UniProtKB - P31654 (DUHM_BPSP1)
Protein
Deoxyuridylate hydroxymethyltransferase
Gene
29
Organism
Bacillus phage SP01 (Bacteriophage SP01)
Status
Functioni
Catalyzes formation of 5-hydroxymethyldeoxyuridylate (HMdUMP) to replace dTMP in the phage genome. These modified residues allow the virus to circumvent DNA-based antiviral defenses.3 Publications
Catalytic activityi
- (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 162 | Sequence analysis | 1 |
GO - Molecular functioni
- hydroxymethyl-, formyl- and related transferase activity Source: CACAO
Keywordsi
Molecular function | Transferase |
Names & Taxonomyi
Protein namesi | Recommended name: Deoxyuridylate hydroxymethyltransferase (EC:2.1.2.-)Short name: Deoxyuridylate hydroxymethylase Alternative name(s): dUMP hydroxymethylase Short name: dUMP-HMase |
Gene namesi | Name:29 |
Organismi | Bacillus phage SP01 (Bacteriophage SP01) |
Taxonomic identifieri | 10685 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Uroviricota › Caudoviricetes › Caudovirales › Herelleviridae › Spounavirinae › Okubovirus |
Virus hosti | Bacillus subtilis [TaxID: 1423] |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000141070 | 1 – 383 | Deoxyuridylate hydroxymethyltransferaseAdd BLAST | 383 |
Interactioni
Subunit structurei
Homodimer.
1 PublicationFamily & Domainsi
Sequence similaritiesi
Belongs to the thymidylate synthase family.Curated
Family and domain databases
Gene3Di | 3.30.572.10, 1 hit |
InterProi | View protein in InterPro IPR023451, Thymidate_synth/dCMP_Mease IPR036926, Thymidate_synth/dCMP_Mease_sf |
Pfami | View protein in Pfam PF00303, Thymidylat_synt, 1 hit |
SUPFAMi | SSF55831, SSF55831, 1 hit |
i Sequence
Sequence statusi: Complete.
P31654-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYTFSGSKPT QLYMDILSTV IKEGDVLAPR GKRIKEIRPV MIEFKNPIRR
60 70 80 90 100
TTFLKGRNIN PFFQVAESLW ILAGRSDVGF LLDYNKNMGQ FSDDGVFFNA
110 120 130 140 150
PYGERLRFWN RSDANNFIYN PLDQLRDVYE KIKADPDTRQ AVAVIYNPLF
160 170 180 190 200
DNINNDTKDR PCNLLLSFKL RNGKLDLSVY NRSNDLHWGT FGANLCQFST
210 220 230 240 250
ILEAMATWLG VEVGSYYQIT DSLHVYLDDY GAKITEDIQK VYGVNLETDE
260 270 280 290 300
APVVEDFEEL LDPNPRMSYT MNELNQFLNE YFGIVDSLMR DDETYMHDGD
310 320 330 340 350
CAQMLLNQIR HEPDEYIKVT LLLMVAKQAL NRGMKDTVAT AMNWIPLCEI
360 370 380
KVSALRFLYK SYPEYINQYD LDEKLMKYIR REE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X60728 Genomic DNA Translation: CAA43136.1 |
PIRi | A42992, SZBPSP |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X60728 Genomic DNA Translation: CAA43136.1 |
PIRi | A42992, SZBPSP |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family and domain databases
Gene3Di | 3.30.572.10, 1 hit |
InterProi | View protein in InterPro IPR023451, Thymidate_synth/dCMP_Mease IPR036926, Thymidate_synth/dCMP_Mease_sf |
Pfami | View protein in Pfam PF00303, Thymidylat_synt, 1 hit |
SUPFAMi | SSF55831, SSF55831, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DUHM_BPSP1 | |
Accessioni | P31654Primary (citable) accession number: P31654 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | December 2, 2020 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |