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UniProtKB - P31680 (DJLA_ECOLI)
Protein
Co-chaperone protein DjlA
Gene
djlA
Organism
Escherichia coli (strain K12)
Status
Functioni
Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.
UniRule annotation3 PublicationsGO - Molecular functioni
- chaperone binding Source: EcoCyc
Keywordsi
Molecular function | Chaperone |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11570-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Co-chaperone protein DjlAUniRule annotationCuratedAlternative name(s): DnaJ-like protein DjlACurated |
Gene namesi | Name:djlA1 PublicationUniRule annotation Synonyms:yabH Ordered Locus Names:b0055, JW0054 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane UniRule annotation3 Publications; Single-pass type III membrane protein UniRule annotation3 Publications
Plasma Membrane
- plasma membrane Source: EcoCyc
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 6 | PeriplasmicUniRule annotation2 Publications | 6 | |
Transmembranei | 7 – 31 | HelicalUniRule annotationAdd BLAST | 25 | |
Topological domaini | 32 – 271 | CytoplasmicUniRule annotation2 PublicationsAdd BLAST | 240 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 15 | L → R: Loss of activation of rcs. 1 Publication | 1 | |
Mutagenesisi | 16 | M → R: Only partial activation of rcs. 1 Publication | 1 | |
Mutagenesisi | 233 | H → Q: Loss of activity. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000209424 | 1 – 271 | Co-chaperone protein DjlAAdd BLAST | 271 |
Proteomic databases
jPOSTi | P31680 |
PaxDbi | P31680 |
PRIDEi | P31680 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotation1 PublicationGO - Molecular functioni
- chaperone binding Source: EcoCyc
Protein-protein interaction databases
BioGRIDi | 4261616, 19 interactors |
IntActi | P31680, 7 interactors |
STRINGi | 511145.b0055 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 205 – 271 | JUniRule annotationAdd BLAST | 67 |
Domaini
The transmembrane domain is a dimerization domain.UniRule annotation1 Publication
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG1076, Bacteria |
HOGENOMi | CLU_066221_1_0_6 |
InParanoidi | P31680 |
PhylomeDBi | P31680 |
Family and domain databases
CDDi | cd06257, DnaJ, 1 hit |
Gene3Di | 1.10.287.110, 1 hit 1.10.3680.10, 1 hit |
HAMAPi | MF_01153, DjlA, 1 hit |
InterProi | View protein in InterPro IPR023749, DjlA IPR007791, DjlA_N IPR001623, DnaJ_domain IPR036869, J_dom_sf IPR029024, TerB-like |
Pfami | View protein in Pfam PF00226, DnaJ, 1 hit PF05099, TerB, 1 hit |
PRINTSi | PR00625, JDOMAIN |
SMARTi | View protein in SMART SM00271, DnaJ, 1 hit |
SUPFAMi | SSF46565, SSF46565, 1 hit |
PROSITEi | View protein in PROSITE PS50076, DNAJ_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P31680-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQYWGKIIGV AVALLMGGGF WGVVLGLLIG HMFDKARSRK MAWFANQRER
60 70 80 90 100
QALFFATTFE VMGHLTKSKG RVTEADIHIA SQLMDRMNLH GASRTAAQNA
110 120 130 140 150
FRVGKSDNYP LREKMRQFRS VCFGRFDLIR MFLEIQIQAA FADGSLHPNE
160 170 180 190 200
RAVLYVIAEE LGISRAQFDQ FLRMMQGGAQ FGGGYQQQTG GGNWQQAQRG
210 220 230 240 250
PTLEDACNVL GVKPTDDATT IKRAYRKLMS EHHPDKLVAK GLPPEMMEMA
260 270
KQKAQEIQQA YELIKQQKGF K
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 195 | Q → L in AAT42473 (PubMed:12664169).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC73166.1 AP009048 Genomic DNA Translation: BAB96623.1 AY625119 Genomic DNA Translation: AAT42473.1 |
PIRi | G64726 |
RefSeqi | NP_414597.1, NC_000913.3 WP_001200579.1, NZ_STEB01000010.1 |
Genome annotation databases
EnsemblBacteriai | AAC73166; AAC73166; b0055 BAB96623; BAB96623; BAB96623 |
GeneIDi | 66671655 948992 |
KEGGi | ecj:JW0054 eco:b0055 |
PATRICi | fig|1411691.4.peg.2228 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC73166.1 AP009048 Genomic DNA Translation: BAB96623.1 AY625119 Genomic DNA Translation: AAT42473.1 |
PIRi | G64726 |
RefSeqi | NP_414597.1, NC_000913.3 WP_001200579.1, NZ_STEB01000010.1 |
3D structure databases
SMRi | P31680 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261616, 19 interactors |
IntActi | P31680, 7 interactors |
STRINGi | 511145.b0055 |
Proteomic databases
jPOSTi | P31680 |
PaxDbi | P31680 |
PRIDEi | P31680 |
Genome annotation databases
EnsemblBacteriai | AAC73166; AAC73166; b0055 BAB96623; BAB96623; BAB96623 |
GeneIDi | 66671655 948992 |
KEGGi | ecj:JW0054 eco:b0055 |
PATRICi | fig|1411691.4.peg.2228 |
Organism-specific databases
EchoBASEi | EB1530 |
Phylogenomic databases
eggNOGi | COG1076, Bacteria |
HOGENOMi | CLU_066221_1_0_6 |
InParanoidi | P31680 |
PhylomeDBi | P31680 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11570-MONOMER |
Miscellaneous databases
PROi | PR:P31680 |
Family and domain databases
CDDi | cd06257, DnaJ, 1 hit |
Gene3Di | 1.10.287.110, 1 hit 1.10.3680.10, 1 hit |
HAMAPi | MF_01153, DjlA, 1 hit |
InterProi | View protein in InterPro IPR023749, DjlA IPR007791, DjlA_N IPR001623, DnaJ_domain IPR036869, J_dom_sf IPR029024, TerB-like |
Pfami | View protein in Pfam PF00226, DnaJ, 1 hit PF05099, TerB, 1 hit |
PRINTSi | PR00625, JDOMAIN |
SMARTi | View protein in SMART SM00271, DnaJ, 1 hit |
SUPFAMi | SSF46565, SSF46565, 1 hit |
PROSITEi | View protein in PROSITE PS50076, DNAJ_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DJLA_ECOLI | |
Accessioni | P31680Primary (citable) accession number: P31680 Secondary accession number(s): Q6IU30 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | February 23, 2022 | |
This is version 162 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |