disulfide bondi735 ↔ 750By similarity
Disulfide bondi752 ↔ 761By similarity
Disulfide bondi768 ↔ 779By similarity
Disulfide bondi773 ↔ 788By similarity
Disulfide bondi790 ↔ 799By similarity
Disulfide bondi807 ↔ 818By similarity
Disulfide bondi812 ↔ 827By similarity
Disulfide bondi829 ↔ 838By similarity
Disulfide bondi845 ↔ 856By similarity
Disulfide bondi850 ↔ 865By similarity
Disulfide bondi867 ↔ 876By similarity
Disulfide bondi882 ↔ 903By similarity
Disulfide bondi897 ↔ 912By similarity
Disulfide bondi914 ↔ 923By similarity
Disulfide bondi930 ↔ 941By similarity
Disulfide bondi935 ↔ 950By similarity
Disulfide bondi952 ↔ 961By similarity
Glycosylationi960N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi968 ↔ 979By similarity
Disulfide bondi973 ↔ 988By similarity
Disulfide bondi990 ↔ 999By similarity
Disulfide bondi1006 ↔ 1019By similarity
Disulfide bondi1011 ↔ 1028By similarity
Disulfide bondi1030 ↔ 1039By similarity
Disulfide bondi1046 ↔ 1057By similarity
Disulfide bondi1051 ↔ 1069By similarity
Disulfide bondi1071 ↔ 1080By similarity
Disulfide bondi1087 ↔ 1098By similarity
Disulfide bondi1092 ↔ 1110By similarity
Disulfide bondi1112 ↔ 1121By similarity
Disulfide bondi1130 ↔ 1142By similarity
Disulfide bondi1136 ↔ 1155By similarity
Glycosylationi1139N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1157 ↔ 1166By similarity
Disulfide bondi1174 ↔ 1187By similarity
Disulfide bondi1183 ↔ 1199By similarity
Disulfide bondi1210 ↔ 1234By similarity
Disulfide bondi1216 ↔ 1229By similarity
Disulfide bondi1225 ↔ 1241By similarity
Disulfide bondi1247 ↔ 1273By similarity
Disulfide bondi1255 ↔ 1268By similarity
Disulfide bondi1264 ↔ 1280By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane.2 Publications
Phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P31695

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P31695

PRoteomics IDEntifications database

More...PRIDEi		P31695

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		293706
338653

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P31695, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P31695

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P31695

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in lung, moderately in heart kidney, and at lower levels in the ovary and skeletal muscle. A very low expression is seen in the brain, intestine, liver and testis.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed in endothelial cells during embryonic development from 9.0 dpc.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000015468, Expressed in lung and 191 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P31695, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds.

Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH4.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		201812, 11 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P31695

Protein interaction database and analysis system

More...IntActi		P31695, 2 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000015612

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P31695, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P31695

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P31695

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 60EGF-like 1PROSITE-ProRule annotationAdd BLAST40
Domaini61 – 112EGF-like 2PROSITE-ProRule annotationAdd BLAST52
Domaini115 – 152EGF-like 3PROSITE-ProRule annotationAdd BLAST38
Domaini153 – 189EGF-like 4PROSITE-ProRule annotationAdd BLAST37
Domaini191 – 229EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini231 – 271EGF-like 6PROSITE-ProRule annotationAdd BLAST41
Domaini273 – 309EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini311 – 350EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini352 – 388EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini389 – 427EGF-like 10PROSITE-ProRule annotationAdd BLAST39
Domaini429 – 470EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini472 – 508EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini510 – 546EGF-like 13; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini548 – 584EGF-like 14; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini586 – 622EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini623 – 656EGF-like 16PROSITE-ProRule annotationAdd BLAST34
Domaini658 – 686EGF-like 17PROSITE-ProRule annotationAdd BLAST29
Domaini688 – 724EGF-like 18PROSITE-ProRule annotationAdd BLAST37
Domaini726 – 762EGF-like 19PROSITE-ProRule annotationAdd BLAST37
Domaini764 – 800EGF-like 20PROSITE-ProRule annotationAdd BLAST37
Domaini803 – 839EGF-like 21PROSITE-ProRule annotationAdd BLAST37
Domaini841 – 877EGF-like 22PROSITE-ProRule annotationAdd BLAST37
Domaini878 – 924EGF-like 23PROSITE-ProRule annotationAdd BLAST47
Domaini926 – 962EGF-like 24PROSITE-ProRule annotationAdd BLAST37
Domaini964 – 1000EGF-like 25PROSITE-ProRule annotationAdd BLAST37
Domaini1002 – 1040EGF-like 26PROSITE-ProRule annotationAdd BLAST39
Domaini1042 – 1081EGF-like 27PROSITE-ProRule annotationAdd BLAST40
Domaini1083 – 1122EGF-like 28PROSITE-ProRule annotationAdd BLAST40
Domaini1126 – 1167EGF-like 29PROSITE-ProRule annotationAdd BLAST42
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1166 – 1209LNR 1Add BLAST44
Repeati1210 – 1241LNR 2Add BLAST32
Repeati1247 – 1287LNR 3Add BLAST41
Repeati1628 – 1657ANK 1Add BLAST30
Repeati1661 – 1691ANK 2Add BLAST31
Repeati1695 – 1724ANK 3Add BLAST30
Repeati1728 – 1757ANK 4Add BLAST30
Repeati1761 – 1790ANK 5Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1345 – 1369DisorderedSequence analysisAdd BLAST25
Regioni1516 – 1535DisorderedSequence analysisAdd BLAST20
Regioni1879 – 1907DisorderedSequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NOTCH family.Curated

Keywords - Domaini

ANK repeat, EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1217, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155030

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000576_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P31695

Identification of Orthologs from Complete Genome Data

More...OMAi		SKEPDAC

Database of Orthologous Groups

More...OrthoDBi		7525at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P31695

TreeFam database of animal gene trees

More...TreeFami		TF351641

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR008297, Notch
IPR035993, Notch-like_dom_sf
IPR022355, Notch_4
IPR000800, Notch_dom
IPR010660, Notch_NOD_dom
IPR011656, Notch_NODP_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 1 hit
PF00008, EGF, 17 hits
PF07645, EGF_CA, 3 hits
PF12661, hEGF, 3 hits
PF06816, NOD, 1 hit
PF07684, NODP, 1 hit
PF00066, Notch, 3 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002279, Notch, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01452, LNOTCHREPEAT
PR01987, NOTCH4

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 6 hits
SM00181, EGF, 28 hits
SM00179, EGF_CA, 21 hits
SM00004, NL, 3 hits
SM01338, NOD, 1 hit
SM01339, NODP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 1 hit
SSF57184, SSF57184, 5 hits
SSF90193, SSF90193, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits
PS00010, ASX_HYDROXYL, 11 hits
PS00022, EGF_1, 28 hits
PS01186, EGF_2, 21 hits
PS50026, EGF_3, 27 hits
PS01187, EGF_CA, 9 hits
PS50258, LNR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P31695-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPQLLLLLL LPLNFPVILT RELLCGGSPE PCANGGTCLR LSRGQGICQC 
        60         70         80         90        100
APGFLGETCQ FPDPCRDTQL CKNGGSCQAL LPTPPSSRSP TSPLTPHFSC 
       110        120        130        140        150
TCPSGFTGDR CQTHLEELCP PSFCSNGGHC YVQASGRPQC SCEPGWTGEQ 
       160        170        180        190        200
CQLRDFCSAN PCANGGVCLA TYPQIQCRCP PGFEGHTCER DINECFLEPG 
       210        220        230        240        250
PCPQGTSCHN TLGSYQCLCP VGQEGPQCKL RKGACPPGSC LNGGTCQLVP 
       260        270        280        290        300
EGHSTFHLCL CPPGFTGLDC EMNPDDCVRH QCQNGATCLD GLDTYTCLCP 
       310        320        330        340        350
KTWKGWDCSE DIDECEARGP PRCRNGGTCQ NTAGSFHCVC VSGWGGAGCE 
       360        370        380        390        400
ENLDDCAAAT CAPGSTCIDR VGSFSCLCPP GRTGLLCHLE DMCLSQPCHV 
       410        420        430        440        450
NAQCSTNPLT GSTLCICQPG YSGSTCHQDL DECQMAQQGP SPCEHGGSCI 
       460        470        480        490        500
NTPGSFNCLC LPGYTGSRCE ADHNECLSQP CHPGSTCLDL LATFHCLCPP 
       510        520        530        540        550
GLEGRLCEVE VNECTSNPCL NQAACHDLLN GFQCLCLPGF TGARCEKDMD 
       560        570        580        590        600
ECSSTPCANG GRCRDQPGAF YCECLPGFEG PHCEKEVDEC LSDPCPVGAS 
       610        620        630        640        650
CLDLPGAFFC LCRPGFTGQL CEVPLCTPNM CQPGQQCQGQ EHRAPCLCPD 
       660        670        680        690        700
GSPGCVPAED NCPCHHGHCQ RSLCVCDEGW TGPECETELG GCISTPCAHG 
       710        720        730        740        750
GTCHPQPSGY NCTCPAGYMG LTCSEEVTAC HSGPCLNGGS CSIRPEGYSC 
       760        770        780        790        800
TCLPSHTGRH CQTAVDHCVS ASCLNGGTCV NKPGTFFCLC ATGFQGLHCE 
       810        820        830        840        850
EKTNPSCADS PCRNKATCQD TPRGARCLCS PGYTGSSCQT LIDLCARKPC 
       860        870        880        890        900
PHTARCLQSG PSFQCLCLQG WTGALCDFPL SCQKAAMSQG IEISGLCQNG 
       910        920        930        940        950
GLCIDTGSSY FCRCPPGFQG KLCQDNVNPC EPNPCHHGST CVPQPSGYVC 
       960        970        980        990       1000
QCAPGYEGQN CSKVLDACQS QPCHNHGTCT SRPGGFHCAC PPGFVGLRCE 
      1010       1020       1030       1040       1050
GDVDECLDRP CHPSGTAACH SLANAFYCQC LPGHTGQRCE VEMDLCQSQP 
      1060       1070       1080       1090       1100
CSNGGSCEIT TGPPPGFTCH CPKGFEGPTC SHKALSCGIH HCHNGGLCLP 
      1110       1120       1130       1140       1150
SPKPGSPPLC ACLSGFGGPD CLTPPAPPGC GPPSPCLHNG TCTETPGLGN 
      1160       1170       1180       1190       1200
PGFQCTCPPD SPGPRCQRPG ASGCEGRGGD GTCDAGCSGP GGDWDGGDCS 
      1210       1220       1230       1240       1250
LGVPDPWKGC PPHSQCWLLF RDGRCHPQCD SEECLFDGYD CEIPLTCIPA 
      1260       1270       1280       1290       1300
YDQYCRDHFH NGHCEKGCNN AECGWDGGDC RPEGEDSEGR PSLALLVVLR 
      1310       1320       1330       1340       1350
PPALDQQLLA LARVLSLTLR VGLWVRKDSE GRNMVFPYPG TRAKEELSGA 
      1360       1370       1380       1390       1400
RDSSSWERQA PPTQPLGKET ESLGAGFVVV MGVDLSRCGP EHPASRCPWD 
      1410       1420       1430       1440       1450
SGLLLRFLAA MAAVGALEPL LPGPLLAAHP QAGTRPSANQ LPWPILCSPV 
      1460       1470       1480       1490       1500
VGVLLLALGA LLVLQLIRRR RREHGALWLP PGFIRRPQTQ QAPHRRRPPL 
      1510       1520       1530       1540       1550
GEDNIGLKAL KPEAEVDEDG VAMCSGPEEG EAEETASASR CQLWPLNSGC 
      1560       1570       1580       1590       1600
GELPQAAMLT PPQECESEVL DVDTCGPDGV TPLMSAVFCG GVQSTTGASP 
      1610       1620       1630       1640       1650
QRLGLGNLEP WEPLLDRGAC PQAHTVGTGE TPLHLAARFS RPTAARRLLE 
      1660       1670       1680       1690       1700
AGANPNQPDR AGRTPLHTAV AADAREVCQL LLASRQTTVD ARTEDGTTPL 
      1710       1720       1730       1740       1750
MLAARLAVED LVEELIAARA DVGARDKRGK TALHWAAAVN NARAARSLLQ 
      1760       1770       1780       1790       1800
AGADKDAQDS REQTPLFLAA REGAVEVAQL LLELGAARGL RDQAGLAPGD 
      1810       1820       1830       1840       1850
VARQRSHWDL LTLLEGAGPT TQEARAHART TPGGGAAPRC RTLSAGARPR 
      1860       1870       1880       1890       1900
GGGACLQART WSVDLGARGG KVYARCRSRS GSCGGPTTRG RRFSAGSRGR 
      1910       1920       1930       1940       1950
RGARASQDDW PRDWVALEAC GSACSAPIPP PSLTPSPERG SPQVAWGLPV 
      1960 
HQEIPLNSVV RNLN
Length:1,964
Mass (Da):206,702
Last modified:April 10, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i53D7F86394FC40BD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UX69G3UX69_MOUSE
Neurogenic locus notch homolog prot...
Notch4
978Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UZH3G3UZH3_MOUSE
Neurogenic locus notch homolog prot...
Notch4
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA32281 differs from that shown. Contaminating sequence. Sequence of unknown origin.Curated
The sequence BAA32283 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAA32284 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAA32285 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti43R → Q in AAB38377 (PubMed:1312643).Curated1
Sequence conflicti298L → P in AAC52630 (PubMed:8681805).Curated1
Sequence conflicti884K → M in AAB38377 (PubMed:1312643).Curated1
Sequence conflicti927V → M in AAB38377 (PubMed:1312643).Curated1
Sequence conflicti966D → E in AAB38377 (PubMed:1312643).Curated1
Sequence conflicti1245L → P in AAC52630 (PubMed:8681805).Curated1
Sequence conflicti1437S → P in AAC52631 (PubMed:8681805).Curated1
Sequence conflicti1437S → P in AAC52630 (PubMed:8681805).Curated1
Sequence conflicti1437S → P in AAB38377 (PubMed:1312643).Curated1
Sequence conflicti1469R → Q in BAA32283 (PubMed:10233982).Curated1
Sequence conflicti1469R → Q in BAA32284 (PubMed:10233982).Curated1
Sequence conflicti1489T → A in AAB38377 (PubMed:1312643).Curated1
Sequence conflicti1549G → S in AAB38377 (PubMed:1312643).Curated1
Sequence conflicti1688T → S in AAB38377 (PubMed:1312643).Curated1
Sequence conflicti1836A → S in AAC52630 (PubMed:8681805).Curated1
Sequence conflicti1836A → S in AAC52631 (PubMed:8681805).Curated1
Sequence conflicti1838P → A in AAB38377 (PubMed:1312643).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M80456 mRNA Translation: AAB38377.1
U43691 mRNA Translation: AAC52630.1
U43691 mRNA Translation: AAC52631.1
AF030001 Genomic DNA Translation: AAB82004.1
CT009767 Genomic DNA Translation: CAM18615.1
AB016771 Genomic DNA Translation: BAA32281.1 Sequence problems.
AB016772 mRNA Translation: BAA32283.1 Different initiation.
AB016773 mRNA Translation: BAA32284.1 Different initiation.
AB016774 mRNA Translation: BAA32285.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS28647.1

Protein sequence database of the Protein Information Resource

More...PIRi		A38072, TVMVT3
T09059

NCBI Reference Sequences

More...RefSeqi		NP_035059.2, NM_010929.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000015612; ENSMUSP00000015612; ENSMUSG00000015468

Database of genes from NCBI RefSeq genomes

More...GeneIDi		18132

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:18132

UCSC genome browser

More...UCSCi		uc008ccs.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80456 mRNA Translation: AAB38377.1
U43691 mRNA Translation: AAC52630.1
U43691 mRNA Translation: AAC52631.1
AF030001 Genomic DNA Translation: AAB82004.1
CT009767 Genomic DNA Translation: CAM18615.1
AB016771 Genomic DNA Translation: BAA32281.1 Sequence problems.
AB016772 mRNA Translation: BAA32283.1 Different initiation.
AB016773 mRNA Translation: BAA32284.1 Different initiation.
AB016774 mRNA Translation: BAA32285.1 Different initiation.
CCDSiCCDS28647.1
PIRiA38072, TVMVT3
T09059
RefSeqiNP_035059.2, NM_010929.2

3D structure databases

AlphaFoldDBiP31695
SMRiP31695
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi201812, 11 interactors
CORUMiP31695
IntActiP31695, 2 interactors
STRINGi10090.ENSMUSP00000015612

PTM databases

GlyGeniP31695, 3 sites
iPTMnetiP31695
PhosphoSitePlusiP31695

Proteomic databases

MaxQBiP31695
PaxDbiP31695
PRIDEiP31695
ProteomicsDBi293706
338653

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		18132

Genome annotation databases

EnsembliENSMUST00000015612; ENSMUSP00000015612; ENSMUSG00000015468
GeneIDi18132
KEGGimmu:18132
UCSCiuc008ccs.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4855
MGIiMGI:107471, Notch4
VEuPathDBiHostDB:ENSMUSG00000015468

Phylogenomic databases

eggNOGiKOG1217, Eukaryota
GeneTreeiENSGT00940000155030
HOGENOMiCLU_000576_0_0_1
InParanoidiP31695
OMAiSKEPDAC
OrthoDBi7525at2759
PhylomeDBiP31695
TreeFamiTF351641

Enzyme and pathway databases

ReactomeiR-MMU-1912420, Pre-NOTCH Processing in Golgi
R-MMU-350054, Notch-HLH transcription pathway
R-MMU-9013700, NOTCH4 Activation and Transmission of Signal to the Nucleus
R-MMU-9604323, Negative regulation of NOTCH4 signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		18132, 3 hits in 72 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Notch4, mouse

Protein Ontology

More...PROi		PR:P31695
RNActiP31695, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000015468, Expressed in lung and 191 other tissues
ExpressionAtlasiP31695, baseline and differential

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR008297, Notch
IPR035993, Notch-like_dom_sf
IPR022355, Notch_4
IPR000800, Notch_dom
IPR010660, Notch_NOD_dom
IPR011656, Notch_NODP_dom
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 1 hit
PF00008, EGF, 17 hits
PF07645, EGF_CA, 3 hits
PF12661, hEGF, 3 hits
PF06816, NOD, 1 hit
PF07684, NODP, 1 hit
PF00066, Notch, 3 hits
PIRSFiPIRSF002279, Notch, 1 hit
PRINTSiPR01452, LNOTCHREPEAT
PR01987, NOTCH4
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SM00181, EGF, 28 hits
SM00179, EGF_CA, 21 hits
SM00004, NL, 3 hits
SM01338, NOD, 1 hit
SM01339, NODP, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF57184, SSF57184, 5 hits
SSF90193, SSF90193, 2 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits
PS00010, ASX_HYDROXYL, 11 hits
PS00022, EGF_1, 28 hits
PS01186, EGF_2, 21 hits
PS50026, EGF_3, 27 hits
PS01187, EGF_CA, 9 hits
PS50258, LNR, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOTC4_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31695
Secondary accession number(s): A2CG28
, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: April 10, 2019
Last modified: May 25, 2022
This is version 204 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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